promethazine has been researched along with Disease Models, Animal in 27 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effect of promethazine on neuronal apoptosis in rats with cerebral infarction (CI) through the phosphatidylinositol 3-hydroxy kinase/protein kinase B (PI3K/Akt) signaling pathway." | 7.91 | Promethazine inhibits neuronal apoptosis via PI3K/Akt signaling pathway in rats with cerebral infarction. ( Chen, XL; Ding, SF; Hu, HL; Kou, D; Li, L; Pan, XD, 2019) |
| "Ouabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution." | 7.65 | Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias. ( Aryanpur, I; Paydar, M; Reyhani, F; Shakibi, JG; Siassi, B, 1976) |
| "To study the effect of promethazine on neuronal apoptosis in rats with cerebral infarction (CI) through the phosphatidylinositol 3-hydroxy kinase/protein kinase B (PI3K/Akt) signaling pathway." | 3.91 | Promethazine inhibits neuronal apoptosis via PI3K/Akt signaling pathway in rats with cerebral infarction. ( Chen, XL; Ding, SF; Hu, HL; Kou, D; Li, L; Pan, XD, 2019) |
| "Ouabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution." | 3.65 | Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias. ( Aryanpur, I; Paydar, M; Reyhani, F; Shakibi, JG; Siassi, B, 1976) |
| "Promethazine (PMZ) is an FDA-approved antihistaminergic drug that was identified as a potentially neuroprotective compound in the NINDS screening program." | 1.33 | Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. ( Beal, MF; Calingasan, NY; Chen, J; Cleren, C; Lorenzo, BJ; Starkov, AA, 2005) |
| "Signs of motion sickness were scored using a rating scale." | 1.28 | Investigation of anti-motion sickness drugs in the squirrel monkey. ( Cheung, BS; Kinter, LB; Kohl, RL; Money, KE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| An, H | 1 |
| Duan, Y | 1 |
| Wu, D | 1 |
| Yip, J | 1 |
| Elmadhoun, O | 1 |
| Wright, JC | 1 |
| Shi, W | 1 |
| Liu, K | 1 |
| He, X | 1 |
| Shi, J | 1 |
| Jiang, F | 1 |
| Ji, X | 1 |
| Ding, Y | 1 |
| Pan, XD | 1 |
| Chen, XL | 1 |
| Ding, SF | 1 |
| Kou, D | 1 |
| Hu, HL | 1 |
| Li, L | 1 |
| Tokunaga, S | 1 |
| Tsutsui, R | 1 |
| Obara, Y | 1 |
| Ishida, T | 1 |
| Kamei, C | 1 |
| Cleren, C | 2 |
| Calingasan, NY | 2 |
| Starkov, A | 1 |
| Jacquard, C | 1 |
| Chen, J | 2 |
| Brouillet, E | 1 |
| Beal, MF | 2 |
| Hoffmeister, C | 1 |
| Trevisan, G | 1 |
| Rossato, MF | 1 |
| de Oliveira, SM | 1 |
| Gomez, MV | 1 |
| Ferreira, J | 1 |
| Silva, SM | 1 |
| Madeira, MD | 1 |
| Starkov, AA | 1 |
| Lorenzo, BJ | 1 |
| Shishikura, T | 1 |
| Shito, K | 1 |
| Uchida, M | 1 |
| Inaba, T | 1 |
| Hall, TJ | 1 |
| Schaueblin, M | 1 |
| Naess, F | 1 |
| Waage, A | 1 |
| Roeise, O | 1 |
| Stadaas, JO | 1 |
| Aasen, AO | 1 |
| Oduola, AM | 1 |
| Sowunmi, A | 1 |
| Milhous, WK | 1 |
| Brewer, TG | 1 |
| Kyle, DE | 1 |
| Gerena, L | 1 |
| Rossan, RN | 1 |
| Salako, LA | 1 |
| Schuster, BG | 1 |
| Shakibi, JG | 1 |
| Aryanpur, I | 1 |
| Paydar, M | 1 |
| Reyhani, F | 1 |
| Siassi, B | 1 |
| Cheung, BS | 1 |
| Money, KE | 1 |
| Kohl, RL | 1 |
| Kinter, LB | 1 |
| André, F | 1 |
| André, C | 1 |
| Cavagna, S | 1 |
| Wink, CS | 1 |
| Hill, EM | 1 |
| Bircher, JL | 1 |
| Kontos, HA | 1 |
| Richardson, DW | 1 |
| Raper, AJ | 1 |
| Patterson, JL | 1 |
| Jansen, LH | 1 |
| Bleumink, E | 1 |
| Butler, DE | 1 |
| Purdon, RA | 1 |
| Bass, P | 1 |
| Cheney, DH | 1 |
| Slogoff, S | 1 |
| Allen, GW | 1 |
| Monroe, RG | 1 |
| LaFarge, CG | 1 |
| Gamble, WJ | 1 |
| Kumar, AE | 1 |
| Manasek, FJ | 1 |
| Kohút, A | 1 |
| Nicák, A | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Shropshire, AT | 1 |
| Rowles, G | 1 |
| Varner, LL | 1 |
| Leuschner, F | 1 |
| Leuschner, A | 1 |
| Dutta, D | 1 |
| Bhargava, KC | 1 |
| Chakravarti, RN | 1 |
| Dhall, SR | 1 |
1 review available for promethazine and Disease Models, Animal
| Article | Year |
|---|---|
Developments in non-anticholinergic anti-ulcer agents.
