proline has been researched along with Disease Models, Animal in 228 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (14.04) | 18.7374 |
| 1990's | 18 (7.89) | 18.2507 |
| 2000's | 60 (26.32) | 29.6817 |
| 2010's | 98 (42.98) | 24.3611 |
| 2020's | 20 (8.77) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, S; Huang, B; Jiang, S; Mao, X; Mo, C; Zhuang, J | 1 |
| Allerton, CMN; Anderson, AS; Aschenbrenner, L; Avery, M; Berritt, S; Boras, B; Cardin, RD; Carlo, A; Coffman, KJ; Dantonio, A; Di, L; Eng, H; Ferre, R; Gajiwala, KS; Gibson, SA; Greasley, SE; Hurst, BL; Kadar, EP; Kalgutkar, AS; Lee, J; Lee, JC; Liu, W; Mason, SW; Noell, S; Novak, JJ; Obach, RS; Ogilvie, K; Owen, DR; Patel, NC; Pettersson, M; Rai, DK; Reese, MR; Sammons, MF; Sathish, JG; Singh, RSP; Steppan, CM; Stewart, AE; Tuttle, JB; Updyke, L; Verhoest, PR; Wei, L; Yang, Q; Zhu, Y | 1 |
| Abdelnabi, R; Augustijns, P; Chatelain, E; De Jonghe, S; Escudié, F; Foo, CS; Hoglund, RM; Jochmans, D; Mols, R; Mowbray, CE; Neyts, J; Scandale, I; Sjö, P; Tarning, J; Vangeel, L; Wattanakul, T; Weynand, B | 1 |
| Chang, HW; Chen, LC; Cheng, TC; Fang, CL; Ho, YS; Kuo, CC; Lee, WJ; Liao, YC; Lin, LC; Tu, SH; Yen, Y | 1 |
| Ahmad, S; Carvalho, GA; Chiareli, RA; da Rocha, ALB; de Carvalho, FS; de Souza Gil, E; Lião, LM; Marques, BL; Menegatti, R; Noël, F; Parreira, RC; Pinto, MCX; Silva, RR; Vaz, BG; Verli, H | 1 |
| Deng, HJ; Gong, HB; Gong, RB; Miao, ZY; Tang, XY; Zhang, CM | 1 |
| Irie, K | 1 |
| Cao, TT; Chen, HH; Guo, W; Lu, R; Shan, XL; Tian, J; Wang, SN; Xu, M; Zhang, C; Zhao, P; Zheng, JL | 1 |
| Gao, Y; Guo, Y; Liu, Y; Lu, F; Piao, Y; Tan, S; Tang, Y | 1 |
| Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R | 1 |
| Gao, J; Mao, J; Tang, J; Wang, X; Zhang, H; Zhang, J | 1 |
| Baró, I; Bihouée, A; Carcouët, A; Castro, C; Charpentier, F; Derangeon, M; Donnart, A; Hivonnait, A; Le Marec, H; Lebreton, J; Patin, J; Steenman, M; Tessier, A | 1 |
| Cai, Y; Chen, X; Demetriades, AM; Shen, J; Shen, X; Sui, A; Xie, B; Yao, Y; Zhu, Y | 1 |
| Chen, H; Guo, W; Hu, P; Lu, R; Shan, X; Tian, J; Wang, S; Wu, Q; Xu, M; Zhang, C; Zhao, P; Zheng, J | 1 |
| Feng, Y; Fu, L; Gao, GF; Huang, B; Li, X; Niu, P; Qi, J; Shi, Y; Song, H; Sun, H; Tan, W; Wang, Q; Wu, Y; Ye, F; Yu, F; Zhao, C | 1 |
| Bao, R; Cui, C; Guo, L; Ran, J; Su, W; Wang, J; Wu, C; Yang, Q; Yuan, J; Zhang, P | 1 |
| Baatsen, P; Caluwé, E; Carmeliet, P; Craps, S; de Zeeuw, P; Duchenne, J; Ghesquiere, B; Gijsbers, R; Gillijns, H; Goetschalckx, K; Herijgers, P; Hermans, H; Herregods, MC; Janssens, S; Luttun, A; Meuris, B; Meyns, B; Oosterlinck, W; Pokreisz, P; Rega, F; Staessen, JA; Trenson, S; Van Wauwe, J; Veltman, D; Voigt, JU; Wei, F | 1 |
| Aksentijević, D; Bridges, HR; Burger, N; Grba, DN; Hirst, J; James, AM; Krieg, T; Kula-Alwar, D; Mottahedin, A; Murphy, MP; Prag, HA; Viscomi, C; Yin, Z | 1 |
| Chen, P; Duan, ZL; Hu, Y; Huang, C; Lei, J; Li, L; Li, MH; Li, WM; Li, WP; Li, YS; Lin, GF; Liu, FL; Liu, JM; Liu, X; Liu, Y; Long, YH; Lu, GW; Luo, RH; Mao, X; Ni, X; Qiao, J; Qu, W; Quan, B; Shen, C; Sun, W; Wang, K; Wang, YF; Wei, YQ; Xu, L; Yang, RC; Yang, S; Yang, W; Yang, X; Yao, R; You, J; Zeng, R; Zhang, HL; Zhang, J; Zheng, YT; Zhou, Y; Zou, J; Zou, QC | 1 |
| Blackburn, JP; Blalock, JE; Gaggar, A; Li, J; Patel, RP; Robison, SW; Viera, L; Xu, X | 1 |
| Chen, JH; Gu, FJ; Sui, XL; Xu, YP; Ye, L; Zhang, AS | 1 |
| Bian, C; Li, LH; Lv, N; Wang, ZC; Yang, L; Zhang, YQ | 1 |
| Horvath, A; Ostorhazi, E; Otvos, L; Szabo, D | 1 |
| Han, Y; Kong, L; Liu, L; Liu, Z; Sun, H; Wang, X; Yu, J; Zhang, A | 1 |
| Antón-Fernández, A; Avila, J; DeFelipe, J; Hernández, F; Merchán-Rubira, J; Muñoz, A | 1 |
| Albaugh, VL; Barbul, A; Mukherjee, K | 1 |
| Banerjee, S; Barnes, S; Cui, H; Dubey, S; Ge, J; Guo, S; Liu, G; Xie, N | 1 |
| Fang, C; Gao, P; Geng, P; Guo, L; Hu, C; Li, E; Liu, Y; Sun, M; Tang, L; Wang, C; Wang, J; Wang, Y; Xu, G; Yin, P; Yu, J; Zeng, J; Zhuang, Z | 1 |
| Feng, YB; Han, YX; Lin, YT; Pang, YJ; Xu, JJ; Xue, Y; Yao, H | 1 |
| Cheng, Z; Feng, J; Li, A; Qian, H; Wu, Y; Xiao, H; Yan, F; Yang, Q; Zhang, X; Zhao, Z | 1 |
| Andreeva, LA; Grigorjeva, ME; Lyapina, LA; Myasoedov, NF; Obergan, TY | 1 |
| Amat, R; Bahri, M; Barceló-Coblijn, G; Campbell, M; Carobbio, S; Dias, AR; Gray, SL; Prieur, X; Relat, J; Rodriguez-Cuenca, S; Vidal-Puig, A | 1 |
| Huang, YR; Ji, M; Liu, DQ; Liu, RT; Wang, SW; Xie, XX; Yu, XL; Zhang, LX; Zhang, Y | 1 |
| Gynther, M; Jaako, K; Jalkanen, AJ; Natunen, TA; Rostalski, H | 1 |
| Guo, F; Li, Y; Liu, Y; Lv, P; Mu, Y; Tang, C; Wang, W | 1 |
| Akthar, S; Blalock, JE; Gaggar, A; Grabiec, AM; Gregory, LG; Hussell, T; Jackson, PL; Li, J; Lloyd, CM; Niven, RM; Patel, DF; Peiró, T; Shoemark, A; Simpson, A; Snelgrove, RJ; Steele, C; Tavernier, G; Trevor, JL; Walker, SA; Xu, X | 1 |
