promethazine has been researched along with Emesis, Postoperative in 18 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frequently, patients identified as high risk for postoperative nausea and vomiting (PONV) are treated prophylactically with intravenous (IV) ondansetron and postoperatively with IV promethazine." | 9.14 | Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. ( Bennett, J; DeLoge, J; Kelly, J; Pellegrini, J, 2009) |
| "Promethazine was significantly more effective than ondansetron for treating PONV after failed ondansetron prophylaxis." | 5.34 | A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis. ( Gan, TJ; Habib, AS; Reuveni, J; Taguchi, A; White, WD, 2007) |
| "Frequently, patients identified as high risk for postoperative nausea and vomiting (PONV) are treated prophylactically with intravenous (IV) ondansetron and postoperatively with IV promethazine." | 5.14 | Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. ( Bennett, J; DeLoge, J; Kelly, J; Pellegrini, J, 2009) |
| "To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction." | 5.09 | Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery. ( Amhan, M; Aves, T; Chuang, AZ; Khalil, S; Lemak, NA; Philbrook, L; Rabb, M; Villanueva, G; Wells, L, 1999) |
| "625 mg of IV droperidol given 30 min before emergence from general anesthesia reduces the incidence of immediate and delayed postoperative nausea and vomiting (PONV) in a general surgical adult patient population, and (2) compared the efficacy of droperidol, ondansetron, and promethazine for the rescue treatment of PONV." | 5.09 | Small-dose droperidol effectively reduces nausea in a general surgical adult patient population. ( Ascari, CM; Durieux, ME; Kloth, RL; Kreisler, NS; Rhyne, HA; Spiekermann, BF; Sullivan, LM, 2000) |
| "The common prophylactic treatment for postoperative nausea and vomiting is a triple therapy of droperidol, promethazine and dexamethasone." | 2.77 | Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial. ( Antor, A; Bergese, S; Fernandez, S; Uribe, A; Viloria, A, 2012) |
| "The secondary endpoint was postoperative nausea and vomiting." | 2.71 | The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy. ( Chia, YY; Chung, NC; Ko, NH; Liu, K; Lo, Y; Tan, PH, 2004) |
| "Promethazine was significantly more effective than ondansetron for treating PONV after failed ondansetron prophylaxis." | 1.34 | A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis. ( Gan, TJ; Habib, AS; Reuveni, J; Taguchi, A; White, WD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Barney, EZ | 1 |
| Fuller, ME | 1 |
| Habib, AS | 4 |
| Deitrick, CL | 1 |
| Mick, DJ | 1 |
| Lauffer, V | 1 |
| Prostka, E | 1 |
| Nowak, D | 1 |
| Ingersoll, G | 1 |
| Zhu, LL | 1 |
| Chen, M | 1 |
| Zhou, Q | 1 |
| Gan, TJ | 3 |
| Candiotti, KA | 1 |
| Klein, SM | 1 |
| Rodriguez, Y | 1 |
| Nielsen, KC | 1 |
| White, WD | 2 |
| Pellegrini, J | 1 |
| DeLoge, J | 1 |
| Bennett, J | 1 |
| Kelly, J | 1 |
| Schwartz, A | 1 |
| Lane, B | 1 |
| Cannella, K | 1 |
| Bowen, C | 1 |
| Copelan, D | 1 |
| Nteff, G | 1 |
| Barnes, K | 1 |
| Poudevigne, M | 1 |
| Lawson, J | 1 |
| Bergese, S | 1 |
| Viloria, A | 1 |
| Uribe, A | 1 |
| Antor, A | 1 |
| Fernandez, S | 1 |
| Sartain, JB | 1 |
| Barry, JJ | 1 |
| Richardson, CA | 1 |
| Branagan, HC | 1 |
| DILLON, GP | 1 |
| BELLVILLE, JW | 1 |
| HOWLAND, WS | 1 |
| BROSS, ID | 1 |
| Chia, YY | 1 |
| Lo, Y | 1 |
| Liu, K | 1 |
| Tan, PH | 1 |
| Chung, NC | 1 |
| Ko, NH | 1 |
| Reuveni, J | 1 |
| Taguchi, A | 1 |
| Parlow, JL | 1 |
| Meikle, AT | 1 |
| van Vlymen, J | 1 |
| Avery, N | 1 |
| Malesker, MA | 1 |
| Malone, PM | 1 |
| Cingle, CM | 1 |
| Cochran, RM | 1 |
| Khalil, S | 1 |
| Philbrook, L | 1 |
| Rabb, M | 1 |
