proline has been researched along with Lung Neoplasms in 59 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (10.17) | 18.7374 |
1990's | 9 (15.25) | 18.2507 |
2000's | 24 (40.68) | 29.6817 |
2010's | 13 (22.03) | 24.3611 |
2020's | 7 (11.86) | 2.80 |
Authors | Studies |
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Liang, L; Wang, X; Yin, W | 1 |
Ma, X; Wei, Y; Yang, Z; Zhang, W; Zhou, F | 1 |
Angel, PM; Ball, L; Bethard, J; Bruner, E; Clift, CL; Drake, RR; Feghali-Bostwick, C | 1 |
Cao, Y; Chen, C; Liu, N; Liu, S; Liu, Y; Mao, C; Ouyang, L; Shi, Y; Tang, H; Tao, Y; Wang, M; Wang, X; Xiao, D; Yan, Q | 1 |
Bao, R; Cui, C; Guo, L; Ran, J; Su, W; Wang, J; Wu, C; Yang, Q; Yuan, J; Zhang, P | 1 |
He, X; Huang, X; Li, Y; Ma, K; Ma, X; Wang, C | 1 |
Cui, C; Guo, L; Wang, J; Wu, C | 1 |
Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
Boon, R; Broekaert, D; Christen, S; Elia, I; Fendt, SM; Grünewald, TGP; Orth, MF; Radaelli, E; Verfaillie, C | 1 |
Brooks, AJ; Chhabra, Y; Kragelund, BB; Meunier, FA; Nikolajsen, LF; Papadopulos, A; Smith, AG; Steinocher, H; Tunny, KA; Waters, MJ; Wong, HY | 1 |
Chen, C; Feng, D; Wang, X; Ye, J; Yin, R; Zhang, S; Zhang, Z; Zhao, X; Zhou, G | 1 |
Chang, Q; Li, YL; Zhao, X | 1 |
Knezevic, CE; Kratz, LE; Marzinke, MA; Ness, MA | 1 |
Chen, K; Cui, C; Guo, L; Lu, Y; Sun, Y; Tang, B; Wang, J; Wang, Y; Wu, C; Xiao, G; Yuan, J; Zhang, K | 1 |
Dahabreh, IJ; Lau, J; Murray, S; Schmid, CH; Trikalinos, TA; Varvarigou, V | 1 |
Lee, M; Venkitaraman, AR | 1 |
Jee, SH; Lee, S; Pamungkas, AD; Park, C; Park, YH | 1 |
Chen, X; Feng, H; Lu, JJ; Pei, L; Wang, Y | 1 |
Chen, CY; Chen, WC; Fong, YC; Hsu, SF; Huang, CY; Kao, ST; Li, TM; Liu, SC; Tang, CH; Tsai, FJ | 1 |
Li, Y; Lv, XJ; Qian, XP; Qiu, LX; Shen, XK; Song, Y | 1 |
Gunduz, M; Mita, Y; Naomoto, Y; Ouchida, M; Sakai, A; Shimizu, K; Tanabe, S; Toyooka, S; Yamamoto, H; Yasuda, Y | 1 |
Kumar, A; Kumar, S; Mathur, N; Pant, MC; Tilak, AR | 1 |
Papadakis, ED; Soulitzis, N; Spandidos, DA | 1 |
Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y | 1 |
Oliver, J; Palou, A; Proenza, AM; Roca, P | 1 |
LORINCZ, AB; RYAN, WL | 1 |
POMEROY, LR; ROACH, MK; SIEGEL, FL | 1 |
Anthwal, S; Arenberg, DA; Keshamouni, VG; Newstead, MJ; Reddy, RC; Standiford, TJ | 1 |
Ahrendt, SA; Hu, Y; McDermott, MP | 1 |
Kasprzak, KS; Salnikow, K | 1 |
Borg, A; Dziadziuszko, R; Jassem, E; Jassem, J; Kobierska-Gulida, G; Limon, J; Rzyman, W; Szymanowska, A | 1 |
Frederiksen, K; Hansen, RD; Overvad, K; Raaschou-Nielsen, O; Sørensen, M; Tjønneland, A; Vogel, U | 1 |
Chen, MH; Cui, SX; Gai, R; Guo, Q; Makuuchi, M; Nakata, M; Qu, XJ; Tang, W; Tian, ZG; Xu, WF; Yuan, YX | 1 |
Bartsch, H; Butkiewicz, D; Dienemann, H; Edler, L; Muley, T; Popanda, O; Risch, A; Schattenberg, T; Schmezer, P; Waas, P | 1 |
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Waheed Roomi, M | 1 |
Bindokas, VP; Jagadeeswaran, R; Jagadeeswaran, S; Salgia, R | 1 |
