Page last updated: 2024-11-03

propanil and Methemoglobinemia

propanil has been researched along with Methemoglobinemia in 9 studies

Propanil: A chlorinated anilide that is used as an herbicide.
propanil : An anilide resulting from the formal condensation of the carboxy group of propanoic acid with the amino group of 3,4-dichloroaniline. It is a herbicide used for the treatment of numerous grasses and broad-leaved weeds in rice, potatoes, and wheat.

Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"In 2008, self-poisoning with the herbicide propanil had a case-fatality of around 11% in Sri Lanka."7.83A bedside test for methaemoglobinemia improved antidote use in propanil poisoning. ( Buckley, NA; Dawson, AH; Dissanayake, D; Dobbins, T; Shihana, F, 2016)
"Propanil is an important cause of death from acute pesticide poisoning, of which methaemoglobinaemia is an important manifestation."7.75Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series. ( Buckley, NA; Dawson, AH; Eddleston, M; Eyer, P; Fahim, M; Heilmair, R; Roberts, DM, 2009)
"Methemoglobinemia produced by exposure to the herbicide propanil (3,4-dichloropropionanilide) is thought to be mediated by toxic metabolites formed during the hepatic clearance of the parent compound."7.68Metabolism of the arylamide herbicide propanil. I. Microsomal metabolism and in vitro methemoglobinemia. ( Freeman, JP; Hinson, JA; McMillan, DC, 1990)
" Commonest causes of hospitalization were intoxication by the carbamate pesticide methomyl [1-(methylthio)ethylideneamino methyl carbamate], a reversible cholinesterase inhibitor, and methemoglobinemia following exposure to 3,4-dichloroaniline."7.66Propanil-chloracne and methomyl toxicity in workers of a pesticide manufacturing plant. ( Baker, EL; Kimbrough, RD; Morse, DL; Wisseman, CL, 1979)
"In 2008, self-poisoning with the herbicide propanil had a case-fatality of around 11% in Sri Lanka."3.83A bedside test for methaemoglobinemia improved antidote use in propanil poisoning. ( Buckley, NA; Dawson, AH; Dissanayake, D; Dobbins, T; Shihana, F, 2016)
"Propanil is an important cause of death from acute pesticide poisoning, of which methaemoglobinaemia is an important manifestation."3.75Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series. ( Buckley, NA; Dawson, AH; Eddleston, M; Eyer, P; Fahim, M; Heilmair, R; Roberts, DM, 2009)
" Commonest causes of hospitalization were intoxication by the carbamate pesticide methomyl [1-(methylthio)ethylideneamino methyl carbamate], a reversible cholinesterase inhibitor, and methemoglobinemia following exposure to 3,4-dichloroaniline."3.66Propanil-chloracne and methomyl toxicity in workers of a pesticide manufacturing plant. ( Baker, EL; Kimbrough, RD; Morse, DL; Wisseman, CL, 1979)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's4 (44.44)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shihana, F2
Dawson, AH2
Dobbins, T1
Dissanayake, D1
Buckley, NA3
Hulse, E1
Roberts, DM1
Heilmair, R1
Fahim, M1
Eddleston, M1
Eyer, P1
De Silva, WA1
Bodinayake, CK1
Morse, DL1
Baker, EL1
Kimbrough, RD1
Wisseman, CL1
McMillan, DC3
Bradshaw, TP1
Hinson, JA3
Jollow, DJ1
McRae, TA1
Freeman, JP1
Singleton, SD1
Murphy, SD1

Other Studies

9 other studies available for propanil and Methemoglobinemia

ArticleYear
A bedside test for methaemoglobinemia improved antidote use in propanil poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:7

    Topics: Adult; Antidotes; Ascorbic Acid; Dose-Response Relationship, Drug; Female; Herbicides; Hospitalizati

2016
Methemoglobin measurements are underestimated by the Radical 7 co-oximeter: experience from a series of moderate to severe propanil poisonings.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:9

    Topics: Herbicides; Humans; Methemoglobin; Methemoglobinemia; Methylene Blue; Oximetry; Propanil; Prospectiv

2016
Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series.
    BMC clinical pharmacology, 2009, Feb-16, Volume: 9

    Topics: Adolescent; Adult; Aniline Compounds; Exchange Transfusion, Whole Blood; Female; Herbicides; Humans;

2009
Propanil poisoning.
    The Ceylon medical journal, 1997, Volume: 42, Issue:2

    Topics: Adult; Antidotes; Exchange Transfusion, Whole Blood; Herbicides; Humans; Male; Methemoglobinemia; Me

1997
Propanil-chloracne and methomyl toxicity in workers of a pesticide manufacturing plant.
    Clinical toxicology, 1979, Volume: 15, Issue:1

    Topics: Acne Vulgaris; Adult; Anilides; Animals; Dermatitis, Occupational; Female; Humans; Insecticides; Mal

1979
Role of metabolites in propanil-induced hemolytic anemia.
    Toxicology and applied pharmacology, 1991, Volume: 110, Issue:1

    Topics: Anemia, Hemolytic; Aniline Compounds; Animals; Chromium Radioisotopes; Environmental Exposure; Eryth

1991
Propanil-induced methemoglobinemia and hemoglobin binding in the rat.
    Toxicology and applied pharmacology, 1990, Sep-15, Volume: 105, Issue:3

    Topics: Animals; Carbon Radioisotopes; Hemoglobins; Male; Methemoglobin; Methemoglobinemia; Propanil; Protei

1990
Metabolism of the arylamide herbicide propanil. I. Microsomal metabolism and in vitro methemoglobinemia.
    Toxicology and applied pharmacology, 1990, Mar-15, Volume: 103, Issue:1

    Topics: Anilides; Animals; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Methemoglobin; Met

1990
Propanil (3,4-dichloropropionanilide)-induced methemoglobin formation in mice in relation to acylamidase activity.
    Toxicology and applied pharmacology, 1973, Volume: 25, Issue:1

    Topics: Amidohydrolases; Anilides; Aniline Compounds; Animals; Cresols; Cyanosis; Dose-Response Relationship

1973