| Wells, L | 1 |
| Aves, T | 1 |
| Villanueva, G | 1 |
| Amhan, M | 1 |
| Chuang, AZ | 1 |
| Lemak, NA | 1 |
| Kreisler, NS | 1 |
| Spiekermann, BF | 1 |
| Ascari, CM | 1 |
| Rhyne, HA | 1 |
| Kloth, RL | 1 |
| Sullivan, LM | 1 |
| Durieux, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalation Intervention for Nausea in the Emergency Department[NCT02092441] | 80 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)[NCT03125811] | Early Phase 1 | 121 participants (Actual) | Interventional | 2017-07-17 | Completed | ||
| Aromatherapy in Management of Postoperative Nausea in Post-Bariatric Surgery Patients[NCT03130218] | 204 participants (Actual) | Interventional | 2017-06-08 | Completed | |||
| A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Studying the Effectiveness of Triple Therapy With Palonosetron, Dexamethasone and Promethazine for Prevention of Post Operative Nausea and Vomiting in High Risk Patients Undergoing Neurological Surgery and General Anesthesia[NCT02635828] | Phase 4 | 40 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Primary outcome is nausea and vomiting measured on a scale from 0 (no nausea) to 10 (worst nausea imaginable) Verbal Numerical Response Scale (VNRS) at 10 minutes post intervention." (NCT02092441)
Timeframe: 10 minutes post intervention
| Intervention | VNRS (Median) |
|---|---|
| Alcohol Prep Pad Group | 3 |
| Normal Saline Prep Pad | 6 |
"Patient satisfaction of smelling prep pad to alleviate nausea on a scale from 1 (completely unsatisfied) to 5 (completely satisfied)" (NCT02092441)
Timeframe: 10 minutes post intervention
| Intervention | 5 point Likert Scale (Median) |
|---|---|
| Alcohol Prep Pad Group | 4 |
| Normal Saline Prep Pad | 2 |
"Scale ranges from 0 (no pain) to 10 (worst pain imaginable)" (NCT02092441)
Timeframe: 10 minutes post intervention
| Intervention | VNRS (Median) |
|---|---|
| Alcohol Prep Pad Group | 6 |
| Normal Saline Prep Pad | 6 |
Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours
| Intervention | hours (Median) |
|---|---|
| Intervention Cohort | 26.4 |
| Comparison Cohort | 28.2 |
To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital
| Intervention | percentage of subjects with PDN (Number) |
|---|---|
| Intervention Cohort | 72 |
| Comparison Cohort | 60 |
(NCT01592708)
Timeframe: 1 week post discharge
| Intervention | percentage of subjects with PDV (Number) |
|---|---|
| Intervention Cohort | 22 |
| Comparison Cohort | 29 |
End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with PON (Number) |
|---|---|
| Intervention Cohort | 24 |
| Comparison Cohort | 70 |
(NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with POV (Number) |
|---|---|
| Intervention Cohort | 11 |
| Comparison Cohort | 28 |
The incidence of significant QTc prolongation was measured by comparing baseline EKG, 24 hours and 120 hours after surgery (NCT02635828)
Timeframe: 24 and 120 hours/discharge after end of surgery
| Intervention | participants (Number) |
|---|---|
| Triple Therapy PONV Prohylaxis | 0 |
The incidence of PONV (NCT02635828)
Timeframe: 24 hours after end of surgery
| Intervention | participants (Number) |
|---|---|
| Triple Therapy PONV Prohylaxis | 12 |
1 review available for promethazine and Emesis, Postoperative
| Article | Year |
|---|---|
The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Antiemetics; Dimenhydrinate; Droperidol; Female; Humans | 2005 |
10 trials available for promethazine and Emesis, Postoperative
| Article | Year |
|---|---|
A comparison of two differing doses of promethazine for the treatment of postoperative nausea and vomiting.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Mid | 2015 |
Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies.
