promethazine has been researched along with Motion Sickness in 56 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Motion Sickness: Disorder caused by motion. It includes sea sickness, train sickness, roller coaster rides, rocking chair, hammock swing, car sickness, air sickness, or SPACE MOTION SICKNESS. Symptoms include nausea, vomiting and/or dizziness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Motion sickness symptoms affect approximately 50% of the crew during space travel and are commonly treated with intramuscular injections of promethazine." | 9.09 | Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms. ( Cowings, PS; Toscano, WB, 2000) |
| ") injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts." | 9.09 | Promethazine as a motion sickness treatment: impact on human performance and mood states. ( Cowings, PS; DeRoshia, C; Miller, NE; Toscano, WB, 2000) |
| "The combination therapy, promethazine and caffeine had been proven effective in treating motion sickness and counteracting some possible side effects of using promethazine alone while the mechanism and interaction remained unclear." | 7.78 | An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness. ( Bai, YQ; Gao, JY; Huang, M; Liang, QL; Luo, GA; Wang, YM; Zhai, ZG, 2012) |
| "The current method of choice for astronauts to treat space motion sickness is an intra-muscular injection of promethazine hydrochloride (PMZ HCl) which is invasive and causes considerable local irritation and discomfort at the site of injection." | 7.74 | Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication. ( Boland, EJ; Dixon, H; McDonough, JA; Nino, JA; Persyn, JT; Putcha, L; Wang, Z, 2007) |
| "Intramuscular promethazine and its efficacy in the treatment of Space Motion Sickness (SMS) were evaluated using standardized questions administered during postflight debriefings to crewmembers immediately after their first Shuttle flight." | 7.68 | Treatment efficacy of intramuscular promethazine for space motion sickness. ( Bagian, JP; Beck, BG; Davis, JR; Jennings, RT, 1993) |
| "The findings indicated that only the combination of promethazine + caffeine showed a statistically significant reduction in nausea and motion sickness severity, and an improvement in reaction time when compared with its placebo control." | 5.12 | Airsickness prevention in helicopter passengers. ( Curry, IP; Estrada, A; Fuller, DR; LeDuc, PA; Phelps, SE, 2007) |
| "Our aim was to establish the effects of cinnarizine, a drug used for the treatment of motion sickness, on daytime sleepiness and performance." | 5.10 | Central effects of cinnarizine: restricted use in aircrew. ( Mills, SL; Nicholson, AN; Stone, BM; Turner, C, 2002) |
| "Motion sickness and the antimotion sickness drugs scopolamine (SCP) and promethazine (PMZ) inhibit gastric emptying (GE)." | 5.09 | Prokinetic effects of erythromycin after antimotion sickness drugs. ( Parish, RC; Stewart, JJ; Wood, CD; Wood, MJ, 2000) |
| "Motion sickness symptoms affect approximately 50% of the crew during space travel and are commonly treated with intramuscular injections of promethazine." | 5.09 | Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms. ( Cowings, PS; Toscano, WB, 2000) |
| ") injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts." | 5.09 | Promethazine as a motion sickness treatment: impact on human performance and mood states. ( Cowings, PS; DeRoshia, C; Miller, NE; Toscano, WB, 2000) |
| "The results of experimental clinical testing of the antinaupathia action of as new compounds, so motion sickness medications (promethazine, ikaron-1 etc." | 3.81 | [A new approach to the search for vestibuloprotectors]. ( Karsanova, SK; Yasnetsov, VV, 2015) |
