promegestone has been researched along with Breast Neoplasms in 166 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (50.00) | 18.7374 |
| 1990's | 50 (30.12) | 18.2507 |
| 2000's | 17 (10.24) | 29.6817 |
| 2010's | 15 (9.04) | 24.3611 |
| 2020's | 1 (0.60) | 2.80 |
| Authors | Studies |
|---|---|
| Bonasera, TA; Carlson, KE; Katzenellenbogen, JA; Kochanny, MJ; Kym, PR; O'Neil, JP; VanBrocklin, HF; Welch, MJ | 1 |
| Carlson, KE; Katzenellenbogen, JA; Lee, JH; Mayne, CG; Zhou, HB | 1 |
| Beato, M; Carbonell, J; de Llobet Cucalon, LI; Ferrari, R; Font-Mateu, J; Le Dily, F; Lioutas, A; Nacht, AS; Vicent, GP; Vidal, E; Zaurin, R | 1 |
| Levi, V; Marini, M; Nacht, AS; Ogara, MF; Pecci, A; Presman, DM; Rodríguez-Seguí, SA; Stortz, M; Vicent, GP | 1 |
| Clare, SE; Davaadelger, B; Khan, SA; Kim, JJ; Lee, O; Murphy, AR | 1 |
| Bajalovic, N; Lin, VCL; Tan, S; Wong, ESP | 1 |
| Chervoneva, I; Freydin, B; Fuchs, SY; Girondo, MA; Goodman, CR; Hooke, JA; Hyslop, T; Kovatich, AJ; Liu, C; Neilson, LM; Peck, AR; Rui, H; Sato, T; Shriver, CD; Tran, TH | 1 |
| Basson, MD; Haslam, SZ; Kariagina, A; Langohr, IM; Opreanu, RC; Xie, J | 1 |
| Kougioumtzi, A; Magklara, A; Tsaparas, P | 1 |
| Allen, JA; Chan, SR; Dehdashti, F; Dence, CS; Fettig, NM; Fowler, AM; Katzenellenbogen, JA; Sharp, TL; Zhou, D | 1 |
| Iizuka, M; Ikaga, R; Kajitani, T; Okazaki, T; Okinaga, H; Susa, T; Tamamori-Adachi, M | 1 |
| McFall, T; Patki, M; Ratnam, M; Rosati, R | 1 |
| Choi, M; Clare, SE; Gupta, A; Ivancic, DZ; Khan, SA; Kim, JJ; Lee, O; Ranjan, M; Wang, J | 1 |
| Aupperlee, MD; Conrad, SE; Durairaj, S; Haslam, SZ; Leipprandt, JR; Miksicek, R; Santos, SJ; Schwartz, RC; Tan, YS; Xie, J | 1 |
| Edwards, DP; Holley, AK; Jenkins, JT; Kiningham, KK; Moore, MR; Spitz, DR | 1 |
| Brown, M; Eaton, ML; Geistlinger, TR; Jansen, MS; Kobayashi, S; Lobenhofer, EK; Lupien, M; McDonnell, DP; Nevins, JR; Otteson, DC; Wade, HE; Zhu, W | 1 |
| Amazit, L; Bellance, C; Guiochon-Mantel, A; Khan, JA; Lombès, M; Loosfelt, H | 1 |
| Chen, CC; Hardy, DB; Mendelson, CR | 1 |
| Alimirah, F; Gupta, A; Mehta, R; Mehta, RG; Murillo, G; Peng, X; Wiehle, R | 1 |
| Sampath, D; Winneker, RC; Zhang, Z | 1 |
| Faivre, E; Horwitz, KB; Lange, CA; Olsen, A; Qiu, M | 1 |
| Altucci, L; Manninen, T; Miettinen, S; Vienonen, A; Wilhelm, E; Ylikomi, T | 1 |
| Cheung-Flynn, J; Denny, WB; Hubler, TR; Scammell, JG; Smith, DF; Valentine, DL | 1 |
| Cui, X; Hopp, TA; Lazard, Z; Lee, AV; Zhang, P | 1 |
| Al-Dhaheri, M; Faber, LE; Pang, H; Rowan, BG | 1 |
| Bott, RC; Perry, GA; Smith, MF; Welshons, WV | 1 |
| Edwards, DP; Narayanan, R; Weigel, NL | 1 |
| Appavu, C; Berrodin, T; Chippari, S; Chopra, R; Cohen, J; Fensome, A; Li, S; Lyttle, CR; Olland, AM; Unwalla, RJ; Wilhem, J; Winneker, RC; Wrobel, J; Zhang, P; Zhang, Z; Zhu, Y | 1 |
| Bray, JA; Bray, JD; Brown, EL; Ghatge, R; Horwitz, KB; Jacobsen, BM; Jelinsky, S; Lyttle, CR; Richer, JK; Saraf, K; Tunkey, C; Winneker, RC | 1 |
| Chalbos, D; Rochefort, H | 2 |
| Ojasoo, T; Raynaud, JP | 1 |
| Bardon, S; Chalbos, D; Rochefort, H; Vignon, F | 2 |
| Belovsky, O; Grill, HJ; Manz, B; Pollow, K | 1 |
| Rochefort, H | 1 |
| Blanchard, B; Taylor, CM; Zava, DT | 1 |
| Zava, DT | 1 |
| Gustafsson, JA; Humla, S; Nordenskjöld, B; Ramberg, I; Wrange, O | 1 |
| De Loecker, W; Janssens, JP; Wittevrongel, C | 1 |
| Bindal, RD; Katzenellenbogen, BS; Katzenellenbogen, JA; Reiner, GC | 1 |
| Bennett, RC; Bryan, RM; Lie, TH; Mercer, RJ; Morgan, FJ; Rennie, GC | 1 |
| Hawkins, RA; Miller, WR; Telford, J | 1 |
| Alexander, PS; Horwitz, KB; Lessey, BA | 1 |
| Barnes, DM; Harland, RN; Howell, A; Ribeiro, GG; Sellwood, RA; Taylor, J | 1 |
| Fennessey, PV; Horwitz, KB; Mockus, MB; Pike, AW; Sheridan, RL | 1 |
| Bonneterre, J; Dewailly, D; Hecquet, B; Lefebvre, J; Peyrat, JP; Vandewalle, B | 1 |
| Alexander, PS; Horwitz, KB | 1 |
| Chalbos, D; Keydar, I; Rochefort, H; Vignon, F | 1 |
| Anderson, KM; Economou, S; Hendrickson, C; Marogil, M; Phelan, J | 1 |
| Gustafsson, JA; Gustafsson, SA; Humla, S; Nordenskjöld, B; Ramberg, I; Skoog, L; Wrange, O | 1 |
| Thorsen, T | 1 |
| Aiginger, P; Horwitz, KB; Kuttenn, F; McGuire, WL | 1 |
| Freeman, L; Jiang, NS; Thibodeau, SN | 1 |
| Namkung, PC; Pétra, PH | 1 |
| Bonnin Lafuente, R; Carrera Font, T; Navarro Moreno, MA; Pastor Ferrer, MC; Planells Torres, P; Rosel Soria, P | 1 |
| Grill, HJ; Manz, B; Pollow, K | 1 |
| Horwitz, KB; Lessey, BA; Mockus, MB | 1 |
| Bower, MA; Horwitz, KB; Lessey, BA; Mockus, MB | 1 |
| Alban, P; Dinda, S; Hurd, C; Jhanwar, SC; Khattree, N; Moudgil, VK; Nag, K | 1 |
| Chetrite, G; Nguyen, BL; Pasqualini, JR | 1 |
| De Young, NJ; Gill, PG; Knowles, SE; Moyse, KJ; Owens, PC; Weger, MA | 1 |
| Demers, LM; Leach, MW; Miner, RS; Wei, LL | 1 |
| Archer, TK; Berard, D; Hager, GL; Mymryk, JS | 1 |
| Archer, TK; Moyer, ML; Nordeen, SK; Zaniewski, E | 1 |
| Botella, J; Cognet, AM; Delansorne, R; Duc, I; Duranti, E; Paris, J | 1 |
| Horwitz, KB; Sartorius, CA; Takimoto, GS; Tung, L | 1 |
| Bona, BJ; Edwards, DP; Lieberman, BA; Nordeen, SK | 1 |
| Dickson, RB; Lippman, ME; Shi, YE; Sobel, ME; Thompson, EW; Torri, J; Yamada, Y; Yieh, L | 1 |
| Albertini, A; Di Lorenzo, D; Ferrari, F; Garattini, E; Giannì, M; Savoldi, GF | 1 |
| Joosten, JW; Kloosterboer, HJ; Schoonen, WG | 2 |
| Baker, C; Hawkins, P; Norris, B; Quinn, PG; Sheridan, PL; Wei, LL | 1 |
| Arnold, SF; Klotz, DM; McLachlan, JA | 1 |
| Gordon, DF; Horwitz, KB; James, RA; Miller, MM; Richer, JK; Wood, WM | 1 |
| Grimison, B; Groshong, SD; Horwitz, KB; Langan, TA; Lange, CA; Owen, GI; Schauer, IE; Sclafani, RA; Todd, MC | 1 |
| Burkley, M; Dinda, S; Hurd, C; Kodali-Gali, S; Moudgil, VK; Sevilla, L | 1 |