Bridle, H; Eisen, T; El Galta, R; Houlston, RS; Matakidou, A; Rudd, MF; Webb, EL | 1 |
Aboul-Fadl, T; El-Sayed, WM; Franklin, MR; Moos, PJ; Roberts, JC | 1 |
Buech, T; Chubanov, V; Grosse, R; Gudermann, T; Roelle, S | 1 |
Andreassen, T; Ekstrøm, PO; Haugen, A; Lind, H; Ryberg, D; Skaug, V; Stangeland, L; Zienolddiny, S | 1 |
Boldrini, L; Fontanini, G; Gisfredi, S; Greco, G; Lucchi, M; Mussi, A; Ursino, S | 1 |
Cao, G; Feng, J; Hou, Y; Lu, H; Shu, J; Zheng, D | 1 |
Andrlíková, J; Deyl, Z; Svojtková, E | 1 |
Amos, CI; Branch, C; Honn, SE; Jin, X; King, TM; Roth, JA; Spitz, MR; Wu, X | 1 |
An, G; Carlson, DM; Oreffo, V; Tesfaigzi, J; Wright, PS; Wu, R | 1 |
McDonald, FJ; Welsh, MJ | 1 |
Kimura, H; Kimura, M; Murata, M; Saisho, H; Tagawa, M; Watanabe, S | 1 |
Levine, AJ; Walker, KK | 1 |
Corbella, J; Estape, J; Firvida, J; Fuentes, M; Galan, C; Gene, M; Gomez-Catalan, J; Huguet, E; Rodamilans, M; To-Figueras, J | 1 |
Bogdan, J; Chyczewski, L; Karna, E; Pałka, J; Słodkowska, J | 1 |
Chyczewski, L; Karna, E; Miltyk, W; Pałka, J; Rudziński, P; Słodkowska, J; Worowski, K | 1 |
Fujisawa, T; Kakisawa, K; Kimura, H; Murata, M; Shirasawa, H; Tagawa, M | 1 |
Belinsky, SA; March, TH; Wardlaw, SA | 1 |
Karna, E; Palka, J; Surazynski, A | 1 |
Christiani, DC; Fan, R; Liu, G; Lynch, TJ; Miller, DP; Su, L; Thurston, SW; Wain, JC; Xu, LL; Zhou, W | 1 |
Baptiste, N; Chen, X; Friedlander, P; Prives, C | 1 |
Bills, DD; Nixon, JE; Scanlan, RA; Sinnhuber, RO; Wales, JH | 1 |
Belloni, PN; Nakajima, M; Nicolson, GL; Welch, DR | 1 |
Greenblatt, M; Lijinsky, W | 1 |
3 review(s) available for proline and Lung Neoplasms
Article | Year |
---|---|
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer.
Topics: Alleles; Bayes Theorem; Breast Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Female; Genes, p53; Genotyping Techniques; Humans; Loss of Heterozygosity; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Polymorphism, Genetic; Proline | 2013 |
A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: evidence from 15,857 subjects.
Topics: Asian People; Codon; Gene Frequency; Genes, p53; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Polymorphism, Single Nucleotide; Proline; Smoking; White People | 2009 |
Ascorbate depletion: a critical step in nickel carcinogenesis?
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; DNA Damage; Homeostasis; Humans; Hydroxylation; Lung Neoplasms; Nickel; Proline; Protein Binding; Rats | 2005 |
56 other study(ies) available for proline and Lung Neoplasms
Article | Year |
---|---|
PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins; CTLA-4 Antigen; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Glutamates; Humans; Leucine; Lung Neoplasms; Proline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Transcription Factors | 2022 |
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19.
