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propafenone and Seizures

propafenone has been researched along with Seizures in 10 studies

Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Propafenone is an anti-arrhythmic drug used in the management of supraventricular and ventricular arrhythmias."5.36Propafenone poisoning--a case report with plasma propafenone concentrations. ( Dargan, PI; Jones, AL; Ludman, A; Ovaska, H; Spencer, EP; Wood, DM, 2010)
"Propafenone at doses 60-90mg/kg significantly increased the threshold of seizures, in turn at doses 5-50mg/kg did not affect this parameter."3.88Influence of propafenone on the anticonvulsant activity of various novel antiepileptic drugs in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M; Wróblewska, D, 2018)
"Propafenone is an infrequently used class IC antiarrhythmic drug."2.39Propafenone overdose. ( English, B; Ford, M; Kerns, W, 1994)
"Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults."1.46Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report. ( Arı, ME; Ekici, F, 2017)
"Mirtazapine is a commonly prescribed antidepressant drug, which is also metabolized through and may modulate the CYP4502D6 pathway leading to altered metabolism of propafenone and possible adverse effects."1.40Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction. ( Aryal, SR; Khan, MA; Rajpurohit, N; Stys, AT; Stys, TP, 2014)
"Propafenone is an uncommonly encountered class IC antidysrhythmic that is a look-alike for the opioid, oxycodone/acetaminophen 5/325."1.37Overdose of propafenone surreptitiously sold as "Percocet". ( Curtis, JA; D'Orazio, JL, 2011)
"Propafenone is an anti-arrhythmic drug used in the management of supraventricular and ventricular arrhythmias."1.36Propafenone poisoning--a case report with plasma propafenone concentrations. ( Dargan, PI; Jones, AL; Ludman, A; Ovaska, H; Spencer, EP; Wood, DM, 2010)
"Propafenone is a class Ic antiarrhythmic agent which also exhibits beta-adrenergic and fast sodium channel blockade."1.30Recurrent convulsions and cardiac conduction disturbances after propafenone overdose. ( Buffet, M; Grossenbacher, F; Lamiable, D; Rambourg-Schepens, MO, 1999)
"Propafenone is a type 1c antiarrhythmic drug that recently has become available for clinical trials within the United States."1.27Propafenone ingestion. ( McHugh, TP; Perina, DG, 1987)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arı, ME1
Ekici, F1
Borowicz-Reutt, KK1
Popławska, M1
Banach, M1
Wróblewska, D1
Rajpurohit, N1
Aryal, SR1
Khan, MA1
Stys, AT1
Stys, TP1
Tsiperfal, A1
Scheibly, K1
Matsuda, K1
Ovaska, H1
Ludman, A1
Spencer, EP1
Wood, DM1
Jones, AL1
Dargan, PI1
D'Orazio, JL1
Curtis, JA1
Kerns, W1
English, B1
Ford, M1
Rambourg-Schepens, MO1
Grossenbacher, F1
Buffet, M1
Lamiable, D1
Friocourt, P1
Martin, C1
Lozac'h, L1
McHugh, TP1
Perina, DG1

Reviews

1 review available for propafenone and Seizures

ArticleYear
Propafenone overdose.
    Annals of emergency medicine, 1994, Volume: 24, Issue:1

    Topics: Adult; Bradycardia; Drug Overdose; Electrocardiography; Heart Block; Humans; Male; Propafenone; Seiz

1994

Other Studies

9 other studies available for propafenone and Seizures

ArticleYear
Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report.
    Balkan medical journal, 2017, Sep-29, Volume: 34, Issue:5

    Topics: Adolescent; Adolescent Behavior; Anticonvulsants; Brugada Syndrome; Chicago; Electrocardiography; El

2017
Influence of propafenone on the anticonvulsant activity of various novel antiepileptic drugs in the mouse maximal electroshock model.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Interactions; Electroshock; Female; Me

2018
Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2014, Volume: 67, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Atrial Fibrillation; Bradycardia; Di

2014
Can QRS Widening be a result of propafenone overdose?
    Progress in cardiovascular nursing, 2008,Fall, Volume: 23, Issue:4

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Consciousness Disorders; Drug Ove

2008
Propafenone poisoning--a case report with plasma propafenone concentrations.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:1

    Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Coma; Combined Modality Therapy; Drug

2010
Overdose of propafenone surreptitiously sold as "Percocet".
    The Journal of emergency medicine, 2011, Volume: 41, Issue:2

    Topics: Adolescent; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Labeling; Drug Overdose; Electrocardi

2011
Recurrent convulsions and cardiac conduction disturbances after propafenone overdose.
    Veterinary and human toxicology, 1999, Volume: 41, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Heart Conduction System; Humans; Propaf

1999
[Self-poisoning with propafenone. Apropos of a case].
    Annales de cardiologie et d'angeiologie, 1988, Volume: 37, Issue:3

    Topics: Adult; Blood Pressure; Heart Block; Humans; Male; Propafenone; Seizures; Suicide, Attempted

1988
Propafenone ingestion.
    Annals of emergency medicine, 1987, Volume: 16, Issue:4

    Topics: Bundle-Branch Block; Child, Preschool; Electrocardiography; Emergencies; Heart Arrest; Heart Block;

1987