propafenone has been researched along with Torsade de Pointes in 8 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 77-year-old female with new onset atrial fibrillation occurring in the absence of structural heart disease developed torsade de pointes during therapy with quinidine bisulfate 500 mg orally every 8 hours." | 7.68 | Propafenone-induced torsade de pointes: cross-reactivity with quinidine. ( Cohen, JM; Gillis, AM; Hii, JT; Mitchell, LB; Wyse, DG, 1991) |
| "A 77-year-old female with new onset atrial fibrillation occurring in the absence of structural heart disease developed torsade de pointes during therapy with quinidine bisulfate 500 mg orally every 8 hours." | 3.68 | Propafenone-induced torsade de pointes: cross-reactivity with quinidine. ( Cohen, JM; Gillis, AM; Hii, JT; Mitchell, LB; Wyse, DG, 1991) |
| "For some arrhythmias, such as atrial fibrillation, it seems likely that drug therapy will remain an important part of treatment." | 2.39 | Is there a need for new antiarrhythmic drugs? ( Roden, DM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mirams, GR | 1 |
| Cui, Y | 1 |
| Sher, A | 1 |
| Fink, M | 1 |
| Cooper, J | 1 |
| Heath, BM | 1 |
| McMahon, NC | 1 |
| Gavaghan, DJ | 1 |
| Noble, D | 1 |
| Wiśniowska, B | 1 |
| Mendyk, A | 1 |
| Fijorek, K | 1 |
| Glinka, A | 1 |
| Polak, S | 1 |
| La Rocca, R | 1 |
| Ferrari-Toninelli, G | 1 |
| Patanè, S | 1 |
| Darbar, D | 1 |
| Roden, DM | 2 |
| Lehtonen, A | 1 |
| Fodstad, H | 1 |
| Laitinen-Forsblom, P | 1 |
| Toivonen, L | 1 |
| Kontula, K | 1 |
| Swan, H | 1 |
| Pelter, MM | 1 |
| Adams, MG | 1 |
| Hii, JT | 1 |
| Wyse, DG | 1 |
| Gillis, AM | 1 |
| Cohen, JM | 1 |
| Mitchell, LB | 1 |
2 reviews available for propafenone and Torsade de Pointes
| Article | Year |
|---|---|
Pharmacogenetics of antiarrhythmic therapy.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arylamine N-Acetyltransferase; ATP Binding Cassette Tr | 2006 |
Is there a need for new antiarrhythmic drugs?
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Heart Conduction System; Humans; Propafeno | 1996 |
6 other studies available for propafenone and Torsade de Pointes
| Article | Year |
|---|---|
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; | 2011 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computationa | 2012 |
Widened QRS interval and left ventricular systolic depression after propafenone and promazine exposure.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Dementia; Dopamine Antagonists; Dose | 2014 |
Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; DNA Mutational Analysis; Electrocardiog | 2007 |
Giant inverted T waves.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Humans; Male; Myocardial Is | 2001 |
Propafenone-induced torsade de pointes: cross-reactivity with quinidine.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cross Reactions; Electrocardiography; Female; Hum | 1991 |