propafenone has been researched along with Acute Disease in 25 studies
Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
propafenone : An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a double-blind, multicenter, multinational, placebo-controlled, and well-controlled trial to prove that the sustained-release (SR) formulation of propafenone is superior to placebo in preventing symptoms of paroxysmal atrial fibrillation (AF)." | 9.10 | Efficacy and safety of propafenone sustained release in the prophylaxis of symptomatic paroxysmal atrial fibrillation (The European Rythmol/Rytmonorm Atrial Fibrillation Trial [ERAFT] Study). ( Camez, A; Eberle, S; Hewkin, A; Kalsch, B; Lip, GY; Lombardi, F; Meinertz, T; Sadowski, ZP, 2002) |
| "To evaluate the efficacy and safety of a single loading oral dose of propafenone in the interruption of recent-onset atrial fibrillation." | 9.08 | Value of single oral loading dose of propafenone in converting recent-onset atrial fibrillation. Results of a randomized, double-blind, controlled study. ( Alvarez, M; Azpitarte, J; Baún, O; Fernández, R; García, R; Martín, F; Moreno, E; Tercedor, L, 1997) |
| "In recent-onset atrial fibrillation, intravenous propafenone has been shown to effectively restore sinus rhythm, whereas the efficacy of intravenous digoxin has been questioned." | 9.08 | Comparison between propafenone and digoxin administered intravenously to patients with acute atrial fibrillation. PAFIT-3 Investigators. The Propafenone in Atrial Fibrillation Italian Trial. ( Bianconi, L; Mennuni, M, 1998) |
| "Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia." | 7.74 | Acute pancreatitis and amiodarone: a case report. ( Chen, CY; Chen, YY; Leung, KK, 2007) |
| "We have investigated the relationship of clinical variables to successful cardioversion of atrial fibrillation (AF) to sinus rhythm using an oral loading dose of propafenone." | 7.70 | Predictors of success in the conversion of new-onset atrial fibrillation using oral propafenone. ( Cete, Y; Ergene, O; Ergene, U; Fowler, J; Nazli, C; Oktay, C, 1998) |
| "Patients received intravenous flecainide, propafenone, or amiodarone on presentation and a second dose after 6 hours if atrial fibrillation persisted." | 5.14 | Management of patients with acute atrial fibrillation in the ED. ( Abbate, R; Conti, A; Del Taglia, B; Gensini, GF; Grifoni, S; Mariannini, Y; Michelucci, A; Padeletti, L; Pepe, G; Vanni, S, 2010) |
| "We report a double-blind, multicenter, multinational, placebo-controlled, and well-controlled trial to prove that the sustained-release (SR) formulation of propafenone is superior to placebo in preventing symptoms of paroxysmal atrial fibrillation (AF)." | 5.10 | Efficacy and safety of propafenone sustained release in the prophylaxis of symptomatic paroxysmal atrial fibrillation (The European Rythmol/Rytmonorm Atrial Fibrillation Trial [ERAFT] Study). ( Camez, A; Eberle, S; Hewkin, A; Kalsch, B; Lip, GY; Lombardi, F; Meinertz, T; Sadowski, ZP, 2002) |
| "To evaluate the efficacy and safety of a single loading oral dose of propafenone in the interruption of recent-onset atrial fibrillation." | 5.08 | Value of single oral loading dose of propafenone in converting recent-onset atrial fibrillation. Results of a randomized, double-blind, controlled study. ( Alvarez, M; Azpitarte, J; Baún, O; Fernández, R; García, R; Martín, F; Moreno, E; Tercedor, L, 1997) |
