promethazine has been researched along with Pain, Postoperative in 17 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 9.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| "This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone." | 9.09 | Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000) |
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 5.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| "This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone." | 5.09 | Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000) |
| " The patients who received bupivacaine at the trocar site clinically had less pain (p < 0." | 5.09 | Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy. ( Faiz, H; Hasaniya, NW; Severino, R; Zayed, FF, 2001) |
| "The secondary endpoint was postoperative nausea and vomiting." | 2.71 | The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy. ( Chia, YY; Chung, NC; Ko, NH; Liu, K; Lo, Y; Tan, PH, 2004) |
| "0 ml, dosage 1." | 2.68 | Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children. ( Davidson, A; Ragg, P, 1997) |
| "A series of 2000 patients with upper urinary calculi underwent PCNL under local infiltration anesthesia." | 1.39 | Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases. ( Chen, B; Chen, Y; Li, B; Li, H; Liu, C; Wen, Y; Xu, A; Xu, K; Xu, Y; Zheng, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zuniga, JR | 1 |
| Papas, AS | 1 |
| Daniels, SE | 1 |
| Patrick, K | 1 |
| Muse, DD | 1 |
| Oreadi, D | 1 |
| Giannakopoulos, HE | 1 |
| Granquist, EJ | 1 |
| Levin, LM | 1 |
| Chou, JC | 1 |
| Maibach, H | 1 |
| Schachtel, BP | 1 |
| Li, H | 1 |
| Xu, K | 1 |
| Li, B | 1 |
| Chen, B | 1 |
| Xu, A | 1 |
| Chen, Y | 1 |
| Xu, Y | 1 |
| Wen, Y | 1 |
| Zheng, S | 1 |
| Liu, C | 1 |
| MARKALOUS, P | 1 |
| MANNARELLI, AA | 1 |
| PENA, EF | 1 |
| Chia, YY | 1 |
| Lo, Y | 1 |
| Liu, K | 1 |
| Tan, PH | 1 |
| Chung, NC | 1 |
| Ko, NH | 1 |
| Weis, OF | 1 |
| Sriwatanakul, K | 1 |
| Alloza, JL | 1 |
| Weintraub, M | 1 |
| Lasagna, L | 1 |
| Bhalotra, AR | 1 |
| Saksena, R | 1 |
| Hyndman, J | 1 |
| Henderson, F | 1 |
| Ragg, P | 1 |
| Davidson, A | 1 |
| Slappendel, R | 1 |
| Weber, EW | 1 |
| Benraad, B | 1 |
| van Limbeek, J | 1 |
| Dirksen, R | 1 |
| Hasaniya, NW | 1 |
| Zayed, FF | 1 |
| Faiz, H | 1 |
| Severino, R | 1 |
| Middleton, RA | 1 |
| Upton, LG | 1 |
| Blumenkopf, B | 1 |
| Reuther, J | 1 |
| Hausamen, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Intravenous Granisetron on Incidence and Severity of Intrathecal Morphine Induced Pruritus in Elective Cesarean Section[NCT03483870] | Phase 2 | 80 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for promethazine and Pain, Postoperative
| Article | Year |
|---|---|
Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Antiemetics; Drug Combinations; Fe | 2019 |
The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 A | 2004 |
Evaluation of diclofenac sodium as a perioperative analgesic.
Topics: Adult; Atropine; Diclofenac; Female; Humans; Male; Meperidine; Middle Aged; Monitoring, Physiologic; | 1994 |
Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children.
Topics: Acetaminophen; Analgesia; Analgesics; Child; Child, Preschool; Codeine; Double-Blind Method; Drug Co | 1997 |
Itching after intrathecal morphine. Incidence and treatment.
Topics: Aged; Analgesics, Opioid; Antipruritics; Arthroplasty, Replacement, Hip; Dose-Response Relationship, | 2000 |
Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy.
Topics: Abdominal Muscles; Anesthesia, Local; Bupivacaine; Cholecystectomy, Laparoscopic; Cholelithiasis; Co | 2001 |
Postoperative evaluation of combined analgesic/sedative.
Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Humans; Pain, Post | 1978 |
Evaluation of sedative/analgesic combination for postoperative pain.
Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug E | 1979 |
Combination analgesic-antispasmodic therapy in postoperative pain.
Topics: Adolescent; Adult; Aged; Baclofen; Diazepam; Drug Therapy, Combination; Female; Humans; Male; Meperi | 1987 |
[Clinical evaluation of a new combination preparation for analgesia in oral surgery].
Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Combinations; Humans; Meperidine; Mid | 1974 |
7 other studies available for promethazine and Pain, Postoperative
| Article | Year |
|---|---|
Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; China; Feasibi | 2013 |
[MITIGATION OF POSTOPERATIVE PAIN. COMPARISON OF EUPROGAN, EUNALGIT AND PYRABUTOL].
Topics: Aminopyrine; Anesthetics; Anesthetics, Local; Barbiturates; Drug Combinations; Humans; Pain; Pain, P | 1963 |
COMPARISON OF POTENCY OF INJECTABLE MEPERIDINE AND PROMETHAZINE-MEPERIDINE CAPSULES IN POSTOPERATIVE PAIN.
Topics: Analgesia; Biomedical Research; Capsules; Humans; Injections, Intramuscular; Meperidine; Pain; Pain | 1964 |
COMPARISON OF ORAL PROMETHAZINE-MEPERIDINE WITH INJECTABLE MEPERIDINE FOR RELIEF OF POSTOPERATIVE PAIN.
Topics: Biomedical Research; Capsules; Dosage Forms; Drug Therapy; Genital Diseases, Female; Humans; Injecti | 1965 |
Attitudes of patients, housestaff, and nurses toward postoperative analgesic care.
Topics: Adolescent; Adult; Aged; Amphetamine; Analgesics; Analgesics, Opioid; Attitude; Attitude of Health P | 1983 |
Oral premedication with methadone, promethazine and diclofenac.
Topics: Administration, Oral; Anxiety; Diclofenac; Female; Humans; Male; Methadone; Pain, Postoperative; Pre | 1993 |
21-day compatibility of hydromorphone hydrochloride and promethazine hydrochloride in a cassette.
Topics: Analgesics, Opioid; Antiemetics; Drug Combinations; Drug Stability; Drug Storage; Humans; Hydromorph | 1996 |