promethazine has been researched along with Acute Liver Injury, Drug-Induced in 33 studies
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Salicylic acid is a widely used nonsteroidal anti-inflammatory drug (NSAID)." | 1.36 | Salicylic acid-induced hepatotoxicity triggered by oxidative stress. ( Doi, H; Horie, T, 2010) |
| " In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion." | 1.28 | Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990) |
| "Promethazine does not inhibit these systems to the same extent as it does the NADPH(2)-ADP-Fe(2+) lipid-peroxidation system." | 1.25 | The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride. ( Slater, TF, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (78.79) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Doi, H | 1 |
| Horie, T | 1 |
| JOGLEKAR, GV | 2 |
| CHITALE, GK | 2 |
| BALWANI, JH | 2 |
| REES, KR | 1 |
| SMITH, JF | 1 |
| CHADWICK, DA | 1 |
| JENNINGS, RC | 1 |
| KARANDIKAR, SM | 1 |
| ITO, F | 1 |
| YAMAMURA, Y | 1 |
| HAYANO, K | 1 |
| CARROLL, R | 2 |
| WIGGLESWORTH, JS | 1 |
| PETZOLD, H | 1 |
| ZIMMERMANN, S | 1 |
| AMER, S | 1 |
| JUDAH, JD | 2 |
| AHMED, K | 2 |
| MCLEAN, AE | 2 |
| TAPP, E | 1 |
| Nayak, NC | 1 |
| Chopra, P | 1 |
| Hunderi, OH | 1 |
| Scalley, RD | 1 |
| Conner, CS | 1 |
| Masuda, Y | 1 |
| Nakamura, Y | 1 |
| Foust, RT | 1 |
| Reddy, KR | 1 |
| Jeffers, LJ | 1 |
| Schiff, ER | 1 |
| Dianzani, MU | 1 |
| Fleckenstein, JL | 1 |
| Nimmo, J | 1 |
| Dixon, MF | 1 |
| Prescott, LF | 1 |
| Boyer, JB | 1 |
| Bastide, P | 1 |
| Tronche, P | 1 |
| Dastugue, G | 1 |
| Healy, PJ | 1 |
| Slater, TF | 3 |
| Sträuli, UD | 1 |
| Sawyer, BC | 1 |
| Kehoe, MJ | 1 |
| Rice, AJ | 1 |
| Plaa, GL | 1 |
| Greenbaum, AL | 1 |
| Kerr, JF | 1 |
| Pound, AW | 1 |
2 reviews available for promethazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
II. Major tranquilizers.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Chlorpromazine; Fluphenazine; Hem | 1971 |
31 other studies available for promethazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Salicylic acid-induced hepatotoxicity triggered by oxidative stress.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxyla | 2010 |
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE IN MICE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorp | 1963 |
THE PRESENCE OF MITOCHONDRIAL ENZYMES IN FAT IN THE LIVER IN CARBON TETRACHLORIDE POISONING.
Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport Complex I | 1963 |
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA.
Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halot | 1964 |
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE - A LONG TERM STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1963 |
THE FATTY LIVER INDUCTION OF ALPHA-ETHYLTHIOISONICOTINAMIDE (ETHIONIAMIDE, 1314TH).
Topics: Chemical and Drug Induced Liver Injury; Choline; Ethionamide; Fatty Liver; Hepatitis; Nucleosides; P | 1964 |
LESIONS OF THE LIVER PRODUCED BY SUDAN DYES.
Topics: Chemical and Drug Induced Liver Injury; Coloring Agents; Hepatitis; Liver Diseases; Mice; Pathology; | 1964 |
THE USE OF THE OSMIUM-ETHYL GALLATE TECHNIQUE IN THE STUDY OF CARBON TETRACHLORIDE LIVER INJURY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gallic | 1964 |
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1965 |
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch | 1965 |
TETRACYCLINE ACCUMULATION IN TOXIC LIVER DAMAGE.
Topics: Amides; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; | 1965 |
Carbon tetrachloride toxicity: failure of promethazine to prevent in vivo liver injury.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis, Animal; | 1980 |
[Intoxication with promethazine as a cause to liver damage].
Topics: Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol; Humans; Liver; Male; Promethazin | 1981 |
Acetaminophen poisoning: a case report of the use of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Codeine; Female; Human | 1978 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li | 1990 |
Nyquil-associated liver injury.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1989 |
The role of free radicals in liver damage.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radicals; Live | 1987 |
Nyquil and acute hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1985 |
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines; | 1973 |
[Protective action of some phenothiazines against the cytotoxicity of carbon tetrachloride in vitro].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; In Vitro Techn | 1967 |
Studies on poisoning by Macrozamia communis. II. Effects of modifying agents upon changes induced in the liver by Macrozamia communis.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Antioxidants; Body Temperature; Chemical and Dru | 1969 |
Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; NAD; NADP; N | 1964 |
The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride.
Topics: Adenine Nucleotides; Animals; Animals, Newborn; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1968 |
The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.
Topics: Acetates; Amides; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1969 |
Changes in lysosomal enzymes in acute experimental liver injury.
Topics: Acid Phosphatase; Amides; Animals; Blood; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1965 |
Acute liver injury due to albitocin.
Topics: Acid Phosphatase; Animals; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cytoplasm; Esterase | 1966 |
Cation changes following liver injury due to carbon tetrachloride.
Topics: Animals; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dibucaine; | 1966 |