Topics: Adult; Ambulatory Care; Anesthesia Recovery Period; Antiemetics; Double-Blind Method; Drug Therapy, | 2009 |
Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV.
Topics: 2-Propanol; Administration, Inhalation; Adult; Antiemetics; Clinical Nursing Research; Female; Hista | 2009 |
Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV.
Topics: 2-Propanol; Administration, Inhalation; Adult; Antiemetics; Clinical Nursing Research; Female; Hista | 2009 |
Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV.
Topics: 2-Propanol; Administration, Inhalation; Adult; Antiemetics; Clinical Nursing Research; Female; Hista | 2009 |
Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV.
Topics: 2-Propanol; Administration, Inhalation; Adult; Antiemetics; Clinical Nursing Research; Female; Hista | 2009 |
Examination of the effectiveness of peppermint aromatherapy on nausea in women post C-section.
Topics: Administration, Inhalation; Adult; Antiemetics; Aromatherapy; Cesarean Section; Female; Holistic Hea | 2012 |
Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial.
Topics: Antiemetics; Aprepitant; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Humans; Morp | 2012 |
Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Antiemetics; Drug The | 2003 |
The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 A | 2004 |
Post discharge nausea and vomiting after ambulatory laparoscopy is not reduced by promethazine prophylaxis.
Topics: Adult; Ambulatory Surgical Procedures; Antiemetics; Cholecystectomy; Double-Blind Method; Female; Gy | 1999 |
Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Per | 1999 |
Small-dose droperidol effectively reduces nausea in a general surgical adult patient population.
Topics: Anesthesia, General; Antiemetics; Double-Blind Method; Droperidol; Female; Humans; Male; Middle Aged | 2000 |
7 other studies available for promethazine and Emesis, Postoperative
| Article | Year |
|---|---|
Comparison of metoclopramide and promethazine for the treatment of postoperative nausea and vomiting in the post-anesthesia care unit: A retrospective database analysis.
Topics: Anesthesia; Antiemetics; Double-Blind Method; Humans; Metoclopramide; Ondansetron; Postoperative Nau | 2020 |
Is Promethazine 6.25 mg Intravenous Dose Really Ideal to Treat Postoperative Nausea and Vomiting?
Topics: Antiemetics; Double-Blind Method; Humans; Nausea; Postoperative Complications; Postoperative Nausea | 2015 |
Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as high risk for developing PONV.
Topics: 2-Propanol; Antiemetics; Humans; Ondansetron; Postoperative Nausea and Vomiting; Preanesthetic Medic | 2009 |
Clinical evaluation of promethazine for prevention of postoperative vomiting.
Topics: Humans; Postoperative Nausea and Vomiting; Promethazine; Vomiting | 1957 |
Postoperative nausea and vomiting. III. Evaluation of the antiemetic drugs fluphenazine (prolixin) and promethazine (phenergan) and comparison with triflupromazine, (vesprin) and cyclizine (marezine).
Topics: Antiemetics; Cyclizine; Fluphenazine; Humans; Postoperative Nausea and Vomiting; Promethazine; Surgi | 1960 |
A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.
Topics: Adult; Anesthesia, General; Antiemetics; Antipruritics; Female; Humans; Male; Medical Records; Middl | 2007 |
Extravasation of i.v. promethazine.
Topics: Adult; Antipruritics; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; Postope | 1999 |