propentofylline has been researched along with Spinal Cord Injuries in 4 studies
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intrathecal treatment with propentofylline (PPF, 10 mM) for 7 consecutive days immediately after spinal injury attenuated the development of mechanical allodynia and thermal hyperalgesia in both hind limbs in a dose-related reduction compared to vehicle treatments (* P<0." | 3.75 | Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. ( Gwak, YS; Hulsebosch, CE, 2009) |
| "In the present study, we examined whether activation of p-38alpha MAPK modulates mechanical allodynia and neuronal hyperexcitability, and if propentofylline (PPF, a glial modulator) modulates specifically localized activated p-38alpha MAPK expression in caudal regions remote from a low thoracic hemisection injury in rats." | 3.75 | Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. ( Gwak, YS; Hulsebosch, CE; Unabia, GC, 2009) |
| "We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a rodent model of neuropathy." | 3.74 | Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. ( DeLeo, JA; Haenggeli, C; Lacroix-Fralish, ML; Nutile-McMenemy, N; Perez, N; Regan, MR; Rothstein, JD; Tawfik, VL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwak, YS | 3 |
| Hulsebosch, CE | 3 |
| Unabia, GC | 2 |
| Crown, ED | 1 |
| Tawfik, VL | 1 |
| Regan, MR | 1 |
| Haenggeli, C | 1 |
| Lacroix-Fralish, ML | 1 |
| Nutile-McMenemy, N | 1 |
| Perez, N | 1 |
| Rothstein, JD | 1 |
| DeLeo, JA | 1 |
4 other studies available for propentofylline and Spinal Cord Injuries
| Article | Year |
|---|---|
Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat.
Topics: Action Potentials; Animals; Astrocytes; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Pr | 2009 |
Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Enzyme Activation; Gliosis; Hyperalgesia; Male; Microgl | 2009 |
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat.
Topics: Animals; gamma-Aminobutyric Acid; Male; Neuroglia; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord Inj | 2008 |
Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection.
Topics: Animals; Astrocytes; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Gene | 2008 |