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promethazine and Edema

promethazine has been researched along with Edema in 40 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"This histamine inhibition was also observed after mast cell pre-treatment with both methyl gallate and 1,2,3,4,6-pentagalloylglucose (100 microg/mL), the isolated compounds from the ethyl acetate fraction."1.35The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. ( Brito, Fde A; Cavalher-Machado, SC; de Oliveira, RR; Figueiredo, MR; Henriques, Md; Heringe, AP; Kaplan, MA; Rosas, EC, 2008)
"The edema was inhibited by previous treatment with promethazine (5 or 10mg/kg) or cyproheptadine (5 or 10mg/kg), but not by indomethacin (2 or 4mg/kg), dexamethasone (1 or 4mg/kg) or cromolyn (40 or 80mg/kg)."1.33Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. ( Bertollo, CM; Coelho, MM; Costa, KA; Glória, MB; Moraes-Santos, T; Nascimento, EB; Oliveira, AC; Rocha, LT; Souza, AL, 2005)
"Pretreatment with promethazine, phenylbutazone, methysergide and indomethacin resulted in a decrease in foot oedema."1.27Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs. ( Böhm, GM; Ito, NM, 1986)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199033 (82.50)18.7374
1990's1 (2.50)18.2507
2000's4 (10.00)29.6817
2010's2 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kimura, LF1
Prezotto-Neto, JP1
Távora, BC1
Faquim-Mauro, EL1
Pereira, NA1
Antoniazzi, MM1
Jared, SG1
Teixeira, CF1
Santoro, ML1
Barbaro, KC1
Cavalher-Machado, SC1
Rosas, EC1
Brito, Fde A1
Heringe, AP1
de Oliveira, RR1
Kaplan, MA1
Figueiredo, MR1
Henriques, Md1
Hoffmeister, C1
Trevisan, G1
Rossato, MF1
de Oliveira, SM1
Gomez, MV1
Ferreira, J1
HALPERN, BN2
BRIOT, M2
WOHLGEMUTH, PR1
O'BRIEN, GR1
MOSS, RL1
BINNS, PM1
HANSTEAD, B1
JOHN, HT1
KROULIK, WJ1
LECOMTE, J5
CESSION-FOSSION, A1
LIBON, JC1
BACQ, ZM1
RENTON, CJ1
POULSEN, T1
SCHMITERLOW, CG1
WESSMAN, CG1
CRUCHAUD, S1
VERMEIL, G1
Nascimento, EB1
Costa, KA1
Bertollo, CM1
Oliveira, AC1
Rocha, LT1
Souza, AL1
Glória, MB1
Moraes-Santos, T1
Coelho, MM1
Shishikura, T1
Shito, K1
Uchida, M1
Inaba, T1
Imanishi, H1
Tomatsu, K1
Nishiyama, Y1
Murata, S1
Kamei, H1
Palop, V1
Pastor, C1
Rubio, E1
Martínez-Mir, I1
Isbister, GK1
Balit, C1
Ravindranathan, N1
Ravitch, MM1
Ito, NM1
Böhm, GM1
Van Cauwenberge, H2
Dixon, JR1
Mountain, JT1
Damas, J1
Lallemand, G1
Brown, JH1
Mackey, HK1
Riggilo, DA1
Schwartz, NL1
Bartsch, R1
Nowak, R1
Femmer, K1
Stade, K1
Webster, ME1
Maling, HM1
Zweig, MH1
Williams, MA1
Anderson, W1
Rassaert, CL1
Richter, RS1
Martin, J1
DiPasquale, G1
Ohtaki, N1
Grob, PJ1
Inderbitzin, TM1
Graf, H1
Biermé, S1
Biermé, R1
Blanc, M1
Ducos, J1
Leuschner, F1
Leuschner, A1
Nizet, A1
Cuypers, Y1
Deetjen, P1
Kramer, K1
Antognini, F1
Giuliani, R1
Romagnoli, D1
Batin, J1
Alberty, J1
Wilhelmi, G1
Gdynia, R1

Other Studies

40 other studies available for promethazine and Edema

ArticleYear
Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice.
    Toxicon : official journal of the International Society on Toxinology, 2015, Volume: 103

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Dinoproston

2015
The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy.
    International immunopharmacology, 2008, Volume: 8, Issue:11

    Topics: Anacardiaceae; Animals; Anti-Allergic Agents; Chemokines; Edema; Histamine; Histamine Release; Hyper

2008
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B

2011
[Inhibitory effect of phenergan on edema caused by ovalbumin and dextran in adrenalectomized rat].
    Archives internationales de pharmacodynamie et de therapie, 1952, Sep-15, Volume: 91, Issue:3-4

    Topics: Adrenal Glands; Animals; Anti-Allergic Agents; Dextrans; Edema; Histamine H1 Antagonists; Ovalbumin;

1952
Postoperative edema in maxillofacial surgery; prevention and treatment with promethazine.
    American journal of surgery, 1957, Volume: 94, Issue:4

