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promethazine and Acute Liver Injury, Drug-Induced

promethazine has been researched along with Acute Liver Injury, Drug-Induced in 33 studies

Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

Research Excerpts

ExcerptRelevanceReference
"Salicylic acid is a widely used nonsteroidal anti-inflammatory drug (NSAID)."1.36Salicylic acid-induced hepatotoxicity triggered by oxidative stress. ( Doi, H; Horie, T, 2010)
" In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion."1.28Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990)
"Promethazine does not inhibit these systems to the same extent as it does the NADPH(2)-ADP-Fe(2+) lipid-peroxidation system."1.25The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride. ( Slater, TF, 1968)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199026 (78.79)18.7374
1990's1 (3.03)18.2507
2000's0 (0.00)29.6817
2010's6 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Doi, H1
Horie, T1
JOGLEKAR, GV2
CHITALE, GK2
BALWANI, JH2
REES, KR1
SMITH, JF1
CHADWICK, DA1
JENNINGS, RC1
KARANDIKAR, SM1
ITO, F1
YAMAMURA, Y1
HAYANO, K1
CARROLL, R2
WIGGLESWORTH, JS1
PETZOLD, H1
ZIMMERMANN, S1
AMER, S1
JUDAH, JD2
AHMED, K2
MCLEAN, AE2
TAPP, E1
Nayak, NC1
Chopra, P1
Hunderi, OH1
Scalley, RD1
Conner, CS1
Masuda, Y1
Nakamura, Y1
Foust, RT1
Reddy, KR1
Jeffers, LJ1
Schiff, ER1
Dianzani, MU1
Fleckenstein, JL1
Nimmo, J1
Dixon, MF1
Prescott, LF1
Boyer, JB1
Bastide, P1
Tronche, P1
Dastugue, G1
Healy, PJ1
Slater, TF3
Sträuli, UD1
Sawyer, BC1
Kehoe, MJ1
Rice, AJ1
Plaa, GL1
Greenbaum, AL1
Kerr, JF1
Pound, AW1

Reviews

2 reviews available for promethazine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
II. Major tranquilizers.
    Southern medical journal, 1971, Volume: 64, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Chlorpromazine; Fluphenazine; Hem

1971

Other Studies

31 other studies available for promethazine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Salicylic acid-induced hepatotoxicity triggered by oxidative stress.
    Chemico-biological interactions, 2010, Feb-12, Volume: 183, Issue:3

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxyla

2010
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE IN MICE.
    Acta pharmacologica et toxicologica, 1963, Volume: 20

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorp

1963
THE PRESENCE OF MITOCHONDRIAL ENZYMES IN FAT IN THE LIVER IN CARBON TETRACHLORIDE POISONING.
    The Journal of pathology and bacteriology, 1963, Volume: 86

    Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport Complex I

1963
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA.
    Lancet (London, England), 1964, Apr-11, Volume: 1, Issue:7337

    Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halot

1964
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE - A LONG TERM STUDY.
    Acta pharmacologica et toxicologica, 1963, Volume: 20

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati

1963
THE FATTY LIVER INDUCTION OF ALPHA-ETHYLTHIOISONICOTINAMIDE (ETHIONIAMIDE, 1314TH).
    Journal of biochemistry, 1964, Volume: 55

    Topics: Chemical and Drug Induced Liver Injury; Choline; Ethionamide; Fatty Liver; Hepatitis; Nucleosides; P

1964
LESIONS OF THE LIVER PRODUCED BY SUDAN DYES.
    The Journal of pathology and bacteriology, 1964, Volume: 87

    Topics: Chemical and Drug Induced Liver Injury; Coloring Agents; Hepatitis; Liver Diseases; Mice; Pathology;

1964
THE USE OF THE OSMIUM-ETHYL GALLATE TECHNIQUE IN THE STUDY OF CARBON TETRACHLORIDE LIVER INJURY.
    The Journal of pathology and bacteriology, 1964, Volume: 87

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gallic

1964
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
    Archiv fur Toxikologie, 1965, Feb-10, Volume: 20

    Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi

1965
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch

1965
TETRACYCLINE ACCUMULATION IN TOXIC LIVER DAMAGE.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Amides; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform;

1965
Carbon tetrachloride toxicity: failure of promethazine to prevent in vivo liver injury.
    The Indian journal of medical research, 1980, Volume: 72

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis, Animal;

1980
[Intoxication with promethazine as a cause to liver damage].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1981, Oct-20, Volume: 101, Issue:29

    Topics: Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol; Humans; Liver; Male; Promethazin

1981
Acetaminophen poisoning: a case report of the use of acetylcysteine.
    American journal of hospital pharmacy, 1978, Volume: 35, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Codeine; Female; Human

1978
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
    Biochemical pharmacology, 1990, Oct-15, Volume: 40, Issue:8

    Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li

1990
Nyquil-associated liver injury.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:4

    Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami

1989
The role of free radicals in liver damage.
    The Proceedings of the Nutrition Society, 1987, Volume: 46, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radicals; Live

1987
Nyquil and acute hepatic necrosis.
    The New England journal of medicine, 1985, Jul-04, Volume: 313, Issue:1

    Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami

1985
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
    Clinical toxicology, 1973, Volume: 6, Issue:1

    Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines;

1973
[Protective action of some phenothiazines against the cytotoxicity of carbon tetrachloride in vitro].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1967, Volume: 161, Issue:5

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; In Vitro Techn

1967
Studies on poisoning by Macrozamia communis. II. Effects of modifying agents upon changes induced in the liver by Macrozamia communis.
    Biochemical pharmacology, 1969, Volume: 18, Issue:1

    Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Antioxidants; Body Temperature; Chemical and Dru

1969
Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning.
    The Biochemical journal, 1964, Volume: 93, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; NAD; NADP; N

1964
The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride.
    The Biochemical journal, 1968, Volume: 106, Issue:1

    Topics: Adenine Nucleotides; Animals; Animals, Newborn; Carbon Tetrachloride Poisoning; Chemical and Drug In

1968
The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.
    Toxicology and applied pharmacology, 1969, Volume: 14, Issue:1

    Topics: Acetates; Amides; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C

1969
Changes in lysosomal enzymes in acute experimental liver injury.
    The Biochemical journal, 1965, Volume: 96, Issue:2

    Topics: Acid Phosphatase; Amides; Animals; Blood; Carbon Tetrachloride Poisoning; Chemical and Drug Induced

1965
Acute liver injury due to albitocin.
    The Australian journal of experimental biology and medical science, 1966, Volume: 44, Issue:2

    Topics: Acid Phosphatase; Animals; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cytoplasm; Esterase

1966
Cation changes following liver injury due to carbon tetrachloride.
    Annales medicinae experimentalis et biologiae Fenniae, 1966, Volume: 44, Issue:2

    Topics: Animals; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dibucaine;

1966