| Balleine, RL; Clarke, CL; Hunt, SM; Yeates, C | 1 |
| Auricchio, F; Beato, M; Bilancio, A; Castoria, G; Di Domenico, M; Gong, W; Lombardi, M; Migliaccio, A; Piccolo, D | 1 |
| Lieberman, BA; Nordeen, SK; Ogden, CA; Taraseviciene, L | 1 |
| Baulieu, EE; Le Bihan, S; Mader, S; Marsaud, V; Mercier-Bodard, C; Renoir, JM; White, JH | 1 |
| Chetrite, G; Le Nestour, E; Pasqualini, JR | 1 |
| Horwitz, KB; Lange, CA; Richer, JK; Shen, T | 1 |
| Gupta, MS; McDougal, A; Ramamoorthy, K; Safe, SH; Sun, G | 1 |
| Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK; Nag, K | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK | 1 |
| Anderson, SM; Boonyaratanakornkit, V; Edwards, DP; Maller, JL; Miller, WT; Ribon, V; Scott, MP; Sherman, L | 1 |
| Faber, LE; Pang, H | 1 |
| Horwitz, KB; Jacobsen, BM; Richer, JK; Schittone, SA | 1 |
| Benraad, TJ; Geurts-Moespot, J; Kho, KH; Koenders, AJ | 1 |
| Bolan, G; Huff, K; Lippman, M | 1 |
| Lloyd, RV | 1 |
| Duffy, GJ; Duffy, MJ | 1 |
| Bona, BJ; Edwards, DP; Estes, PA; Fadok, VA; Nordeen, SK; Oñate, S; Welch, WJ | 1 |
| Beck, CA; Edwards, DP; Weigel, NL | 1 |
| Castronovo, V; Engel, J; Liu, FT; Sobel, ME; Stetler-Stevenson, WG; van den Brûle, FA | 1 |
| DeMarzo, AM; Edwards, DP; Nordeen, SK; Oñate, SA | 1 |
| Nguyen, BL; Pasqualini, JR; Varin, C | 1 |
| Cabrera, JJ; Chirino, R; Falcón, O; Fernández, L; Fernández, P; Jiménez, P; León, L; López, A; Navarro, D; Rivero, JF | 1 |
| Nguyen, BL; Pasqualini, JR; Schatz, B; Varin, C | 1 |
| Goldfine, ID; Hartmann, KK; Maddux, BA; Papa, V; Rosenthal, SM; Siiteri, PK | 1 |
| De Young, NJ; Dixon, PD; Gill, PG; Horsfall, DJ; Lensink, IL; Tilley, WD | 1 |
| Jeng, MH; Jordan, VC | 1 |
| Ishimoto, A; Tanaka, H; Yanagawa, S | 1 |
| Albertini, A; Di Lorenzo, D; Zava, D | 1 |
| Kuttenn, F; Malet, C; Mauvais-Jarvis, P; Vacca, A | 1 |
| Katzenellenbogen, BS; Keith, D; Read, LD; Slamon, DJ | 1 |
| Bircher, JA; Hathaway, LD; Moore, MR | 1 |
| Beier, S; Elger, W; Grill, HJ; Juchem, M; Manz, B; Pollow, K; Schmidt-Gollwitzer, K | 1 |
| Chalbos, D; Chambon, M; Escot, C; Galtier, F; Joyeux, C; Maudelonde, T; Rochefort, H | 1 |
| Brunetti, A; Goldfine, ID; Papa, V; Reese, CC; Siiteri, PK; Vigneri, R | 1 |
| Dauvois, S; Dumont, M; Haagensen, DE; Labrie, F; Simard, J | 1 |
| Bader, C; Monet, JD; Thomas, M | 1 |
| Carlson, KE; Katzenellenbogen, JA; Mathias, CJ; Pinney, KG; Pomper, MG; van Brocklin, H; Welch, MJ | 1 |
| Berkenstam, A; Carlstedt-Duke, J; Gustafsson, JA; Jörnvall, H; Strömstedt, PE | 1 |
| Katzenellenbogen, BS; Norman, MJ | 1 |
| Hagley, RD; Hissom, JR; Moore, MR | 1 |
| Castronovo, V; Liotta, LA; Sobel, ME; Taraboletti, G | 1 |
| Carlson, KE; Coppey, M; Katzenellenbogen, JA; Magdelenat, H | 1 |
| Darbre, PD; Glover, JF | 1 |
| Chalbos, D; Chambon, M; Rochefort, H; Vial, HJ | 1 |
| Cavaillès, V; Defrenne, A; Garcia, M; Rochefort, H; Touitou, I | 1 |
| Aakvaag, A; Eskild, W; Hansson, V; Jahnsen, T; Lahooti, H; Landmark, BF; Levy, FO; Ree, AH | 1 |
| Dalquist, KE; Graham, ML; Horwitz, KB | 1 |
| Dufour, JM; Labrie, F; Poulin, R | 1 |
| Bunn, PA; Gonzalez-Aller, C; Graham, ML; Horwitz, KB; Jewett, PB | 1 |
| Bowden, RT; Hissom, JR; Moore, MR | 1 |
| Berger, U; Coombes, RC; Greene, GL; McClelland, RA; Thethi, S; Wilson, P | 1 |
| Greene, GL; Katzenellenbogen, BS; Read, LD | 1 |
| Berkenstam, A; Glaumann, H; Gustafsson, JA | 1 |
| Berkenstam, A; Glaumann, H; Gustafsson, JA; Martin, M; Norstedt, G | 1 |
| Assailly, J; Bader, CA; Brami, M; Dautigny, N; Monet, JD; Thomas, M; Ulmann, A | 1 |
| Horiuchi, R; Iino, Y; Ishida, T; Izuo, M; Kurebayashi, J; Nakamura, T; Takigawa, H | 1 |
| Lazarus, L; Murphy, LJ; Sutherland, RL | 1 |
| Arnemann, J; Beato, M; Cato, AC; Miksicek, R; Schütz, G | 1 |
| Hagino, Y; Kuwano, M; Ono, M; Ueda, H | 1 |
| Cato, AC; Henderson, D; Ponta, H | 1 |
| Berg, NJ; Coulam, CB; Graham, ML; Ingle, JN; Riehl, E; Spelsberg, TC; Umehara, T | 1 |
| Fox, CF; Rao, KV; Sarup, JC | 1 |
| Imaoka, S; Iwanaga, T; Koyama, H; Miyauchi, K; Noguchi, S | 1 |
| Edwards, DP; Elashry-Stowers, D; Speers, WC; Zava, DT | 1 |
| Moore, MR | 1 |
| Bagchi, MK; Edwards, DP; Elliston, JF; O'Malley, BW; Tsai, MJ; Tsai, SY | 1 |
| Berg, NJ; Colvard, DS; Graham, ML; Ingle, JN; Jankus, WR; Jiang, NS; Spelsberg, TC | 1 |
| Katzenellenbogen, BS; Nardulli, AM | 1 |
| Fox, CF; Rao, KV; Sarup, JC; Williams, RE | 1 |
| Bosman, FT; De Goeij, AF; Hondius, GG; Rousch, MJ; Scheres, HM | 1 |
| Francis, MD; Gordon, DF; Horwitz, KB; Krett, NL; O'Malley, BW; Wei, LL; Wood, WM | 1 |
| Greene, GL; Katzenellenbogen, BS; Miller, JS; Read, LD; Snider, CE | 1 |
| Brentani, MM; Liberato, MH; Lopes, MT; Widman, A | 1 |
| Chalbos, D; Haagensen, D; Parish, T; Rochefort, H | 1 |
| Chamness, GC; Ruiz, AA; Salman, M; Stotter, PL | 1 |
| Hissom, JR; Moore, MR | 1 |
| Ailhaud, G; Chalbos, D; Chambon, M; Rochefort, H | 1 |
| Bader, CA; Brami, M; Dautigny, N; Monet, JD; Thomas, M | 1 |
| Abendstein, B; Daxenbichler, G; Marth, C | 1 |
| Bardon, S; Derocq, D; Gill, PG; Rochefort, H; Vignon, F | 1 |
| Alibert, C; Chalbos, D; May, F; Rochefort, H; Westley, B | 1 |
| Katzenellenbogen, BS; Mullick, A | 2 |
| Freidenberg, GR; Horwitz, KB | 1 |
| Katzenellenbogen, BS; Reiner, GC | 1 |
| Hagley, RD; Moore, MR | 1 |
| Horwitz, KB | 1 |
| Lewko, WM; van Aswegen, CH; Wittliff, JL | 1 |
3 review(s) available for promegestone and Breast Neoplasms
| Article | Year |
|---|---|
Steroidal and nonsteroidal antiestrogens in breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Cell Survival; Cells, Cultured; Estradiol; Estrogen Antagonists; Female; Humans; Models, Biological; Promegestone; Receptors, Estrogen; Tamoxifen | 1984 |
Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer.