| "In recent-onset atrial fibrillation, intravenous propafenone has been shown to effectively restore sinus rhythm, whereas the efficacy of intravenous digoxin has been questioned." | 5.08 | Comparison between propafenone and digoxin administered intravenously to patients with acute atrial fibrillation. PAFIT-3 Investigators. The Propafenone in Atrial Fibrillation Italian Trial. ( Bianconi, L; Mennuni, M, 1998) |
| "Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia." | 3.74 | Acute pancreatitis and amiodarone: a case report. ( Chen, CY; Chen, YY; Leung, KK, 2007) |
| "We have investigated the relationship of clinical variables to successful cardioversion of atrial fibrillation (AF) to sinus rhythm using an oral loading dose of propafenone." | 3.70 | Predictors of success in the conversion of new-onset atrial fibrillation using oral propafenone. ( Cete, Y; Ergene, O; Ergene, U; Fowler, J; Nazli, C; Oktay, C, 1998) |
| "Maximum occurence of arrhythmias was observed 2." | 1.32 | Acute toxicity of propafenone in a case of suicidal attempt. ( Markovic, P; Petrikova, V; Rajnic, A; Stancak, B, 2004) |
| "The amiodarone was omitted in 17 cases because of its side effects." | 1.32 | [Treatment of atrial fibrillation in a Hungarian hospital department of cardiologic internal medicine at the turn of the millennium]. ( Borbély, M; Dani, G; Erdej, F; Hajdara, I; Katona, A; Márk, L; Nagy, E; Sziklai, G, 2004) |
| " Age-related delays in hepatic drug metabolism should explain the hazardous increase in the bioavailability of this drug." | 1.31 | Propafenone-related cholestatic hepatitis in an elderly patient. ( Forgione, A; Gasbarrini, G; Giorgi, A; Grieco, A; Miele, L, 2002) |
| "Propafenone is an effective drug for the acute conversion of spontaneous monomorphic sustained ventricular tachycardia, especially in patients without organic heart disease." | 1.29 | [The efficacy and safety of intravenous propafenone in the acute treatment of spontaneous sustained ventricular tachycardia]. ( Madrid, AH; Marín-Huerta, E; Mestre, JL; Moro, C; Novo, L, 1994) |
| "Diprafenone (D) is a new class I c antiarrhythmic agent, structurally similar to propafenone." | 1.27 | Use of diprafenone, a new potent propafenone-analogue, in acute experimental myocardial ischaemia and infarction. ( Bender, F; Gülker, H; Haverkamp, W; Hindricks, G; Thale, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lip, GY | 2 |
| Watson, T | 1 |
| Dogan, A | 1 |
| Akcay, S | 1 |
| Karabacak, M | 1 |
| Turker, Y | 1 |
| Ozaydin, M | 1 |
| Erdogan, D | 1 |
| Niu, G | 1 |
| Scherlag, BJ | 1 |
| Lu, Z | 1 |
| Ghias, M | 1 |
| Zhang, Y | 1 |
| Patterson, E | 1 |
| Dasari, TW | 1 |
| Zacharias, S | 1 |
| Lazzara, R | 1 |
| Jackman, WM | 1 |
| Po, SS | 1 |
| Conti, A | 1 |
| Del Taglia, B | 1 |
| Mariannini, Y | 1 |
| Pepe, G | 1 |
| Vanni, S | 1 |
| Grifoni, S | 1 |
| Abbate, R | 1 |
| Michelucci, A | 1 |
| Padeletti, L | 1 |
| Gensini, GF | 1 |
| Bellone, A | 1 |
| Etteri, M | 1 |
| Vettorello, M | 1 |
| Bonetti, C | 1 |
| Clerici, D | 1 |
| Gini, G | 1 |
| Maino, C | 1 |
| Mariani, M | 1 |
| Natalizi, A | 1 |
| Nessi, I | 1 |
| Rampoldi, A | 1 |
| Colombo, L | 1 |
| Grieco, A | 1 |
| Forgione, A | 1 |
| Giorgi, A | 1 |
| Miele, L | 1 |
| Gasbarrini, G | 1 |
| Meinertz, T | 1 |
| Lombardi, F | 1 |
| Sadowski, ZP | 1 |