Topics: Adenocarcinoma of Lung; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Interleukin-17; Interleukin-6; Lactams; Leucine; Lung Neoplasms; Molecular Docking Simulation; Network Pharmacology; Nitriles; Proline; Receptors, Cytokine; Ritonavir; SARS-CoV-2; United States | 2022 |
Extracellular matrix alterations in low-grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry.
Topics: Adenocarcinoma of Lung; Adult; Area Under Curve; Chromatography, Liquid; Collagen; Extracellular Matrix; Female; Humans; Hydroxylation; Lung Neoplasms; Male; Matrix Metalloproteinase 13; Middle Aged; Proline; Proof of Concept Study; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tissue Array Analysis; Tumor Microenvironment | 2020 |
Cancer progression is mediated by proline catabolism in non-small cell lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Progression; Humans; Lung Neoplasms; Mice; Proline; Transfection | 2020 |
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cytoskeletal Proteins; delta-1-Pyrroline-5-Carboxylate Reductase; Disease Models, Animal; Dynamins; Female; Gene Knockout Techniques; Humans; LIM Domain Proteins; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; Muscle Proteins; Neoplasm Proteins; Proline; Proto-Oncogene Proteins p21(ras); Pyrroline Carboxylate Reductases; Survival Analysis | 2020 |
Small extracellular ring domain is necessary for CD82/KAI1'anti-metastasis function.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Genes, Tumor Suppressor; Humans; Kangai-1 Protein; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Peptide Fragments; Proline; Protein Domains; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2021 |
PINCH-1 promotes Δ
Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; LIM Domain Proteins; Lung Neoplasms; Membrane Proteins; Mice; Mice, Transgenic; Proline; RNA, Messenger | 2021 |
A Specific Mixture of Nutrients Suppresses Ovarian Cancer A-2780 Tumor Incidence, Growth, and Metastasis to Lungs.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Lysine; Matrix Metalloproteinase 9; Mice; Mice, Nude; Micronutrients; Neoplasm Metastasis; Ovarian Neoplasms; Plant Extracts; Proline; Quercetin; Tea; Xenograft Model Antitumor Assays | 2017 |
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Topics: Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; delta-1-Pyrroline-5-Carboxylate Reductase; Humans; Lung Neoplasms; Mice, Inbred C57BL; Proline; Proline Oxidase; Pyrroline Carboxylate Reductases; Spheroids, Cellular | 2017 |
A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cohort Studies; Computational Biology; Disease Progression; DNA Mutational Analysis; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lung; Lung Neoplasms; Magnetic Resonance Spectroscopy; Male; Mice; Phosphorylation; Polymorphism, Single Nucleotide; Proline; Protein Binding; Protein Domains; Proteolysis; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Threonine; Ubiquitin-Protein Ligases; Ubiquitination | 2018 |
Sepia Ink Oligopeptide Induces Apoptosis of Lung Cancer Cells via Mitochondrial Pathway.
Topics: A549 Cells; Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Caspase 12; Caspase 8; Caspase 9; Cell Proliferation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; fas Receptor; Humans; Ink; Leupeptins; Lung Neoplasms; Mitochondria; Oligopeptides; Proline; Proto-Oncogene Proteins c-bcl-2; Sepia; Thiocarbamates; Transcription Factor CHOP | 2018 |
Total synthesis and cyclization strategy of samoamide A, a cytotoxic cyclic octapeptide rich in proline and phenlalanine isolated from marine cyanobacterium.
Topics: Antineoplastic Agents; Aquatic Organisms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyanobacteria; Humans; Lung Neoplasms; Molecular Structure; Peptides, Cyclic; Phenylalanine; Proline | 2019 |
Elevated creatinine in a patient on IVIG-therapy.
