propafenone has been researched along with Acute Liver Injury, Drug-Induced in 10 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Age-related delays in hepatic drug metabolism should explain the hazardous increase in the bioavailability of this drug." | 1.31 | Propafenone-related cholestatic hepatitis in an elderly patient. ( Forgione, A; Gasbarrini, G; Giorgi, A; Grieco, A; Miele, L, 2002) |
| "Propafenone hydrochloride is a drug used for treating arrhythmia." | 1.31 | [Liver function test impairment induced by propafenone in a 73 year old woman]. ( Arinzon, Z; Fridman, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Li, J | 1 |
| Shi, J | 1 |
| Jia, C | 1 |
| Li, W | 1 |
| Peng, Y | 1 |
| Zheng, J | 1 |
| Grieco, A | 1 |
| Forgione, A | 1 |
| Giorgi, A | 1 |
| Miele, L | 1 |
| Gasbarrini, G | 1 |
| Cocozzella, D | 1 |
| Curciarello, J | 1 |
| Corallini, O | 1 |
| Olivera, A | 1 |
| Alburquerque, MM | 1 |
| Fraquelli, E | 1 |
| Zamagna, L | 1 |
| Olenchuck, A | 1 |
| Cremona, A | 1 |
| Schuff-Werner, P | 1 |
| Kaiser, D | 1 |
| Lüders, CJ | 1 |
| Berg, PA | 1 |
| Gandolfi, A | 1 |
| Rota, E | 1 |
| Zanghieri, G | 1 |
| Tolomelli, S | 1 |
| Bagnulo, A | 1 |
| Mengoli, M | 1 |
| Arinzon, Z | 1 |
| Fridman, R | 1 |
2 reviews available for propafenone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Acute cholestatic hepatitis caused by propafenone. Report of a case and review of the literature].
Topics: Acute Disease; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahep | 2001 |
8 other studies available for propafenone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.
Topics: Acetylcysteine; Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P | 2022 |
Propafenone-related cholestatic hepatitis in an elderly patient.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Inju | 2002 |
Propafenone hepatotoxicity: report of two new cases.
Topics: Aged; Atrial Fibrillation; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 2003 |
[Propafenon-induced cholestatic liver injury--a further example for allergic drug hepatitis (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotrans | 1981 |
[Liver function test impairment induced by propafenone in a 73 year old woman].
Topics: Aged; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Fem | 2001 |