promethazine has been researched along with Pain in 48 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery." | 9.27 | Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018) |
| "This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery." | 5.27 | Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018) |
| " The patients who received bupivacaine at the trocar site clinically had less pain (p < 0." | 5.09 | Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy. ( Faiz, H; Hasaniya, NW; Severino, R; Zayed, FF, 2001) |
| " This study was designed to: 1) compare the safety and efficacy of intravenous fentanyl, intravenous fentanyl combined with midazolam, and intramuscular meperidine-promethazine-chlorpromazine (MPC) compound when used for painful emergency department (ED) procedures: and 2) to determine whether the addition of et-CO2 monitoring enabled earlier identification of respiratory depression in this population." | 5.08 | The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. ( Berns, SD; Boenning, DA; Hart, LS; Houck, CS, 1997) |
| " As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges." | 3.78 | Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites. ( Choi, CJ; Cunningham, BT; George, S; Weyhenmeyer, J; Wu, HY, 2012) |
| "The edema was inhibited by previous treatment with promethazine (5 or 10mg/kg) or cyproheptadine (5 or 10mg/kg), but not by indomethacin (2 or 4mg/kg), dexamethasone (1 or 4mg/kg) or cromolyn (40 or 80mg/kg)." | 1.33 | Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. ( Bertollo, CM; Coelho, MM; Costa, KA; Glória, MB; Moraes-Santos, T; Nascimento, EB; Oliveira, AC; Rocha, LT; Souza, AL, 2005) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| " The sigmoid Emax model was fitted to the observed composite effect, and dose-response characteristics for two opposite effects were described." | 1.27 | Promethazine both facilitates and inhibits nociception in rats: effect of the testing procedure. ( Paalzow, GH; Paalzow, LK, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (64.58) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 6 (12.50) | 29.6817 |
| 2010's | 3 (6.25) | 24.3611 |
| 2020's | 1 (2.08) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Lu, C | 1 |
| Liu, X | 1 |
| Zhang, G | 1 |
| Zhang, J | 1 |
| Gao, M | 1 |
| Liu, D | 1 |
| Zhang, X | 1 |
| Liu, Y | 1 |
| van Amerongen, G | 1 |
| Siebenga, P | 1 |
| de Kam, ML | 1 |
| Hay, JL | 1 |
| Groeneveld, GJ | 1 |
| Hoffmeister, C | 1 |
| Trevisan, G | 1 |
| Rossato, MF | 1 |
| de Oliveira, SM | 1 |
| Gomez, MV | 1 |
| Ferreira, J | 1 |
| Choi, CJ | 1 |
| Wu, HY | 1 |
| George, S | 1 |
| Weyhenmeyer, J | 1 |
| Cunningham, BT | 1 |
| KLEIN, MR | 1 |
| DELEGUE, L | 1 |
| TOWNES, CD | 1 |
| MANN, SH | 1 |
| EGBERT, LD | 1 |
| NORTON, ML | 1 |
| ECKENHOFF, JE | 1 |
| DRIPPS, RD | 1 |
| BONO, F | 1 |
| GAZZANIGA, M | 1 |
| CLIFFORD, DH | 1 |
| CRANIN, AN | 1 |
| CRANIN, SL | 1 |
| LAJOIE, WJ | 1 |
| DUNDEE, JW | 1 |
| LOVE, WJ | 1 |
| MOORE, J | 1 |
| MARKALOUS, P | 1 |
| STEIN, ID | 1 |
| MACAULAY, AI | 1 |
| MANNARELLI, AA | 1 |
| ULLERY, JC | 1 |
| KAH, R | 1 |
| XU, SF | 1 |
| SHEN, XT | 1 |
| LI, ZL | 1 |
| WU, BY | 1 |
| JANG, CS | 1 |
| PENA, EF | 1 |
| BLAIR, AE | 1 |
