Page last updated: 2024-11-03

promethazine and Anaphylactic Reaction

promethazine has been researched along with Anaphylactic Reaction in 42 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Research Excerpts

ExcerptRelevanceReference
"To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom."9.09Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. ( Cardoso, JL; Fan, HW; Ferrari, RA; França, FO; Malaque, CM; Marcopito, LF; Theakston, RD; Warrell, DA, 1999)
"To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom."5.09Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. ( Cardoso, JL; Fan, HW; Ferrari, RA; França, FO; Malaque, CM; Marcopito, LF; Theakston, RD; Warrell, DA, 1999)
"The effects of mepyramine, promethazine, chlorpromazine and lysergic acid diethylamide have been compared on the capillary permeability changes of the skin, produced by histamine, by 5-hydroxytryptamine and by passive cutaneous anaphylaxis in mice."3.64On the nature of the chemical mediators involved in anaphylactic reactions in mice. ( HALPERN, BN; NEVEU, T; SPECTOR, S, 1963)
"Envenoming from snakebites is most effectively treated by antivenom."2.76Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. ( Armitage, JM; Aronson, JK; de Silva, HA; de Silva, HJ; Hittharage, A; Jayamanne, S; Kalupahana, R; Lalloo, DG; Pathmeswaran, A; Ranasinha, CD; Ratnatilaka, GA; Samarakoon, SB; Uluwatthage, W, 2011)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199032 (76.19)18.7374
1990's5 (11.90)18.2507
2000's2 (4.76)29.6817
2010's3 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Silva, HA1
Pathmeswaran, A1
Ranasinha, CD1
Jayamanne, S1
Samarakoon, SB1
Hittharage, A1
Kalupahana, R1
Ratnatilaka, GA1
Uluwatthage, W1
Aronson, JK1
Armitage, JM1
Lalloo, DG1
de Silva, HJ1
Stuart Hannah, RC1
Heddle, R1
Smith, W1
Ellis, BC1
Brown, SG1
CIRSTEA, M4
HALPERN, BN1
NEVEU, T1
SPECTOR, S1
TORII, T1
KINOSHITA, S1
SUHACIU, G2
LEHKY, T1
ZMESKALOVA, D1
MALEK, J1
HERXHEIMER, H1
STRESEMANN, E1
ANDERSON, R1
HARDENBERGH, E1
Thong, CL1
Lambros, M1
Stewart, MG1
Kam, PC1
Williams, DJ1
Jensen, SD1
Nimorakiotakis, B1
Müller, R1
Winkel, KD1
BENACERRAF, B1
FISCHEL, EE1
Alexander, ER1
Fresh, JW1
Lewis, AJ1
Dervinis, A1
Rosenthale, ME1
Tryba, M1
Zevounou, F1
Zenz, M1
Damas, J2
Radermecker, M1
Lecomte, J3
Kelefiotis, D1
Vakirtzi-Lemonias, C1
Arunanthy, S1
Hertzberg, SR1
Fan, HW1
Marcopito, LF1
Cardoso, JL1
França, FO1
Malaque, CM1
Ferrari, RA1
Theakston, RD1
Warrell, DA1
Tong, KH1
Henricsson, A1
Bergentz, SE1
Pearn, J1
Hawgood, S1
Mandappa, JM1
Chandrasekhara, PM1
Nelvigi, RG1
Roberts, M1
Fisher, M1
Nolan, JC1
Stephens, DJ1
Proakis, AG1
Leonard, CA1
Johnson, DN1
Kilpatrick, BF1
Foxwell, MH1
Yanni, JM1
Schöning, B1
Lorenz, W1
Doenicke, A1
Mills, PJ1
Salmon, J2
Boroş, I1
Fregnan, GB1
Glässer, AH1
Julou, L1
Ducrot, R1
Bardone, MC1
Detaille, JY1
Feo, C1
Guyonnet, JC1
Loiseau, G1
Pasquet, J1
Harada, M1
Takeuchi, M1
Katagiri, K1
Takagi, K1
Fukao, T1
Colombi, PA1
Alonso, A1
Teo, SK1
Cheah, JS1
Pedersoli, WM1
Kelly, AJ1
Boman, A1
Tollackson, KA1
Frick, OL1
Dutta, D1
Bhargava, KC1
Chakravarti, RN1
Dhall, SR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Low Dose Adrenaline, Promethazine, & Hydrocortisone (Alone and in Combination) to Prevent Acute Adverse Reactions to Antivenom in People Bitten by Snakes: Randomised, Double Blind, Placebo-Controlled Trial[NCT00270777]Phase 41,000 participants (Anticipated)Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for promethazine and Anaphylactic Reaction

