propafenone has been researched along with Seizures in 10 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propafenone is an anti-arrhythmic drug used in the management of supraventricular and ventricular arrhythmias." | 5.36 | Propafenone poisoning--a case report with plasma propafenone concentrations. ( Dargan, PI; Jones, AL; Ludman, A; Ovaska, H; Spencer, EP; Wood, DM, 2010) |
| "Propafenone at doses 60-90mg/kg significantly increased the threshold of seizures, in turn at doses 5-50mg/kg did not affect this parameter." | 3.88 | Influence of propafenone on the anticonvulsant activity of various novel antiepileptic drugs in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M; Wróblewska, D, 2018) |
| "Propafenone is an infrequently used class IC antiarrhythmic drug." | 2.39 | Propafenone overdose. ( English, B; Ford, M; Kerns, W, 1994) |
| "Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults." | 1.46 | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report. ( Arı, ME; Ekici, F, 2017) |
| "Mirtazapine is a commonly prescribed antidepressant drug, which is also metabolized through and may modulate the CYP4502D6 pathway leading to altered metabolism of propafenone and possible adverse effects." | 1.40 | Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction. ( Aryal, SR; Khan, MA; Rajpurohit, N; Stys, AT; Stys, TP, 2014) |
| "Propafenone is an uncommonly encountered class IC antidysrhythmic that is a look-alike for the opioid, oxycodone/acetaminophen 5/325." | 1.37 | Overdose of propafenone surreptitiously sold as "Percocet". ( Curtis, JA; D'Orazio, JL, 2011) |
| "Propafenone is an anti-arrhythmic drug used in the management of supraventricular and ventricular arrhythmias." | 1.36 | Propafenone poisoning--a case report with plasma propafenone concentrations. ( Dargan, PI; Jones, AL; Ludman, A; Ovaska, H; Spencer, EP; Wood, DM, 2010) |
| "Propafenone is a class Ic antiarrhythmic agent which also exhibits beta-adrenergic and fast sodium channel blockade." | 1.30 | Recurrent convulsions and cardiac conduction disturbances after propafenone overdose. ( Buffet, M; Grossenbacher, F; Lamiable, D; Rambourg-Schepens, MO, 1999) |
| "Propafenone is a type 1c antiarrhythmic drug that recently has become available for clinical trials within the United States." | 1.27 | Propafenone ingestion. ( McHugh, TP; Perina, DG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arı, ME | 1 |
| Ekici, F | 1 |
| Borowicz-Reutt, KK | 1 |
| Popławska, M | 1 |
| Banach, M | 1 |
| Wróblewska, D | 1 |
| Rajpurohit, N | 1 |
| Aryal, SR | 1 |
| Khan, MA | 1 |
| Stys, AT | 1 |
| Stys, TP | 1 |
| Tsiperfal, A | 1 |
| Scheibly, K | 1 |
| Matsuda, K | 1 |
| Ovaska, H | 1 |
| Ludman, A | 1 |
| Spencer, EP | 1 |
| Wood, DM | 1 |
| Jones, AL | 1 |
| Dargan, PI | 1 |
| D'Orazio, JL | 1 |
| Curtis, JA | 1 |
| Kerns, W | 1 |
| English, B | 1 |
| Ford, M | 1 |
| Rambourg-Schepens, MO | 1 |
| Grossenbacher, F | 1 |
| Buffet, M | 1 |
| Lamiable, D | 1 |
| Friocourt, P | 1 |
| Martin, C | 1 |
| Lozac'h, L | 1 |
| McHugh, TP | 1 |
| Perina, DG | 1 |
1 review available for propafenone and Seizures
| Article | Year |
|---|---|
Propafenone overdose.
Topics: Adult; Bradycardia; Drug Overdose; Electrocardiography; Heart Block; Humans; Male; Propafenone; Seiz | 1994 |
9 other studies available for propafenone and Seizures
| Article | Year |
|---|---|
Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report.
Topics: Adolescent; Adolescent Behavior; Anticonvulsants; Brugada Syndrome; Chicago; Electrocardiography; El | 2017 |
Influence of propafenone on the anticonvulsant activity of various novel antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Interactions; Electroshock; Female; Me | 2018 |
Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.
Topics: Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Atrial Fibrillation; Bradycardia; Di | 2014 |
Can QRS Widening be a result of propafenone overdose?
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Consciousness Disorders; Drug Ove | 2008 |
Propafenone poisoning--a case report with plasma propafenone concentrations.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Coma; Combined Modality Therapy; Drug | 2010 |
Overdose of propafenone surreptitiously sold as "Percocet".
Topics: Adolescent; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Labeling; Drug Overdose; Electrocardi | 2011 |
Recurrent convulsions and cardiac conduction disturbances after propafenone overdose.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Heart Conduction System; Humans; Propaf | 1999 |
[Self-poisoning with propafenone. Apropos of a case].
Topics: Adult; Blood Pressure; Heart Block; Humans; Male; Propafenone; Seizures; Suicide, Attempted | 1988 |
Propafenone ingestion.
Topics: Bundle-Branch Block; Child, Preschool; Electrocardiography; Emergencies; Heart Arrest; Heart Block; | 1987 |