promethazine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 1 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Philadelphia positive chronic myeloid leukemia (CML) K562 cells were the most sensitive cell line." | 1.56 | AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. ( Colturato-Kido, C; Costa, CA; Ferraz, LS; Medeiros, HCD; Moraes, VWR; Paredes-Gamero, EJ; Rodrigues, T; Tersariol, ILS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Medeiros, HCD | 1 |
| Colturato-Kido, C | 1 |
| Ferraz, LS | 1 |
| Costa, CA | 1 |
| Moraes, VWR | 1 |
| Paredes-Gamero, EJ | 1 |
| Tersariol, ILS | 1 |
| Rodrigues, T | 1 |
1 other study available for promethazine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Cell Line, Tum | 2020 |