propidium has been researched along with Parkinson Disease in 3 studies
Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A combination of Annexin V binding and propidium iodide (PI) exclusion was used to distinguish apoptosis from necrosis in flow cytometry experiments and FACS profiles of permeabilised PI-labelled cells were employed for the assessment of cell cycle distribution." | 7.73 | Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. ( Glover, V; Igosheva, N; Lorz, C; Mehmet, H; O'Conner, E, 2005) |
| " A combination of Annexin V binding and propidium iodide (PI) exclusion was used to distinguish apoptosis from necrosis in flow cytometry experiments and FACS profiles of permeabilised PI-labelled cells were employed for the assessment of cell cycle distribution." | 3.73 | Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. ( Glover, V; Igosheva, N; Lorz, C; Mehmet, H; O'Conner, E, 2005) |
| "The cause of dopaminergic cell death in Parkinson's disease (PD) remains unknown, but may involve oxidative stress and mitochondrial complex I deficiency." | 1.30 | Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. ( Cooper, JM; Schapira, AH; Seaton, TA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moldzio, R | 1 |
| Piskernik, C | 1 |
| Radad, K | 1 |
| Rausch, WD | 1 |
| Igosheva, N | 1 |
| Lorz, C | 1 |
| O'Conner, E | 1 |
| Glover, V | 1 |
| Mehmet, H | 1 |
| Seaton, TA | 1 |
| Cooper, JM | 1 |
| Schapira, AH | 1 |
3 other studies available for propidium and Parkinson Disease
| Article | Year |
|---|---|
Rotenone damages striatal organotypic slice culture.
Topics: Animals; Corpus Striatum; Indicators and Reagents; Insecticides; L-Lactate Dehydrogenase; Mice; Mice | 2008 |
Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells.
Topics: Annexin A5; Antiparkinson Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Membrane Permeabilit | 2005 |
Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Coloring Agents; Cyclosporine; Dopamine Agents; Enz | 1998 |