| Dai, Z; Ji, Y; Ma, X; Sun, S; Tso, P; Wu, G; Wu, Z; Yang, Y | 1 |
| Gao, F; Li, F; Li, XY; Liu, ST; Miao, Y; Sun, XH; Wang, X; Wang, Z; Yang, XL; Zhang, ML; Zhong, SM; Zhu, K | 1 |
| Chen, T; Gao, L; Huang, B; Huang, C; Shi, X | 1 |
| Chen, XL; Chen, XZ; Jin, H; Li, BQ; Li, XL; Ling, B; Pan, XH; Sun, J; Xiu, GH; Zhou, X | 1 |
| Guan, M; He, Q; Li, J; Qiu, C; Wang, L; Weng, X; Zhang, J | 1 |
| Grinde, MT; Haugen, MH; Henriksen, IM; Hilmarsdottir, B; Kim, J; Moestue, SA; Mælandsmo, GM; Rye, MB; Tunset, HM | 1 |
| Chen, X; Qin, S; Zhao, X; Zhou, S | 1 |
| Ji, C; Ma, ZG; Tang, S; Yan, LR | 1 |
| Pan, YX; Shi, JX; Wang, CX; You, WC; Zhang, X; Zhang, XS; Zhou, ML; Zhou, XM | 1 |
| Jeon, J; Kim, M; Kim, YH; Lee, KO; Min, KH; Song, J; Suh, KH | 1 |
| Esmer, H; Ettle, B; Klucken, J; Kragh, CL; Marxreiter, F; Masliah, E; May, VE; Nuber, S; Patrick, C; Riess, O; Winkler, J; Winner, B | 1 |
| Ceballos, C; Dickson, DW; Hyman, BT; Lin, WL; Polydoro, M; Ren, Y; Sahara, N; Sanchez, L; Spires-Jones, TL | 1 |
| Anders, HJ; Darisipudi, MN; Gruner, S; Haap, W; Hartmann, G; Kulkarni, OP; Lichtnekert, J; Mulay, SR; Rupanagudi, KV; Schott, B | 1 |
| Briggs, SW; Galanopoulou, AS; Hall, CB; Mowrey, W | 1 |
| Chaki, S; Fukumoto, K; Iijima, M; Kurosu, S; Kuwada, T; Sekiguchi, Y; Shimazaki, T; Tokugawa, K; Yoshimizu, T | 1 |
| Harvey, BK; Maguire-Zeiss, KA; Männistö, PT; Myöhänen, TT; Richie, CT; Savolainen, MH | 1 |
| Gudascheva, TA; Ivanova, EA; Kapitsa, IG; Ostrovskaya, RU; Ozerova, IV; Seredenin, SB; Voronina, TA | 1 |
| Kang, TJ; Lu, Y; Qu, C; Tong, QQ; Zhang, C; Zhou, YJ | 1 |
| Blalock, JE; Gaggar, A; Garrett, C; Handley, G; Jackson, PL; McNicholas, CM; Miller, BE; O'Reilly, PJ; Rennard, SI; Roda, MA; Sullivan, DI; Szul, T; Tal-Singer, R; Wells, JM | 1 |
| Acker, C; Azose, M; Buthorn, J; D'Abramo, C; Davies, P; Greenwald, BS; Jimenez, H; Koppel, J; Lesser, M; Lewis, J; Liu, Z | 1 |
| Banday, AA; Bhatt, SR; Lokhandwala, MF | 1 |
| Aliani, M; House, JD; Mayengbam, S; Raposo, S | 2 |
| Baccile, JA; Brakhage, AA; Heinekamp, T; Hertweck, C; Keller, NP; Macheleidt, J; Neuwirth, T; Scherlach, K; Schmidt-Heck, W; Schroeder, FC; Spraker, J; Straßburger, M | 1 |
| McIlwrath, SL; Westlund, KN | 1 |
| Gu, HF; Jiang, JH; Liu, Z; Peng, J; Tang, XQ; Tang, YL; Wang, S; Yang, YZ | 1 |
| Chen, W; Hu, S; Jiang, GQ; Jiang, X; Wei, J; Xu, GY; Zhang, HH; Zhou, YL; Zhu, H | 1 |
| Arena, J; Hitt, D; Koliatsos, VE; Marsh-Armstrong, N; Nguyen, JV; Rha, E; Ryu, J; Vranis, P; Xu, L | 1 |
| Abe, H; Aikata, H; Chayama, K; Ellis, JD; Hayes, CN; Hiraga, N; Imamura, M; Ishida, Y; Kan, H; Miyaki, E; Tateno, C; Tsuge, M; Uchida, T; Yoshimi, S | 1 |
| Jeong, HJ; Kim, HM; Nam, SY; Yoou, MS | 1 |
| Han, P; Lei, Y; Lu, X; Qiao, Q; Xu, Z; Yang, J; Yao, M; Yin, W; Zhao, H | 1 |
| Alewood, PF; Dekan, Z; Deuis, JR; Durek, T; Hoffmann, T; Lewis, RJ; Nassar, MA; Sousa, SR; Vetter, I; Weidner, C; Wingerd, JS; Winter, Z; Zimmermann, K | 1 |
| Andres, CR; Baranek, T; Blasco, H; Bruno, C; Corcia, P; Descat, A; Dessein, AF; Goossens, JF; Leman, S; Madji Hounoum, B; Marouillat, S; Nadal-Desbarats, L; Patin, F; Vourc'h, P | 1 |
| Crabtree, GW; Gogos, JA; Gordon, JA; Park, AJ | 1 |
| Agulla, J; Almeida, Á; Bobo-Jiménez, V; Bolaños, JP; Castillo, J; Duarte, JJ; Gómez-Sánchez, JC; Ramos-Araque, ME; Rodríguez, C; Sobrino, T | 1 |
| Iida, M; Kato, M; Kumasaka, MY; Li, X; Ohgami, N; Oshino, R; Yajima, I | 1 |
| Iyer, S; Kwan, R; Liao, J; Liu, L; Moons, D; Omary, MB; Park, MJ | 1 |
| Gil-Pisa, I; Giralt, E; Gómez, L; Meana, JJ; Mendieta, L; Munarriz-Cuezva, E; Prades, R; Royo, S; Tarragó, T; Urigüen, L | 1 |
| Connelly, KA; Gilbert, RE; Kapus, A; Kepecs, D; Thai, K; Wu, X; Zhang, Y | 1 |
| Chen, O; Huang, S; Wang, Y; Wei, D; Xue, J; Zhang, Z; Zhu, W; Zhu, X | 1 |
| André, EA; Braatz, EM; Liu, JP; Zeitlin, SO | 1 |
| Ha, CM; Heo, SC; Jang, IH; Kang, H; Kim, JH; Kim, SC; Ko, HC; Kwon, YW; Lee, SC; Lee, TW; Park, GT; Ryu, Y; Yoon, JW | 1 |
| Dergunova, LV; Dmitrieva, VG; Limborska, SA; Medvedeva, EV; Myasoedov, NF | 1 |
| Bender, HU; Steel, G; Valle, D; Willis, A | 1 |
| Bugg, CW; Dunn, DE; Khoshnan, A; Lo, DC; Patterson, PH; Southwell, AL | 1 |
| Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, M; Roomi, NW | 1 |
| Ahanchi, SS; Hrabie, JA; Jiang, Q; Kapadia, MR; Keefer, LK; Kibbe, MR; Martinez, J; Pearce, CG; Saavedra, JE; Tsihlis, ND; Varu, VN | 1 |
| Lim, G; Mao, J; Sung, B; Wang, S | 1 |
| Bahlo, M; Cain, SM; David, LS; Foote, SJ; Garcia, E; Kyi, M; Ng, C; O'Brien, TJ; Powell, KL; Reid, CA; Sirdesai, S; Snutch, TP; Tyson, JR | 1 |