    Topics: Biomedical Research; Edema; Face; Humans; Maxilla; Postoperative Period; Promethazine; Surgery, Oral

1957
Control of postextraction edema with promethazine; a preliminary report.
    Oral surgery, oral medicine, and oral pathology, 1958, Volume: 11, Issue:5

    Topics: Edema; Humans; Promethazine; Tooth Extraction

1958
TRACHEAL OEDEMA TREATED BY INSTILLATION OF ADRENALINE.
    The Journal of laryngology and otology, 1963, Volume: 77

    Topics: Cortisone; Diagnosis; Diarrhea; Edema; Epinephrine; Erythema Nodosum; Hydrocortisone; Oxytetracyclin

1963
IDIOPATHIC SCROTAL OEDEMA OF CHILDREN.
    British journal of urology, 1964, Volume: 36

    Topics: Biopsy; Child; Diagnosis, Differential; Edema; Genital Diseases, Male; Humans; Hypersensitivity; Mal

1964
MANAGEMENT OF CASUALTIES IN THE CHICAGO SCHOOL FIRE.
    Hospital progress, 1964, Volume: 45

    Topics: Adolescent; Blood Proteins; Blood Transfusion; Burns; Chicago; Child; Debridement; Disasters; Edema;

1964
[ON SOME GENERAL PHARMACODYNAMIC EFFECTS OF CYSTAMINE IN THE RAT].
    Archives internationales de pharmacodynamie et de therapie, 1964, Apr-01, Volume: 148

    Topics: Adrenalectomy; Anti-Allergic Agents; Antihypertensive Agents; Bis-Trimethylammonium Compounds; Blood

1964
RECURRENT OEDEMA OF THE SMALL INTESTINE.
    The British journal of surgery, 1965, Volume: 52

    Topics: Diagnosis; Drug Therapy; Edema; Hypersensitivity; Ileitis; Intestine, Small; Intestines; Pathology;

1965
Investigations into the effects of atropine, sympatholytics, sodium nitrite, and promethazine on pulmonary oedema provoked by carbon dioxide.
    Acta pharmacologica et toxicologica, 1954, Volume: 10, Issue:4

    Topics: Atropine; Carbon Dioxide; Edema; Lung Diseases; Promethazine; Pulmonary Edema; Sodium Nitrite; Sympa

1954
The protective action of phenergan against acute pulmonary edema produced in the guinea-pig by large doses of adrenaline.
    Acta physiologica Scandinavica, 1951, Jul-30, Volume: 23, Issue:1

    Topics: Edema; Epinephrine; Guinea Pigs; Humans; Lung; Phenothiazines; Promethazine; Pulmonary Edema

1951
[The inhibitory action of promethazine and adrenalin on dextran edema in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1952, Volume: 146, Issue:1-2

    Topics: Animals; Anti-Allergic Agents; Dextrans; Edema; Epinephrine; Histamine H1 Antagonists; Promethazine;

1952
[Action of a synthetic antihistamine, phenergan, on acute pulmonary edema caused in a rabbit by an intra-cisternal injection of coagulant mixture].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1950, Volume: 144, Issue:3-4

    Topics: Animals; Anti-Allergic Agents; Coagulants; Edema; Histamine; Histamine H1 Antagonists; Lung; Prometh

1950
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.
    Toxicon : official journal of the International Society on Toxinology, 2005, Volume: 45, Issue:5

    Topics: Analysis of Variance; Animals; Behavior, Animal; Cyproheptadine; Dipyrone; Edema; Indomethacin; Inje

2005
A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.
    Journal of pharmacological sciences, 2006, Volume: 101, Issue:4

    Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antigens; Cromolyn Sodium; Cyclosporine; Dinitrobenze

2006
[Mechanism of action of certain fibrinolytic bis-tetrahydroisoquinolines: their antagonists and histamine- and 5-hydroxytryptamine-releasing effects (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1980, Volume: 76, Issue:1

    Topics: Animals; Cyproheptadine; Edema; Fibrinolysis; Fibrinolytic Agents; Histamine Release; Isoquinolines;

1980
[Topical antihistaminics. Is their use justified?].
    Atencion primaria, 1996, Jun-15, Volume: 18, Issue:1

    Topics: Administration, Topical; Child, Preschool; Drug Hypersensitivity; Edema; Female; Histamine H1 Antago

1996
Eye exposure to squashed spiders.
    The Medical journal of Australia, 2001, Oct-01, Volume: 175, Issue:7

    Topics: Administration, Oral; Administration, Topical; Adult; Animals; Edema; Eye Burns; Eye Diseases; Femal

2001
Allergic reaction to lignocaine. A case report.
    British dental journal, 1975, Feb-04, Volume: 138, Issue:3

    Topics: Anesthesia, Dental; Anesthesia, Local; Child; Drug Hypersensitivity; Edema; Eyelid Diseases; Female;

1975
Observations on the healing of wounds of the intestines.
    Surgery, 1975, Volume: 77, Issue:5

    Topics: Abscess; Animals; Dexamethasone; Dogs; Duodenum; Edema; Gastrectomy; Hemorrhage; Humans; Intestinal