| GIRARD, M | 1 |
| FRAISSE, H | 1 |
| Nascimento, EB | 1 |
| Costa, KA | 1 |
| Bertollo, CM | 1 |
| Oliveira, AC | 1 |
| Rocha, LT | 1 |
| Souza, AL | 1 |
| Glória, MB | 1 |
| Moraes-Santos, T | 1 |
| Coelho, MM | 1 |
| Craig, A | 1 |
| Foster, A | 1 |
| Mobley, E | 1 |
| Wang, Z | 1 |
| Schutzman, SA | 1 |
| Liebelt, E | 1 |
| Wisk, M | 1 |
| Burg, J | 1 |
| Hart, LS | 1 |
| Berns, SD | 1 |
| Houck, CS | 1 |
| Boenning, DA | 1 |
| Hasaniya, NW | 1 |
| Zayed, FF | 1 |
| Faiz, H | 1 |
| Severino, R | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Ng, EH | 1 |
| Miao, B | 1 |
| Ho, PC | 1 |
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
| Ben-Shlomo, I | 1 |
| Amodai, I | 1 |
| Levran, D | 1 |
| Dor, J | 1 |
| Etchin, A | 1 |
| Perl, AZ | 1 |
| Cui, Y | 1 |
| Chen, G | 1 |
| Zhang, Q | 1 |
| Jiang, J | 1 |
| Wu, G | 1 |
| Xu, S | 1 |
| Zeltzer, LK | 1 |
| Anderson, CT | 1 |
| Schechter, NL | 1 |
| Neil, A | 1 |
| Benoist, JM | 1 |
| Kayser, V | 1 |
| Guilbaud, G | 1 |
| Paalzow, GH | 1 |
| Paalzow, LK | 1 |
| Vella, L | 1 |
| Francis, D | 1 |
| Houlton, P | 1 |
| Reynolds, F | 1 |
| McQuitty, FM | 1 |
| Brenner, WE | 1 |
| Hendricks, CH | 1 |
| Braaksma, JT | 1 |
| Fishburne, JI | 1 |
| Staurovsky, LG | 1 |
| Ryhänen, P | 1 |
| Hollmén, A | 1 |
| Hinkula, A | 1 |
| Pakonen, ML | 1 |
| Pihlajaniemi, H | 1 |
| Kerkelä, A | 1 |
| Mima, T | 1 |
| Uchiyama, S | 1 |
| Onchi, Y | 1 |
| Paccalin, MJ | 1 |
| Melikoglu, S | 1 |
| Messerich, J | 1 |
| Filipescu, A | 1 |
| Spirescu, J | 1 |
| Elomaa, M | 1 |
| Pautola, A | 1 |
| Altonen, M | 1 |
| Knape, H | 1 |
| Wilhelmi, G | 1 |
| Gdynia, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Organ Protective Effect of Histamine H1 Receptor Antagonist In Patients With Severe Burns: A Clinical Study[NCT06126991] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| A Randomised Control Trial to Determine Whether Intervention Based on a Microstream Capnography-based Ventilation Monitoring System Will Decrease Hypoxaemaia During Intravenous Sedation With Midazolam.[NCT01949012] | 190 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
1 review available for promethazine and Pain
| Article | Year |
|---|---|
Pediatric pain: current status and new directions.
Topics: Child; Child, Preschool; Chlorpromazine; Drug Combinations; Humans; Infant; Infant, Newborn; Meperid | 1990 |
9 trials available for promethazine and Pain
| Article | Year |
|---|---|
Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Allergic Agents; Attention; Cognition; Cold Tem | 2018 |
Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair.
Topics: Administration, Oral; Analgesics, Opioid; Child, Preschool; Chlorpromazine; Dermatologic Surgical Pr | 1996 |
The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department.
Topics: Capnography; Carbon Dioxide; Child; Chlorpromazine; Conscious Sedation; Drug Combinations; Emergency | 1997 |
Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy.
Topics: Abdominal Muscles; Anesthesia, Local; Bupivacaine; Cholecystectomy, Laparoscopic; Cholelithiasis; Co | 2001 |
Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Meperi | 2002 |
Comparison of the antiemetics metoclopramide and promethazine in labour.
