Page last updated: 2024-11-03

promethazine and Pain, Postoperative

promethazine has been researched along with Pain, Postoperative in 17 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Pain, Postoperative: Pain during the period after surgery.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12."9.30Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019)
"This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone."9.09Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000)
"To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12."5.30Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019)
"This study was designed to determine whether low doses of intrathecal morphine still result in itching and it evaluates the outcome of a standardized treatment using promethazine and - for intractable itch - naloxone."5.09Itching after intrathecal morphine. Incidence and treatment. ( Benraad, B; Dirksen, R; Slappendel, R; van Limbeek, J; Weber, EW, 2000)
" The patients who received bupivacaine at the trocar site clinically had less pain (p < 0."5.09Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy. ( Faiz, H; Hasaniya, NW; Severino, R; Zayed, FF, 2001)
"The secondary endpoint was postoperative nausea and vomiting."2.71The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy. ( Chia, YY; Chung, NC; Ko, NH; Liu, K; Lo, Y; Tan, PH, 2004)
"0 ml, dosage 1."2.68Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children. ( Davidson, A; Ragg, P, 1997)
"A series of 2000 patients with upper urinary calculi underwent PCNL under local infiltration anesthesia."1.39Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases. ( Chen, B; Chen, Y; Li, B; Li, H; Liu, C; Wen, Y; Xu, A; Xu, K; Xu, Y; Zheng, S, 2013)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19908 (47.06)18.7374
1990's4 (23.53)18.2507
2000's3 (17.65)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zuniga, JR1
Papas, AS1
Daniels, SE1
Patrick, K1
Muse, DD1
Oreadi, D1
Giannakopoulos, HE1
Granquist, EJ1
Levin, LM1
Chou, JC1
Maibach, H1
Schachtel, BP1
Li, H1
Xu, K1
Li, B1
Chen, B1
Xu, A1
Chen, Y1
Xu, Y1
Wen, Y1
Zheng, S1
Liu, C1
MARKALOUS, P1
MANNARELLI, AA1
PENA, EF1
Chia, YY1
Lo, Y1
Liu, K1
Tan, PH1
Chung, NC1
Ko, NH1
Weis, OF1
Sriwatanakul, K1
Alloza, JL1
Weintraub, M1
Lasagna, L1
Bhalotra, AR1
Saksena, R1
Hyndman, J1
Henderson, F1
Ragg, P1
Davidson, A1
Slappendel, R1
Weber, EW1
Benraad, B1
van Limbeek, J1
Dirksen, R1
Hasaniya, NW1
Zayed, FF1
Faiz, H1
Severino, R1
Middleton, RA1
Upton, LG1
Blumenkopf, B1
Reuther, J1
Hausamen, JE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Granisetron on Incidence and Severity of Intrathecal Morphine Induced Pruritus in Elective Cesarean Section[NCT03483870]Phase 280 participants (Actual)Interventional2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for promethazine and Pain, Postoperative

ArticleYear
Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi
    Pain medicine (Malden, Mass.), 2019, 12-01, Volume: 20, Issue:12

    Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Antiemetics; Drug Combinations; Fe

2019
The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:5

    Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 A

2004
Evaluation of diclofenac sodium as a perioperative analgesic.
    Indian journal of medical sciences, 1994, Volume: 48, Issue:12

    Topics: Adult; Atropine; Diclofenac; Female; Humans; Male; Meperidine; Middle Aged; Monitoring, Physiologic;

1994
Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:1

    Topics: Acetaminophen; Analgesia; Analgesics; Child; Child, Preschool; Codeine; Double-Blind Method; Drug Co

1997
Itching after intrathecal morphine. Incidence and treatment.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Antipruritics; Arthroplasty, Replacement, Hip; Dose-Response Relationship,

2000
Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy.
    Surgical endoscopy, 2001, Volume: 15, Issue:9

    Topics: Abdominal Muscles; Anesthesia, Local; Bupivacaine; Cholecystectomy, Laparoscopic; Cholelithiasis; Co

2001
Postoperative evaluation of combined analgesic/sedative.
    Dental survey, 1978, Volume: 54, Issue:2

    Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Humans; Pain, Post

1978
Evaluation of sedative/analgesic combination for postoperative pain.
    Oral surgery, oral medicine, and oral pathology, 1979, Volume: 47, Issue:6

    Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug E

1979
Combination analgesic-antispasmodic therapy in postoperative pain.
    Spine, 1987, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Baclofen; Diazepam; Drug Therapy, Combination; Female; Humans; Male; Meperi

1987
[Clinical evaluation of a new combination preparation for analgesia in oral surgery].
    Die Medizinische Welt, 1974, May-03, Volume: 25, Issue:18

    Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Combinations; Humans; Meperidine; Mid

1974

Other Studies

7 other studies available for promethazine and Pain, Postoperative

ArticleYear
Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases.
    Urology, 2013, Volume: 82, Issue:5

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; China; Feasibi

2013
[MITIGATION OF POSTOPERATIVE PAIN. COMPARISON OF EUPROGAN, EUNALGIT AND PYRABUTOL].
    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1963, Volume: 42

    Topics: Aminopyrine; Anesthetics; Anesthetics, Local; Barbiturates; Drug Combinations; Humans; Pain; Pain, P

1963
COMPARISON OF POTENCY OF INJECTABLE MEPERIDINE AND PROMETHAZINE-MEPERIDINE CAPSULES IN POSTOPERATIVE PAIN.
    The Journal of the American Osteopathic Association, 1964, Volume: 63

    Topics: Analgesia; Biomedical Research; Capsules; Humans; Injections, Intramuscular; Meperidine; Pain; Pain

1964
COMPARISON OF ORAL PROMETHAZINE-MEPERIDINE WITH INJECTABLE MEPERIDINE FOR RELIEF OF POSTOPERATIVE PAIN.
    Obstetrics and gynecology, 1965, Volume: 25

    Topics: Biomedical Research; Capsules; Dosage Forms; Drug Therapy; Genital Diseases, Female; Humans; Injecti

1965
Attitudes of patients, housestaff, and nurses toward postoperative analgesic care.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Amphetamine; Analgesics; Analgesics, Opioid; Attitude; Attitude of Health P

1983
Oral premedication with methadone, promethazine and diclofenac.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:2

    Topics: Administration, Oral; Anxiety; Diclofenac; Female; Humans; Male; Methadone; Pain, Postoperative; Pre

1993
21-day compatibility of hydromorphone hydrochloride and promethazine hydrochloride in a cassette.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Oct-01, Volume: 53, Issue:19

    Topics: Analgesics, Opioid; Antiemetics; Drug Combinations; Drug Stability; Drug Storage; Humans; Hydromorph

1996