| "The combination therapy, promethazine and caffeine had been proven effective in treating motion sickness and counteracting some possible side effects of using promethazine alone while the mechanism and interaction remained unclear." | 3.78 | An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness. ( Bai, YQ; Gao, JY; Huang, M; Liang, QL; Luo, GA; Wang, YM; Zhai, ZG, 2012) |
| "The current method of choice for astronauts to treat space motion sickness is an intra-muscular injection of promethazine hydrochloride (PMZ HCl) which is invasive and causes considerable local irritation and discomfort at the site of injection." | 3.74 | Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication. ( Boland, EJ; Dixon, H; McDonough, JA; Nino, JA; Persyn, JT; Putcha, L; Wang, Z, 2007) |
| "Since March 1989, intramuscular (IM) promethazine has been successfully used to treat the symptoms of space motion sickness." | 3.69 | A retrospective study of promethazine and its failure to produce the expected incidence of sedation during space flight. ( Bagian, JP; Ward, DF, 1994) |
| "Intramuscular promethazine and its efficacy in the treatment of Space Motion Sickness (SMS) were evaluated using standardized questions administered during postflight debriefings to crewmembers immediately after their first Shuttle flight." | 3.68 | Treatment efficacy of intramuscular promethazine for space motion sickness. ( Bagian, JP; Beck, BG; Davis, JR; Jennings, RT, 1993) |
| "Motion sickness was scaled from 1 (no sickness) to an endpoint of 20, at which time the subject was too sick to continue or was about to vomit." | 2.71 | The relation of motion sickness to the spatial-temporal properties of velocity storage. ( Cohen, B; Dai, M; Kunin, M; Raphan, T, 2003) |
| "We propose that motion sickness is mediated through the orientation properties of velocity storage in the vestibular system that tend to align eye velocity produced by the angular vestibulo-ocular reflex (aVOR) with gravito-inertial acceleration (GIA)." | 1.32 | The critical role of velocity storage in production of motion sickness. ( Cohen, B; Dai, M; Raphan, T, 2003) |
| "Signs of motion sickness were scored using a rating scale." | 1.28 | Investigation of anti-motion sickness drugs in the squirrel monkey. ( Cheung, BS; Kinter, LB; Kohl, RL; Money, KE, 1992) |
| "When promethazine 25 mg was given as an oral or I." | 1.27 | Side effects of antimotion sickness drugs. ( Manno, BR; Manno, JE; Redetzki, HM; Vekovius, WA; Wood, CD; Wood, M, 1984) |
| "Motion sickness affects approximately 90 percent of the population at some time during life, and for many the problem is recurrent and severe." | 1.27 | Motion sickness. ( Lovan, WD, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (53.57) | 18.7374 |
| 1990's | 9 (16.07) | 18.2507 |
| 2000's | 12 (21.43) | 29.6817 |
| 2010's | 5 (8.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weerts, AP | 1 |
| Pattyn, N | 1 |
| Van de Heyning, PH | 1 |
| Wuyts, FL | 1 |
| Yasnetsov, VV | 2 |
| Karsanova, SK | 1 |
| Banting, J | 1 |
| Meriano, T | 1 |
| Haware, RV | 1 |
| Chaudhari, PD | 1 |
| Parakh, SR | 1 |
| Bauer-Brandl, A | 1 |
| Cheung, B | 1 |
| Nakashima, AM | 1 |
| Hofer, KD | 1 |
| Huang, M | 1 |
| Gao, JY | 1 |
| Zhai, ZG | 1 |
| Liang, QL | 1 |
| Wang, YM | 1 |
| Bai, YQ | 1 |
| Luo, GA | 1 |
| Dai, M | 2 |
| Kunin, M | 1 |
| Raphan, T | 2 |
| Cohen, B | 2 |
| JENSEN, BM | 1 |
| HARPER, J | 1 |
| GLASER, EM | 1 |
| HERVEY, GR | 1 |
| Setness, PA | 1 |
| Van Beusekom, M | 1 |
| Paul, MA | 1 |
| MacLellan, M | 1 |
| Gray, G | 1 |
| McDonough, JA | 1 |
