propafenone and Cholestasis, Intrahepatic studies

propafenone and Cholestasis, Intrahepatic

Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.

Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).

Research Excerpts

Excerpt	Relevance	Reference
" Age-related delays in hepatic drug metabolism should explain the hazardous increase in the bioavailability of this drug."	1.31	Propafenone-related cholestatic hepatitis in an elderly patient. ( Forgione, A; Gasbarrini, G; Giorgi, A; Grieco, A; Miele, L, 2002)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

3 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Grieco, A	1
Forgione, A	1
Giorgi, A	1
Miele, L	1
Gasbarrini, G	1
Martín, EP	1
Cervantes, JL	1
Yangüela, J	1
Gandolfi, A	1
Rota, E	1
Zanghieri, G	1
Tolomelli, S	1
Bagnulo, A	1
Mengoli, M	1

Studies

Grieco, A

Forgione, A

Giorgi, A

Miele, L

Gasbarrini, G

Martín, EP

Cervantes, JL

Yangüela, J

Gandolfi, A

Rota, E

Zanghieri, G

Tolomelli, S

Bagnulo, A

Mengoli, M

Reviews

1 review available for propafenone and Cholestasis, Intrahepatic

Article	Year
[Acute cholestatic hepatitis caused by propafenone. Report of a case and review of the literature]. Recenti progressi in medicina, 2001, Volume: 92, Issue:3 Topics: Acute Disease; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahep	2001

Article

Year

[Acute cholestatic hepatitis caused by propafenone. Report of a case and review of the literature].

Recenti progressi in medicina, 2001, Volume: 92, Issue:3

Topics: Acute Disease; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahep

2001

Other Studies

2 other studies available for propafenone and Cholestasis, Intrahepatic

Article	Year
Propafenone-related cholestatic hepatitis in an elderly patient. Italian heart journal : official journal of the Italian Federation of Cardiology, 2002, Volume: 3, Issue:7 Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Inju	2002
[Propafenone hepatotoxicity]. Revista espanola de enfermedades digestivas, 2004, Volume: 96, Issue:10 Topics: Aged; Anti-Arrhythmia Agents; Cholestasis, Intrahepatic; Female; Humans; Liver Function Tests; Propa	2004

Article

Year

Italian heart journal : official journal of the Italian Federation of Cardiology, 2002, Volume: 3, Issue:7

Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Inju

2002

[Propafenone hepatotoxicity].

Revista espanola de enfermedades digestivas, 2004, Volume: 96, Issue:10

Topics: Aged; Anti-Arrhythmia Agents; Cholestasis, Intrahepatic; Female; Humans; Liver Function Tests; Propa

2004