Topics: Breast Neoplasms; Cell Line; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Promegestone; Sulfatases; Sulfotransferases; Sulfurtransferases; Testosterone | 1992 |
Regulation of fatty acid synthetase by progesterone in normal and tumoral human mammary glands.
Topics: Breast; Breast Diseases; Breast Neoplasms; Endometrium; Enzyme Induction; Epithelium; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Norpregnadienes; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured | 1990 |
1 trial(s) available for promegestone and Breast Neoplasms
| Article | Year |
|---|---|
[Promegestone, a new progestin].
Topics: Animals; Breast Neoplasms; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Mice; Norpregnadienes; Premenstrual Syndrome; Promegestone; Rabbits; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Receptors, Progesterone | 1983 |
162 other study(ies) available for promegestone and Breast Neoplasms
| Article | Year |
|---|---|
Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.
Topics: Adipose Tissue; Affinity Labels; Animals; Breast Neoplasms; Female; Fluorine Radioisotopes; Norpregnenes; Ovary; Pregnenediones; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Tissue Distribution; Uterus | 1993 |
Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.
Topics: Animals; Benzoxazines; Binding, Competitive; Breast Neoplasms; Female; Fluorine; Fluorine Radioisotopes; Models, Molecular; Promegestone; Radioligand Assay; Rats; Receptors, Progesterone; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Thiones | 2010 |
A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations.
Topics: Animals; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatin; Enhancer Elements, Genetic; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; MCF-7 Cells; Mice; Progestins; Promegestone; Receptors, Progesterone | 2021 |
The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; Cell Dedifferentiation; Cell Line, Tumor; Cell Proliferation; Chromatin; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Glucocorticoids; Humans; Progestins; Promegestone; Protein Binding; Receptors, Glucocorticoid; Receptors, Progesterone; Transcription, Genetic | 2019 |
Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; DNA-Binding Proteins; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Norpregnadienes; Promegestone; Protein Binding; Receptors, Progesterone; Repressor Proteins; Transcription Factors | 2018 |
Ligand-activated progesterone receptor B activates transcription factor EB to promote autophagy in human breast cancer cells.
Topics: Adenocarcinoma; Autophagosomes; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Lysosomes; MCF-7 Cells; Microtubule-Associated Proteins; Neoplasm Proteins; Promegestone; Protein Interaction Mapping; Protein Transport; Receptors, Progesterone; Recombinant Proteins; Signal Transduction; Transcriptional Activation | 2019 |
Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; DNA-Binding Proteins; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Keratin-5; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Premenopause; Progesterone; Progesterone Congeners; Prolactin; Promegestone; Proto-Oncogene Proteins c-bcl-6; Receptors, Estrogen; STAT5 Transcription Factor | 2014 |
Progesterone decreases levels of the adhesion protein E-cadherin and promotes invasiveness of steroid receptor positive breast cancers.
Topics: Animals; Breast Neoplasms; Cadherins; Carcinoma, Ductal; Cell Line, Tumor; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Experimental; Neoplasm Invasiveness; Progesterone; Promegestone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Wnt Signaling Pathway | 2013 |
Deep sequencing reveals new aspects of progesterone receptor signaling in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Humans; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Signal Transduction; Up-Regulation | 2014 |
Longitudinal noninvasive imaging of progesterone receptor as a predictive biomarker of tumor responsiveness to estrogen deprivation therapy.
Topics: Animals; Antineoplastic Agents, Hormonal; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Diagnostic Imaging; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Fluorodeoxyglucose F18; Humans; Ligands; Mammary Neoplasms, Experimental; Mice; Positron-Emission Tomography; Promegestone; Receptors, Progesterone; Tomography, X-Ray Computed | 2015 |
Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Dihydrotestosterone; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Parathyroid Hormone-Related Protein; Promegestone; Prostatic Neoplasms; Receptors, Androgen | 2015 |
Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estradiol; Female; HEK293 Cells; Humans; Neoplasm Invasiveness; Postmenopause; Premenopause; Promegestone; Protein Isoforms; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction | 2015 |
Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; MCF-7 Cells; Norpregnadienes; Oligonucleotide Array Sequence Analysis; Promegestone | 2016 |
Progesterone receptor A-regulated gene expression in mammary organoid cultures.
Topics: Animals; Breast Neoplasms; Cells, Cultured; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Organoids; Progestins; Promegestone; Receptors, Progesterone | 2009 |
Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells.
Topics: Base Sequence; Breast Neoplasms; Butadienes; Cell Line, Tumor; DNA Primers; Female; Hormone Antagonists; Humans; MAP Kinase Signaling System; Mifepristone; Neoplasm Invasiveness; Nitriles; Progesterone Congeners; Promegestone; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Superoxide Dismutase | 2009 |
Multimodal regulation of E2F1 gene expression by progestins.
Topics: Breast Neoplasms; Cell Line, Tumor; E2F1 Transcription Factor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Kruppel-Like Transcription Factors; Mitogen-Activated Protein Kinases; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Plicamycin; Progestins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Retinoblastoma Protein; Signal Transduction; Tacrolimus Binding Proteins | 2010 |
p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.
Topics: Breast Neoplasms; Cell Line, Tumor; Endometrial Neoplasms; Female; Gonanes; Humans; Ligands; MAP Kinase Kinase Kinase 1; Mifepristone; Mitogen-Activated Protein Kinase 1; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Stability; Receptors, Progesterone; Transcription, Genetic | 2011 |
Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1).
Topics: Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Dual Specificity Phosphatase 1; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Progesterone; Promegestone; Real-Time Polymerase Chain Reaction; Receptors, Progesterone; RNA Interference | 2011 |
Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.
Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, erbB-1; Humans; Letrozole; Nitriles; Norpregnadienes; Progestins; Promegestone; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; Tamoxifen; Testosterone; Triazoles; Tumor Stem Cell Assay | 2013 |
The angiogenic factor Cyr61 is induced by the progestin R5020 and is necessary for mammary adenocarcinoma cell growth.
Topics: Adenocarcinoma; Antibodies; Breast Neoplasms; Cell Division; Cysteine-Rich Protein 61; Drug Synergism; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Neovascularization, Pathologic; Progesterone Congeners; Promegestone; S Phase; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2002 |
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Breast Neoplasms; Butadienes; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Ligands; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Mutation; Nitriles; Phosphorylation; Promegestone; Proteasome Endopeptidase Complex; Receptors, Progesterone; Serine; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Regulation of nuclear receptor and cofactor expression in breast cancer cell lines.
Topics: Acetyltransferases; Breast Neoplasms; Cell Cycle Proteins; Cyclic AMP Response Element-Binding Protein; Estradiol; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Humans; Insulin; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; p300-CBP Transcription Factors; Promegestone; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Steroid; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Silencer Elements, Transcriptional; Transcription Factors; Tumor Cells, Cultured | 2003 |
The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness.
