propafenone has been researched along with Sensitivity and Specificity in 16 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propafenone enantiomers were resolved on a 10-microm Chiralcel OD-R column (250 x 4." | 1.30 | Enantioselective analysis of propafenone in plasma using a polysaccharide-based chiral stationary phase under reversed-phase conditions. ( Bonato, PS; de Gaitani, CM; Lanchote, VL, 1998) |
| "Flecainide and quinidine were less potent inhibitors of IK than was propafenone with IC50s of 15 and 14 microM compared with an IC50 of 5 microM for propafenone." | 1.29 | K+ channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. ( Castle, NA; Slawsky, MT, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shirayama, Y | 1 |
| Doki, K | 1 |
| Sekiguchi, Y | 1 |
| Aonuma, K | 1 |
| Kohda, Y | 1 |
| Homma, M | 1 |
| Zhang, QL | 1 |
| Hu, JH | 1 |
| Zhu, QG | 1 |
| Li, FQ | 1 |
| Liu, JY | 1 |
| Wang, D | 1 |
| Li, X | 2 |
| Zhu, D | 1 |
| You, T | 1 |
| Wu, YJ | 1 |
| Ma, MM | 1 |
| Zheng, S | 1 |
| Afshar, M | 1 |
| Rouini, M | 1 |
| Beldner, S | 1 |
| Lin, D | 1 |
| Marchlinski, FE | 1 |
| Kaiser, D | 1 |
| Smiesko, M | 1 |
| Kopp, S | 1 |
| Chiba, P | 1 |
| Ecker, GF | 1 |
| Zhang, L | 1 |
| Wang, R | 1 |
| Yu, Y | 1 |
| Zhang, Y | 1 |
| Hinderling, PH | 1 |
| Tendolkar, A | 1 |
| Dee, CM | 1 |
| Barr, WH | 1 |
| Seiberling, M | 1 |
| Duerr, H | 1 |
| Slawsky, MT | 1 |
| Castle, NA | 1 |
| de Gaitani, CM | 1 |
| Lanchote, VL | 1 |
| Bonato, PS | 1 |
| Kubalec, P | 1 |
| Brandsteterová, E | 1 |
| Hofmann, U | 1 |
| Pecia, M | 1 |
| Heinkele, G | 1 |
| Dilger, K | 1 |
| Kroemer, HK | 1 |
| Eichelbaum, M | 1 |
| Yao, TW | 1 |
| Zhou, Q | 1 |
| Zeng, S | 1 |
| Michelucci, A | 1 |
| Lazzeri, C | 1 |
| Padeletti, L | 1 |
| Bagliani, G | 1 |
| Colella, A | 1 |
| Sabini, A | 1 |
| Zipoli, R | 1 |
| Costoli, A | 1 |
| Pieragnoli, P | 1 |
| Gensini, GF | 1 |
| Franchi, F | 1 |
| Zhong, D | 1 |
| Chen, X | 1 |
| Gu, J | 1 |
| Guo, J | 1 |
1 trial available for propafenone and Sensitivity and Specificity
| Article | Year |
|---|---|
Single-dose interaction study of diprafenone HCl and propranolol HCl in healthy volunteers.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Drug Administration Schedule; Drug Combinations; Drug Int | 1995 |
15 other studies available for propafenone and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous determination of serum propafenone and its metabolites using high-performance liquid chromatography.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Linear Models; Male; Middle Aged; | 2018 |
Development of a novel HPLC-MS/MS method for the determination of aconitine and its application to in vitro and rat microdialysis samples.
Topics: Aconitine; Animals; Calibration; Chromatography, High Pressure Liquid; Data Interpretation, Statisti | 2009 |
Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach.
Topics: Analysis of Variance; Cardiovascular Agents; Electrophoresis, Capillary; Female; Humans; Hydrogen-Io | 2011 |
Enantioselective assay of S+ - and R- -propafenone in human urine by using RP-HPLC with pre-column chiral derivatization.
Topics: Chromatography, High Pressure Liquid; Humans; Propafenone; Reproducibility of Results; Sensitivity a | 2004 |
A rapid HPLC assay for the simultaneous determination of propafenone and its major metabolites in human serum.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Hum | 2004 |
Flecainide and propafenone induced ST-segment elevation in patients with atrial fibrillation: clue to specificity of Brugada-type electrocardiographic changes.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bundle-Branch Block; Dose-Response Relationship, Drug; | 2004 |
Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Drug Resistance, Multiple; Human | 2005 |
Capillary electrophoresis with laser-induced fluorescence and pre-column derivatization for the analysis of illicit drugs.
Topics: Amphetamine; Calibration; Central Nervous System Stimulants; Electrophoresis, Capillary; Ephedrine; | 2007 |
K+ channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Electrophysiology; Flecainide; Heart; Heart Ventri | 1994 |
Enantioselective analysis of propafenone in plasma using a polysaccharide-based chiral stationary phase under reversed-phase conditions.
Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Humans; Isomerism; Propafenone; Reproducibility of R | 1998 |
Determination of propafenone and its main metabolite 5-hydroxypropafenone in human serum with direct injection into a column-switching chromatographic system.
Topics: Chromatography, High Pressure Liquid; Humans; Propafenone; Reproducibility of Results; Sensitivity a | 1999 |
Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Propafenone; Reference Standards; Reproducibility of R | 2000 |
Stereoselective determination of propafenone enantiomers in transgenic Chinese hamster CHL cells expressing human cytochrome P450.
Topics: Animals; Animals, Genetically Modified; Calibration; Chromatography, High Pressure Liquid; Cricetina | 2000 |
Altered values of heart rate variability in patients with relapse of atrial fibrillation during the first week after electrical cardioversion: preliminary data.
Topics: Aged; Amiodarone; Atrial Fibrillation; Circadian Rhythm; Electric Countershock; Electrocardiography, | 2001 |
Applications of liquid chromatography-tandem mass spectrometry in drug and biomedical analyses.
Topics: Amlodipine; Chromatography, Liquid; Humans; Mass Spectrometry; Nitrendipine; Propafenone; Roxithromy | 2001 |