Topics: Clinical Trials as Topic; Consciousness; Double-Blind Method; Female; Humans; Meperidine; Metoclopra | 1985 |
Relief of fain in labour. A controlled double-blind trial comparing pethidine and various phenothiazine derivatives.
Topics: Analgesics; Clinical Trials as Topic; Female; Humans; Hypnotics and Sedatives; Injections, Intramusc | 1967 |
[Effects of sedatives on postoperative pain].
Topics: Blood Pressure; Chlorpromazine; Clinical Trials as Topic; Humans; Hypnotics and Sedatives; Injection | 1971 |
[An experimental study on the premedication effect of promethazine and diazepam].
Topics: Adult; Dental Pulp Test; Diazepam; Female; Humans; Male; Pain; Placebos; Premedication; Promethazine | 1971 |
38 other studies available for promethazine and Pain
| Article | Year |
|---|---|
Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.
Topics: Animals; Cetirizine; Fentanyl; Histamine; Histamine H1 Antagonists; Midazolam; Pain; Promethazine; R | 2023 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B | 2011 |
Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites.
Topics: Biosensing Techniques; Humans; Injections, Intravenous; Nanoparticles; Pain; Point-of-Care Systems; | 2012 |
[Tests of neurolytic drugs in neurosurgical operations in children].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Brain; Child; Chlorpromazine; Humans; Meperidine; P | 1957 |
Intravenous sedation in cataract surgery.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Cataract; Cataract Extraction; Chlorpromazine; Huma | 1958 |
A comparison in man of the effects of promethazine, secobarbital, and meperidine alone and in combination on certain respiratory functions and for use in preanesthetic medication.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Humans; Meperidine; Pain; Preanesthet | 1958 |
[Use of the meprobamate-promethazine-meperidine combination in preanesthesia].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Humans; Meperidine; Meprobamate; Pain; Pain Managem | 1959 |
Effect of preanesthetic medication with promazine and promethazine on pentobarbital anesthesia and subsequent hypothermia in the cat.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Cats; Hypothermia; Hypothermia, Induced; P | 1960 |
Synergistic basal narcosedation. A basic technique employing promethazine, meperidine, and secobarbital.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Meperidine; Pain; Pain Management; Promethazine; Se | 1960 |
Analgesia in electromyography.
Topics: Analgesia; Electromyography; Humans; Meperidine; Methadone; Pain; Pain Management; Promethazine | 1963 |
ALTERATIONS IN RESPONSE TO SOMATIC PAIN ASSOCIATED WITH ANAESTHESIA. XV. FURTHER STUDIES WITH PHENOTHIAZINE DERIVATIVES AND SIMILAR DRUGS.
Topics: Analgesics; Analgesics, Non-Narcotic; Anesthesia; Antiemetics; Antipyretics; Chlorpromazine; Chlorpr | 1963 |
[MITIGATION OF POSTOPERATIVE PAIN. COMPARISON OF EUPROGAN, EUNALGIT AND PYRABUTOL].
Topics: Aminopyrine; Anesthetics; Anesthetics, Local; Barbiturates; Drug Combinations; Humans; Pain; Pain, P | 1963 |
CONTROL OF PAIN IN CERTAIN PERIPHERAL VASCULAR DISORDERS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Diphenhydramine; Drug Therapy; Foot Diseases; Ge | 1964 |
COMPARISON OF POTENCY OF INJECTABLE MEPERIDINE AND PROMETHAZINE-MEPERIDINE CAPSULES IN POSTOPERATIVE PAIN.
Topics: Analgesia; Biomedical Research; Capsules; Humans; Injections, Intramuscular; Meperidine; Pain; Pain | 1964 |
THE USE OF MEPERGAN FOR RELIEF OF PAIN IN GYNECOLOGIC TUMOR PATIENTS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Biomedical Research; Female; Genital Neoplasms, | 1964 |
[ON THE MECHANISM OF SINOMENINE "ANALGESIA"].