Topics: Animals; Base Sequence; Breast Neoplasms; Carcinoma, Hepatocellular; Gene Expression; Humans; Liver Neoplasms; Molecular Sequence Data; Progesterone Congeners; Promegestone; Promoter Regions, Genetic; Saimiri; Sequence Homology, Nucleic Acid; Tacrolimus; Tacrolimus Binding Proteins; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2.
Topics: Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Hormone Antagonists; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mifepristone; Phosphoproteins; Progesterone; Progestins; Promegestone; Protein Isoforms; Receptor, Insulin; Receptors, Progesterone; RNA, Messenger; Signal Transduction; Somatomedins; Up-Regulation | 2003 |
Epidermal growth factor suppresses induction by progestin of the adhesion protein desmoplakin in T47D breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Size; Cytoskeletal Proteins; Desmoplakins; Epidermal Growth Factor; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Progesterone; Promegestone; S Phase | 2004 |
Basis of melengestrol acetate action as a progestin.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cattle; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Hormone Antagonists; Humans; Inhibitory Concentration 50; Melengestrol Acetate; Pregnenediones; Progesterone; Progestins; Promegestone; Receptors, Progesterone | 2005 |
Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
Topics: Acetyltransferases; Animals; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Chromatin Immunoprecipitation; Cyclin-Dependent Kinases; Cytoplasm; Enzyme Inhibitors; Genes, Reporter; Histone Acetyltransferases; Humans; Hydroxamic Acids; Mammary Tumor Virus, Mouse; Mice; Phosphorylation; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Trans-Activators; Transcription, Genetic; Transcriptional Activation | 2005 |
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
Topics: Alkaline Phosphatase; Amino Acid Substitution; Benzoxazines; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Humans; Ligands; Mutagenesis, Site-Directed; Promegestone; Pyrroles; Receptors, Progesterone; Recombinant Proteins; X-Ray Diffraction | 2005 |
Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells.
Topics: Alkaline Phosphatase; Androstenes; Breast Neoplasms; Cell Line, Tumor; Cluster Analysis; Desogestrel; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Levonorgestrel; Ligands; Medroxyprogesterone Acetate; Oligonucleotide Array Sequence Analysis; Progesterone; Progestins; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic | 2005 |
Dual effects of the progestin R5020 on proteins released by the T47D human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Dihydrotestosterone; Estradiol; Female; Humans; Mannose; Medroxyprogesterone; Medroxyprogesterone Acetate; Methionine; Norpregnadienes; Progesterone; Promegestone; Proteins; Receptors, Progesterone | 1984 |
Criteria for the establishment of a double-labeling assay for simultaneous determination of estrogen and progesterone receptors.
Topics: Binding, Competitive; Breast Neoplasms; Cytosol; Diethylstilbestrol; Estradiol; False Negative Reactions; False Positive Reactions; Female; Humans; Iodine Radioisotopes; Isotope Labeling; Promegestone; Radioligand Assay; Receptors, Estrogen; Receptors, Progesterone; Time Factors; Tritium; Uterus | 1984 |
Biochemical basis of breast cancer treatment by androgens and progestins.
Topics: Androgens; Animals; Breast Neoplasms; Cell Division; Cell Line; Drug Resistance; Estrogen Antagonists; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Norpregnadienes; Promegestone; Rats; Receptors, Estrogen; Receptors, Progesterone | 1984 |
A simple method to determine whole cell uptake of radiolabelled oestrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture.
Topics: Breast Neoplasms; Cell Division; Cell Line; DNA; Estradiol; Humans; Methods; Progesterone; Promegestone; Subcellular Fractions; Time Factors | 1984 |
Interlaboratory variability in the determination of estrogen receptor and progesterone receptor content in human breast tumors: quality control in Switzerland.
Topics: Breast Neoplasms; Cytosol; Diethylstilbestrol; Female; Humans; Laboratories; Promegestone; Quality Control; Receptors, Estrogen; Receptors, Progesterone; Switzerland | 1984 |
Estrogen and progestin receptor analysis in human breast cancer by isoelectric focusing in slabs of polyacrylamide gel.
Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Isoelectric Focusing; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Tritium | 1984 |
A 250-kilodalton cellular protein is induced by progestins in two human breast cancer cell lines MCF7 and T47D.
Topics: Breast Neoplasms; Cell Line; Chemical Phenomena; Chemistry; Dexamethasone; Dihydrotestosterone; Electrophoresis; Estradiol; Female; Humans; Molecular Weight; Neoplasm Proteins; Progestins; Promegestone | 1984 |
Interaction of ionizing irradiation with steroid receptors in human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Nucleus; Cytosol; DNA, Neoplasm; Estradiol; Female; Humans; Kinetics; Neoplasm Proteins; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1984 |
Biological activity and receptor binding of a strongly interacting estrogen in human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Cytosol; Estradiol; Female; Humans; Kinetics; Plasminogen Activators; Promegestone; Rats; Receptors, Estradiol; Receptors, Estrogen; Receptors, Progesterone; Uterus | 1984 |
Progesterone receptors in breast cancer.
Topics: Adult; Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Neoplasm Recurrence, Local; Norpregnadienes; Prognosis; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies | 1984 |
Binding of [3H]-methyltrienolone (R1881) by human breast cancers.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cytosol; Estrenes; Female; Humans; Male; Metribolone; Progesterone; Promegestone; Prostate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Progesterone; Testosterone Congeners; Uterus | 1983 |
The subunit structure of human breast cancer progesterone receptors: characterization by chromatography and photoaffinity labeling.
Topics: Affinity Labels; Breast Neoplasms; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Female; Humans; Macromolecular Substances; Photochemistry; Promegestone; Receptors, Progesterone | 1983 |
Antiestrogenic effect of R5020, a synthetic progestin in human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Cells, Cultured; Depression, Chemical; DNA; Estradiol; Female; Humans; Norpregnadienes; Promegestone; Protein Biosynthesis; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Time Factors | 1983 |
Variation of receptor status in cancer of the breast.
Topics: Biopsy; Breast Neoplasms; Estradiol; Female; Humans; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Time Factors | 1983 |
Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism.
Topics: Breast Neoplasms; Cell Line; Cycloheximide; Female; Humans; Kinetics; Progesterone; Promegestone; Protein Biosynthesis; Receptors, Progesterone | 1983 |
Nuclear estradiol-binding sites in human breast cancer.
Topics: Adenocarcinoma; Binding, Competitive; Breast Neoplasms; Cell Nucleus; Estradiol; Female; Humans; Kinetics; Promegestone; Receptors, Estradiol; Receptors, Estrogen | 1983 |
In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation.
Topics: Affinity Labels; Breast Neoplasms; Cell Line; Cell Nucleus; Cytoplasm; Humans; Macromolecular Substances; Molecular Weight; Norpregnadienes; Promegestone; Receptors, Progesterone; Ultraviolet Rays | 1983 |
Estrogens stimulate cell proliferation and induce secretory proteins in a human breast cancer cell line (T47D).
Topics: Breast Neoplasms; Cell Division; Cell Line; Dexamethasone; Dihydrotestosterone; DNA Replication; Estradiol; Estrogens; Female; Humans; Insulin; Progesterone; Promegestone; Protein Biosynthesis | 1982 |
Sodium molybdate increases the amount of progesterone and estrogen receptor detected in certain human breast cancer cytosols.
Topics: Breast Neoplasms; Cytosol; Female; Humans; Molybdenum; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1980 |
Progestin-receptor analysis in human breast cancer cytosol by isoelectric focusing in slabs of polyacrylamide gel.
Topics: Animals; Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Electrophoresis, Polyacrylamide Gel; Female; Humans; Isoelectric Focusing; Isoelectric Point; Promegestone; Rats; Receptors, Progesterone; Uterus | 1981 |
Interaction of heparin with the cytosol progesterone receptor from human mammary tumours: separate estimation of the 4 and 7 S binding components with a simple dextran-charcoal assay.
Topics: Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Female; Heparin; Humans; Molybdenum; Norpregnadienes; Promegestone; Receptors, Progesterone | 1981 |
Nuclear estrogen receptor release from antiestrogen suppression: amplified induction of progesterone receptor in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Cell Nucleus; Dactinomycin; Estradiol; Female; Humans; Kinetics; Nafoxidine; Promegestone; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone | 1981 |
Simultaneous measurement of estrogen and progesterone receptors in tumor cytosols with use of 125I-labeled estradiol and of 3H-R5020.
Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Iodine Radioisotopes; Isotope Labeling; Kinetics; Norpregnadienes; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Tritium; Uterine Neoplasms | 1981 |
Measurement of progesterone receptors in human breast tumors: comparison of various methods of analysis.
Topics: Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Female; Humans; Methods; Promegestone; Receptors, Progesterone; Regression Analysis | 1981 |
[Progesterone receptors in breast cancer (author's transl)].
Topics: Adult; Age Factors; Aged; Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1981 |
Improvement of routine estrogen and progesterone assay: double labeling with 125-I-labeled estradiol and [3H]R5020.
Topics: Breast Neoplasms; Estradiol; Humans; Iodine Radioisotopes; Promegestone; Radioligand Assay; Receptors, Estrogen; Receptors, Progesterone; Tritium | 1982 |
Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance.
Topics: Breast Neoplasms; Bromodeoxyuridine; Butyrates; Cell Nucleus; Cells, Cultured; Cycloheximide; Cytoplasm; Estradiol; Female; Humans; Nafoxidine; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1982 |
Estrogen-insensitive progesterone receptors in a human breast cancer cell line: characterization of receptors and of a ligand exchange assay.
Topics: Breast Neoplasms; Cell Line; Cell Nucleus; Cytosol; Estrogens; Female; Humans; Kinetics; Ligands; Progesterone; Promegestone; Receptors, Progesterone | 1982 |
Hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line.
Topics: Base Sequence; Blood; Breast Neoplasms; Cell Division; Charcoal; Culture Media; DNA-Binding Proteins; Down-Regulation; Estradiol; Hormone Antagonists; Humans; Mifepristone; Molecular Sequence Data; Oligodeoxyribonucleotides; Progesterone Congeners; Promegestone; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020).
Topics: 17-Hydroxysteroid Dehydrogenases; Biotransformation; Breast Neoplasms; Danazol; Estradiol; Estrogen Antagonists; Estrone; Humans; Neoplasms, Hormone-Dependent; Polyunsaturated Alkamides; Promegestone; Tumor Cells, Cultured | 1995 |
Estrogen and progesterone regulate secretion of insulin-like growth factor binding proteins by human breast cancer cells.
Topics: Breast Neoplasms; Carrier Proteins; Cell Division; Culture Media, Serum-Free; Estradiol; Female; Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor II; Promegestone; Radioimmunoassay; Somatomedins; Tumor Cells, Cultured | 1993 |
Evidence for progesterone receptors in human osteoblast-like cells.
Topics: Alkaline Phosphatase; Base Sequence; Breast Neoplasms; Cell Line; Enzyme Induction; Female; Humans; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Osteoblasts; Poly A; Polymerase Chain Reaction; Progesterone; Promegestone; Radioligand Assay; Receptors, Progesterone; RNA; RNA, Messenger; Transcription, Genetic; Tritium | 1993 |
Mouse mammary tumor virus chromatin in human breast cancer cells is constitutively hypersensitive and exhibits steroid hormone-independent loading of transcription factors in vivo.
Topics: Breast Neoplasms; Chromatin; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Humans; In Vitro Techniques; Mammary Tumor Virus, Mouse; Micrococcal Nuclease; Nucleosomes; Promegestone; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
The differential capacity of glucocorticoids and progestins to alter chromatin structure and induce gene expression in human breast cancer cells.
Topics: Breast Neoplasms; Carcinoma; Chromatin; Dexamethasone; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Genes, Reporter; Humans; Mammary Tumor Virus, Mouse; NFI Transcription Factors; Promegestone; Promoter Regions, Genetic; Receptors, Glucocorticoid; Receptors, Progesterone; Transcription Factors; Tumor Cells, Cultured | 1994 |
Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Humans; Megestrol; Norpregnadienes; Pregnenediones; Progesterone Congeners; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1994 |
Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Base Sequence; beta-Galactosidase; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclic AMP; DNA-Binding Proteins; Female; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphates; Progesterone; Promegestone; Receptors, Progesterone; Recombinant Proteins; Transcription Factors; Transfection; Tumor Cells, Cultured | 1993 |
The constitution of a progesterone response element.
Topics: Baculoviridae; Base Composition; Base Sequence; Binding Sites; Breast Neoplasms; DNA; DNA, Viral; Gene Expression; Humans; Mammary Tumor Virus, Mouse; Mifepristone; Molecular Sequence Data; Mutation; Progestins; Promegestone; Receptors, Progesterone; Transfection; Tumor Cells, Cultured | 1993 |
Expression of 67 kDa laminin receptor in human breast cancer cells: regulation by progestins.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Basement Membrane; Blotting, Western; Breast Neoplasms; Cell Adhesion; Female; Fibronectins; Humans; Laminin; Mice; Mice, Nude; Mifepristone; Neoplasm Metastasis; Promegestone; Receptors, Laminin; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation | 1993 |
Progesterone induced expression of alkaline phosphatase is associated with a secretory phenotype in T47D breast cancer cells.
Topics: Alkaline Phosphatase; Blotting, Northern; Breast Neoplasms; Enzyme Induction; Female; Humans; Isoenzymes; Kinetics; Lipid Metabolism; Lipids; Progesterone; Promegestone; RNA, Messenger; RNA, Neoplasm; Time Factors; Tumor Cells, Cultured | 1993 |
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Desogestrel; Estradiol; Estrogen Antagonists; Female; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Models, Statistical; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured | 1995 |
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.
Topics: Breast Neoplasms; Carcinoma; Cell Division; Desogestrel; Dose-Response Relationship, Drug; Estradiol; Estrenes; Estrogen Antagonists; Female; Furans; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Mifepristone; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Tumor Cells, Cultured | 1995 |
An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Enhancer Elements, Genetic; Gonanes; HeLa Cells; Hormone Antagonists; Humans; Methionine; Mifepristone; Progesterone Congeners; Progestins; Promegestone; Protein Biosynthesis; Receptors, Progesterone; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Inhibition of 17 beta-estradiol and progesterone activity in human breast and endometrial cancer cells by carbamate insecticides.
Topics: Binding, Competitive; Breast Neoplasms; Carbamates; Endometrial Neoplasms; Estradiol; Estrogen Antagonists; Female; Humans; Insecticides; Luciferases; Progesterone; Progesterone Congeners; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured; Uterine Neoplasms | 1997 |
Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: implications for tamoxifen carcinogenicity.
Topics: Breast Neoplasms; Carcinogens; Isomerism; Oxygenases; Progesterone; Promegestone; Receptors, Progesterone; Tamoxifen; Tumor Cells, Cultured | 1997 |
Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1).
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Gene Expression Regulation; Gonanes; Hormone Antagonists; Humans; Microtubule-Associated Proteins; Mifepristone; Progesterone; Promegestone; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
Inhibition of proliferation of T47D human breast cancer cells: alterations in progesterone receptor and p53 tumor suppressor protein.
Topics: Antineoplastic Agents; Aurintricarboxylic Acid; Blotting, Western; Breast Neoplasms; Cell Division; DNA-Binding Proteins; Down-Regulation; Drug Screening Assays, Antitumor; Electrophoresis, Polyacrylamide Gel; Humans; Neoplasms, Hormone-Dependent; Phenanthrolines; Progesterone Congeners; Promegestone; Receptors, Progesterone; Rifampin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Characterization of a truncated progesterone receptor protein in breast tumors.
Topics: Breast Neoplasms; Cytosol; Exons; Gene Deletion; Gene Expression; Hot Temperature; Humans; Immunoblotting; Molecular Weight; Photoaffinity Labels; Promegestone; Receptors, Progesterone; RNA Processing, Post-Transcriptional; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor.
Topics: Animals; Breast Neoplasms; Carcinoma; COS Cells; CSK Tyrosine-Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Estradiol; Gene Expression Regulation; Guanosine Triphosphate; Hormone Antagonists; Humans; Mitogen-Activated Protein Kinase 1; Point Mutation; Promegestone; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; src-Family Kinases; Tamoxifen; Transcriptional Activation; Tumor Cells, Cultured | 1998 |
Extreme position dependence of a canonical hormone response element.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; Chloramphenicol O-Acetyltransferase; Dexamethasone; Enhancer Elements, Genetic; Female; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Humans; Molecular Sequence Data; Progesterone Congeners; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; TATA Box; Transcription, Genetic | 1998 |
Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chloramphenicol O-Acetyltransferase; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Macromolecular Substances; Mice; Polyenes; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; RNA, Messenger; Sirolimus; Tacrolimus; Transcription, Genetic; Triamcinolone Acetonide; Tumor Cells, Cultured | 1998 |
Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020).
