promethazine and Anaphylactic Reaction studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom."	9.09	Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. ( Cardoso, JL; Fan, HW; Ferrari, RA; França, FO; Malaque, CM; Marcopito, LF; Theakston, RD; Warrell, DA, 1999)
"To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom."	5.09	Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. ( Cardoso, JL; Fan, HW; Ferrari, RA; França, FO; Malaque, CM; Marcopito, LF; Theakston, RD; Warrell, DA, 1999)
"The effects of mepyramine, promethazine, chlorpromazine and lysergic acid diethylamide have been compared on the capillary permeability changes of the skin, produced by histamine, by 5-hydroxytryptamine and by passive cutaneous anaphylaxis in mice."	3.64	On the nature of the chemical mediators involved in anaphylactic reactions in mice. ( HALPERN, BN; NEVEU, T; SPECTOR, S, 1963)
"Envenoming from snakebites is most effectively treated by antivenom."	2.76	Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. ( Armitage, JM; Aronson, JK; de Silva, HA; de Silva, HJ; Hittharage, A; Jayamanne, S; Kalupahana, R; Lalloo, DG; Pathmeswaran, A; Ranasinha, CD; Ratnatilaka, GA; Samarakoon, SB; Uluwatthage, W, 2011)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (76.19)	18.7374
1990's	5 (11.90)	18.2507
2000's	2 (4.76)	29.6817
2010's	3 (7.14)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
de Silva, HA	1
Pathmeswaran, A	1
Ranasinha, CD	1
Jayamanne, S	1
Samarakoon, SB	1
Hittharage, A	1
Kalupahana, R	1
Ratnatilaka, GA	1
Uluwatthage, W	1
Aronson, JK	1
Armitage, JM	1
Lalloo, DG	1
de Silva, HJ	1
Stuart Hannah, RC	1
Heddle, R	1
Smith, W	1
Ellis, BC	1
Brown, SG	1
CIRSTEA, M	4
HALPERN, BN	1
NEVEU, T	1
SPECTOR, S	1
TORII, T	1
KINOSHITA, S	1
SUHACIU, G	2
LEHKY, T	1
ZMESKALOVA, D	1
MALEK, J	1
HERXHEIMER, H	1
STRESEMANN, E	1
ANDERSON, R	1
HARDENBERGH, E	1
Thong, CL	1
Lambros, M	1
Stewart, MG	1
Kam, PC	1
Williams, DJ	1
Jensen, SD	1
Nimorakiotakis, B	1
Müller, R	1
Winkel, KD	1
BENACERRAF, B	1
FISCHEL, EE	1
Alexander, ER	1
Fresh, JW	1
Lewis, AJ	1
Dervinis, A	1
Rosenthale, ME	1
Tryba, M	1
Zevounou, F	1
Zenz, M	1
Damas, J	2
Radermecker, M	1
Lecomte, J	3
Kelefiotis, D	1
Vakirtzi-Lemonias, C	1
Arunanthy, S	1
Hertzberg, SR	1
Fan, HW	1
Marcopito, LF	1
Cardoso, JL	1
França, FO	1
Malaque, CM	1
Ferrari, RA	1
Theakston, RD	1
Warrell, DA	1
Tong, KH	1
Henricsson, A	1
Bergentz, SE	1
Pearn, J	1
Hawgood, S	1
Mandappa, JM	1
Chandrasekhara, PM	1
Nelvigi, RG	1
Roberts, M	1
Fisher, M	1
Nolan, JC	1
Stephens, DJ	1
Proakis, AG	1
Leonard, CA	1
Johnson, DN	1
Kilpatrick, BF	1
Foxwell, MH	1
Yanni, JM	1
Schöning, B	1
Lorenz, W	1
Doenicke, A	1
Mills, PJ	1
Salmon, J	2
Boroş, I	1
Fregnan, GB	1
Glässer, AH	1
Julou, L	1
Ducrot, R	1
Bardone, MC	1
Detaille, JY	1
Feo, C	1
Guyonnet, JC	1
Loiseau, G	1
Pasquet, J	1
Harada, M	1
Takeuchi, M	1
Katagiri, K	1
Takagi, K	1
Fukao, T	1
Colombi, PA	1
Alonso, A	1
Teo, SK	1
Cheah, JS	1
Pedersoli, WM	1
Kelly, AJ	1
Boman, A	1
Tollackson, KA	1
Frick, OL	1
Dutta, D	1
Bhargava, KC	1
Chakravarti, RN	1
Dhall, SR	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Low Dose Adrenaline, Promethazine, & Hydrocortisone (Alone and in Combination) to Prevent Acute Adverse Reactions to Antivenom in People Bitten by Snakes: Randomised, Double Blind, Placebo-Controlled Trial[NCT00270777]			Phase 4	1,000 participants (Anticipated)	Interventional	2005-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. PLoS medicine, 2011, Volume: 8, Issue:5 Topics: Adolescent; Adult; Anaphylaxis; Antivenins; Dose-Response Relationship, Drug; Double-Blind Method; E	2011