| Persyn, JT | 1 |
| Nino, JA | 1 |
| Dixon, H | 1 |
| Boland, EJ | 1 |
| Wang, Z | 1 |
| Putcha, L | 1 |
| Estrada, A | 1 |
| LeDuc, PA | 1 |
| Curry, IP | 1 |
| Phelps, SE | 1 |
| Fuller, DR | 1 |
| Cowings, P | 1 |
| Toscano, W | 1 |
| Deroshia, C | 2 |
| Taylor, B | 1 |
| Hines, A | 1 |
| Bright, A | 1 |
| Dodds, A | 1 |
| Brand, JJ | 2 |
| Wood, CD | 11 |
| Manno, JE | 4 |
| Manno, BR | 4 |
| Redetzki, HM | 3 |
| Wood, M | 1 |
| Vekovius, WA | 1 |
| Lovan, WD | 1 |
| Collins, WE | 2 |
| Schroeder, DJ | 2 |
| Elam, GW | 2 |
| Stewart, JJ | 3 |
| Wood, MJ | 6 |
| Mims, ME | 3 |
| Lackner, JR | 2 |
| Graybiel, A | 8 |
| Davis, JR | 1 |
| Jennings, RT | 1 |
| Beck, BG | 1 |
| Bagian, JP | 3 |
| Murray, JB | 1 |
| Ward, DF | 1 |
| Parish, RC | 1 |
| Cowings, PS | 2 |
| Toscano, WB | 2 |
| Miller, NE | 1 |
| Nicholson, AN | 1 |
| Stone, BM | 1 |
| Turner, C | 1 |
| Mills, SL | 1 |
| Knepton, J | 3 |
| Shaw, J | 1 |
| Hoche, JP | 1 |
| Perkins, GF | 1 |
| Mims, M | 1 |
| Cheung, BS | 1 |
| Money, KE | 1 |
| Kohl, RL | 1 |
| Kinter, LB | 1 |
| Oenbrink, RJ | 1 |
| Sunahara, FA | 1 |
| Farewell, J | 1 |
| Mintz, L | 1 |
| Johnson, WH | 1 |
| Marks, E | 1 |
| Swiecicki, W | 1 |
| Petrin, A | 1 |
| Green, JA | 1 |
| McMurray, GN | 1 |
| Naess, K | 1 |
| May, W | 1 |
| Preston, FS | 1 |
| Heggie, RM | 1 |
| Entwistle, IR | 1 |
4 reviews available for promethazine and Motion Sickness
| Article | Year |
|---|---|
Sea State Green.
Topics: Acupressure; Antiemetics; Cholinergic Antagonists; Dopamine Antagonists; Emergency Medical Technicia | 2016 |
Psychophysiological aspects of motion sickness.
Topics: Administration, Cutaneous; Dextroamphetamine; Histamine H1 Antagonists; Humans; Meclizine; Motion Si | 1997 |
[Prevention and treatment of motion sickness].
Topics: Autonomic Agents; Dimenhydrinate; Histamine H1 Antagonists; Humans; Hydroxyzine; Meprobamate; Motion | 1974 |
[Motion sickness and its treatment (author's transl)].
Topics: Amphetamine; Drug Combinations; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Motion | 1974 |
21 trials available for promethazine and Motion Sickness
| Article | Year |
|---|---|
Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males.
Topics: Adult; Antiemetics; Baclofen; Cinnarizine; Cognition; Cognition Disorders; Dimenhydrinate; Double-Bl | 2014 |
Various anti-motion sickness drugs and core body temperature changes.
Topics: Adult; Antiemetics; Body Temperature; Coriolis Force; Dextroamphetamine; Double-Blind Method; Female | 2011 |
The relation of motion sickness to the spatial-temporal properties of velocity storage.
Topics: Adult; Antiemetics; Cross-Over Studies; Dizziness; Double-Blind Method; Eye Movements; Female; Head | 2003 |
Motion-sickness medications for aircrew: impact on psychomotor performance.
Topics: Adult; Aerospace Medicine; Aircraft; Antiemetics; Canada; Dimenhydrinate; Female; Humans; Male; Mecl | 2005 |
Airsickness prevention in helicopter passengers.
Topics: Acoustic Stimulation; Adolescent; Adult; Aircraft; Antiemetics; Health Surveys; Humans; Male; Mecliz | 2007 |
Prokinetic effects of erythromycin after antimotion sickness drugs.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Erythromycin Ethylsuccinate; Female; Gast | 2000 |
Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms.
Topics: Adult; Anti-Allergic Agents; Autogenic Training; Biofeedback, Psychology; Dose-Response Relationship | 2000 |
Promethazine as a motion sickness treatment: impact on human performance and mood states.
Topics: Adult; Affect; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Method; Histamin | 2000 |
Central effects of cinnarizine: restricted use in aircrew.
