propafenone has been researched along with Uremia in 2 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In sera from patients with chronic renal failure the increase in propafenone binding ratio or the decrease in unbound fraction was associated with the increase in alpha 1-acid glycoprotein concentrations, and there was a correlation (r = 0." | 1.28 | In vitro protein binding of propafenone in normal and uraemic human sera. ( Axelson, JE; Chan, GL; Kerr, CR; McErlane, KM; Price, JD, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poirier, JM | 1 |
| Joannides, R | 1 |
| Geffroy-Josse, S | 1 |
| Fillastre, JP | 1 |
| Etienne, I | 1 |
| Chan, GL | 1 |
| Axelson, JE | 1 |
| Price, JD | 1 |
| McErlane, KM | 1 |
| Kerr, CR | 1 |
2 other studies available for propafenone and Uremia
| Article | Year |
|---|---|
Propafenone pharmacokinetics in uremic patients treated by peritoneal dialysis.
Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Kidney Failure, Chronic; Middle Aged; Peritoneal Dialysi | 1992 |
In vitro protein binding of propafenone in normal and uraemic human sera.
Topics: Adult; Blood Proteins; Dialysis; Humans; Kidney Failure, Chronic; Male; Orosomucoid; Propafenone; Pr | 1989 |