[Prevention of anaphylactoid reactions using intramuscular promethazine and cimetidine. Studies of a histamine infusion model]. Der Anaesthesist, 1984, Volume: 33, Issue:5 Topics: Adult; Anaphylaxis; Blood Pressure; Cimetidine; Drug Therapy, Combination; Hemodynamics; Histamine;	1984
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. BMJ (Clinical research ed.), 1999, May-29, Volume: 318, Issue:7196 Topics: Adolescent; Adult; Anaphylaxis; Animals; Antivenins; Bothrops; Child; Double-Blind Method; Female; H	1999
[Histamine H1 and H2 receptor blockade as a supplementary premedication principle in elective surgery]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Mar-26, Volume: 74, Issue:13 Topics: Adult; Anaphylaxis; Cimetidine; Clinical Trials as Topic; Dimethindene; Drug Eruptions; Histamine H1	1985

Article	Year
Fatal gas gangrene related to self-injection treatment of anaphylaxis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 106, Issue:6 Topics: Anaphylaxis; Clostridium perfringens; Epinephrine; Fatal Outcome; Female; Gas Gangrene; Humans; Inje	2011
Parenteral antihistamines cause hypotension in anaphylaxis. Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:1 Topics: Adult; Anaphylaxis; Female; Histamine Antagonists; Humans; Hypotension; Infusions, Parenteral; Male;	2013
[On the mechanism of the production of delayed death in anaphylactic shock in guinea pigs]. International archives of allergy and applied immunology, 1962, Volume: 21 Topics: Anaphylaxis; Animals; Death; Guinea Pigs; Hypersensitivity; Immune System Diseases; Promethazine; Sh	1962
On the nature of the chemical mediators involved in anaphylactic reactions in mice. British journal of pharmacology and chemotherapy, 1963, Volume: 20 Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Capillary Permeability; Chlorpromazine; Histamine; Hista	1963
[Emergency treatment in anaphylactoid shock]. Naika. Internal medicine, 1962, Volume: 10 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aminophylline; Anaphylaxis; Anti-Allergic Agen	1962
[On the mechanism of belated death due to anaphylacic shock in the guinea pig]. Revue des sciences medicales, 1962, Volume: 7 Topics: Anaphylaxis; Death; Guinea Pigs; Humans; Promethazine; Shock	1962
STUDIES ON EXPERIMENTAL THERAPY OF ANAPHYLACTIC SHOCK IN DOGS. Archives internationales de physiologie et de biochimie, 1963, Volume: 71 Topics: Anaphylaxis; Angiotensins; Animals; Blood Transfusion; Dogs; Epinephrine; Horses; Hypoxia; Norepinep	1963
[STUDY OF THE EFFECT OF DEXTRAN ON THE PATHOGENESIS OF ALLERGIC REACTIONS IN RATS]. Ceskoslovenska farmacie, 1963, Volume: 12 Topics: Anaphylaxis; Anti-Allergic Agents; Cortisone; Dextrans; Histamine H1 Antagonists; Hypersensitivity;	1963
THE EFFECT OF SOME NEW ANTIHISTAMINES ON THE ANAPHYLACTIC MICROSHOCK OF THE GUINEA-PIG. British journal of pharmacology and chemotherapy, 1963, Volume: 21 Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antipsychotic Agents; Cyclic S-Oxides; Cyproheptadine; G	1963
ANAPHYLACTOID REACTION OF THE MOUSE TO DEXTRAN. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 117 Topics: Anaphylaxis; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesiology; Animals; C	1964
An unexpected cause of an acute hypersensitivity reaction during recovery from anaesthesia. Anaesthesia and intensive care, 2005, Volume: 33, Issue:4 Topics: Acute Disease; Aged; Anaphylaxis; Anesthesia Recovery Period; Anesthesia, Local; Anti-Allergic Agent	2005
Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea. Toxicon : official journal of the International Society on Toxinology, 2007, Volume: 49, Issue:6 Topics: Adolescent; Adult; Anaphylaxis; Animals; Antivenins; Child; Child, Preschool; Emergency Treatment; E	2007
Effect of phenergan (N-dimethylamino-2-propyl-1-thiodiphenylamine, 3277 RP) on the Arthus reaction in rabbits. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:3 Topics: Anaphylaxis; Animals; Arthus Reaction; Hypersensitivity; Immune System Diseases; Phenothiazines; Pro	1949
Prevention of anaphylactic death in the mouse toxicity prevention test for TRIC agents. American journal of ophthalmology, 1967, Volume: 63, Issue:5 Topics: Anaphylaxis; Animals; Biological Assay; Chlamydia; Chlorpromazine; Cortisone; Epinephrine; Mice; Pro	1967
Bronchodilator and antiallergic effects of thiazinamium chloride in guinea pigs, rats, cats and dogs. European journal of pharmacology, 1982, May-21, Volume: 80, Issue:2-3 Topics: Anaphylaxis; Animals; Ascaris; Asthma; Bronchodilator Agents; Cats; Cromolyn Sodium; Dogs; Female; G	1982
[Anaphylactic shock in brown Norway rats with reagins and no precipitins in the blood (author's transl)]. Pathologie-biologie, 1980, Volume: 28, Issue:10 Topics: Anaphylaxis; Animals; Blood Pressure; Diethylcarbamazine; Immunoglobulin E; Indomethacin; Methysergi	1980
In vivo responses of mouse blood cells to platelet-activating factor (PAF): role of the mediators of anaphylaxis. Agents and actions, 1993, Volume: 40, Issue:3-4 Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cells; Chlorpromazine; Erythroc	1993
A life-threatening anaphylactoid reaction to polyvalent snake antivenom despite pretreatment. The Medical journal of Australia, 1998, Sep-07, Volume: 169, Issue:5 Topics: Adult; Anaphylaxis; Antivenins; Epinephrine; Humans; Hydrocortisone; Male; Promethazine; Snake Venom	1998
Angioedema/anaphylaxis. Australian family physician, 1999, Volume: 28, Issue:7 Topics: Adult; Anaphylaxis; Angioedema; Australia; Child; Diphenhydramine; Epinephrine; Histamine H1 Antagon	1999
The possible role of vasoactive substances for the hemodynamic effects of rapidly injected antilymphocyte globulin. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1977, Volume: 9, Issue:5 Topics: Anaphylaxis; Animals; Antilymphocyte Serum; Aspirin; Blood Cell Count; Blood Platelets; Dogs; Hemody	1977
Bee-sting anaphylaxis in childhood. The Medical journal of Australia, 1979, Sep-08, Volume: 2, Issue:5 Topics: Aerosols; Albuterol; Anaphylaxis; Bee Venoms; Bicarbonates; Child; Child, Preschool; Desensitization	1979
Anaphylaxis to suxamethonium. Two case reports. British journal of anaesthesia, 1975, Volume: 47, Issue:4 Topics: Adolescent; Adult; Anaphylaxis; Blood Pressure; Chlorpheniramine; Dexamethasone; Female; Gluconates;	1975
Anaphylactoid reaction to iopamiro (after pretreatment). Australasian radiology, 1992, Volume: 36, Issue:2 Topics: Anaphylaxis; Cimetidine; Humans; Iopamidol; Male; Middle Aged; Prednisone; Premedication; Promethazi	1992
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine. Agents and actions, 1989, Volume: 28, Issue:1-2 Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; C	1989
Anaphylactoid reaction to oral premedication with temazepam and promethazine. Anaesthesia, 1988, Volume: 43, Issue:1 Topics: Adult; Anaphylaxis; Anti-Anxiety Agents; Female; Humans; Preanesthetic Medication; Promethazine; Tem	1988