| Kalsch, B | 1 |
| Camez, A | 1 |
| Hewkin, A | 1 |
| Eberle, S | 1 |
| Kolettis, TM | 1 |
| Naka, KK | 1 |
| Katsouras, C | 1 |
| Michalis, LK | 1 |
| Bourantas, K | 1 |
| Stancak, B | 1 |
| Markovic, P | 1 |
| Rajnic, A | 1 |
| Petrikova, V | 1 |
| Márk, L | 1 |
| Erdej, F | 1 |
| Dani, G | 1 |
| Borbély, M | 1 |
| Sziklai, G | 1 |
| Nagy, E | 1 |
| Hajdara, I | 1 |
| Katona, A | 1 |
| Haque, A | 1 |
| Kannankeril, PJ | 1 |
| Chen, YY | 1 |
| Chen, CY | 1 |
| Leung, KK | 1 |
| Schüppel, R | 1 |
| Probst, M | 1 |
| Mestre, JL | 1 |
| Moro, C | 1 |
| Madrid, AH | 1 |
| Novo, L | 1 |
| Marín-Huerta, E | 1 |
| Mannino, MM | 1 |
| Mehta, D | 1 |
| Gomes, JA | 1 |
| Oltrona, L | 1 |
| Broccolino, M | 1 |
| Merlini, PA | 1 |
| Spinola, A | 1 |
| Pezzano, A | 1 |
| Mannucci, PM | 1 |
| Azpitarte, J | 1 |
| Alvarez, M | 1 |
| Baún, O | 1 |
| García, R | 1 |
| Moreno, E | 1 |
| Martín, F | 1 |
| Tercedor, L | 1 |
| Fernández, R | 1 |
| Bianconi, L | 2 |
| Mennuni, M | 1 |
| Ergene, U | 1 |
| Ergene, O | 1 |
| Cete, Y | 1 |
| Fowler, J | 1 |
| Nazli, C | 1 |
| Oktay, C | 1 |
| Gandolfi, A | 1 |
| Rota, E | 1 |
| Zanghieri, G | 1 |
| Tolomelli, S | 1 |
| Bagnulo, A | 1 |
| Mengoli, M | 1 |
| Sandrikov, VA | 1 |
| Ol'binskaia, LI | 1 |
| Demurov, EA | 1 |
| Sadovnikov, VI | 1 |
| Mikhailov, IuN | 1 |
| Gentili, C | 1 |
| Giordano, F | 1 |
| Alois, A | 1 |
| Massa, E | 1 |
| Healy, B | 1 |
| Picciotto, G | 1 |
| Siragusa, V | 1 |
| Cellura, M | 1 |
| Ventimiglia, C | 1 |
| Rotolo, L | 1 |
| Thale, J | 1 |
| Gülker, H | 1 |
| Hindricks, G | 1 |
| Haverkamp, W | 1 |
| Bender, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial[NCT00933634] | 247 participants (Anticipated) | Interventional | 2006-01-31 | Completed | |||
| Atrial Fibrillation Registry at the Emergency Department of the Medical University of Vienna: A Tool for Structured Diagnosis and Treatment[NCT03272620] | 3,000 participants (Anticipated) | Observational [Patient Registry] | 2014-10-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for propafenone and Acute Disease
| Article | Year |
|---|---|
Atrial fibrillation (acute onset).
Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Propafenone; Sotalol | 2008 |
[Acute cholestatic hepatitis caused by propafenone. Report of a case and review of the literature].
Topics: Acute Disease; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahep | 2001 |
5 trials available for propafenone and Acute Disease
| Article | Year |
|---|---|
Management of patients with acute atrial fibrillation in the ED.
Topics: Acute Disease; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; | 2010 |
Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Counte | 2012 |
Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Counte | 2012 |
Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Counte | 2012 |
Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Counte | 2012 |
Efficacy and safety of propafenone sustained release in the prophylaxis of symptomatic paroxysmal atrial fibrillation (The European Rythmol/Rytmonorm Atrial Fibrillation Trial [ERAFT] Study).
Topics: Acute Disease; Anti-Arrhythmia Agents; Atrial Fibrillation; Delayed-Action Preparations; Double-Blin | 2002 |
Value of single oral loading dose of propafenone in converting recent-onset atrial fibrillation. Results of a randomized, double-blind, controlled study.