Topics: Breast Neoplasms; Estrone; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Promegestone; RNA, Messenger; RNA, Neoplasm; Sulfotransferases; Tumor Cells, Cultured | 1998 |
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Epidermal Growth Factor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Progesterone; Promegestone; Receptor Cross-Talk; Receptors, Growth Factor; Signal Transduction; Up-Regulation | 1998 |
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Binding, Competitive; Breast Neoplasms; Cell Division; Estradiol; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation; Genes, Reporter; Humans; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Neoplasms, Hormone-Dependent; Organ Size; Peroxidases; Polychlorinated Biphenyls; Promegestone; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Uterus | 1999 |
Agonist and antagonist-induced qualitative and quantitative alterations of progesterone receptor from breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Division; Charcoal; Culture Media; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1999 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
Differential regulation of retinoblastoma protein by hormonal and antihormonal agents in T47D breast cancer cells.
Topics: Breast Neoplasms; Estradiol; Estrogen Receptor Modulators; Estrogens; Fulvestrant; Gonanes; Humans; Mifepristone; Phosphorylation; Progesterone; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Retinoblastoma Protein; Tumor Cells, Cultured | 2001 |
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.
Topics: Amino Acid Motifs; Animals; Breast Neoplasms; Cell Line; CSK Tyrosine-Protein Kinase; Female; Humans; Immunoblotting; Mitogen-Activated Protein Kinases; Models, Biological; Mutagenesis, Site-Directed; Oocytes; Progesterone; Progesterone Congeners; Promegestone; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Receptors, Progesterone; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; src-Family Kinases; Transfection; Two-Hybrid System Techniques; Xenopus laevis | 2001 |
Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Division; Estradiol; Female; Humans; In Vitro Techniques; Promegestone; Receptors, Estrogen; S Phase; Sirolimus; Tumor Cells, Cultured | 2001 |
New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation.
Topics: Breast Neoplasms; Dimerization; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Ligands; Plasmids; Progesterone Congeners; Promegestone; Receptors, Progesterone; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Estradiol and progesterone receptor activities in stored lyophilised target tissue.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Cattle; Drug Stability; Estradiol; Female; Freeze Drying; Humans; Kinetics; Mammary Neoplasms, Experimental; Promegestone; Rats; Receptors, Progesterone; Time Factors; Uterus | 1978 |
Progesterone and glucocorticoid interactions with receptor in breast cancer cells in long-term tissue culture.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Dexamethasone; Female; Humans; Hydrocortisone; Leucine; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Progesterone; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; Receptors, Steroid; Thymidine | 1977 |
Studies on the progesterone receptor content and steroid metabolism in normal and pathological human breast tissues.
Topics: Adenofibroma; Binding, Competitive; Breast; Breast Diseases; Breast Neoplasms; Carcinoma; Female; Humans; Kinetics; Progesterone; Promegestone; Receptors, Progesterone | 1979 |
Studies on progesterone receptors in human breast carcionomas: use of natural and synthetic ligands.
Topics: Breast Neoplasms; Female; Humans; Ligands; Norpregnenes; Pregnenediones; Progesterone; Promegestone; Protein Binding; Receptors, Progesterone | 1979 |
Heat shock alters the composition of heteromeric steroid receptor complexes and enhances receptor activity in vivo.
Topics: Arsenic; Arsenites; Blotting, Western; Breast Neoplasms; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cytosol; DNA; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Hot Temperature; Humans; Mammary Tumor Virus, Mouse; Phosphorylation; Promegestone; Receptors, Progesterone; Sodium Compounds; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Female; Humans; Isoquinolines; Mammary Tumor Virus, Mouse; Molecular Weight; Okadaic Acid; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Promegestone; Promoter Regions, Genetic; Protein Kinase C; Receptors, Progesterone; Transcription, Genetic; Transfection | 1992 |
Genes involved in tumor invasion and metastasis are differentially modulated by estradiol and progestin in human breast-cancer cells.
Topics: Breast Neoplasms; Collagenases; Estradiol; Female; Gene Expression Regulation; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Promegestone; Receptors, Laminin; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 1992 |
Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor.
Topics: Baculoviridae; Biopolymers; Breast Neoplasms; DNA-Binding Proteins; Humans; Mifepristone; Precipitin Tests; Promegestone; Receptors, Progesterone; Recombinant Proteins; Tumor Cells, Cultured | 1992 |
Effect of the progestagen R5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47d human mammary cancer cells: correlation with progesterone receptor levels.
Topics: Biotransformation; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Neoplasms, Hormone-Dependent; Progesterone; Promegestone; Receptors, Progesterone; Tritium; Tumor Cells, Cultured | 1992 |
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Cytosol; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Antagonists; Female; Heat-Shock Proteins; Humans; Immunohistochemistry; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Reference Values; Sarcoma | 1992 |
Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.
Topics: Breast Neoplasms; Down-Regulation; Humans; Insulin-Like Growth Factor II; Progestins; Promegestone; Receptors, Cell Surface; Receptors, Somatomedin; RNA, Messenger; Tumor Cells, Cultured | 1991 |
Inhibition of T47D human breast cancer cell growth by the synthetic progestin R5020: effects of serum, estradiol, insulin, and EGF.
Topics: Animals; Blood Physiological Phenomena; Breast Neoplasms; Cattle; Cell Division; Culture Media, Serum-Free; Depression, Chemical; Drug Interactions; Epidermal Growth Factor; Estradiol; Female; Humans; Insulin; Promegestone; Tumor Cells, Cultured | 1991 |
Growth stimulation and differential regulation of transforming growth factor-beta 1 (TGF beta 1), TGF beta 2, and TGF beta 3 messenger RNA levels by norethindrone in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Estradiol; Gene Expression Regulation; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Norethindrone; Promegestone; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Tamoxifen; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Identification of a novel mammary cell line-specific enhancer element in the long terminal repeat of mouse mammary tumor virus, which interacts with its hormone-responsive element.
Topics: Breast Neoplasms; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Chromosome Deletion; Dexamethasone; Enhancer Elements, Genetic; Female; HeLa Cells; Humans; Mammary Tumor Virus, Mouse; Promegestone; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Simian virus 40; Transcription, Genetic; Transfection | 1991 |
Progestin regulation of alkaline phosphatase in the human breast cancer cell line T47D.
Topics: Acid Phosphatase; Alkaline Phosphatase; Breast Neoplasms; Cell Line; Cycloheximide; Enzyme Induction; Female; Humans; Kinetics; Organ Specificity; Promegestone; Steroids; Tunicamycin | 1991 |
17 beta-estradiol dehydrogenase (E2DH) activity in T47D cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; Estradiol; Estradiol Dehydrogenases; Female; Humans; Kinetics; Promegestone; Receptors, Estrogen; Receptors, Steroid | 1991 |
Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines.
Topics: Breast Neoplasms; Estrogen Antagonists; Estrogens; Humans; Mifepristone; Neoplasms, Hormone-Dependent; Progestins; Prognosis; Promegestone; Proto-Oncogene Proteins; Pyrrolidines; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Thiophenes; Tumor Cells, Cultured | 1990 |
Progestin stimulation of thymidine kinase in the human breast cancer cell line T47D.
Topics: Breast Neoplasms; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Mifepristone; Progestins; Promegestone; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 1991 |
Lack of binding of gestodene to estrogen receptor in human breast cancer tissue.
Topics: Binding, Competitive; Breast Neoplasms; Female; Humans; In Vitro Techniques; Myometrium; Norpregnenes; Progesterone Congeners; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1990 |
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Division; Cell Line; Drug Synergism; Female; Humans; Immunoglobulin G; Insulin; Insulin-Like Growth Factor I; Kinetics; Progesterone; Promegestone; Receptor, Insulin; RNA, Messenger; Transcription, Genetic | 1990 |
Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells.
Topics: Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Drug Interactions; Estradiol; Flutamide; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Mifepristone; Neoplasm Proteins; Promegestone; Tumor Cells, Cultured | 1990 |
Sex steroid hormone modulation of NADPH pathways in MCF-7 cells.
Topics: Breast Neoplasms; Cell Division; Drug Interactions; Estradiol; Glucosephosphate Dehydrogenase; Humans; Mifepristone; NADP; Norpregnadienes; Premedication; Promegestone; Tamoxifen; Tumor Cells, Cultured | 1990 |
Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors.