Topics: Alkaloids; Analgesia; Biological Assay; Mice; Morphinans; Pain; Pharmacology; Promethazine; Research | 1964 |
COMPARISON OF ORAL PROMETHAZINE-MEPERIDINE WITH INJECTABLE MEPERIDINE FOR RELIEF OF POSTOPERATIVE PAIN.
Topics: Biomedical Research; Capsules; Dosage Forms; Drug Therapy; Genital Diseases, Female; Humans; Injecti | 1965 |
THE EFFICACY OF PLACEBO ON PAIN PERCEPTION THRESHOLD.
Topics: Alphaprodine; Biomedical Research; Blood Pressure; Dental Pulp; Electric Stimulation; Heart Rate; Hu | 1965 |
[Action of phenergan syrup on gastric pains].
Topics: Abdominal Pain; Histamine; Humans; Pain; Promethazine; Stomach | 1950 |
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyproheptadine; Dipyrone; Edema; Indomethacin; Inje | 2005 |
Pain, inflammation and a nodule after IV medication.
Topics: Adult; Female; Forearm; Gastroenteritis; Histamine H1 Antagonists; Humans; Inflammation; Injections, | 2005 |
Complicated pain management in a CYP450 2D6 poor metabolizer.
Topics: Analgesics, Opioid; Antiemetics; Cytochrome P-450 CYP2D6; Female; Humans; Middle Aged; Pain; Prometh | 2007 |
Antihistamine antinociception is mediated by Gi-protein activation.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Diphenhydramine; Dose-Response Relati | 2002 |
Sedation and analgesia for minor painful procedures.
Topics: Analgesics; Anesthetics, Local; Barbiturates; Child; Chlorpromazine; Drug Therapy, Combination; Huma | 1977 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
Midazolam-fentanyl sedation in conjunction with local anesthesia during oocyte retrieval for in vitro fertilization.
Topics: Drug Therapy, Combination; Female; Fentanyl; Fertilization in Vitro; Humans; Injections, Intramuscul | 1992 |
IM MPC in children: safe and effective or a poor choice?
Topics: Child; Chlorpromazine; Drug Therapy, Combination; Emergencies; Humans; Injections, Intramuscular; Me | 1991 |
[Effects of promethazine on acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Electroacupuncture; Female; Male; Pain; Promethazine; Rabbits; Senso | 1990 |
Initial nociceptive sensitization in carrageenin-induced rat paw inflammation is dependent on amine autacoid mechanisms: electrophysiological and behavioural evidence obtained with a quaternary antihistamine, thiazinamium.
Topics: Animals; Behavior, Animal; Carrageenan; Inflammation; Injections, Subcutaneous; Male; Nociceptors; P | 1987 |
Promethazine both facilitates and inhibits nociception in rats: effect of the testing procedure.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Male; Nociceptors; Pain; Promethazi | 1985 |
Intra-amniotic administration of prostaglandin F 2 for induction of therapeutic abortion. A comparison of four dosage schedules.
Topics: Abortion, Therapeutic; Adolescent; Adult; Amniotic Fluid; Dose-Response Relationship, Drug; Female; | 1972 |
Patient's views on general anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam; | 1973 |
[On the medical treatment of acute pancreatitis].
Topics: Acute Disease; Diet Therapy; Ergoloid Mesylates; Humans; Meperidine; Pain; Pancreatitis; Promethazin | 1967 |
[Pain therapy in internal medicine].
Topics: Adult; Aged; Antipyrine; Bromides; Butyrates; Drug Combinations; Female; Humans; Male; Methylamines; | 1972 |
[Modern treatment of pain in internal diseases].
Topics: Adult; Anxiety; Drug Combinations; Humans; Internal Medicine; Male; Middle Aged; Pain; Phenothiazine | 1971 |
[The pain syndrome of the edentulous alveolar crest and its treatment].
Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine; | 1969 |
A comparison of neuroleptanesthesia and halothane in neurosurgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta | 1970 |
[On the phlogogenic properties of lactic acid in animal experiments].
Topics: Animals; Capillary Permeability; Conjunctivitis; Edema; Exudates and Transudates; Guinea Pigs; Infla | 1968 |