ArticleYear
[Histamine H1 and H2 receptor blockade as a supplementary premedication principle in elective surgery].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Mar-26, Volume: 74, Issue:13

    Topics: Adult; Anaphylaxis; Cimetidine; Clinical Trials as Topic; Dimethindene; Drug Eruptions; Histamine H1

1985

Trials

4 trials available for promethazine and Anaphylactic Reaction

ArticleYear
Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial.
    PLoS medicine, 2011, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Anaphylaxis; Antivenins; Dose-Response Relationship, Drug; Double-Blind Method; E

2011
[Prevention of anaphylactoid reactions using intramuscular promethazine and cimetidine. Studies of a histamine infusion model].
    Der Anaesthesist, 1984, Volume: 33, Issue:5

    Topics: Adult; Anaphylaxis; Blood Pressure; Cimetidine; Drug Therapy, Combination; Hemodynamics; Histamine;

1984
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites.
    BMJ (Clinical research ed.), 1999, May-29, Volume: 318, Issue:7196

    Topics: Adolescent; Adult; Anaphylaxis; Animals; Antivenins; Bothrops; Child; Double-Blind Method; Female; H

1999
[Histamine H1 and H2 receptor blockade as a supplementary premedication principle in elective surgery].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Mar-26, Volume: 74, Issue:13

    Topics: Adult; Anaphylaxis; Cimetidine; Clinical Trials as Topic; Dimethindene; Drug Eruptions; Histamine H1

1985

Other Studies

38 other studies available for promethazine and Anaphylactic Reaction

ArticleYear
Fatal gas gangrene related to self-injection treatment of anaphylaxis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 106, Issue:6

    Topics: Anaphylaxis; Clostridium perfringens; Epinephrine; Fatal Outcome; Female; Gas Gangrene; Humans; Inje

2011
Parenteral antihistamines cause hypotension in anaphylaxis.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:1

    Topics: Adult; Anaphylaxis; Female; Histamine Antagonists; Humans; Hypotension; Infusions, Parenteral; Male;

2013
[On the mechanism of the production of delayed death in anaphylactic shock in guinea pigs].
    International archives of allergy and applied immunology, 1962, Volume: 21

    Topics: Anaphylaxis; Animals; Death; Guinea Pigs; Hypersensitivity; Immune System Diseases; Promethazine; Sh

1962
On the nature of the chemical mediators involved in anaphylactic reactions in mice.
    British journal of pharmacology and chemotherapy, 1963, Volume: 20

    Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Capillary Permeability; Chlorpromazine; Histamine; Hista

1963
[Emergency treatment in anaphylactoid shock].
    Naika. Internal medicine, 1962, Volume: 10

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aminophylline; Anaphylaxis; Anti-Allergic Agen

1962
[On the mechanism of belated death due to anaphylacic shock in the guinea pig].
    Revue des sciences medicales, 1962, Volume: 7

    Topics: Anaphylaxis; Death; Guinea Pigs; Humans; Promethazine; Shock

1962
STUDIES ON EXPERIMENTAL THERAPY OF ANAPHYLACTIC SHOCK IN DOGS.
    Archives internationales de physiologie et de biochimie, 1963, Volume: 71

    Topics: Anaphylaxis; Angiotensins; Animals; Blood Transfusion; Dogs; Epinephrine; Horses; Hypoxia; Norepinep

1963
[STUDY OF THE EFFECT OF DEXTRAN ON THE PATHOGENESIS OF ALLERGIC REACTIONS IN RATS].
    Ceskoslovenska farmacie, 1963, Volume: 12

    Topics: Anaphylaxis; Anti-Allergic Agents; Cortisone; Dextrans; Histamine H1 Antagonists; Hypersensitivity;

