promethazine has been researched along with Pruritus in 16 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus." | 9.12 | Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. ( Alam, RU; Costa, RC; da Cruz, AW; Dos Santos, GR; Horta, ML; Morejon, LC; Terhorst, L; Welling, LC, 2006) |
| "Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever." | 9.11 | Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004) |
| "This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone." | 9.09 | Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000) |
| "We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus." | 5.12 | Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. ( Alam, RU; Costa, RC; da Cruz, AW; Dos Santos, GR; Horta, ML; Morejon, LC; Terhorst, L; Welling, LC, 2006) |
| "Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever." | 5.11 | Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004) |
| "This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone." | 5.09 | Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000) |
| "5% dioxopromethazine in Prothanon gel for palpebral pruritus and developed severe dermatitis of the lower eyelids with spread to the sun-exposed areas." | 3.70 | Dioxopromethazine-induced photoallergic contact dermatitis followed by persistent light reaction. ( Schauder, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Navarini, AA | 1 |
| Stoeckle, M | 1 |
| Navarini, S | 1 |
| Mossdorf, E | 1 |
| Jullu, BS | 1 |
| Mchomvu, R | 1 |
| Mbata, M | 1 |
| Kibatala, P | 1 |
| Tanner, M | 1 |
| Hatz, C | 1 |
| Schmid-Grendelmeier, P | 1 |
| Kamei, H | 1 |
| Isaji, A | 1 |
| Noda, Y | 1 |
| Ishikawa, K | 1 |
| Senzaki, K | 1 |
| Yamada, K | 1 |
| Sugiura, K | 1 |
| Tomita, Y | 1 |
| Nabeshima, T | 1 |
| Sartain, JB | 1 |
| Barry, JJ | 1 |
| Richardson, CA | 1 |
| Branagan, HC | 1 |
| MASLOV, PE | 1 |
| JUHLIN, L | 1 |
| SKOGH, M | 1 |
| Ajayi, AA | 1 |
| Kolawole, BA | 1 |
| Udoh, SJ | 1 |
| Horta, ML | 1 |
| Morejon, LC | 1 |
| da Cruz, AW | 1 |
| Dos Santos, GR | 1 |
| Welling, LC | 1 |
| Terhorst, L | 1 |
| Costa, RC | 1 |
| Alam, RU | 1 |
| Borelli, S | 1 |
| Schellert, P | 1 |
| Chee, YC | 1 |
| Schutzman, SA | 1 |
| Liebelt, E | 1 |
| Wisk, M | 1 |
| Burg, J | 1 |
| Schauder, S | 1 |
| Slappendel, R | 1 |
| Weber, EW | 1 |
| Benraad, B | 1 |
| van Limbeek, J | 1 |
| Dirksen, R | 1 |
| Strandberg, K | 1 |
| Rajka, G | 1 |
| Nitzschner, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Intravenous Granisetron on Incidence and Severity of Intrathecal Morphine Induced Pruritus in Elective Cesarean Section[NCT03483870] | Phase 2 | 80 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for promethazine and Pruritus
| Article | Year |
|---|---|
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers.
Topics: Adolescent; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Olop | 2012 |
Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Antiemetics; Drug The | 2003 |
Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching.
Topics: Administration, Oral; Adult; Animals; Antimalarials; Antipruritics; Area Under Curve; Chloroquine; D | 2004 |
Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Antipruritics; C | 2006 |
[On the efficacy of psychopharmaceutic agents in atopic neurodermatitis: comparative study of diazepam (Valium), promethazine (Phenergan) and placebo].
Topics: Adolescent; Adult; Dermatitis, Atopic; Diazepam; Female; Humans; Male; Middle Aged; Neurodermatitis; | 1967 |
Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair.
Topics: Administration, Oral; Analgesics, Opioid; Child, Preschool; Chlorpromazine; Dermatologic Surgical Pr | 1996 |
Itching after intrathecal morphine. Incidence and treatment.
Topics: Aged; Analgesics, Opioid; Antipruritics; Arthroplasty, Replacement, Hip; Dose-Response Relationship, | 2000 |
Comparison of the antihistaminic effects in skin of a tertiary (promethazine) and a quarternary phenothiazine (N-hydroxyethylpromethazine).
Topics: Adolescent; Adult; Drug Evaluation; Histamine; Histamine H1 Antagonists; Humans; Injections, Subcuta | 1974 |
Evaluation of drug influence on the itch duration in the skin of patients with atopic dermatitis, various eczemas and psoriasis. I. Experiments in involved skin. Comparison with itch threshold technique.
Topics: Clinical Trials as Topic; Dermatitis, Atopic; Eczema; Histamine H1 Antagonists; Humans; Methotrimepr | 1968 |
[The introduction of 9,9-dioxopromethazine (Prothanon) into the treatment of skin diseases in hospitalized patients].
Topics: Blood; Blood Glucose; Clinical Trials as Topic; Dermatitis Herpetiformis; Dermatologic Agents; Drug | 1970 |
6 other studies available for promethazine and Pruritus
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.
Topics: Administration, Oral; Administration, Topical; Antiretroviral Therapy, Highly Active; CD4-CD8 Ratio; | 2010 |
[Antihistaminic preparation diprasine in pruritic dermatoses in children].
Topics: Humans; Promethazine; Pruritus; Skin Diseases | 1960 |
A double-blind investigation to test the antipruritic effect of some phenothiazine derivatives.
Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Allergic Agents; Antipruritics; Antipyretics; Double-Blin | 1961 |
Effects of cimetidine, ranitidine and promethazine on histamine--induced dermal weals and pruritus--a case study.
Topics: Adult; Cimetidine; Drug Eruptions; Drug Therapy, Combination; Histamine; Humans; Male; Methyltestost | 1983 |
Dioxopromethazine-induced photoallergic contact dermatitis followed by persistent light reaction.
Topics: Antipruritics; Balsams; Dermatitis, Photoallergic; Eyelid Diseases; Facial Dermatoses; Female; Gels; | 1998 |