Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3
Glioma treatment remains a challenge with a low survival rate due to the lack of effective therapeutics. Monoamine oxidase A (MAO A) plays a role in glioma development, and MAO A inhibitors reduce glioma growth. Histone deacetylase (HDAC) inhibition has emerged as a promising therapy for various malignancies including gliomas. We have synthesized and evaluated Topics: Acetylation; Animals; Cell Line, Tumor; Cell Proliferation; Drug Design; Enzyme Inhibitors; Glioma; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Isoenzymes; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Pargyline; Propylamines; Structure-Activity Relationship; Transplantation, Heterologous | 2022 |