1963
THE EFFECT OF SOME NEW ANTIHISTAMINES ON THE ANAPHYLACTIC MICROSHOCK OF THE GUINEA-PIG.
    British journal of pharmacology and chemotherapy, 1963, Volume: 21

    Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antipsychotic Agents; Cyclic S-Oxides; Cyproheptadine; G

1963
ANAPHYLACTOID REACTION OF THE MOUSE TO DEXTRAN.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 117

    Topics: Anaphylaxis; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesiology; Animals; C

1964
An unexpected cause of an acute hypersensitivity reaction during recovery from anaesthesia.
    Anaesthesia and intensive care, 2005, Volume: 33, Issue:4

    Topics: Acute Disease; Aged; Anaphylaxis; Anesthesia Recovery Period; Anesthesia, Local; Anti-Allergic Agent

2005
Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea.
    Toxicon : official journal of the International Society on Toxinology, 2007, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Anaphylaxis; Animals; Antivenins; Child; Child, Preschool; Emergency Treatment; E

2007
Effect of phenergan (N-dimethylamino-2-propyl-1-thiodiphenylamine, 3277 RP) on the Arthus reaction in rabbits.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:3

    Topics: Anaphylaxis; Animals; Arthus Reaction; Hypersensitivity; Immune System Diseases; Phenothiazines; Pro

1949
Prevention of anaphylactic death in the mouse toxicity prevention test for TRIC agents.
    American journal of ophthalmology, 1967, Volume: 63, Issue:5

    Topics: Anaphylaxis; Animals; Biological Assay; Chlamydia; Chlorpromazine; Cortisone; Epinephrine; Mice; Pro

1967
Bronchodilator and antiallergic effects of thiazinamium chloride in guinea pigs, rats, cats and dogs.
    European journal of pharmacology, 1982, May-21, Volume: 80, Issue:2-3

    Topics: Anaphylaxis; Animals; Ascaris; Asthma; Bronchodilator Agents; Cats; Cromolyn Sodium; Dogs; Female; G

1982
[Anaphylactic shock in brown Norway rats with reagins and no precipitins in the blood (author's transl)].
    Pathologie-biologie, 1980, Volume: 28, Issue:10

    Topics: Anaphylaxis; Animals; Blood Pressure; Diethylcarbamazine; Immunoglobulin E; Indomethacin; Methysergi

1980
In vivo responses of mouse blood cells to platelet-activating factor (PAF): role of the mediators of anaphylaxis.
    Agents and actions, 1993, Volume: 40, Issue:3-4

    Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cells; Chlorpromazine; Erythroc

1993
A life-threatening anaphylactoid reaction to polyvalent snake antivenom despite pretreatment.
    The Medical journal of Australia, 1998, Sep-07, Volume: 169, Issue:5

    Topics: Adult; Anaphylaxis; Antivenins; Epinephrine; Humans; Hydrocortisone; Male; Promethazine; Snake Venom

1998
Angioedema/anaphylaxis.
    Australian family physician, 1999, Volume: 28, Issue:7

    Topics: Adult; Anaphylaxis; Angioedema; Australia; Child; Diphenhydramine; Epinephrine; Histamine H1 Antagon

1999
The possible role of vasoactive substances for the hemodynamic effects of rapidly injected antilymphocyte globulin.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1977, Volume: 9, Issue:5

    Topics: Anaphylaxis; Animals; Antilymphocyte Serum; Aspirin; Blood Cell Count; Blood Platelets; Dogs; Hemody

1977
Bee-sting anaphylaxis in childhood.
    The Medical journal of Australia, 1979, Sep-08, Volume: 2, Issue:5

    Topics: Aerosols; Albuterol; Anaphylaxis; Bee Venoms; Bicarbonates; Child; Child, Preschool; Desensitization

1979
Anaphylaxis to suxamethonium. Two case reports.
    British journal of anaesthesia, 1975, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Anaphylaxis; Blood Pressure; Chlorpheniramine; Dexamethasone; Female; Gluconates;

1975
Anaphylactoid reaction to iopamiro (after pretreatment).
    Australasian radiology, 1992, Volume: 36, Issue:2

    Topics: Anaphylaxis; Cimetidine; Humans; Iopamidol; Male; Middle Aged; Prednisone; Premedication; Promethazi