| Alimardanov, A; Butera, JA; Di, L; Hennan, JK; Huselton, C; Kerns, E; Larsen, BD; Liu, K; McDonald, L; Morgan, GA; Petersen, JS; Rossman, EI; Swillo, RE; Unwalla, R; Wang, Q | 1 |
| Aeed, H; Alin, A; Brazowski, E; Bruck, R; Goldiner, I; Kirchner, M; Matas, Z; Shirin, H | 1 |
| Butera, J; Feldman, HS; Gardell, SJ; Gruver, M; Haugan, K; Hennan, JK; Kantrowitz, J; Krueger, JA; Liu, K; Morgan, GA; Petersen, JS; Rossman, EI; Swillo, RE | 1 |
| Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N | 1 |
| Berg, N; Coleman, M; Crowther, RA; Gasparini, L; Goedert, M; Martin, KR; Spillantini, MG | 1 |
| Bai, F; Bai, G; Geng, P; Liu, Z; Shi, Q; Yang, Y; Zhang, Q; Zhu, YY | 1 |
| Denbow, DM; Furuse, M; Hamasu, K; Kabuki, Y; Shigemi, K; Tomonaga, S | 1 |
| Butera, JA; Di, L; Hennan, JK; Huselton, C; Larsen, BD; Morgan, GA; Piatnitski Chekler, EL; Rossman, EI; Swillo, RE | 1 |
| Baker, PR; Bonacci, G; Cole, MP; Freeman, BA; Ramani, R; Rudolph, TK; Rudolph, V; Schopfer, FJ; Woodcock, SR | 1 |
| Butera, J; Gardell, SJ; Hennan, JK; Kantrowitz, J; Morgan, GA; Petersen, JS; Rossman, EI; Swillo, RE; Vlasuk, GP | 1 |
| Chichilnisky, EJ; Dabrowski, W; Hottowy, P; Hulse, C; Jepson, LH; Litke, AM; Sekirnjak, C; Sher, A | 1 |
| Dorian, P; Hennan, JK; Hu, X; Laurent, G; Leong-Poi, H; Mangat, I; Moe, GW; Ramadeen, A; Rossman, EI; So, PP; Tarulli, E | 1 |
| Bagrov, AY; Cooper, CJ; El-Okdi, N; Elkareh, J; Fedorova, OV; Gohara, S; Gupta, S; Haller, S; Malhotra, D; Periyasamy, SM; Shapiro, JI; Shidyak, A; Taleb, M; Tian, J; Xie, Z | 1 |
| Aakhus, S; Aukrust, P; Christensen, G; Dahl, CP; Damås, JK; Finsen, AV; Florholmen, G; Gullestad, L; Halvorsen, B; Husberg, C; Oie, E; Ueland, T; Vinge, LE; Waehre, A; Yndestad, A | 1 |
| Alleva, E; Calamandrei, G; Gasparini, L; Goedert, M; Scattoni, ML; Spillantini, MG | 1 |
| Acosta, ML; Christie, DL; Fletcher, EL; Kalloniatis, M; Ready, S; Shin, YS | 1 |
| Mandelkow, EM; Sydow, A | 1 |
| Delwing, D; Ferreira, AG; Kolling, J; Lima, DD; Mackedanz, V; Schuck, PF; Tagliari, B; Wajner, M; Wyse, AT | 1 |
| Chen, MS; Lin, CP; Lin, FA; Yang, CH; Yang, CM; Yeh, PT | 1 |
| Bilican, B; Chandran, S; Goedert, M; Hampton, DW; Spillantini, MG; Webber, DJ | 1 |
| Blalock, JE; Braber, S; Folkerts, G; Garssen, J; Henricks, PA; Jackson, PL; Koelink, PJ; Kraneveld, AD; Nijkamp, FP | 1 |
| DiMario, PJ; He, F | 1 |
| Bjorge, D; Schwan, WR; Wetzel, KJ | 1 |
| Feng, X; Lu, J; Tang, K; Wang, Y; Xin, H; Zhang, L | 1 |
| Borchert, GL; Gunn, TM; Jung, S; Millet, YH; Nolan, KA; Phang, JM; Silvius, D | 1 |
| Bogo, MR; Bonan, CD; Cunha, AA; da Cunha, MJ; Ferreira, AG; Netto, CA; Pereira, TC; Stefanello, FM; Wyse, AT | 1 |
| Bae, YS; Baek, SH; Kim, HJ; Kim, SD; Lee, HY; Park, JS; Shim, JW; Yoo, YH; Zabel, BA | 1 |
| Chi, LY; Chi, ZF; Feng, YB; Man, X; Yao, H | 1 |
| Adamowicz, DH; Carlson, GA; Fox, LM; Hyman, BT; Pitstick, R; Spires-Jones, TL; William, CM | 1 |
| Iovino, M; Spillantini, MG; Vuono, R | 1 |
| Abdul, HM; Butterfield, DA; Cai, J; Di Domenico, F; Markesbery, WR; Pierce, WM; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Gerhardt, E; Kermer, P; Outeiro, TF; Szego, ÉM | 1 |
| Chen, KJ; Han, WH; Kao, LY; Lin, KK; Pang, JH; Sun, MH; Tsao, YP | 1 |
| Bonan, CD; Piato, AL; Savio, LE; Vuaden, FC; Wyse, AT | 1 |
| Chen, A; Diaz-Ruiz, C; Ho, L; Ksiezak-Reding, H; Pasinetti, GM; Santa-Maria, I; Wang, J | 1 |
| Druga, R; Folbergrová, J; Otáhal, J | 1 |
| Chan, F; Price, BA; Sandoval, IM; Simons, DL; Wensel, TG; Wilson, JH; Wu, SM | 1 |
| Detjen, KM; Hauff, P; Otto, N; Schlegelberger, B; Scholz, A; Schulz, P; Wiedenmann, B | 1 |
| Borghgraef, P; Demedts, D; Devijver, H; Kremer, A; Maurin, H; Van Leuven, F | 1 |
| Chen, T; Corcoran, NM; Grundy, R; Hovens, CM; Jones, NC; Nguyen, T; O'Brien, TJ; Velakoulis, D | 1 |
| Ferrell, WD; Jones, BW; Lee, DC; Marc, RE; Moritz, OL; Tam, BM; Vazquez-Chona, FR | 1 |
| Bigio, EH; Binder, L; Denial, S; Greenwood, A; Lu, KP; Nakamura, K; Nicholson, L; Zhou, XZ | 1 |
| Axten, JM; Blackledge, CW; Bobko, MA; Campobasso, N; Duquenne, C; Gallagher, TF; Grant, SW; Kulkarni, S; Lewandowski, T; Medina, JR; Miller, WH; Peng, T; Pinckney, T; Van Aller, GS; Ward, P; Zonis, R | 1 |
| Cheng, Q; Diano, S; Gadepalli, RS; Gailani, D; Rabey, FM; Rimoldi, JM; Shariat-Madar, Z; Tabrizian, T | 1 |
| Ando, K; Bégard, S; Bélarbi, K; Blum, D; Bretteville, A; Buée, L; Caillet-Boudin, ML; Demey-Thomas, E; Dourlen, P; Drobecq, H; Eddarkaoui, S; Galas, MC; Ghestem, A; Hamdane, M; Landrieu, I; Lippens, G; Maurage, CA; Melnyk, P; Sambo, AV; Sergeant, N; Smet, C; Verdier, Y; Vingtdeux, V; Vinh, J | 1 |
| Clabough, EB; Neveklovska, M; Steffan, JS; Zeitlin, SO | 1 |
| Britschgi, M; Johns, H; Masliah, E; Rockenstein, E; Takeda-Uchimura, Y; Wyss-Coray, T | 1 |