Topics: Adult; Aerospace Medicine; Cinnarizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H | 2002 |
Evaluation of a new antinauseant drug for the prevention of motion sickness.
Topics: Administration, Oral; Adolescent; Adult; Antiemetics; Clinical Trials as Topic; Dose-Response Relati | 1977 |
Prevention of experimental motion sickness by scopolamine absorbed through the skin.
Topics: Administration, Topical; Adult; Clinical Trials as Topic; Drug Combinations; Ephedrine; Humans; Male | 1976 |
Human assay of antimotion sickness drugs.
Topics: Adult; Amphetamine; Clinical Trials as Topic; Dimenhydrinate; Dose-Response Relationship, Drug; Drug | 1975 |
Effectiveness and duration of intramuscular antimotion sickness medications.
Topics: Caffeine; Ephedrine; Female; Humans; Injections, Intramuscular; Male; Motion Sickness; Promethazine; | 1992 |
Pharmacological interventions for motion sickness: cardiovascular effects.
Topics: Adult; Dextroamphetamine; Double-Blind Method; Drug Combinations; Ephedrine; Hemodynamics; Humans; M | 1987 |
Mechanisms of antimotion sickness drugs.
Topics: Adult; Dextroamphetamine; Dimenhydrinate; Double-Blind Method; Female; Humans; Male; Motion Sickness | 1987 |
Evaluation of antimotion sickness drug side effects on performance.
Topics: Adolescent; Adult; Aerospace Medicine; Arousal; Clinical Trials as Topic; Cyclizine; Dextroamphetami | 1985 |
Effects of some motion sickness suppressants on static and dynamic tracking performance.
Topics: Aerospace Medicine; Affect; Arousal; Dextroamphetamine; Dimenhydrinate; Dose-Response Relationship, | 1985 |
Effectivity of antimotion sickness drugs during artificial gravity simulations.
Topics: Adult; Aircraft; Clinical Trials as Topic; Dextroamphetamine; Dimenhydrinate; Drug Evaluation; Ephed | 1973 |
An evaluation of metoclopramide as an anti-emetic in seasickness.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypnotics a | 1973 |
Evaluation of sixteen anti-motion sickness drugs under controlled laboratory conditions.
Topics: Adolescent; Adult; Amphetamine; Antiemetics; Benzamides; Chlorpromazine; Clinical Trials as Topic; C | 1968 |
[The treatment of seasickness with Kinetosin].
Topics: Caffeine; Clinical Trials as Topic; Ephedrine; Humans; Motion Sickness; Promethazine | 1965 |
31 other studies available for promethazine and Motion Sickness
| Article | Year |
|---|---|
[A new approach to the search for vestibuloprotectors].
Topics: Acetamides; Animals; Drug Design; Glutamic Acid; Humans; Melatonin; Motion Sickness; Picolines; Prom | 2015 |
Development of a melting tablet containing promethazine HCl against motion sickness.
Topics: Administration, Oral; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Design; Dr | 2008 |
An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness.
Topics: Caffeine; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Motion Sickness; P | 2012 |
The treatment of seasickness.
Topics: Humans; Motion Sickness; Promethazine | 1961 |
The critical role of velocity storage in production of motion sickness.
Topics: Adult; Cross-Over Studies; Dizziness; Double-Blind Method; Eye Movements; Female; Head Movements; Hi | 2003 |
Prevention and treatment of travel sickness with promethazine chlorotheophyllinate.
Topics: Humans; Motion Sickness; Promethazine; Theophylline | 1951 |
The prevention of seasickness with hyoscine, benadryl, and phenergan.
Topics: Biomedical Research; Diphenhydramine; Histamine H1 Antagonists; Humans; Motion Sickness; Promethazin | 1951 |
Patient Notes: motion sickness.
Topics: Adult; Child; Histamine H1 Antagonists; Humans; Motion Sickness; Muscarinic Antagonists; Nonprescrip | 2004 |
Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication.
Topics: Administration, Intranasal; Animals; Capsules; Cell Line; Cell Survival; Drug Carriers; Gels; Humans | 2007 |
Converging indicators for assessing individual differences in adaptation to extreme environments.