Topics: Anesthetics, Local; Animals; Antimalarials; Carbonic Anhydrase Inhibitors; Carrageenan; Denervation; | 1970 |
26 other studies available for promethazine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Combined Modality Therapy; Disease Models, Animal; Hy | 2017 |
Promethazine inhibits neuronal apoptosis via PI3K/Akt signaling pathway in rats with cerebral infarction.
Topics: Animals; Apoptosis; Cerebral Infarction; Disease Models, Animal; Gene Expression Regulation; Injecti | 2019 |
Effects of histamine H1-antagonists on sleep-awake state in rats placed on a grid suspended over water or on sawdust.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Chlorpheniramine; Diphenhydramine; Disease | 2009 |
Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Disease Models, Animal; Huntington Disease; | 2010 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B | 2011 |
Effects of chronic alcohol consumption and withdrawal on the response of the male and female hypothalamic-pituitary-adrenal axis to acute immune stress.
Topics: Alcohol Drinking; Animals; Corticosterone; Corticotropin-Releasing Hormone; Disease Models, Animal; | 2012 |
Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium Signaling; Disease Models, Animal; Dopamine; | 2005 |
A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antigens; Cromolyn Sodium; Cyclosporine; Dinitrobenze | 2006 |
Promethazine inhibits osteoclastic bone resorption in vitro.
Topics: Aging; Animals; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Cells, Cultured; Disease Mo | 1994 |
Effects of a combined drug regimen on tumour necrosis factor and plasma kallikrein activity in experimental endotoxaemia.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Escherichia coli Infections; Hemodynamic | 1994 |
In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.
Topics: Adult; Animals; Antimalarials; Antipruritics; Aotidae; Aotus trivirgatus; Chloroquine; Disease Model | 1998 |
Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Cats; Disease Models, Animal; Electrocardiography; Mann | 1976 |
Investigation of anti-motion sickness drugs in the squirrel monkey.
Topics: Animals; Dextroamphetamine; Disease Models, Animal; Drug Therapy, Combination; Ephedrine; Male; Moti | 1992 |
Role of histamine in the cell turnover changes associated with experimental gastric ulceration in the mastomys.
Topics: Animals; Cell Division; Cimetidine; Clemastine; Disease Models, Animal; Female; Histamine H1 Antagon | 1985 |
Effects of promethazine HCl on osteoporotic femora of adult castrated male rats.
Topics: Animals; Bone Diseases, Metabolic; Disease Models, Animal; Femur; Male; Orchiectomy; Osteoporosis; P | 1988 |
[Clinical prevention and therapy of Sudeck's syndrome. Bases of animal experiments].
Topics: Adult; Animals; Biopsy; Diazepam; Disease Models, Animal; Ergoloid Mesylates; Female; Histocytochemi | 1971 |
Mechanisms of action of hypocapnic alkalosis on limb blood vessels in man and dog.
Topics: Alkalosis; Alkalosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Disease | 1972 |
Flare and rash reactions in contact allergy of the guinea-pig.
Topics: Aminocaproates; Animals; Arthus Reaction; Dermatitis, Contact; Disease Models, Animal; Female; Guine | 1970 |
Ketamine-induced stress ulcers in the rat.
Topics: Anesthesia, Intravenous; Animals; Disease Models, Animal; Halothane; Humans; Ketamine; Phenoxybenzam | 1974 |
Left ventricular performance and coronary flow after coronary embolization with plastic microspheres.
Topics: Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Disease Models, Animal; Dog | 1971 |
[Stomach ulcer caused by phenylbutazone and its influencing in rats of different age groups].
Topics: Age Factors; Animals; Disease Models, Animal; Epinephrine; Phenylbutazone; Promethazine; Rats; Stoma | 1972 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |
[Percutaneous influencing of experimental swellings and tissue lesions in rats].
Topics: Animals; Disease Models, Animal; Edema; Erythema; Heparin; Phenylbutazone; Promethazine; Rats; Rutin | 1971 |
Therapeutic studies in experimental amniotic fluid embolism in rabbits.
Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli | 1970 |