| Bayles, KW; Fey, PD; Halouska, SM; Hanke, ML; Kielian, T; Nuxoll, AS; Powers, R; Sadykov, MR | 1 |
| Geng, Y; Li, Z; Shao, Y; Zhang, Y | 1 |
| Cornejo Castro, EM; Fog, K; Jensen, PH; Kahle, PJ; Rannikko, EH; Shaik, JH; Vesterager, LB; Weber, SS | 1 |
| Kotake, Y; Moore, DR; Sang, H; Tabatabaie, T; Vasquez-Walden, A | 1 |
| Whyte, MK | 1 |
| Senftleben, U | 1 |
| Keefer, LK; Oldfield, EH; Pluta, RM; Saavedra, JE; Walbridge, S; Weyerbrock, A | 1 |
| Guseva, AA; Kopylova, GN; Smirnova, EA; Umarova, BA; Zhuikova, SE | 1 |
| Itter, G; Jung, W; Juretschke, P; Linz, W; Schoelkens, BA | 1 |
| Aoyagi, Y; Fujisawa, H; Kodama, Y; Kominami, R; Maruyama, M; Mishima, Y; Niwa, O; Obata, M; Schaffner, W; Tamura, Y; Yoshikai, Y | 1 |
| Badmaeva, KE; Bakaeva, ZV; Samonina, GE; Zheliaznik, NIa | 1 |
| Frasier, M; Haas, C; Kahle, P; Lee, JM; Magnuson, D; McCarthy, L; Walzer, M; Wolozin, B | 1 |
| Butterfield, DA; Calabrese, V; Frasier, M; Poon, HF; Shreve, N; Wolozin, B | 1 |
| Johnson, RB | 1 |
| Bothma, T; Harvey, BH; Nel, A; Stein, DJ; Wegener, G | 1 |
| Bavaresco, CS; Netto, CA; Streck, EL; Wyse, AT | 1 |
| Chen, MS; Fang, IM; Lin, CP; Yang, CH; Yang, CM | 1 |
| Gamanos, M; Lai, W; Ledeboer, A; Maier, SF; Martin, D; Quan, N; Watkins, LR | 1 |
| Doulgkeris, CM; Eleftheriou, PT; Galanakis, D; Gavalas, AM; Kourounakis, AP; Kourounakis, PN; Rekka, EA; Tsiakitzis, KC; Victoratos, P | 1 |
| Lehmann, L; McCormick, J; Schwan, WR | 1 |
| Aguennouz, M; Altavilla, D; Bitto, A; Messina, S; Minutoli, L; Monici, MC; Squadrito, F; Vita, G | 1 |
| Ben Yaou, R; Bonne, G; Decostre, V | 1 |
| D'Souza, M; Frisina, RD; Tadros, SF; Waxmonsky, NC; Zettel, ML; Zhu, X | 1 |
| Pfister, RR; Sommers, CI | 1 |
| Agata, N; Ebihara, T; Kawai, T; Lin, CY; Mukherjee, PM; Olsen, BR; Onji, M; Reichenberger, E; Saheki, Y; Senoo, M; Ueki, Y | 1 |
| Gaedicke, G; Huebener, N; Lode, HN; Strandsby, A | 1 |
| Moritz, OL; Tam, BM | 1 |
| Asuni, AA; Boutajangout, A; Quartermain, D; Sigurdsson, EM | 1 |
| Ahanchi, SS; Chow, LW; Eng, JW; Hrabie, JA; Hulvat, JF; Jiang, Q; Kapadia, MR; Keefer, LK; Kibbe, MR; Martinez, J; Murar, J; Popowich, DA; Saavedra, JE; Stupp, SI; Tsihlis, ND | 1 |
| Chen, L; Chen, Z; Deng, C; Du, X; Jin, M; Li, C; Li, F; Qi, H; Su, N; Xu, X; Xue, J; Yang, J; Yin, L; Zhao, L | 1 |
| Caragounis, A; Crouch, PJ; Du, T; Filiz, G; Price, KA; White, AR | 1 |
| Gieselmann, V | 1 |
| Fujigaki, Y; Hishida, A; Luo, J; Sun, Y; Tsuji, T; Yasuda, H | 1 |
| Alverson, J; Fry, LM; O'Rourke, KI; Schneider, DA; White, SN; Yan, H | 1 |
| Boccagno, JA; Horovitz, ZP; Murthy, VS; Steinbacher, TE; Vollmer, RR | 1 |
| Antonaccio, J; Rubin, B | 1 |
| Loyke, HF | 1 |
| Jackson, D; Mowat, AP; Tanner, MS | 1 |
| Antonaccio, MJ | 1 |
| Bashey, RI; Jimenez, SA; Millan, A | 1 |
| Coulais, Y; Cros, J; Guiraud, R; Marcelon, G | 1 |
| Bovee, KC; Medow, MS; Reynolds, R; Segal, S | 1 |
| Bing, RF; Marks, ES; Swales, JD; Thurston, H | 1 |
| Hammerman, MR; Hruska, KA; Klahr, S | 1 |
| Arthus, MF; Bergeron, M; Scriver, CR | 1 |
| Chanussot, F; Clerc, T; Diaconescu, N; Jadot, G; Lafont, H; Laruelle, C; Sbarra, V | 1 |
| Sved, AF; Tsukamoto, K | 1 |
| Buchmiller, TL; Diamond, JS; Fonkalsrud, EW; Lam, ML; Shaw, KS; Stokes, R | 1 |
| Bodo, M; Gabriel, E; Müller, PK; Niu, C; Notbohm, H; Wolf, E; Yang, C | 1 |
| Ahrendt, GM; Barbul, A; Tantry, US | 1 |
| Mori, M; Nishimura, M | 1 |
| Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH | 1 |
| Jørgensen, PH | 1 |
| Finley, F; Galgiani, JN; Kirkland, TN; Orsborn, KI | 1 |
| Drenser, KA; Flannery, JG; Hauswirth, WW; LaVail, MM; Lewin, AS; Nishikawa, S; Yasumura, D | 1 |
| Campbell, EA; Gentry, CT; Panesar, MS; Patel, S; Urban, L; Walpole, CS | 1 |
| Boyle, EM; Canty, TG; Caps, MT; Farr, AL; Frank, N; Kovacich, JC; Morgan, EN; Pohlman, TH; Verrier, ED | 1 |
| Cossart, P; Dramsi, S; Fedor-Chaiken, M; Gottardi, C; Gumbiner, B; Lecuit, M | 1 |
| Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L | 1 |
| Alder, JD; Chen, HJ; Curty, CB; DeGoey, DA; Funk, KW; Grampovnik, DJ; Kishore, V; Klein, LL; Lartey, PA; Leone, CL; Li, L; Lundell, EO; Meulbroek, JA; Nilius, AM; Plattner, JJ; Thomas, SA; Wodka, D; Yeung, CM | 1 |
| Hong, HJ; Loh, SH; Yen, MH | 1 |
| Gacko, M | 1 |
| Coppey, L; Li, WG; Oskarsson, HJ; Weiss, RM | 1 |
| Boyle, EM; Farr, AL; Frank, N; Lefler, SR; Lille, ST; Mowlavi, A; Mulligan, DC; Su, CY; Suchy, H | 1 |
| Bartsch, R; Hönack, D; Löscher, W; Tober, C | 1 |
| Bean, M; Brenner, MC; Buttrick, PM; Geenen, D; Huang, X; Nwogu, JI | 1 |
| Cheever, AW; Fuentes, JM; Hesse, M; La Flamme, AC; Modolell, M; Pearce, EJ; Schito, M; Wynn, TA | 1 |
| Hulsebosch, CE; Johnson, KM; Mills, CD | 1 |
| Guo, JS; Hu, MY; Wang, JY; Zhang, QS | 1 |