Topics: Acute Disease; Administration, Oral; Anti-Arrhythmia Agents; Atrial Fibrillation; Dose-Response Rela | 1997 |
Comparison between propafenone and digoxin administered intravenously to patients with acute atrial fibrillation. PAFIT-3 Investigators. The Propafenone in Atrial Fibrillation Italian Trial.
Topics: Acute Disease; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Electrocardiograph | 1998 |
18 other studies available for propafenone and Acute Disease
| Article | Year |
|---|---|
The effect of pretreatment with renin-angiotensin-aldosterone system blockers on cardioversion success and acute recurrence of atrial fibrillation.
Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease-Free Survival; Elect | 2009 |
An acute experimental model demonstrating 2 different forms of sustained atrial tachyarrhythmias.
Topics: Acetylcholine; Acute Disease; Animals; Anti-Arrhythmia Agents; Atrial Appendage; Atrial Fibrillation | 2009 |
Propafenone-related cholestatic hepatitis in an elderly patient.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Inju | 2002 |
Transient intraventricular conduction delay associated with concurrent intake of propafenone and antineoplastic agents.
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Antineoplastic Agents; Drug Interact | 2003 |
Acute toxicity of propafenone in a case of suicidal attempt.
Topics: Acute Disease; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Male; Poisoning; Propafe | 2004 |
[Treatment of atrial fibrillation in a Hungarian hospital department of cardiologic internal medicine at the turn of the millennium].
Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrill | 2004 |
Respiratory distress in a young infant.
Topics: Acute Disease; Anti-Arrhythmia Agents; Bronchiolitis; Electrocardiography; Humans; Infant; Male; Pro | 2005 |
Acute pancreatitis and amiodarone: a case report.
Topics: Acute Disease; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Pancreatitis; Propafenone; | 2007 |
Acute cholestatic hepatitis and the sudden rise of the pacing threshold 5 weeks after VVI-pacemaker implantation.
Topics: Acute Disease; Aged; Cardiac Pacing, Artificial; Cholestasis; Electrocardiography; Hepatitis; Humans | 1994 |
[The efficacy and safety of intravenous propafenone in the acute treatment of spontaneous sustained ventricular tachycardia].
Topics: Acute Disease; Aged; Chi-Square Distribution; Drug Evaluation; Electrocardiography; Female; Humans; | 1994 |
Current treatment options for paroxysmal supraventricular tachycardia.
Topics: Acute Disease; Catheter Ablation; Chronic Disease; Flecainide; Humans; Propafenone; Tachycardia, Atr | 1994 |
Activation of the hemostatic mechanism after pharmacological cardioversion of acute nonvalvular atrial fibrillation.
Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Antithrombin III; Atrial Fibrillation; Biomarkers | 1997 |
Predictors of success in the conversion of new-onset atrial fibrillation using oral propafenone.
Topics: Acute Disease; Administration, Oral; Analysis of Variance; Anti-Arrhythmia Agents; Atrial Fibrillati | 1998 |
[Effect of baxacor on the hemodynamics and contractile function of the myocardium in acute ischemia (an experimental study)].
Topics: Acute Disease; Animals; Coronary Disease; Dogs; Female; Heart Rate; Hemodynamics; Male; Myocardial C | 1978 |
Efficacy of intravenous propafenone in acute atrial fibrillation complicating open-heart surgery.
Topics: Acute Disease; Aged; Atrial Fibrillation; Blood Pressure; Cardiac Output; Cardiac Surgical Procedure | 1992 |
From the National Institutes of Health.
Topics: Acute Disease; ADP Ribose Transferases; Amoxicillin; Arrhythmias, Cardiac; Bacterial Toxins; Cardiom | 1991 |
[Acute propafenone poisoning. Description of a case].
Topics: Acute Disease; Adolescent; Female; Humans; Propafenone; Suicide, Attempted | 1990 |
Use of diprafenone, a new potent propafenone-analogue, in acute experimental myocardial ischaemia and infarction.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Chemical Phenomena; Chemis | 1987 |