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propafenone and Uremia

propafenone has been researched along with Uremia in 2 studies

Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

ExcerptRelevanceReference
"In sera from patients with chronic renal failure the increase in propafenone binding ratio or the decrease in unbound fraction was associated with the increase in alpha 1-acid glycoprotein concentrations, and there was a correlation (r = 0."1.28In vitro protein binding of propafenone in normal and uraemic human sera. ( Axelson, JE; Chan, GL; Kerr, CR; McErlane, KM; Price, JD, 1989)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Poirier, JM1
Joannides, R1
Geffroy-Josse, S1
Fillastre, JP1
Etienne, I1
Chan, GL1
Axelson, JE1
Price, JD1
McErlane, KM1
Kerr, CR1

Other Studies

2 other studies available for propafenone and Uremia

ArticleYear
Propafenone pharmacokinetics in uremic patients treated by peritoneal dialysis.
    Clinical nephrology, 1992, Volume: 38, Issue:4

    Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Kidney Failure, Chronic; Middle Aged; Peritoneal Dialysi

1992
In vitro protein binding of propafenone in normal and uraemic human sera.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:5

    Topics: Adult; Blood Proteins; Dialysis; Humans; Kidney Failure, Chronic; Male; Orosomucoid; Propafenone; Pr

1989