| Adham, IM; Engel, W; Müller, C; Nayernia, K; Sancken, U; Shamsadin, R | 1 |
| Casals-Stenzel, J; Lever, AF; Millar, JA; Morton, JJ; Riegger, AJ; Tree, M | 1 |
| Davis, JO; DeForrest, JM; Freeman, RH; Rowe, BP; Seymour, AA; Williams, GM | 1 |
| Antonaccio, MJ; Horovitz, ZP; Panasevich, RE; Rubin, B | 1 |
| Fuller, GC; Rodil, JV; Yermakoff, JK | 1 |
| Keller, NR; Yu, SY | 1 |
| Eilon, G; Gworek, SC; Raisz, LG; Simmons, HA | 1 |
| Yamori, Y | 1 |
| Isseroff, H; Reino, D; Sawma, JT | 1 |
| Arquilla, ER; Nakajo, M; Weringer, EJ | 1 |
| Berson, EL; Cowley, GS; Dryja, TP; Gordon, JW; Hayes, A; Molday, RS; Mukai, S; Olsson, JE; Pawlyk, BS; Roof, D | 1 |
| Calzoni, P; Cavarra, E; de Santi, MM; Gardi, C; Lungarella, G; Martorana, PA; van Even, P | 1 |
| Chikugo, T; Hamada, Y; Morita, N; Ohta, Y; Okamoto, K; Shiokawa, H | 1 |
| Golub, LM; Kaneko, H; Ramamurthy, NS; Sasaki, T | 1 |
| Chan, KH; Li, WW; Yew, DT | 1 |
| Crowell, RL; Finkelstein, SD; Grun, JB; Landau, BJ; Schultz, M | 1 |
| Last, JA | 1 |
| Evans, C; Gueyikian, I; Klein, I; Oratz, M; Rothschild, MA; Schreiber, SS | 1 |
| Wajgt, A; Wender, M; Zgorzalewicz, B | 1 |
| Anderson, MS; Kastin, AJ; Plotnikoff, NP; Schally, AV | 1 |
| Blake, RL | 1 |
| Gudbjarnason, S; Mathes, P; Ravens, KG | 1 |
| Thompson, RC | 1 |
| Nakagawa, H; Shin, KH; Tsurufuji, S | 1 |
| Costello, D; Cutroneo, KR; Fuller, GC | 1 |
| Haufe, F; Haufe, U; Lubs, H; Machill, G | 1 |
| Halme, J; Kahanpää, K; Karhunen, P; Lindy, S; Uitto, J | 1 |
11 review(s) available for proline and Disease Models, Animal
| Article | Year |
|---|---|
[Meta-analysis of Ac-SDKP inhibition of Pulmonary fibrosis in animal models].
Topics: Animals; Disease Models, Animal; Fibrosis; Proline; Pulmonary Fibrosis; Rats; Rats, Wistar | 2023 |
Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing.
Topics: Amino Acids; Animals; Collagen; Dietary Supplements; Disease Models, Animal; Humans; Proline; Wound Healing | 2017 |
PRODH variants and risk for schizophrenia.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Gene Expression Regulation; Genetic Linkage; Heterozygote; Humans; Mice; Models, Biological; Models, Genetic; Phenotype; Proline; Regression Analysis; Schizophrenia | 2008 |
NF-kappaB in critical diseases: a bad guy?
Topics: Animals; Antioxidants; Critical Illness; Disease Models, Animal; Gene Expression Regulation; Homeostasis; Humans; Inflammation; Mice; Multiple Organ Failure; NF-kappa B; Oxidation-Reduction; Proline; Signal Transduction; Thiocarbamates; Time Factors; Transcription Factors; Zymosan | 2003 |
Laminopathies affecting skeletal and cardiac muscles: clinical and pathophysiological aspects.
Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Humans; Lamin Type A; Lamins; Leucine; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophy, Emery-Dreifuss; Myocardium; Nuclear Envelope; Proline | 2005 |
The role of metals in modulating metalloprotease activity in the AD brain.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Brain; Cell Culture Techniques; Chelating Agents; Clioquinol; Copper; Disease Models, Animal; Egtazic Acid; Enzyme Activation; ErbB Receptors; Humans; Intracellular Space; Matrix Metalloproteinases, Secreted; Mitogen-Activated Protein Kinases; Plaque, Amyloid; Proline; Thiocarbamates; Trace Elements; Zinc | 2008 |
[Pharmacological effects of captopril].
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Blood Pressure; Bradykinin; Captopril; Cats; Disease Models, Animal; Dogs; Hemodynamics; Humans; Hypertension; Mice; Proline; Rabbits; Rats; Renin | 1981 |
Development and pharmacology of angiotensin converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Kinetics; Nervous System; Proline; Renal Circulation; Renin-Angiotensin System; Substrate Specificity; Vascular Resistance; Water-Electrolyte Balance | 1983 |
Growth hormone, skin and wound healing--experimental studies in the rat.
Topics: Animals; Biomechanical Phenomena; Collagen; Disease Models, Animal; Female; Human Growth Hormone; Humans; Hydroxyproline; Proline; Rats; Rats, Wistar; Skin; Wound Healing | 1997 |
[Experimental aortic aneurysm].
Topics: Aneurysm, Ruptured; Animals; Aortic Aneurysm; Collagen; Disease Models, Animal; Elastin; Hemodynamics; Proline | 2000 |
Changes in the collagen pathway in fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Collagen; Connective Tissue Diseases; Cross-Linking Reagents; Disease Models, Animal; Humans; Kinetics; Liver; Liver Cirrhosis; Lung; Organ Size; Ozone; Penicillamine; Proline; Pulmonary Fibrosis; Rats | 1985 |
1 trial(s) available for proline and Disease Models, Animal
| Article | Year |
|---|---|
An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.