Topics: Adaptation, Physiological; Adolescent; Adult; Female; Heart Rate; Humans; Male; Middle Aged; Militar | 2007 |
Motion sickness and its prevention by drugs.
Topics: Cyclizine; Diphenhydramine; Ear, Inner; Humans; Meclizine; Motion Sickness; Promethazine; Scopolamin | 1967 |
Side effects of antimotion sickness drugs.
Topics: Adolescent; Adult; Cornell Medical Index; Dextroamphetamine; Drug Combinations; Female; Humans; Male | 1984 |
Motion sickness.
Topics: Adaptation, Physiological; Age Factors; Amphetamines; Antiemetics; Central Nervous System; Drug Comb | 1984 |
A comparison of some effects of three antimotion sickness drugs on nystagmic responses to angular accelerations and to optokinetic stimuli.
Topics: Acceleration; Dextroamphetamine; Dimenhydrinate; Dose-Response Relationship, Drug; Drug Therapy, Com | 1982 |
Effects of motion sickness and antimotion sickness drugs on gastric function.
Topics: Adolescent; Adult; Electromyography; Erythromycin; Female; Gastric Emptying; Humans; Male; Motion Si | 1994 |
Use of promethazine to hasten adaptation to provocative motion.
Topics: Adaptation, Physiological; Adult; Arousal; Head; Humans; Male; Mental Processes; Motion Sickness; Mo | 1994 |
Treatment efficacy of intramuscular promethazine for space motion sickness.
Topics: Female; Humans; Injections, Intramuscular; Male; Motion Sickness; Promethazine; Space Flight | 1993 |
A retrospective study of promethazine and its failure to produce the expected incidence of sedation during space flight.
Topics: Humans; Hypnotics and Sedatives; Injections, Intramuscular; Motion Sickness; Promethazine; Retrospec | 1994 |
Comparison of efficacy of ginger with various antimotion sickness drugs.
Topics: Administration, Oral; Adolescent; Adult; Antiemetics; Dextroamphetamine; Dimenhydrinate; Female; Hum | 1988 |
Prevention and treatment of space sickness in shuttle-orbiter missions.
Topics: Adult; Delayed-Action Preparations; Dimenhydrinate; Drug Combinations; Ephedrine; Humans; Meclizine; | 1979 |
Antimotion sickness and antiemetic drugs.
Topics: Antiemetics; Cyclizine; Dextroamphetamine; Dimenhydrinate; Drug Combinations; Ephedrine; Humans; Mot | 1979 |
Hope for the queasy.
Topics: Amphetamines; Drug Synergism; Ephedrine; Humans; Military Medicine; Motion Sickness; Promethazine; S | 1976 |
Investigation of anti-motion sickness drugs in the squirrel monkey.
Topics: Animals; Dextroamphetamine; Disease Models, Animal; Drug Therapy, Combination; Ephedrine; Male; Moti | 1992 |
First intramuscular administration in the U.S. Space Program.
Topics: Humans; Injections, Intramuscular; Male; Motion Sickness; Promethazine; Space Flight | 1991 |
Another approach to motion sickness.
Topics: Humans; Meclizine; Motion Sickness; Promethazine; Travel | 1991 |
Treatment of severe motion sickness with antimotion sickness drug injections.
Topics: Dimenhydrinate; Humans; Injections, Intramuscular; Motion Sickness; Promethazine; Scopolamine; Space | 1987 |
Evaluation of antimotion sickness drugs: a new effective remedy revealed.
Topics: Adolescent; Adult; Amine Oxidase (Copper-Containing); Betahistine; Dextroamphetamine; Ephedrine; Eth | 1970 |
[Motion sickness].
Topics: Amphetamine; Humans; Motion Sickness; Promethazine; Scopolamine | 1971 |
A survey of recent motion sickness research.
Topics: Analgesics; Animals; Azocines; Cyclazocine; Diphenhydramine; Guinea Pigs; Humans; Motion Sickness; N | 1970 |
Motion sickness.
Topics: Dextroamphetamine; Humans; Motion Sickness; Promethazine; Scopolamine | 1971 |
Seasickness.
Topics: Humans; Injections, Intramuscular; Motion Sickness; Promethazine; Ships | 1968 |