Page last updated: 2024-11-03

promethazine and Headache

promethazine has been researched along with Headache in 12 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises."9.08The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996)
"Prochlorperazine was superior to promethazine in the rate of headache reduction and rate of home drowsiness, with similar rates of akathesia, nausea resolution, patient satisfaction, and headache recurrence within 5 days of discharge."6.73Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial. ( Bachrach, EA; Callan, JE; Kostic, MA; Rieg, TS, 2008)
"In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises."5.08The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996)
"Prochlorperazine was superior to promethazine in the rate of headache reduction and rate of home drowsiness, with similar rates of akathesia, nausea resolution, patient satisfaction, and headache recurrence within 5 days of discharge."2.73Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial. ( Bachrach, EA; Callan, JE; Kostic, MA; Rieg, TS, 2008)
" The specific objectives of research are to identify physiologic, pharmacokinetic, and pharmacodynamic changes in space; to develop simple, reliable, non-invasive, safe and effective acute and sustained-release dosage forms and regimens for pharmacological interventions in space; and to create and maintain a comprehensive space PK-PD and therapeutics database."1.30Pharmacotherapeutics in space. ( Putcha, L, 1999)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19909 (75.00)18.7374
1990's2 (16.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Callan, JE1
Kostic, MA1
Bachrach, EA1
Rieg, TS1
MANGANOTTI, G1
SILVESTRI, U1
Harden, RN1
Gracely, RH1
Carter, T1
Warner, G1
Putcha, L1
Mathew, NT1
Nitzschner, H1
Ahlgren, P1
Wieck, HH1
Isaac, M2
Pandit, SK2
Dundee, JW2
Galway, JE1
Zohairy, AF1
McDowell, SA1
Mitchell, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031]Phase 454 participants (Actual)Interventional2016-03-17Completed
Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130]Phase 458 participants (Actual)Interventional2017-05-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Anxiety

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm33.7
Study Arm21.2

Headache Following Intervention

Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm63.5
Study Arm43.5

Nausea

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm38.9
Study Arm22.9

The Number of Participants Experiencing Vomiting

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm2
Study Arm3

The Number of Patients Experiencing Restlessness

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm3
Study Arm3

Reviews

1 review available for promethazine and Headache

ArticleYear
[CONTRIBUTION TO THE STUDY OF THE LYELL SYNDROME].
    Archivio italiano di dermatologia, venereologia, e sessuologia, 1964, Volume: 32

    Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; D

1964

Trials

5 trials available for promethazine and Headache

ArticleYear
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
    The Journal of emergency medicine, 2008, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H

2008
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
    The Journal of emergency medicine, 2008, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H

2008
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
    The Journal of emergency medicine, 2008, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H

2008
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
    The Journal of emergency medicine, 2008, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H

2008
The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department.
    Headache, 1996, Volume: 36, Issue:6

    Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St

1996
Amelioration of ergotamine withdrawal symptoms with naproxen.
    Headache, 1987, Volume: 27, Issue:3

    Topics: Adult; Clinical Trials as Topic; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Naproxen;

1987
[The introduction of 9,9-dioxopromethazine (Prothanon) into the treatment of skin diseases in hospitalized patients].
    Die Pharmazie, 1970, Feb-02, Volume: 25, Issue:2

    Topics: Blood; Blood Glucose; Clinical Trials as Topic; Dermatitis Herpetiformis; Dermatologic Agents; Drug

1970
Postoperative headache after nitrous oxide-oxygen-halothane anaesthesia.
    British journal of anaesthesia, 1969, Volume: 41, Issue:11

    Topics: Adolescent; Adult; Anesthesia, Inhalation; Atropine; Female; Halothane; Headache; Humans; Male; Mepe

1969

Other Studies

6 other studies available for promethazine and Headache

ArticleYear
Pharmacotherapeutics in space.
    Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 1999, Volume: 6, Issue:1

    Topics: Acetaminophen; Aerospace Medicine; Analgesics, Non-Narcotic; Headache; Histamine H1 Antagonists; Hum

1999
Dimer-X. A new contrast medium for lumbar myelography without spinal anaesthesia.
    Acta radiologica: diagnosis, 1972, Volume: 13, Issue:0

    Topics: Fever; Fluoroscopy; Headache; Humans; Injections, Spinal; Iothalamic Acid; Lumbar Vertebrae; Myelogr

1972
[Headache. Diagnosis and therapy in general practice].
    Fortschritte der Medizin, 1974, Jun-13, Volume: 92, Issue:17

    Topics: Carbamazepine; Chlorpromazine; Depression; Ergotamine; Giant Cell Arteritis; Headache; Humans; Migra

1974
Intravenous ethanol anaesthesia. A study of sequelae and their implications.
    Acta anaesthesiologica Scandinavica, 1971, Volume: 15, Issue:3

    Topics: Alcohol Deterrents; Alcoholic Intoxication; Amnesia; Anesthesia, Intravenous; Atropine; Barbiturates

1971
Clinical studies of induction agents. XXXIV: Further investigations with ethanol.
    British journal of anaesthesia, 1970, Volume: 42, Issue:4

    Topics: Anesthesia, Intravenous; Atropine; Barbiturates; Chlordiazepoxide; Delirium; Drug Antagonism; Ethano

1970
Psychotropic drugs.
    British medical journal, 1968, Feb-10, Volume: 1, Issue:5588

    Topics: Adult; Female; Headache; Humans; Monoamine Oxidase Inhibitors; Promethazine; Psychopharmacology

1968