Topics: Aged; Animals; Bronchoalveolar Lavage Fluid; Cohort Studies; Disease Models, Animal; Emphysema; Epoxide Hydrolases; Female; Glycine; Humans; Inflammation; Lung; Male; Mice; Middle Aged; Myocardium; Neutrophils; Proline; Pulmonary Disease, Chronic Obstructive; Smoking | 2014 |
216 other study(ies) available for proline and Disease Models, Animal
| Article | Year |
|---|---|
LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glu
Topics: Animals; Bone Neoplasms; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Exosomes; Glutamine; Humans; Male; Mice; MicroRNAs; Osteoblasts; Phenotype; Polypyrimidine Tract-Binding Protein; Proline; Prostatic Neoplasms; RNA Splicing Factors; RNA, Long Noncoding; Tumor Microenvironment | 2021 |
An oral SARS-CoV-2 M
Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Coronavirus; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Therapy, Combination; Humans; Lactams; Leucine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitriles; Proline; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors; Virus Replication | 2021 |
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Topics: A549 Cells; Administration, Oral; Animals; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lactams; Leucine; Mesocricetus; Nitriles; Proline; Respiratory Mucosa; SARS-CoV-2; Vero Cells; Viral Protease Inhibitors; Virus Replication | 2022 |
Tea polyphenol epigallocatechin-3-gallate inhibits cell proliferation in a patient-derived triple-negative breast cancer xenograft mouse model via inhibition of proline-dehydrogenase-induced effects.
Topics: Animals; Catechin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Heterografts; Humans; Mice; Polyphenols; Proline; Proline Oxidase; Tea; Triple Negative Breast Neoplasms | 2021 |
L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mice; Molecular Docking Simulation; Neuroprotection; Proline; Receptors, N-Methyl-D-Aspartate | 2023 |
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Models, Molecular; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Proline; Protein Aggregates; Protein Aggregation, Pathological; Protein Structure, Tertiary | 2020 |
Stachydrine hydrochloride alleviates pressure overload-induced heart failure and calcium mishandling on mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Arterial Pressure; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiovascular Agents; Cells, Cultured; Disease Models, Animal; Heart Failure; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Sarcoplasmic Reticulum; Telmisartan; Ventricular Function, Left | 2020 |
Metabolomic changes of blood plasma associated with two phases of rat OIR.
Topics: Animals; Animals, Newborn; Biomarkers; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glutamine; Hyperoxia; Hypoxia; Metabolome; Metabolomics; Ornithine; Oxidative Stress; Oxygen; Proline; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinopathy of Prematurity | 2020 |
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine | 2019 |
Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.
Topics: Animals; Antineoplastic Agents; Caffeic Acids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Assays; Humans; Hydroxamic Acids; Hydroxyproline; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Molecular Docking Simulation; Neoplasms; Proline; Rats; Recombinant Proteins; Sulfones | 2020 |
Gap-134, a Connexin43 activator, prevents age-related development of ventricular fibrosis in Scn5a
Topics: Animals; Benzamides; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Connexin 43; Disease Models, Animal; Fibroblasts; Fibrosis; Mice, 129 Strain; Mice, Knockout; Myocardium; NAV1.5 Voltage-Gated Sodium Channel; Phosphorylation; Proline; Pyrazoles; Signal Transduction; Up-Regulation; Ventricular Remodeling | 2020 |
Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages.
Topics: Animals; Blotting, Western; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique, Indirect; I-kappa B Kinase; Intravitreal Injections; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Oxygen; Phosphorylation; Proline; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; Signal Transduction; Thiocarbamates; Transcription Factor RelA | 2020 |
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Topics: Animals; Calcineurin; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Hypertrophy, Left Ventricular; Mice, Inbred C57BL; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Proline; Rats, Wistar; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Topics: Animals; Antiviral Agents; Betacoronavirus; Binding Sites; Catalytic Domain; Chlorocebus aethiops; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Crystallography, X-Ray; Cysteine Endopeptidases; Disease Models, Animal; High-Throughput Screening Assays; Models, Molecular; Pandemics; Pneumonia, Viral; Proline; Protease Inhibitors; Pyrrolidines; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sulfonic Acids; Vero Cells; Viral Nonstructural Proteins; Virus Replication | 2020 |
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cytoskeletal Proteins; delta-1-Pyrroline-5-Carboxylate Reductase; Disease Models, Animal; Dynamins; Female; Gene Knockout Techniques; Humans; LIM Domain Proteins; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; Muscle Proteins; Neoplasm Proteins; Proline; Proto-Oncogene Proteins p21(ras); Pyrroline Carboxylate Reductases; Survival Analysis | 2020 |
Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease.
Topics: ADAMTS Proteins; Aged; Animals; Aorta; Aortic Valve Stenosis; Collagen Type I; Collagen Type I, alpha 1 Chain; Constriction, Pathologic; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Extracellular Matrix Proteins; Fatty Acids; Female; Gene Expression Profiling; Heart Atria; Heart Valve Prosthesis Implantation; Heart Ventricles; Humans; Male; Mice; Mice, Transgenic; Microvascular Density; Microvessels; Procollagen; Proline; Pyrophosphatases; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, RNA; Thrombospondins | 2021 |
Structural basis for a complex I mutation that blocks pathological ROS production.
Topics: Amino Acid Substitution; Animals; Cryoelectron Microscopy; Disease Models, Animal; Disease Resistance; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Humans; Isolated Heart Preparation; Leucine; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membranes; Myocardial Reperfusion Injury; NAD; NADH Dehydrogenase; Oxidation-Reduction; Point Mutation; Proline; Reactive Oxygen Species | 2021 |
SARS-CoV-2 M
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chemokine CXCL10; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Design; Humans; Interferon-beta; Lung; Mice; Mice, Transgenic; Oligopeptides; Proline; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Viral Load; Virus Replication | 2021 |
A mechanism for matrikine regulation in acute inflammatory lung injury.
Topics: Acute Lung Injury; Animals; Anti-Bacterial Agents; Biological Transport, Active; Cefadroxil; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; COVID-19; Disease Models, Animal; Extracellular Matrix; Extracellular Matrix Proteins; Humans; Inflammation; Mice; Oligopeptides; Proline; Symporters | 2021 |
Monocytes, endoplasmic reticulum stress and metabolomics in dogs with multiple organ dysfunction syndrome treated by continuous venovenous hemodiafiltration.
Topics: Animals; Caspase 12; Cell Survival; Disease Models, Animal; Dogs; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hemodiafiltration; Heparin; Human Umbilical Vein Endothelial Cells; Humans; Male; MAP Kinase Kinase 4; Metabolomics; Methionine; Monocytes; Multiple Organ Failure; Ornithine; Proline; Random Allocation; Transcription Factor CHOP | 2017 |
Involvement of NF-κB and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.
Topics: Animals; Antibodies; Antioxidants; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Nerve Tissue Proteins; Pain Threshold; Physical Stimulation; Proline; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Signal Transduction; Spinal Cord; Thiocarbamates; Up-Regulation | 2018 |
Transdermally administered proline-arginine-rich host defense peptides show systemic efficacy in a lethal mouse bacteremia model.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Administration, Cutaneous; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Arginine; Bacteremia; Bacterial Load; Carbapenems; Colistin; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Ear; Humans; Mice; Proline; Skin; Survival Analysis | 2017 |
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Dicarboxylic Acids; Disease Models, Animal; Early Diagnosis; Glucuronic Acid; Glyoxylates; Humans; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Pentoses; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Starch; Sucrose; Tryptophan | 2017 |
Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model.
