propafenone has been researched along with Glioblastoma in 2 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 8.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 4.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Yu, J | 1 |
| Pan, H | 1 |
| Hu, P | 1 |
| Hao, Y | 1 |
| Cai, W | 1 |
| Zhu, H | 1 |
| Yu, AD | 1 |
| Xie, X | 1 |
| Ma, D | 1 |
| Yuan, J | 1 |
| Faudone, G | 1 |
| Bischoff-Kont, I | 1 |
| Rachor, L | 1 |
| Willems, S | 1 |
| Zhubi, R | 1 |
| Kaiser, A | 1 |
| Chaikuad, A | 1 |
| Knapp, S | 1 |
| Fürst, R | 1 |
| Heering, J | 1 |
| Merk, D | 1 |
2 other studies available for propafenone and Glioblastoma
| Article | Year |
|---|---|
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; G | 2007 |
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular S | 2021 |