Topics: Animals; Breast Neoplasms; Female; Humans; Neoplasms, Hormone-Dependent; Norpregnadienes; Pregnenediones; Promegestone; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Radiosequence analysis of the human progestin receptor charged with [3H]promegestone. A comparison with the glucocorticoid receptor.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Cell Line; Cysteine; Cytosol; Dexamethasone; Female; Humans; Liver; Methionine; Molecular Sequence Data; Norpregnadienes; Promegestone; Rats; Receptors, Glucocorticoid; Receptors, Progesterone; Sequence Homology, Nucleic Acid; Triamcinolone Acetonide; Tritium | 1990 |
Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen.
Topics: Blood; Breast Neoplasms; Dose-Response Relationship, Drug; Estrogens; Humans; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kinetics; Linoleic Acid; Linoleic Acids; Promegestone; Receptors, Progesterone; Selenium; Serum Albumin, Bovine; Somatomedins; Transferrin; Tumor Cells, Cultured | 1990 |
Progestin stimulation of lactate dehydrogenase in the human breast cancer cell line T-47D.
Topics: Breast Neoplasms; Cell Line; Estrenes; Female; Humans; L-Lactate Dehydrogenase; Mifepristone; Neoplasm Proteins; Progestins; Promegestone; RNA | 1987 |
Modulation of laminin receptor expression by estrogen and progestins in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Movement; Estradiol; Fluorescent Antibody Technique; Humans; Laminin; Pregnenediones; Progesterone Congeners; Promegestone; Receptors, Immunologic; Receptors, Laminin; RNA, Messenger; Tumor Cells, Cultured | 1989 |
Receptor binding of NBD-labeled fluorescent estrogens and progestins in whole cells and cell-free preparations.
Topics: Affinity Labels; Binding, Competitive; Breast Neoplasms; Cell Line; Cell Nucleus; Cytoplasm; Estradiol; Estrenes; Fluorescent Dyes; Hexestrol; Humans; Mifepristone; Nafoxidine; Oxadiazoles; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1989 |
Multihormone regulation of MMTV-LTR in transfected T-47-D human breast cancer cells.
Topics: Breast Neoplasms; Dexamethasone; Diethylstilbestrol; Estradiol; Gene Expression Regulation; Genetic Markers; Hormones; Humans; Mammary Tumor Virus, Mouse; Plasmids; Promegestone; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repetitive Sequences, Nucleic Acid; Tamoxifen; Testosterone; Transfection; Tumor Cells, Cultured | 1989 |
Progestins and androgens stimulate lipid accumulation in T47D breast cancer cells via their own receptors.
Topics: Acetates; Breast Neoplasms; Dihydrotestosterone; Dose-Response Relationship, Drug; Fatty Acids; Flutamide; Humans; In Vitro Techniques; Lipid Metabolism; Microscopy, Electron; Mifepristone; Norpregnadienes; Promegestone; Receptors, Androgen; Receptors, Progesterone; Triglycerides; Tumor Cells, Cultured | 1989 |
Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells.
Topics: Animals; Blotting, Northern; Breast Neoplasms; Cathepsin D; Cell Line; Epidermal Growth Factor; Estradiol; Female; Gene Expression Regulation; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Promegestone; Rats; RNA, Messenger; Transfection; Uterine Neoplasms | 1989 |
Autologous down-regulation of messenger ribonucleic acid and protein levels for estrogen receptors in MCF-7 cells: an inverse correlation to progesterone receptor levels.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Estradiol; Humans; Immunologic Techniques; Osmolar Concentration; Promegestone; Proteins; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Time Factors | 1989 |
Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: analysis of breast cancer cell mixtures and genetic instability of the T47D line.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line; DNA, Neoplasm; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Promegestone; Receptors, Progesterone | 1989 |
Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: antagonism by insulin.
Topics: Animals; Breast Neoplasms; Cattle; Cell Division; Estradiol; Estrogen Antagonists; Humans; Insulin; Neoplasms, Hormone-Dependent; Progesterone Congeners; Promegestone; Receptor, Insulin; Receptors, Progesterone; Swine; Tumor Cells, Cultured | 1989 |
Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: characterization of an assay in breast cancer cell lines.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line; DNA, Neoplasm; Female; Flow Cytometry; Formaldehyde; Humans; Polyethylene Glycols; Polymers; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1989 |
Effects of progestins, estrogens, and antihormones on growth and lactate dehydrogenase in the human breast cancer cell line T47D.
Topics: Breast Neoplasms; Cell Division; Estrenes; Estrogens; Hormone Antagonists; Humans; L-Lactate Dehydrogenase; Mifepristone; Progestins; Promegestone; Tumor Cells, Cultured | 1989 |
Comparison of an immunocytochemical assay for progesterone receptor with a biochemical method of measurement and immunocytochemical examination of the relationship between progesterone and estrogen receptors.
Topics: Antibodies, Monoclonal; Breast; Breast Neoplasms; Cytosol; Female; Fibrocystic Breast Disease; Humans; Immunohistochemistry; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1989 |
Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; Estradiol; Estrenes; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Mifepristone; Norpregnadienes; Promegestone; Protein Biosynthesis; Receptors, Estrogen; RNA, Messenger; Somatomedins; Tumor Cells, Cultured | 1989 |
Unspecific and sequence-specific deoxyribonucleic acid binding of the partially purified human progesterone receptor.
Topics: Affinity Labels; Animals; Breast Neoplasms; Centrifugation, Density Gradient; Chromatography; Cytosol; Deoxyribonuclease I; DNA; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Humans; Immunoenzyme Techniques; Mammary Tumor Virus, Mouse; Photochemistry; Promegestone; Promoter Regions, Genetic; Rats; Receptors, Glucocorticoid; Receptors, Progesterone; Tumor Cells, Cultured | 1988 |
Hormonal regulation of estrogen receptor messenger ribonucleic acid in T47Dco and MCF-7 breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Cytosol; Enzyme-Linked Immunosorbent Assay; Estradiol; Gene Expression Regulation; Humans; Kinetics; Nucleic Acid Hybridization; Promegestone; Receptors, Estrogen; Receptors, Progesterone; RNA Probes; RNA, Messenger; Tumor Cells, Cultured | 1989 |
Comparative effects of 17 beta-estradiol, progestin R5020, tamoxifen and RU38486 on lactate dehydrogenase activity in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Dexamethasone; Dihydrotestosterone; Estradiol; Estrenes; Female; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Mifepristone; Norpregnadienes; Promegestone; Tamoxifen | 1989 |
[Effects of estrogen and endocrine therapeutic agents on the estrogen receptor, progesterone receptor and DNA synthesis in MCF-7 human breast cancer cells using the whole cell uptake method].
Topics: Breast Neoplasms; Cell Line; DNA, Neoplasm; Estradiol; Female; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Neoplasms, Hormone-Dependent; Norpregnadienes; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Tumor Cells, Cultured | 1987 |
Regulation of growth hormone and epidermal growth factor receptors by progestins in breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; ErbB Receptors; Female; Growth Hormone; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Pregnenediones; Progesterone; Progestins; Promegestone; Receptors, Cell Surface; Receptors, Somatotropin | 1985 |
The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.
Topics: Breast Neoplasms; Cell Line; Cytosol; Dexamethasone; Female; Genes; Genes, Viral; Humans; Mammary Tumor Virus, Mouse; Progesterone; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Repetitive Sequences, Nucleic Acid; Thymidine Kinase; Transcription, Genetic | 1986 |
Human mammary cancer cell mutants with altered hormone receptor activity.
Topics: Androstanols; Breast Neoplasms; Cell Division; Cell Line; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Kinetics; Mutation; Promegestone; Receptors, Cell Surface; Receptors, Estradiol; Receptors, Progesterone; Tamoxifen | 1986 |
The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.
Topics: Acetyltransferases; Androgens; Animals; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; DNA, Viral; Estradiol; Female; Genes; Genes, Viral; Humans; Kinetics; Mammary Tumor Virus, Mouse; Mice; Plasmids; Progesterone; Promegestone; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Transcription, Genetic | 1987 |
A nuclear binding assay to assess the biological activity of steroid receptors in isolated animal and human tissues.
Topics: Animals; Biological Assay; Breast Neoplasms; Cell Nucleus; Chickens; Endometrium; Estradiol; Female; Humans; Kinetics; Microbial Collagenase; Oviducts; Progesterone; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Transcription, Genetic | 1987 |
Decreased progesterone binding and attenuated progesterone action in cultured human breast carcinoma cells treated with epidermal growth factor.