Topics: Animals; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Golgi Apparatus; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Transgenic; Neurofibrillary Tangles; Phosphopyruvate Hydratase; Phosphorylation; Proline; Pyramidal Cells; Receptors, Fibroblast Growth Factor; Serine; Sialoglycoproteins; tau Proteins; Tauopathies | 2017 |
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
Topics: Actins; Animals; Benzeneacetamides; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Activation; Fibronectins; Glutaminase; Glutamine; Humans; Hydroxylation; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Myofibroblasts; Proline; Pulmonary Fibrosis; RNA Interference; RNA, Small Interfering; Sulfides; Thiadiazoles; TOR Serine-Threonine Kinases | 2018 |
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Metabolome; Metabolomics; Phenotype; Proline; Sorafenib; Xenograft Model Antitumor Assays | 2018 |
2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Male; Memory; MicroRNAs; Proline; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Up-Regulation | 2018 |
Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Gene Expression Regulation; Hippocampus; Injections, Intraperitoneal; Interleukin-6; Lipopolysaccharides; Neuroprotective Agents; NF-kappa B; Proline; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha | 2018 |
The Status of the Hemostasis System under the Influence of Proline Peptides during the Development of Experimental Metabolic Syndrome.
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Hemostasis; Male; Metabolic Syndrome; Oligopeptides; Proline; Rats; Rats, Wistar | 2018 |
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Fatty Liver; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Leucine; Mice; Mice, Transgenic; Mutation, Missense; PPAR gamma; Proline | 2018 |
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
Topics: Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Immunologic; Exploratory Behavior; Female; Frontotemporal Dementia; Hepatitis B Vaccines; Immunization; Immunodominant Epitopes; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Proline; Recognition, Psychology; Serine; tau Proteins; Treatment Outcome; Vaccines, Virus-Like Particle | 2018 |
Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.
Topics: Animals; Animals, Newborn; Cell Membrane; Cerebral Cortex; Coculture Techniques; Culture Media; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neurodegenerative Diseases; Neurogenic Inflammation; Neurons; Neuroprotection; Primary Cell Culture; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Up-Regulation | 2019 |
The interplay of LncRNA ANRIL and miR-181b on the inflammation-relevant coronary artery disease through mediating NF-κB signalling pathway.
Topics: Animals; Coronary Artery Disease; Disease Models, Animal; Female; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Male; Mice; MicroRNAs; Middle Aged; NF-kappa B; Proline; RNA, Long Noncoding; Signal Transduction; Thiocarbamates; Transcription Factor RelA | 2018 |
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Topics: Airway Remodeling; Airway Resistance; Animals; Asthma; Bronchi; Cell Count; Disease Models, Animal; Epithelial Cells; Epoxide Hydrolases; Extracellular Matrix; Humans; Hypersensitivity; Inflammation; Inflammation Mediators; Mice, Inbred C57BL; Mucus; Neutrophils; Oligopeptides; Proline; Pyroglyphidae; Respiratory Hypersensitivity; Sputum; T-Lymphocytes, Helper-Inducer | 2018 |
Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress.
Topics: Animals; Apoptosis; Colitis; Dextran Sulfate; Disease Models, Animal; Glycine; Hydroxyproline; Interleukin-6; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Proline; RAW 264.7 Cells; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2018 |
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Animal; Ephrin-B1; Excitatory Amino Acid Agents; Glaucoma; Glial Fibrillary Acidic Protein; Intercellular Signaling Peptides and Proteins; Male; Morpholines; Phenols; Piperidines; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha | 2018 |
Mutant UBQLN2
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Autophagy; Choline O-Acetyltransferase; Disease Models, Animal; DNA-Binding Proteins; Doxycycline; Gene Expression Regulation; Histidine; Lysosomal-Associated Membrane Protein 2; Motor Disorders; Motor Neurons; Muscle, Skeletal; Mutation; Proline; Psychomotor Performance; Rats; Rats, Transgenic; Spinal Cord; Ubiquitins | 2018 |
Role of Bone Marrow Mesenchymal Stromal Cells in Attenuating Inflammatory Reaction in Lipopolysaccaride-induced Acute Kidney Injury of Rats Associated with TLR4-NF-κB Signaling Pathway Inhibition.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Antioxidants; Blood Urea Nitrogen; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; NF-kappa B; Proline; Rats; RNA, Messenger; Signal Transduction; Thiocarbamates; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
Modulation of the airway smooth muscle phenotype in a murine asthma model and effects of nuclear factor-κB inhibition.
Topics: Airway Remodeling; Animals; Asthma; Blotting, Western; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Muscle, Smooth; NF-kappa B; Phenotype; Proline; Random Allocation; Real-Time Polymerase Chain Reaction; Reference Values; Signal Transduction; Thiocarbamates | 2019 |
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Computational Biology; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Profiling; Glutaminase; Glutamine; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Metabolomics; Mice; Models, Biological; Proline; Xenograft Model Antitumor Assays | 2019 |
l-Proline protects mice challenged by Klebsiella pneumoniae bacteremia.
Topics: Animals; Anti-Bacterial Agents; Arginine; Bacteremia; Biomarkers; Disease Models, Animal; Female; Klebsiella Infections; Klebsiella pneumoniae; Metabolomics; Mice; Mice, Inbred C57BL; Proline | 2021 |
Influences of the TLR4/NF-κB pathway on memory function and inflammatory factors in rats with cerebral small vessel disease.
Topics: Animals; Cerebral Small Vessel Diseases; Disease Models, Animal; Interleukin-1beta; Lipopolysaccharides; Male; NF-kappa B; Proline; Rats; Signal Transduction; Sulfonamides; Thiocarbamates; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Activation of nuclear factor-κB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Disease Models, Animal; Enzyme Activation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; NF-kappa B; Proline; Protein Transport; Rabbits; Subarachnoid Hemorrhage; Thiocarbamates; Tumor Necrosis Factor-alpha | 2013 |
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.
Topics: Animals; Arthritis; Benzoxazoles; Cathepsin B; Cathepsin K; Cathepsins; Collagen; Disease Models, Animal; Dogs; Enzyme Inhibitors; Half-Life; Humans; Mice; Mice, Inbred ICR; Microsomes; Proline; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2013 |
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.
Topics: Alanine; alpha-Synuclein; Animals; Anxiety; Avoidance Learning; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Doxycycline; Gene Expression Regulation; Hippocampus; Humans; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurogenesis; Neuroglia; Neuropeptides; Olfactory Bulb; Proline | 2013 |
Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.
Topics: Analysis of Variance; Animals; Antibodies; Brain; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Molecular Weight; Mutation; Oligodendroglia; Proline; Rats; tau Proteins; Tauopathies | 2014 |
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Topics: Animals; B-Lymphocytes; Blotting, Western; Cathepsins; CD4-Positive T-Lymphocytes; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Histocompatibility Antigens Class I; Immunoglobulin G; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Proline; Real-Time Polymerase Chain Reaction | 2015 |
CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Infant; Male; Maze Learning; Monitoring, Physiologic; Proline; Rats; Spasms, Infantile | 2014 |
Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidiuretic Hormone Receptor Antagonists; CHO Cells; Corticosterone; Cricetulus; Depression; Disease Models, Animal; Humans; Indoles; Male; Mice; Proline; Pyridines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Vasopressin | 2014 |
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Topics: Alanine; alpha-Synuclein; Animals; Autophagy; Brain; Brain Diseases; Cell Line, Transformed; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors | 2014 |
Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Proline; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles | 2014 |
The effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction.
Topics: Animals; Apoptosis; Biomarkers; Blood Urea Nitrogen; Caspase 12; Caspase 9; Disease Models, Animal; Immunohistochemistry; Kidney; Male; Proline; Rabbits; Rats; Rats, Wistar; Ureteral Obstruction; Urologic Surgical Procedures, Male | 2014 |
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins | 2014 |
Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B.