Topics: Carcinoma, Non-Small-Cell Lung; Creatinine; Female; Humans; Immunoglobulins, Intravenous; Lung Neoplasms; Middle Aged; Paraneoplastic Syndromes; Proline | 2018 |
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Cell Proliferation; Cell Survival; Cytoskeletal Proteins; delta-1-Pyrroline-5-Carboxylate Reductase; Extracellular Matrix; Female; Humans; Lung Neoplasms; Male; Membrane Proteins; Mice, Transgenic; Mitochondria; Muscle Proteins; Neoplasm Proteins; Proline; Pyrroline Carboxylate Reductases | 2019 |
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.
Topics: Alanine; BRCA2 Protein; Cytokinesis; DNA-Binding Proteins; HeLa Cells; High Mobility Group Proteins; Humans; Lung Neoplasms; Mutation; Proline | 2014 |
High resolution metabolomics to discriminate compounds in serum of male lung cancer patients in South Korea.
Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Chromatography, Liquid; Cluster Analysis; Humans; Lung Neoplasms; Male; Metabolomics; Middle Aged; Predictive Value of Tests; Proline; Republic of Korea; Risk Factors; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Vitamin A | 2016 |
Osthole inhibited TGF β-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells.
Topics: A549 Cells; Cadherins; Coumarins; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; NF-kappa B; Proline; Snail Family Transcription Factors; Thiocarbamates; Transcription Factor RelA; Transforming Growth Factor beta | 2017 |
Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Movement; Chromones; Flavonoids; Focal Adhesion Kinase 1; Humans; Integrin alphaVbeta3; Lung Neoplasms; Morpholines; NF-kappa B; Oncogene Protein v-akt; Osteopontin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proline; Signal Transduction; Thiocarbamates; Tosylphenylalanyl Chloromethyl Ketone | 2009 |
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Incidence; Isoleucine; Japan; Lung Neoplasms; Male; Methionine; Middle Aged; Neoplasms; Polymorphism, Single Nucleotide; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Risk Factors | 2010 |
Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma of lungs in a North Indian population.
Topics: Aged; Amino Acid Substitution; Arginine; Asian People; Carcinoma, Squamous Cell; Case-Control Studies; Female; Genes, p53; Genetic Predisposition to Disease; Genetics, Population; Genotype; Humans; India; Lung Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Proline | 2013 |
Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes.
Topics: Aged; Arginine; Bronchoalveolar Lavage Fluid; Codon; DNA Primers; Female; Gene Deletion; Genes, p53; Genotype; Germ-Line Mutation; Heterozygote; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Polymorphism, Genetic; Proline; Sputum; Tumor Suppressor Protein p53; Tumor Virus Infections | 2002 |
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Breast and lung cancer are associated with a decrease in blood cell amino acid content.
Topics: Adult; Aged; Amino Acids; Amino Acids, Essential; Asparagine; Blood Cells; Breast Neoplasms; Female; Glutamic Acid; Humans; Lung Neoplasms; Male; Middle Aged; Ornithine; Plasma; Proline; Valine | 2003 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
MULTIPLE DISCRIMINANT ANALYSIS OF PLASMA AMINO ACID PATTERNS.
Topics: Adenocarcinoma; Alcoholism; Amino Acids; Autoanalysis; Biomedical Research; Blood; Blood Chemical Analysis; Carcinoma, Bronchogenic; Computers; Diagnosis, Differential; Discriminant Analysis; Ethanol; Fasting; Humans; Lung Neoplasms; Prognosis; Proline; Proteins; Research; Schizophrenia; Tuberculosis; Tuberculosis, Pulmonary | 1964 |
PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer.
Topics: Amino Acid Motifs; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chemokine CXCL1; Chemokine CXCL11; Chemokine CXCL5; Chemokines, CXC; Chemotaxis; Chromans; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Factor VIII; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Ligands; Lung Neoplasms; Mice; Mice, SCID; Microcirculation; Neoplasm Transplantation; Neovascularization, Pathologic; NF-kappa B; Pioglitazone; PPAR gamma; Proline; Thiazolidinediones; Thiocarbamates; Transfection; Troglitazone | 2005 |
The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer.