Topics: Animals; Breast Neoplasms; Cell Line; Epidermal Growth Factor; Female; Humans; Insulin; Male; Mice; Progesterone; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1988 |
Comparison of enzyme immunoassay with dextran-coated charcoal method in the determination of progesterone receptor in breast cancer cytosols.
Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Immunoenzyme Techniques; Neoplasm Proteins; Promegestone; Radioligand Assay; Receptors, Estrogen; Receptors, Progesterone | 1988 |
Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Carcinoma; Cell Nucleus; Cytosol; Estrenes; Female; Humans; Immunohistochemistry; Mifepristone; Molecular Weight; Promegestone; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone | 1988 |
Comment on 'Difference between R5020 and the anti progestin RU486 in antiproliferative effects on human breast cancer cells'.
Topics: Breast Neoplasms; Cell Division; Estrenes; Humans; Mifepristone; Norpregnadienes; Promegestone | 1988 |
Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element.
Topics: Breast Neoplasms; Cell Line; Enhancer Elements, Genetic; Estradiol; Estrenes; Female; Humans; Hydrocortisone; Mifepristone; Progesterone; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1988 |
Microassay for nuclear binding of steroid receptors with use of intact cells from small samples of avian and human tissue.
Topics: Animals; Binding, Competitive; Biopsy, Needle; Breast Neoplasms; Cell Nucleus; Chickens; DNA; Estradiol; Hormones; Humans; Microchemistry; Oviducts; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid | 1988 |
Progesterone receptor regulation in T47D human breast cancer cells: analysis by density labeling of progesterone receptor synthesis and degradation and their modulation by progestin.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Electrophoresis, Polyacrylamide Gel; Female; Half-Life; Humans; Molecular Weight; Progestins; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1988 |
Resolution of high and low affinity progesterone receptors from human breast carcinoma T47D cells.
Topics: Binding, Competitive; Breast Neoplasms; Detergents; Humans; Kinetics; Osmolar Concentration; Potassium Chloride; Progesterone; Promegestone; Receptors, Progesterone; Subcellular Fractions; Tumor Cells, Cultured | 1988 |
Progesterone receptor quantification with radiolabeled promegestone (R 5020) in frozen sections of endometrium and breast cancer tissue.
Topics: Animals; Breast Neoplasms; Carcinoma; Cattle; Endometrium; Female; Freezing; Humans; Kinetics; Lipids; Promegestone; Receptors, Progesterone; Solubility | 1988 |
Multiple human progesterone receptor messenger ribonucleic acids and their autoregulation by progestin agonists and antagonists in breast cancer cells.
Topics: Breast Neoplasms; Cell Line; DNA, Neoplasm; Female; Homeostasis; Humans; Kinetics; Norpregnadienes; Nucleic Acid Hybridization; Progesterone; Promegestone; Receptors, Progesterone; RNA, Messenger | 1988 |
Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines.
Topics: Breast Neoplasms; Estrenes; Estrogen Antagonists; Estrogens; Female; Humans; Ligands; Mifepristone; Promegestone; Receptors, Progesterone; RNA, Messenger; Tumor Cells, Cultured | 1988 |
Occupied and unoccupied type II estrogen binding sites in human breast cancer.
Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Kinetics; Promegestone; Receptors, Estrogen | 1987 |
Identification and androgen regulation of two proteins released by T47D human breast cancer cells.
Topics: Androgens; Antibodies, Monoclonal; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Line; Dexamethasone; Dihydrotestosterone; Estradiol; Flutamide; Gene Expression Regulation; Glycoproteins; Humans; Membrane Transport Proteins; Molecular Weight; Neoplasm Proteins; Promegestone; Receptors, Androgen; Seminal Plasma Proteins; Zn-Alpha-2-Glycoprotein | 1987 |
A progesterone receptor affinity chromatography reagent: 17 alpha-hexynyl nortestosterone sepharose.
Topics: Animals; Breast Neoplasms; Cell Line; Chemical Phenomena; Chemistry; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Female; Humans; Nandrolone; Promegestone; Rats; Rats, Inbred Strains; Receptors, Progesterone; Sepharose; Uterus | 1987 |
Progestin effects on growth in the human breast cancer cell line T-47D--possible therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Drug Combinations; Estradiol; Humans; Norpregnadienes; Phenolsulfonphthalein; Promegestone; Receptors, Estrogen; Receptors, Progesterone | 1987 |
Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells.
Topics: Antibodies; Breast Neoplasms; Cell Division; Cell Line; DNA; Enzyme Induction; Fatty Acid Synthases; Humans; Molecular Weight; Pantothenic Acid; Progesterone Congeners; Promegestone; Receptors, Progesterone; RNA, Messenger | 1987 |
Effects of 17 beta-estradiol and R5020 on glucose-6-phosphate dehydrogenase activity in MCF-7 human breast cancer cells: a cytochemical assay.
Topics: Breast Neoplasms; Cell Division; Cells, Cultured; Estradiol; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Kinetics; NAD; Norpregnadienes; Promegestone | 1987 |
Evaluation of RU-27987 as a ligand to determine the progesterone receptor.
Topics: Breast Neoplasms; Cytosol; Dexamethasone; Humans; Kinetics; Ligands; Norpregnadienes; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; Thymus Gland | 1987 |
Difference between R5020 and the antiprogestin RU486 in antiproliferative effects on human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Estradiol; Estrenes; Glucocorticoids; Humans; Mifepristone; Norpregnadienes; Phenolsulfonphthalein; Promegestone; Protein Biosynthesis; Receptors, Estrogen; Tumor Cells, Cultured | 1987 |
Cloning of cDNA sequences of a progestin-regulated mRNA from MCF7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Female; Humans; Kinetics; Methionine; Molecular Weight; Neoplasm Proteins; Norpregnadienes; Nucleic Acid Hybridization; Promegestone; RNA, Messenger; Transcription, Genetic | 1986 |
Progesterone receptor synthesis and degradation in MCF-7 human breast cancer cells as studied by dense amino acid incorporation. Evidence for a non-hormone binding receptor precursor.
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Line; Centrifugation, Density Gradient; Deuterium; Estradiol; Female; Half-Life; Humans; Isotope Labeling; Models, Chemical; Nitrogen Isotopes; Promegestone; Protein Precursors; Receptors, Progesterone | 1986 |
Growth inhibition and increase of insulin receptors in antiestrogen-resistant T47DCO human breast cancer cells by progestins: implications for endocrine therapies.
Topics: 17-alpha-Hydroxyprogesterone; Androgens; Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Dexamethasone; DNA, Neoplasm; Drug Resistance; Estradiol; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Kinetics; Norpregnadienes; Promegestone; Receptor, Insulin; Receptors, Progesterone | 1985 |
Characterization of estrogen and progesterone receptors and the dissociated regulation of growth and progesterone receptor stimulation by estrogen in MDA-MB-134 human breast cancer cells.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle; Cell Line; Cell Nucleus; Cytosol; Estradiol; Estrogens; Female; Humans; Molecular Weight; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Structure-Activity Relationship; Tamoxifen | 1986 |
Antiprogestin-receptor complexes: differences in the interaction of the antiprogestin RU38,486 and the progestin R5020 with the progesterone receptor of human breast cancer cells.
Topics: Binding, Competitive; Breast Neoplasms; Cell Line; Centrifugation, Density Gradient; Deoxyribonucleases; Estrenes; Female; Humans; Mifepristone; Norpregnadienes; Promegestone; Receptors, Progesterone; Ribonucleases; Sulfhydryl Compounds; Urea | 1986 |
A progestin effect on lactate dehydrogenase in the human breast cancer cell line T-47D.
Topics: Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Norpregnadienes; Progesterone; Promegestone | 1985 |
The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.
Topics: Affinity Labels; Breast Neoplasms; Cells, Cultured; Estrenes; Estrogens; Female; Humans; Mifepristone; Progestins; Promegestone; Receptor, Insulin; Receptors, Glucocorticoid; Receptors, Progesterone | 1985 |
Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Survival; Cells, Cultured; Dexamethasone; Estradiol; Female; Glycine; Humans; Lactones; Mycotoxins; Promegestone; Receptors, Steroid; Sesquiterpenes; Thymidine; Tritium | 1985 |