promethazine has been researched along with Stroke in 5 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects." | 9.30 | Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. ( Chandra, A; Cheng, Z; Ding, Y; Du, H; Geng, X; Tong, Y; Zhu, H, 2019) |
| "While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects." | 5.30 | Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. ( Chandra, A; Cheng, Z; Ding, Y; Du, H; Geng, X; Tong, Y; Zhu, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| An, H | 1 |
| Duan, Y | 1 |
| Wu, D | 1 |
| Yip, J | 3 |
| Elmadhoun, O | 2 |
| Wright, JC | 1 |
| Shi, W | 1 |
| Liu, K | 1 |
| He, X | 1 |
| Shi, J | 1 |
| Jiang, F | 1 |
| Ji, X | 2 |
| Ding, Y | 4 |
| Li, F | 2 |
| Geng, X | 3 |
| Zhu, H | 1 |
| Chandra, A | 1 |
| Cheng, Z | 1 |
| Tong, Y | 1 |
| Du, H | 1 |
| Peng, C | 1 |
| Shen, J | 1 |
| Stavrovskaya, IG | 1 |
| Narayanan, MV | 1 |
| Zhang, W | 1 |
| Krasnikov, BF | 1 |
| Heemskerk, J | 1 |
| Young, SS | 1 |
| Blass, JP | 1 |
| Brown, AM | 1 |
| Beal, MF | 1 |
| Friedlander, RM | 1 |
| Kristal, BS | 1 |
1 trial available for promethazine and Stroke
| Article | Year |
|---|---|
Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke.
Topics: Adult; Aged; Aspirin; Atorvastatin; Chlorpromazine; Double-Blind Method; Drug Therapy, Combination; | 2019 |
4 other studies available for promethazine and Stroke
| Article | Year |
|---|---|
Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Combined Modality Therapy; Disease Models, Animal; Hy | 2017 |
Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Chlorpromazine; Male; Promethazine; Rats; Rats, Spragu | 2019 |
Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke.
Topics: Animals; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ischemic Attac | 2017 |
Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Apoptosis; Calcium; Calmodulin; Caspases; Cell | 2004 |