[Prostaglandins are not responsible for anaphylactic hypotension in the rat]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:2-3 Topics: Anaphylaxis; Animals; Histamine H1 Antagonists; Hypotension; Indomethacin; Injections, Intravenous;	1974
Influence of the drugs on the immuno-allergic reactivity. IV. The action of tranquillizers on passive anaphylaxis in guinea-pig. Revue roumaine de morphologie et de physiologie, 1974, Volume: 20, Issue:1 Topics: Anaphylaxis; Animals; Chlordiazepoxide; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Histam	1974
[On the eventually anaphylactic nature of the arterial hypotension induced by dextrans in the rat]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1967, Jul-20, Volume: 161, Issue:2 Topics: Aminocaproates; Anaphylaxis; Animals; Dextrans; Histamine Release; Hypotension; Methysergide; Promet	1967
Synergistic action of an anti-5-hydroxytryptamine, anti-histamines and cortisone in experimental anaphylaxis. Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1965, Volume: 13, Issue:3 Topics: Anaphylaxis; Animals; Aspirin; Body Temperature; Chlorpheniramine; Cortisone; Histamine H1 Antagonis	1965
[Study of the pharmacological properties of 3-dimethylsulfonamido 10-(2-dimethylamino-propyl) phenothiazine (8.599 RP)]. Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 159, Issue:1 Topics: Anaphylaxis; Animals; Central Nervous System; Guinea Pigs; Histamine H1 Antagonists; Mice; Parasympa	1966
[Quantitative determination of passive cutaneous anaphylaxis and effects of anti-histaminics on anaphylaxis in guinea pigs]. Arerugi = [Allergy], 1966, Volume: 15, Issue:1 Topics: Anaphylaxis; Animals; Capillary Permeability; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists	1966
Effects of some drugs on capillary permeability in the anaphylaxis of the mouse. Japanese journal of pharmacology, 1971, Volume: 21, Issue:4 Topics: Aminopyrine; Anaphylaxis; Animals; Anti-Inflammatory Agents; Antilymphocyte Serum; Aprotinin; Aspiri	1971
[Action of diphenhydramine, chlorpheniramine, HS 592 and PB 400 on histamine and SRS-A induced wheals in skin of rats]. Alergia, 1972, Volume: 20, Issue:2 Topics: Anaphylaxis; Animals; Chlorpheniramine; Clemastine; Diphenhydramine; Histamine; Histamine H1 Antagon	1972
Severe reaction to the bite of the triatomid bug (Triatoma rubrofasciata) in Singapore. The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:7 Topics: Adult; Anaphylaxis; Blood Pressure; Epinephrine; Humans; Hydrocortisone; Hypersensitivity; Insect Bi	1973
Effects of acute anaphylactic shock on arterial blood pressure of anesthetized chickens. American journal of veterinary research, 1973, Volume: 34, Issue:7 Topics: Acetylcholine; Anaphylaxis; Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Chickens; Ch	1973
Correspondence: Anaphylaxis under anaesthesia. Anaesthesia and intensive care, 1973, Volume: 1, Issue:4 Topics: Adult; Anaphylaxis; Anesthesia, Intravenous; Bicarbonates; Dexamethasone; Drug Hypersensitivity; Fem	1973
Response of human smooth muscle in Schultz-Dale experiments. The Journal of allergy, 1966, Volume: 37, Issue:4 Topics: Allergens; Anaphylaxis; Antigen-Antibody Reactions; Atropine; Desensitization, Immunologic; Female;	1966
Therapeutic studies in experimental amniotic fluid embolism in rabbits. American journal of obstetrics and gynecology, 1970, Apr-15, Volume: 106, Issue:8 Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli	1970

promethazine and Anaphylactic Reaction

Research Excerpts

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