Compounds > promethazine
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promethazine and Carbon Tetrachloride Poisoning

promethazine has been researched along with Carbon Tetrachloride Poisoning in 26 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Carbon Tetrachloride Poisoning: Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.

Research Excerpts

ExcerptRelevanceReference
" In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion."1.28Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990)
"Promethazine does not inhibit these systems to the same extent as it does the NADPH(2)-ADP-Fe(2+) lipid-peroxidation system."1.25The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride. ( Slater, TF, 1968)
" The RNA phosphorus redistribution, the decrease in inorganic pyrophosphatase and the increases in neotetrazolium reductase activities were at least partially prevented by a concomitant dosing with promethazine."1.25The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine. ( Sawyer, BC; Slater, TF, 1969)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199025 (96.15)18.7374
1990's1 (3.85)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
FOX, CF1
DINMAN, BD1
FRAJOLA, WJ1
JOGLEKAR, GV2
CHITALE, GK2
BALWANI, JH2
REES, KR1
SMITH, JF1
KARANDIKAR, SM1
WIGGLESWORTH, JS1
PETZOLD, H1
ZIMMERMANN, S1
AMER, S1
JUDAH, JD2
AHMED, K2
MCLEAN, AE2
TAPP, E1
CARROLL, R1
Poli, G3
Cheeseman, K1
Slater, TF7
Dianzani, MU4
Nayak, NC1
Chopra, P1
Gravela, E1
Chiarpotto, E2
Albano, E1
Masuda, Y1
Nakamura, Y1
Cheeseman, KH1
Biasi, F1
Esterbauer, H1
Boyer, JB1
Bastide, P1
Tronche, P1
Dastugue, G1
Nadeau, D1
Marchand, C1
Sträuli, UD1
Sawyer, BC2
Wooles, WR1
Rice, AJ1
Plaa, GL1
Kaszewska-Jablońska, I1
Serratoni, FT1
Schnitzer, B1
Smith, EB1
Greenbaum, AL1

Other Studies

26 other studies available for promethazine and Carbon Tetrachloride Poisoning

ArticleYear
CCl4 poisoning II: Serum enzymes, free fatty acids and liver pathology; effects of phenoxybenzamine and phenergan.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 111

    Topics: Carbon Tetrachloride Poisoning; Fatty Acids, Nonesterified; Liver Diseases; Mitochondria; Oxidoreduc

1962
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE IN MICE.
    Acta pharmacologica et toxicologica, 1963, Volume: 20

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorp

1963
THE PRESENCE OF MITOCHONDRIAL ENZYMES IN FAT IN THE LIVER IN CARBON TETRACHLORIDE POISONING.
    The Journal of pathology and bacteriology, 1963, Volume: 86

    Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport Complex I

1963
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE - A LONG TERM STUDY.
    Acta pharmacologica et toxicologica, 1963, Volume: 20

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati

1963
THE USE OF THE OSMIUM-ETHYL GALLATE TECHNIQUE IN THE STUDY OF CARBON TETRACHLORIDE LIVER INJURY.
    The Journal of pathology and bacteriology, 1964, Volume: 87

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gallic

1964
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
    Archiv fur Toxikologie, 1965, Feb-10, Volume: 20

    Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi

1965
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch

1965
TETRACYCLINE ACCUMULATION IN TOXIC LIVER DAMAGE.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Amides; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform;

1965
The role of lipid peroxidation in CCl4-induced damage to liver microsomal enzymes: comparative studies in vitro using microsomes and isolated liver cells.
    Chemico-biological interactions, 1981, Volume: 37, Issue:1-2

    Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Glucose-6-Phosphatase; Glut

1981
Biochemical implications of current studies on vitamin E.
    Annals of the New York Academy of Sciences, 1982, Volume: 393

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Free Radicals; Liver; Membranes; Prom

1982
Carbon tetrachloride toxicity: failure of promethazine to prevent in vivo liver injury.
    The Indian journal of medical research, 1980, Volume: 72

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis, Animal;

1980
Influence of lipid peroxidation on lipoprotein secretion by isolated hepatocytes.
    Lipids, 1981, Volume: 16, Issue:11

    Topics: Animals; Benzene Derivatives; Carbon Tetrachloride Poisoning; Chlorides; Ferric Compounds; Lipid Per

1981
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
    Biochemical pharmacology, 1990, Oct-15, Volume: 40, Issue:8

    Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li

1990
Promethazine inhibits the formation of aldehydic products of lipid peroxidation but not covalent binding resulting from the exposure of rat liver fractions to CCl4.
    The Biochemical journal, 1989, Dec-01, Volume: 264, Issue:2

    Topics: Aldehydes; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Kinetics;

1989
The role of free radicals in liver damage.
    The Proceedings of the Nutrition Society, 1987, Volume: 46, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radicals; Live

1987
[Protective action of some phenothiazines against the cytotoxicity of carbon tetrachloride in vitro].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1967, Volume: 161, Issue:5

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; In Vitro Techn

1967
Importance of the route of administration of ccl 4 in the protective effect of promethazine.
    Biochemical pharmacology, 1973, May-15, Volume: 22, Issue:10

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Glucose-6-Phosp

1973
Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning.
    The Biochemical journal, 1964, Volume: 93, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; NAD; NADP; N

1964
Prevention of the acute ethanol-induced fatty liver by antihistamines and stimulants of hepatic microsomal enzyme activity.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:2

    Topics: Animals; Brompheniramine; Carbon Tetrachloride Poisoning; Diphenhydramine; Ethanol; Fatty Acids, Non

1968
The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride.
    The Biochemical journal, 1968, Volume: 106, Issue:1

    Topics: Adenine Nucleotides; Animals; Animals, Newborn; Carbon Tetrachloride Poisoning; Chemical and Drug In

1968
The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.
    Toxicology and applied pharmacology, 1969, Volume: 14, Issue:1

    Topics: Acetates; Amides; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C

1969
[Iron of the subcellular fractions of liver tissue. 3. Effect of promethazine on hepatocellular changes in carbon tetrachloride poisoning].
    Polskie Archiwum Medycyny Wewnetrznej, 1972, Volume: 48, Issue:6

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Iron; Liver; Necrosis; Promethazine;

1972
The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine.
    The Biochemical journal, 1969, Volume: 111, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Cytochromes; Female; Liver; Microsomes; Oxidoreductases; Pe

1969
Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study.
    Archives of pathology, 1969, Volume: 87, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Endoplasmic Reticulum; Liver; Male; Microscopy, Electron; M

1969
Changes in lysosomal enzymes in acute experimental liver injury.
    The Biochemical journal, 1965, Volume: 96, Issue:2

    Topics: Acid Phosphatase; Amides; Animals; Blood; Carbon Tetrachloride Poisoning; Chemical and Drug Induced

1965
Cation changes following liver injury due to carbon tetrachloride.
    Annales medicinae experimentalis et biologiae Fenniae, 1966, Volume: 44, Issue:2

    Topics: Animals; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dibucaine;

1966