Topics: Aged; Alleles; Arginine; Carcinoma, Non-Small-Cell Lung; Codon; Female; Gene Frequency; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Mutation; Polymorphism, Genetic; Proline; Regression Analysis; Survival Analysis; Tumor Suppressor Protein p53 | 2005 |
Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism.
Topics: Adenocarcinoma; Arginine; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Polymorphism, Genetic; Proline; Risk Factors; Tumor Suppressor Protein p53 | 2006 |
GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.
Topics: Alcohol Drinking; Cohort Studies; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lung Neoplasms; Middle Aged; Polymorphism, Genetic; Proline; Risk Factors; Smoking | 2007 |
Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2, to suppress tumor invasion and metastasis.
Topics: Animals; Breast Neoplasms; Caffeic Acids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Lung Neoplasms; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Molecular Structure; Proline; Protease Inhibitors; Xenograft Model Antitumor Assays | 2006 |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Carcinoma, Squamous Cell; Codon; Cyclin-Dependent Kinase Inhibitor p21; Female; Genetic Variation; Humans; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Proline; Risk Factors; Serine; Smoking; Tumor Suppressor Protein p53 | 2007 |
In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Camellia sinensis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Dietary Supplements; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Humans; Laminin; Lung Neoplasms; Lysine; Mice; Mice, Nude; Plant Extracts; Proline; Proteoglycans | 2006 |
Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.
Topics: Animals; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Hydrogen Peroxide; Indoles; Lung Neoplasms; Muridae; Phosphorylation; Piperazines; Proline; Proto-Oncogene Proteins c-met; Reactive Oxygen Species; Signal Transduction; Sulfonamides; Thiocarbamates; Tyrosine | 2007 |
Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis of survival in 619 female patients.
Topics: Amino Acid Substitution; Cohort Studies; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasm Staging; Polymorphism, Single Nucleotide; Prognosis; Proline; Survival Analysis; Tumor Suppressor Protein p53 | 2007 |
Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse.
Topics: Animals; Carcinogens; Dietary Supplements; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Molecular Structure; Neoplasms, Experimental; Nicotiana; Nitrosamines; Organoselenium Compounds; Proline | 2007 |
Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells.
Topics: Calcium; Carcinoma, Small Cell; Cell Line; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Focal Adhesion Kinase 2; Galanin; Humans; Lung Neoplasms; Proline; src-Family Kinases | 2008 |
Frequency of TP53 mutations in relation to Arg72Pro genotypes in non small cell lung cancer.
Topics: Aged; Alleles; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Codon; DNA Mutational Analysis; Female; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Lung Neoplasms; Male; Middle Aged; Norway; Polymorphism, Single Nucleotide; Proline; Smoking; Tumor Suppressor Protein p53 | 2007 |
Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients.
Topics: Aged; Aged, 80 and over; Arginine; Carcinoma, Non-Small-Cell Lung; Codon; Female; Gene Frequency; Genes, p53; Genotype; Homozygote; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Prognosis; Proline; Survival Rate | 2008 |
Lung cancer risk associated with Thr495Pro polymorphism of GHR in Chinese population.
Topics: Adenocarcinoma; Aged; Asian People; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Chi-Square Distribution; Female; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Proline; Receptors, Somatotropin; Risk Assessment; Risk Factors; Smoking; Threonine | 2008 |
Decrease in pyrrole-2-carboxylic acid excretion during lung cancer disease.
Topics: Collagen; Humans; Hydroxyproline; Lung Neoplasms; Proline | 1982 |
Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype.
