promethazine has been researched along with Space Adaptation Syndrome in 10 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Space motion sickness is currently treated pharmacologically with the empiric use of the H1 antihistamine promethazine, but use of this intervention is limited by the side effect of significant sedation." | 2.71 | Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. ( Blake, D; Chelonis, JJ; Dornhoffer, J, 2004) |
| " The specific objectives of research are to identify physiologic, pharmacokinetic, and pharmacodynamic changes in space; to develop simple, reliable, non-invasive, safe and effective acute and sustained-release dosage forms and regimens for pharmacological interventions in space; and to create and maintain a comprehensive space PK-PD and therapeutics database." | 1.30 | Pharmacotherapeutics in space. ( Putcha, L, 1999) |
| "promethazine and 6 of 8 treated with promethazine suppositories after symptom development had immediate (within 1-2 h) symptom relief and required no additional medication." | 1.29 | Comparison of treatment strategies for Space Motion Sickness. ( Beck, BG; Davis, JR; Jennings, RT, 1993) |
| "Cases of Space Motion Sickness were graded as mild, moderate or severe based on published criteria, and medication effectiveness was judged based on subjective reports of symptom relief." | 1.28 | Comparison of treatment strategies for Space Motion Sickness. ( Beck, BG; Davis, JR; Jennings, RT, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fiedler, J | 1 |
| Feiveson, AH | 1 |
| Hayat, MJ | 1 |
| Vaksman, Z | 1 |
| Boyd, JL | 1 |
| Putcha, L | 2 |
| Weerts, AP | 1 |
| De Meyer, G | 1 |
| Pauwels, G | 1 |
| Vanspauwen, R | 1 |
| Dornhoffer, JL | 1 |
| Van de Heyning, PH | 1 |
| Wuyts, FL | 1 |
| Dornhoffer, J | 1 |
| Chelonis, JJ | 1 |
| Blake, D | 1 |
| Dobie, TG | 1 |
| May, JG | 1 |
| Brown, TE | 1 |
| Eckberg, DL | 1 |
| Oman, CM | 1 |
| Davis, JR | 2 |
| Jennings, RT | 2 |
| Beck, BG | 2 |
| Graybiel, A | 1 |
1 review available for promethazine and Space Adaptation Syndrome
| Article | Year |
|---|---|
Cognitive-behavioral management of motion sickness.
Topics: Biofeedback, Psychology; Cinnarizine; Cognitive Behavioral Therapy; Desensitization, Psychologic; De | 1994 |
3 trials available for promethazine and Space Adaptation Syndrome
| Article | Year |
|---|---|
Pharmaceutical countermeasures have opposite effects on the utricles and semicircular canals in man.
Topics: Adult; Antiemetics; Female; Humans; Lorazepam; Male; Meclizine; Middle Aged; Promethazine; Reflex, V | 2012 |
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness.
Topics: Adolescent; Adult; Double-Blind Method; Female; GABA Modulators; Histamine H1 Antagonists; Humans; L | 2004 |
Promethazine affects autonomic cardiovascular mechanisms minimally.
Topics: Adult; Antiemetics; Autonomic Nervous System; Baroreflex; Blood Pressure; Cardiovascular System; Cat | 1997 |
6 other studies available for promethazine and Space Adaptation Syndrome
| Article | Year |
|---|---|
Joint modeling of performance and subjective reporting to assess sensitivity to drug-induced sleepiness.
Topics: Algorithms; Bayes Theorem; Cognition; Cross-Over Studies; Diagnostic Self Evaluation; Disorders of E | 2010 |
Spacelab experiments on space motion sickness.
Topics: Adaptation, Physiological; Adrenergic Agents; Antiemetics; Dextroamphetamine; Disease Susceptibility | 1987 |
Comparison of treatment strategies for Space Motion Sickness.
Topics: Aerospace Medicine; Antiemetics; Astronauts; Central Nervous System Stimulants; Dextroamphetamine; H | 1992 |
Comparison of treatment strategies for Space Motion Sickness.
Topics: Aerospace Medicine; Antiemetics; Dextroamphetamine; Female; Humans; Male; Promethazine; Scopolamine; | 1993 |
Pharmacotherapeutics in space.
Topics: Acetaminophen; Aerospace Medicine; Analgesics, Non-Narcotic; Headache; Histamine H1 Antagonists; Hum | 1999 |
The prevention of motion sickness in orbital flight.
Topics: Aerospace Medicine; Antiemetics; Dextroamphetamine; Dimenhydrinate; Ephedrine; Head Movements; Hista | 1976 |