1975
Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs.
    Research in veterinary science, 1986, Volume: 41, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Chickens; Edema; Indometha

1986
[Histamine liberating capacity of 7 mono (O-beta-hydroxyethyl) rutoside in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:4-5

    Topics: Animals; Blood Pressure; Capillary Permeability; Edema; Heart Rate; Histamine; Histamine Release; In

1974
Role of histamine and related substances in development of tolerance to edemagenic gases.
    Toxicology and applied pharmacology, 1965, Volume: 7, Issue:5

    Topics: Animals; Aspirin; Chemical Phenomena; Chemistry; Drug Tolerance; Edema; Female; Histamine; Histamine

1965
[Histamine liberator properties of hexadimethrine in rats].
    Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 162, Issue:1

    Topics: Animals; Blood Pressure; Dextrans; Edema; Histamine Release; Promethazine; Quaternary Ammonium Compo

1966
[Plasma kinogens and vasomotor reactions provoked in rats by dextran].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1968, Oct-19, Volume: 162, Issue:3

    Topics: Animals; Benzopyrans; Blood Pressure; Dextrans; Edema; Factor XII; Promethazine; Rats; Vasomotor Sys

1968
[Generalized edema in the rat caused by rutosides].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1971, Volume: 165, Issue:12

    Topics: Animals; Edema; Histamine; Injections, Intraperitoneal; Leg; Male; Methysergide; Promethazine; Rats;

1971
Studies on the acute inflammatory response. II. Influence of antihistaminics and catecholamines on formaldehyde-induced edema.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 160, Issue:1

    Topics: Anilides; Animals; Catecholamines; Edema; Formaldehyde; Guinea Pigs; Hindlimb; Histamine; Histamine

1968
[Pharmacology of the new antihistaminic 9,9-dioxopromethazine (Prothanon)].
    Die Pharmazie, 1970, Feb-02, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Bronchia

1970
Urate crystal induced inflammation in the rat: evidence for the combined actions of kinins, histamine and components of complement.
    Immunological communications, 1972, Volume: 1, Issue:2

    Topics: Animals; Carboxypeptidases; Colchicine; Complement System Proteins; Cyproheptadine; Edema; Female; G

1972
Effect of steroidal and nonsteroidal anti-inflammatory compounds in a milkweed-sap-induced rat pedal edema.
    Steroids and lipids research, 1973, Volume: 4, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Chlorpromazine; Cyproheptadine; Dexame

1973
Delayed hypersensitivity (DNCB contact dermatitis) in panleukopenic guinea pigs.
    International archives of allergy and applied immunology, 1969, Volume: 35, Issue:2

    Topics: Animals; Benzene; Cyclophosphamide; Dermatitis, Contact; Dinitrophenols; Edema; Erythema; Guinea Pig

1969
[Therapy of pregnancy toxemias (EPH-gestosis, preeclampsia)].
    Deutsche medizinische Wochenschrift (1946), 1972, Apr-28, Volume: 97, Issue:17

    Topics: Blood Pressure Determination; Chlorpromazine; Dextrans; Diazepam; Diet Therapy; Edema; Female; Human

1972
Three years experience of preventive treatment in foeto-placental anasarca. A hypothesis on pathogenesis.
    Annali di ostetricia, ginecologia, medicina perinatale, 1971, Volume: 92, Issue:9

    Topics: Edema; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Pregnancy; Promethazine

1971
[Percutaneous influencing of experimental swellings and tissue lesions in rats].
    Bratislavske lekarske listy, 1971, Volume: 56, Issue:5

    Topics: Animals; Disease Models, Animal; Edema; Erythema; Heparin; Phenylbutazone; Promethazine; Rats; Rutin

1971
Functional capacity of the isolated perfused dog kidney.
    Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere, 1967, Volume: 296, Issue:3

    Topics: Animals; Creatinine; Diet, Sodium-Restricted; Diuresis; Dogs; Edema; Glomerular Filtration Rate; In

1967
[Postoperative edema as cause of high respiratory obstruction in dental and maxillo-facial surgery (its prevention and therapy by means of the pharmacological combination "betamethazone-21-phosphate with escine and promethiazine"].
    Mondo odontostomatologico, 1970, Feb-28, Volume: 12, Issue:1

    Topics: Betamethasone; Edema; Humans; Postoperative Complications; Promethazine; Surgery, Oral

1970
[Cutaneous hemorrhagic edema infants, the equivalent of rheumatoid purpura].
    Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1968, Volume: 75, Issue:1

    Topics: Adrenal Cortex Hormones; Edema; Female; Hemorrhage; Humans; Infant; Promethazine; Purpura; Skin Dise

1968
[On the phlogogenic properties of lactic acid in animal experiments].
    Arzneimittel-Forschung, 1968, Volume: 18, Issue:12

    Topics: Animals; Capillary Permeability; Conjunctivitis; Edema; Exudates and Transudates; Guinea Pigs; Infla

1968