Topics: Aged; Alleles; Analysis of Variance; Base Sequence; Black People; Case-Control Studies; Female; Genes, p53; Genotype; Humans; Lung Neoplasms; Male; Mexican Americans; Middle Aged; Molecular Sequence Data; Polymorphism, Genetic; Proline; Risk Factors; Smoking | 1995 |
A small proline-rich protein regulated by vitamin A in tracheal epithelial cells is induced in lung tumors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biomarkers, Tumor; Blotting, Northern; Cells, Cultured; Cricetinae; DNA; Epithelial Cells; Haplorhini; Humans; In Situ Hybridization; Lung Neoplasms; Mesocricetus; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Precipitin Tests; Proline; Proline-Rich Protein Domains; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Swine; Trachea; Vitamin A | 1993 |
Binding of the proline-rich region of the epithelial Na+ channel to SH3 domains and its association with specific cellular proteins.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Autoradiography; Binding Sites; Cell Line; Epithelium; Glutathione Transferase; Humans; Lung Neoplasms; Macromolecular Substances; Methionine; Molecular Sequence Data; Neoplasm Proteins; Phosphoproteins; Proline; Radioimmunoprecipitation Assay; Rats; Recombinant Fusion Proteins; Sodium Channels; src Homology Domains; Substrate Specificity; Sulfur Radioisotopes; Tumor Cells, Cultured | 1995 |
Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history.
Topics: Arginine; Base Sequence; Case-Control Studies; Disease Susceptibility; Female; Genes, p53; Genotype; Heterozygote; Homozygote; Humans; Lung Neoplasms; Male; Middle Aged; Molecular Sequence Data; Polymorphism, Genetic; Proline; Smoking | 1996 |
Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
Topics: Amino Acid Sequence; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Line; Chickens; DNA Damage; Genes, p53; Haplorhini; Humans; Lung Neoplasms; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Rats; Recombinant Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 1996 |
Glutathione-S-Transferase M1 and codon 72 p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Amino Acid Sequence; Arginine; Carcinoma; Carcinoma, Small Cell; Codon; Female; Gene Deletion; Gene Frequency; Genes, p53; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Japan; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Proline; Risk Factors; Smoking; Spain | 1996 |
Prolidase and prolinase activities in moderately and poorly differentiated lung adenocarcinoma.
Topics: Adenocarcinoma; Cell Differentiation; Collagen; Dipeptidases; Humans; Hydroxyproline; Lung; Lung Neoplasms; Neoplasm Proteins; Peptide Fragments; Proline | 1997 |
Prolidase activity and beta 1 integrin expression in moderately and poorly differentiated lung adenocarcinomas.
Topics: Adenocarcinoma; Cell Differentiation; Collagen; Dipeptidases; Humans; Integrin beta1; Lung; Lung Neoplasms; Neoplasm Proteins; Proline | 1997 |
Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients.
Topics: Adenocarcinoma; Aged; Alleles; Arginine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Codon; Disease Susceptibility; Female; Genes, p53; Genetic Carrier Screening; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Risk Factors; Smoking | 1998 |
Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Susceptibility; Humans; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Nitrosamines; Precancerous Conditions; Proline; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Pyrazoles; RNA, Messenger; Sulfonamides; Thiocarbamates; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale.
Topics: Biomarkers, Tumor; Blotting, Western; Collagen; Dipeptidases; Humans; Integrin beta1; Lung Neoplasms; Neoplasm Proteins; Proline | 2000 |
Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma.
Topics: Adenocarcinoma; Aged; Alleles; Arginine; Carcinoma, Squamous Cell; Case-Control Studies; Codon; Female; Genes, p53; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Proline | 2001 |
The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Clone Cells; Colchicine; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Daunorubicin; DNA Damage; DNA, Neoplasm; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Lung Neoplasms; Models, Biological; Proline; Promoter Regions, Genetic; Protein Structure, Tertiary; Recombinant Fusion Proteins; Structure-Activity Relationship; Tetracycline; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Null carcinogenic effect of large doses of nitrosoproline and nitrosohydroxyproline in Wistar rats.
Topics: Animals; Carcinoma, Hepatocellular; Dimethylnitrosamine; Drug Synergism; Fatty Acids, Unsaturated; Hydroxyproline; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Proline; Rats | 1976 |
Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.
Topics: Adenocarcinoma; Animals; Basement Membrane; Clone Cells; Collagen; Culture Media; Extracellular Matrix; Female; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Molecular Weight; Neoplasm Metastasis; Proline; Rats; Rats, Inbred F344 | 1987 |
Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.
Topics: Adenoma; Animals; Arginine; Carcinogens; Female; Hydroxyproline; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrites; Nitroso Compounds; Piperidines; Proline; Pyrrolidines | 1972 |