Page last updated: 2024-11-03

promethazine and Pruritus

promethazine has been researched along with Pruritus in 16 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus."9.12Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. ( Alam, RU; Costa, RC; da Cruz, AW; Dos Santos, GR; Horta, ML; Morejon, LC; Terhorst, L; Welling, LC, 2006)
"Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever."9.11Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004)
"This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone."9.09Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000)
"We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus."5.12Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. ( Alam, RU; Costa, RC; da Cruz, AW; Dos Santos, GR; Horta, ML; Morejon, LC; Terhorst, L; Welling, LC, 2006)
"Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever."5.11Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004)
"This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone."5.09Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000)
"5% dioxopromethazine in Prothanon gel for palpebral pruritus and developed severe dermatitis of the lower eyelids with spread to the sun-exposed areas."3.70Dioxopromethazine-induced photoallergic contact dermatitis followed by persistent light reaction. ( Schauder, S, 1998)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's2 (12.50)18.2507
2000's4 (25.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Navarini, AA1
Stoeckle, M1
Navarini, S1
Mossdorf, E1
Jullu, BS1
Mchomvu, R1
Mbata, M1
Kibatala, P1
Tanner, M1
Hatz, C1
Schmid-Grendelmeier, P1
Kamei, H1
Isaji, A1
Noda, Y1
Ishikawa, K1
Senzaki, K1
Yamada, K1
Sugiura, K1
Tomita, Y1
Nabeshima, T1
Sartain, JB1
Barry, JJ1
Richardson, CA1
Branagan, HC1
MASLOV, PE1
JUHLIN, L1
SKOGH, M1
Ajayi, AA1
Kolawole, BA1
Udoh, SJ1
Horta, ML1
Morejon, LC1
da Cruz, AW1
Dos Santos, GR1
Welling, LC1
Terhorst, L1
Costa, RC1
Alam, RU1
Borelli, S1
Schellert, P1
Chee, YC1
Schutzman, SA1
Liebelt, E1
Wisk, M1
Burg, J1
Schauder, S1
Slappendel, R1
Weber, EW1
Benraad, B1
van Limbeek, J1
Dirksen, R1
Strandberg, K1
Rajka, G1
Nitzschner, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Granisetron on Incidence and Severity of Intrathecal Morphine Induced Pruritus in Elective Cesarean Section[NCT03483870]Phase 280 participants (Actual)Interventional2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for promethazine and Pruritus

ArticleYear
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers.
    Archives of dermatological research, 2012, Volume: 304, Issue:4

    Topics: Adolescent; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Olop

2012
Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Antiemetics; Drug The

2003
Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching.
    International journal of dermatology, 2004, Volume: 43, Issue:12

    Topics: Administration, Oral; Adult; Animals; Antimalarials; Antipruritics; Area Under Curve; Chloroquine; D

2004
Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
    British journal of anaesthesia, 2006, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Antipruritics; C

2006
[On the efficacy of psychopharmaceutic agents in atopic neurodermatitis: comparative study of diazepam (Valium), promethazine (Phenergan) and placebo].
    Dermatologica, 1967, Volume: 135, Issue:6

    Topics: Adolescent; Adult; Dermatitis, Atopic; Diazepam; Female; Humans; Male; Middle Aged; Neurodermatitis;

1967
Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair.
    Annals of emergency medicine, 1996, Volume: 28, Issue:4

    Topics: Administration, Oral; Analgesics, Opioid; Child, Preschool; Chlorpromazine; Dermatologic Surgical Pr

1996
Itching after intrathecal morphine. Incidence and treatment.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Antipruritics; Arthroplasty, Replacement, Hip; Dose-Response Relationship,

2000
Comparison of the antihistaminic effects in skin of a tertiary (promethazine) and a quarternary phenothiazine (N-hydroxyethylpromethazine).
    Acta allergologica, 1974, Volume: 29, Issue:6

    Topics: Adolescent; Adult; Drug Evaluation; Histamine; Histamine H1 Antagonists; Humans; Injections, Subcuta

1974
Evaluation of drug influence on the itch duration in the skin of patients with atopic dermatitis, various eczemas and psoriasis. I. Experiments in involved skin. Comparison with itch threshold technique.
    Acta dermato-venereologica, 1968, Volume: 48, Issue:2

    Topics: Clinical Trials as Topic; Dermatitis, Atopic; Eczema; Histamine H1 Antagonists; Humans; Methotrimepr

1968
[The introduction of 9,9-dioxopromethazine (Prothanon) into the treatment of skin diseases in hospitalized patients].
    Die Pharmazie, 1970, Feb-02, Volume: 25, Issue:2

    Topics: Blood; Blood Glucose; Clinical Trials as Topic; Dermatitis Herpetiformis; Dermatologic Agents; Drug

1970

Other Studies

6 other studies available for promethazine and Pruritus

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.
    International journal of dermatology, 2010, Volume: 49, Issue:1

    Topics: Administration, Oral; Administration, Topical; Antiretroviral Therapy, Highly Active; CD4-CD8 Ratio;

2010
[Antihistaminic preparation diprasine in pruritic dermatoses in children].
    Vestnik rentgenologii i radiologii, 1960, Volume: 34

    Topics: Humans; Promethazine; Pruritus; Skin Diseases

1960
A double-blind investigation to test the antipruritic effect of some phenothiazine derivatives.
    Acta dermato-venereologica, 1961, Volume: 41

    Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Allergic Agents; Antipruritics; Antipyretics; Double-Blin

1961
Effects of cimetidine, ranitidine and promethazine on histamine--induced dermal weals and pruritus--a case study.
    Singapore medical journal, 1983, Volume: 24, Issue:3

    Topics: Adult; Cimetidine; Drug Eruptions; Drug Therapy, Combination; Histamine; Humans; Male; Methyltestost

1983
Dioxopromethazine-induced photoallergic contact dermatitis followed by persistent light reaction.
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1998, Volume: 9, Issue:3

    Topics: Antipruritics; Balsams; Dermatitis, Photoallergic; Eyelid Diseases; Facial Dermatoses; Female; Gels;

1998