promethazine has been researched along with Headache in 12 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises." | 9.08 | The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996) |
| "Prochlorperazine was superior to promethazine in the rate of headache reduction and rate of home drowsiness, with similar rates of akathesia, nausea resolution, patient satisfaction, and headache recurrence within 5 days of discharge." | 6.73 | Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial. ( Bachrach, EA; Callan, JE; Kostic, MA; Rieg, TS, 2008) |
| "In a prospective, double-blind, randomized study, ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline given by intramuscular injection were compared as treatment for acute headache crises." | 5.08 | The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department. ( Carter, T; Gracely, RH; Harden, RN; Warner, G, 1996) |
| "Prochlorperazine was superior to promethazine in the rate of headache reduction and rate of home drowsiness, with similar rates of akathesia, nausea resolution, patient satisfaction, and headache recurrence within 5 days of discharge." | 2.73 | Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial. ( Bachrach, EA; Callan, JE; Kostic, MA; Rieg, TS, 2008) |
| " The specific objectives of research are to identify physiologic, pharmacokinetic, and pharmacodynamic changes in space; to develop simple, reliable, non-invasive, safe and effective acute and sustained-release dosage forms and regimens for pharmacological interventions in space; and to create and maintain a comprehensive space PK-PD and therapeutics database." | 1.30 | Pharmacotherapeutics in space. ( Putcha, L, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Callan, JE | 1 |
| Kostic, MA | 1 |
| Bachrach, EA | 1 |
| Rieg, TS | 1 |
| MANGANOTTI, G | 1 |
| SILVESTRI, U | 1 |
| Harden, RN | 1 |
| Gracely, RH | 1 |
| Carter, T | 1 |
| Warner, G | 1 |
| Putcha, L | 1 |
| Mathew, NT | 1 |
| Nitzschner, H | 1 |
| Ahlgren, P | 1 |
| Wieck, HH | 1 |
| Isaac, M | 2 |
| Pandit, SK | 2 |
| Dundee, JW | 2 |
| Galway, JE | 1 |
| Zohairy, AF | 1 |
| McDowell, SA | 1 |
| Mitchell, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
1 review available for promethazine and Headache
| Article | Year |
|---|---|
[CONTRIBUTION TO THE STUDY OF THE LYELL SYNDROME].
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; D | 1964 |
5 trials available for promethazine and Headache
| Article | Year |
|---|---|
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H | 2008 |
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H | 2008 |
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H | 2008 |
Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial.
Topics: Adolescent; Adult; Dopamine Antagonists; Double-Blind Method; Emergency Service, Hospital; Female; H | 2008 |
The placebo effect in acute headache management: ketorolac, meperidine, and saline in the emergency department.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 1996 |
Amelioration of ergotamine withdrawal symptoms with naproxen.
Topics: Adult; Clinical Trials as Topic; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Naproxen; | 1987 |
[The introduction of 9,9-dioxopromethazine (Prothanon) into the treatment of skin diseases in hospitalized patients].
Topics: Blood; Blood Glucose; Clinical Trials as Topic; Dermatitis Herpetiformis; Dermatologic Agents; Drug | 1970 |
Postoperative headache after nitrous oxide-oxygen-halothane anaesthesia.
Topics: Adolescent; Adult; Anesthesia, Inhalation; Atropine; Female; Halothane; Headache; Humans; Male; Mepe | 1969 |
6 other studies available for promethazine and Headache
| Article | Year |
|---|---|
Pharmacotherapeutics in space.
Topics: Acetaminophen; Aerospace Medicine; Analgesics, Non-Narcotic; Headache; Histamine H1 Antagonists; Hum | 1999 |
Dimer-X. A new contrast medium for lumbar myelography without spinal anaesthesia.
Topics: Fever; Fluoroscopy; Headache; Humans; Injections, Spinal; Iothalamic Acid; Lumbar Vertebrae; Myelogr | 1972 |
[Headache. Diagnosis and therapy in general practice].
Topics: Carbamazepine; Chlorpromazine; Depression; Ergotamine; Giant Cell Arteritis; Headache; Humans; Migra | 1974 |
Intravenous ethanol anaesthesia. A study of sequelae and their implications.
Topics: Alcohol Deterrents; Alcoholic Intoxication; Amnesia; Anesthesia, Intravenous; Atropine; Barbiturates | 1971 |
Clinical studies of induction agents. XXXIV: Further investigations with ethanol.
Topics: Anesthesia, Intravenous; Atropine; Barbiturates; Chlordiazepoxide; Delirium; Drug Antagonism; Ethano | 1970 |
Psychotropic drugs.
Topics: Adult; Female; Headache; Humans; Monoamine Oxidase Inhibitors; Promethazine; Psychopharmacology | 1968 |