propionic acid has been researched along with Alzheimer Disease in 4 studies
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings show that intracerebroventricular injection of streptozotocin accelerated cognitive dysfunction associated with increasing levels of glycogen synthase kinase 3 beta (GSK3β) activity, tau protein phosphorylation at the T231 site (pT231), amyloid-β (Aβ) deposition, amyloid-β protein precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, fecal propionic acid (PPA) levels and cognition-related neuronal loss and decreasing postsynaptic density protein 95 (PSD95) levels in 3 × Tg-AD mice." | 8.02 | Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. ( Chen, JL; Chen, YH; Chieu, MW; Hsieh-Li, HM; Hsu, CC; Huang, HJ; Ke, YY; Liao, JF; Tsai, YC, 2021) |
| "Our findings show that intracerebroventricular injection of streptozotocin accelerated cognitive dysfunction associated with increasing levels of glycogen synthase kinase 3 beta (GSK3β) activity, tau protein phosphorylation at the T231 site (pT231), amyloid-β (Aβ) deposition, amyloid-β protein precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, fecal propionic acid (PPA) levels and cognition-related neuronal loss and decreasing postsynaptic density protein 95 (PSD95) levels in 3 × Tg-AD mice." | 4.02 | Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. ( Chen, JL; Chen, YH; Chieu, MW; Hsieh-Li, HM; Hsu, CC; Huang, HJ; Ke, YY; Liao, JF; Tsai, YC, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, HJ | 1 |
| Chen, JL | 1 |
| Liao, JF | 1 |
| Chen, YH | 1 |
| Chieu, MW | 1 |
| Ke, YY | 1 |
| Hsu, CC | 1 |
| Tsai, YC | 1 |
| Hsieh-Li, HM | 1 |
| Tan, FHP | 1 |
| Ting, ACJ | 1 |
| Najimudin, N | 1 |
| Watanabe, N | 1 |
| Shamsuddin, S | 1 |
| Zainuddin, A | 1 |
| Osada, H | 1 |
| Azzam, G | 1 |
| Ciccone, L | 1 |
| Nencetti, S | 1 |
| Tonali, N | 1 |
| Fruchart-Gaillard, C | 1 |
| Shepard, W | 1 |
| Nuti, E | 1 |
| Camodeca, C | 1 |
| Rossello, A | 1 |
| Orlandini, E | 1 |
| Brady, SF | 1 |
| Singh, S | 1 |
| Crouthamel, MC | 1 |
| Holloway, MK | 1 |
| Coburn, CA | 1 |
| Garsky, VM | 1 |
| Bogusky, M | 1 |
| Pennington, MW | 1 |
| Vacca, JP | 1 |
| Hazuda, D | 1 |
| Lai, MT | 1 |
4 other studies available for propionic acid and Alzheimer Disease
| Article | Year |
|---|---|
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Disease Models, Animal; Gliosis; Glycogen Synthas | 2021 |
3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer's Disease Drosophila.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Drosophila; Peptide Fragments; Propionates; Tetra | 2023 |
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.
Topics: Alzheimer Disease; Binding Sites; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Confo | 2020 |
Rational design and synthesis of selective BACE-1 inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cathepsin D; | 2004 |