1992
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.
    Agents and actions, 1989, Volume: 28, Issue:1-2

    Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; C

1989
Anaphylactoid reaction to oral premedication with temazepam and promethazine.
    Anaesthesia, 1988, Volume: 43, Issue:1

    Topics: Adult; Anaphylaxis; Anti-Anxiety Agents; Female; Humans; Preanesthetic Medication; Promethazine; Tem

1988
[Prostaglandins are not responsible for anaphylactic hypotension in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:2-3

    Topics: Anaphylaxis; Animals; Histamine H1 Antagonists; Hypotension; Indomethacin; Injections, Intravenous;

1974
Influence of the drugs on the immuno-allergic reactivity. IV. The action of tranquillizers on passive anaphylaxis in guinea-pig.
    Revue roumaine de morphologie et de physiologie, 1974, Volume: 20, Issue:1

    Topics: Anaphylaxis; Animals; Chlordiazepoxide; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Histam

1974
[On the eventually anaphylactic nature of the arterial hypotension induced by dextrans in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1967, Jul-20, Volume: 161, Issue:2

    Topics: Aminocaproates; Anaphylaxis; Animals; Dextrans; Histamine Release; Hypotension; Methysergide; Promet

1967
Synergistic action of an anti-5-hydroxytryptamine, anti-histamines and cortisone in experimental anaphylaxis.
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1965, Volume: 13, Issue:3

    Topics: Anaphylaxis; Animals; Aspirin; Body Temperature; Chlorpheniramine; Cortisone; Histamine H1 Antagonis

1965
[Study of the pharmacological properties of 3-dimethylsulfonamido 10-(2-dimethylamino-propyl) phenothiazine (8.599 RP)].
    Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 159, Issue:1

    Topics: Anaphylaxis; Animals; Central Nervous System; Guinea Pigs; Histamine H1 Antagonists; Mice; Parasympa

1966
[Quantitative determination of passive cutaneous anaphylaxis and effects of anti-histaminics on anaphylaxis in guinea pigs].
    Arerugi = [Allergy], 1966, Volume: 15, Issue:1

    Topics: Anaphylaxis; Animals; Capillary Permeability; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists

1966
Effects of some drugs on capillary permeability in the anaphylaxis of the mouse.
    Japanese journal of pharmacology, 1971, Volume: 21, Issue:4

    Topics: Aminopyrine; Anaphylaxis; Animals; Anti-Inflammatory Agents; Antilymphocyte Serum; Aprotinin; Aspiri

1971
[Action of diphenhydramine, chlorpheniramine, HS 592 and PB 400 on histamine and SRS-A induced wheals in skin of rats].
    Alergia, 1972, Volume: 20, Issue:2

    Topics: Anaphylaxis; Animals; Chlorpheniramine; Clemastine; Diphenhydramine; Histamine; Histamine H1 Antagon

1972
Severe reaction to the bite of the triatomid bug (Triatoma rubrofasciata) in Singapore.
    The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:7

    Topics: Adult; Anaphylaxis; Blood Pressure; Epinephrine; Humans; Hydrocortisone; Hypersensitivity; Insect Bi

1973
Effects of acute anaphylactic shock on arterial blood pressure of anesthetized chickens.
    American journal of veterinary research, 1973, Volume: 34, Issue:7

    Topics: Acetylcholine; Anaphylaxis; Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Chickens; Ch

1973
Correspondence: Anaphylaxis under anaesthesia.
    Anaesthesia and intensive care, 1973, Volume: 1, Issue:4

    Topics: Adult; Anaphylaxis; Anesthesia, Intravenous; Bicarbonates; Dexamethasone; Drug Hypersensitivity; Fem

1973
Response of human smooth muscle in Schultz-Dale experiments.
    The Journal of allergy, 1966, Volume: 37, Issue:4

    Topics: Allergens; Anaphylaxis; Antigen-Antibody Reactions; Atropine; Desensitization, Immunologic; Female;

1966
Therapeutic studies in experimental amniotic fluid embolism in rabbits.
    American journal of obstetrics and gynecology, 1970, Apr-15, Volume: 106, Issue:8

    Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli

1970