Topics: Animals; Aorta; Buthionine Sulfoximine; Cells, Cultured; Disease Models, Animal; Humans; Hypertension; Muscle, Smooth, Vascular; NF-kappa B; Oxidants; Oxidative Stress; Proline; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Signal Transduction; Thiocarbamates; Up-Regulation; Vasoconstriction | 2014 |
Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
Topics: Animals; Asymptomatic Diseases; Biomarkers; Cystathionine; Cystathionine gamma-Lyase; Diet; Disease Models, Animal; Disease Progression; Flax; Homocysteine; Hyperhomocysteinemia; Liver; Male; Non-alcoholic Fatty Liver Disease; Proline; Pyridoxal Phosphate; Pyridoxine; Random Allocation; Rats, Sprague-Dawley; Seeds; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.
Topics: Animals; Aspergillus fumigatus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Lung; Mice; Multigene Family; Peptide Synthases; Proline; Pulmonary Aspergillosis; Signal Transduction | 2015 |
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Ethanol; Excitatory Amino Acid Agonists; Humans; Hyperalgesia; Liver; Male; Morphine; Nociceptin; Nociception; Opioid Peptides; Pain Threshold; Pancreas; Pancreatitis, Alcoholic; Proline; Rats, Inbred F344; Receptors, Metabotropic Glutamate; Time Factors; Visceral Pain | 2015 |
TLR4/NF-κB signaling contributes to chronic unpredictable mild stress-induced atherosclerosis in ApoE-/- mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Corticosterone; Cytokines; Disease Models, Animal; Inflammation Mediators; Lipids; Male; Mice; Mice, Knockout; NF-kappa B; Proline; RNA Interference; RNA, Small Interfering; Signal Transduction; Stress, Physiological; Thiocarbamates; Toll-Like Receptor 4 | 2015 |
Enhanced binding capability of nuclear factor-κB with demethylated P2X3 receptor gene contributes to cancer pain in rats.
Topics: Action Potentials; Animals; Antineoplastic Agents; Bone Neoplasms; Case-Control Studies; Disease Models, Animal; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; Methylation; Neurons; NF-kappa B; Nitriles; Pain; Pain Management; Pain Threshold; Proline; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sulfones; Thiocarbamates | 2015 |
Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Disease Models, Animal; gamma-Synuclein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Proline; Pyramidal Tracts; Retina; Retinal Ganglion Cells; Serine; tau Proteins; Tauopathies; Visual Pathways | 2015 |
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
Topics: Animals; Antiviral Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Gene Expression Profiling; Hepacivirus; Hepatitis C; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mice; Mice, Transgenic; Mutation, Missense; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Virus Replication | 2016 |
A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats.
Topics: Amino Acids; Aminobutyrates; Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diet; Disease Models, Animal; Flax; Glutamic Acid; Liver; Male; Proline; Pyridoxine; Rats; Vitamin B 6; Vitamin B 6 Deficiency | 2016 |
Efficacy of proline in the treatment of menopause.
Topics: Administration, Oral; Animals; Disease Models, Animal; Female; Humans; Menopause; Mice, Inbred BALB C; Models, Biological; Osteoporosis, Postmenopausal; Proline; Treatment Outcome | 2016 |
Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A Protease Activity.
Topics: Animals; Computer Systems; Disease Models, Animal; Hepacivirus; Liver; Luciferases; Mice, Transgenic; Oligopeptides; Plasmids; Proline; Protease Inhibitors; Reproducibility of Results; Viral Nonstructural Proteins | 2016 |
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.
Topics: Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetulus; Disease Models, Animal; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; NAV1.7 Voltage-Gated Sodium Channel; Nerve Fibers; Pain; Peptides; Phenyl Ethers; Proline; Saphenous Vein; Scorpion Venoms; Sodium Channel Blockers; Spider Venoms; Sulfonamides | 2016 |
Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Disease Models, Animal; Female; Humans; Longitudinal Studies; Male; Metabolomics; Mice, Transgenic; Motor Neurons; Proline; Superoxide Dismutase; Tryptophan | 2017 |
Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Topics: Animals; Central Nervous System; Cytosol; Disease Models, Animal; Gamma Rhythm; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamate Decarboxylase; Humans; Mice; Proline; Proline Oxidase; Schizophrenia; Vigabatrin | 2016 |
Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism.
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Arginine; Bone Marrow Cells; Brain; Cells, Cultured; Cerebral Hemorrhage; Chemokine CXCL12; Collagenases; Disease Models, Animal; Endothelial Progenitor Cells; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Neovascularization, Physiologic; Polymorphism, Single Nucleotide; Proline; Tomography, X-Ray Computed; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2017 |
Manganese-mediated acceleration of age-related hearing loss in mice.
Topics: Aging; Animals; Disease Models, Animal; Hearing Loss; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Manganese; Mice; Mice, Transgenic; Nerve Degeneration; Phosphorylation; Proline; Proto-Oncogene Proteins c-ret; Spiral Ganglion; Up-Regulation | 2016 |
Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.
Topics: Amylases; Animals; Ceruletide; Choline; Clusterin; delta-1-Pyrroline-5-Carboxylate Reductase; Disease Models, Animal; Ethionine; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred BALB C; Pancreatitis; Proline; Protein Processing, Post-Translational; Proteome; Pyrroline Carboxylate Reductases; Species Specificity | 2017 |
The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia.
Topics: Animals; Cell Line, Tumor; Cognition; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Maze Learning; Mice, Inbred C57BL; Motor Activity; Poly I-C; Prepulse Inhibition; Proline; Prolyl Oligopeptidases; Psychotropic Drugs; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Serine Endopeptidases; Serine Proteinase Inhibitors | 2017 |
Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Topics: Acetylation; Anilides; Animals; Biopsy; Blood Pressure; Collagen; Disease Models, Animal; Disease Progression; Feeding Behavior; Fibrosis; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Heart Diseases; Heart Function Tests; HEK293 Cells; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Proline; Rats, Inbred F344; Renal Insufficiency, Chronic; RNA, Messenger; Sirtuin 1; Smad3 Protein; Thiazoles; Transforming Growth Factor beta1 | 2017 |
Upregulation of CCL3/MIP-1alpha regulated by MAPKs and NF-kappaB mediates microglial inflammatory response in LPS-induced brain injury.
Topics: Animals; Antibodies; Antioxidants; Brain Injuries; CD11b Antigen; Chemokine CCL3; Disease Models, Animal; Encephalitis; Enzyme Activators; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Wistar; Thiocarbamates; Time Factors; Up-Regulation | 2016 |
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
Topics: Animals; Autophagy; Brain; Cells, Cultured; Disease Models, Animal; Gene Knock-In Techniques; Huntingtin Protein; Huntington Disease; Male; Maze Learning; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Peptides; Proline; Protein Domains; Sequence Deletion | 2017 |
N-Acetylated Proline-Glycine-Proline Accelerates Cutaneous Wound Healing and Neovascularization by Human Endothelial Progenitor Cells.
Topics: Administration, Topical; Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelial Progenitor Cells; Mice, Knockout; Mice, Nude; Neovascularization, Physiologic; Oligopeptides; Proline; Rats; Receptors, Interleukin-8B; Treatment Outcome; Wound Healing; Wounds and Injuries | 2017 |
Semax, an analog of ACTH
Topics: Adrenocorticotropic Hormone; Animals; Antigen Presentation; Brain Ischemia; Disease Models, Animal; Gene Expression Profiling; Genes, Immunoglobulin Heavy Chain; Immunoglobulin Heavy Chains; Male; Middle Cerebral Artery; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Proline; Rats; Rats, Wistar; Stress, Physiological; Transcriptome | 2017 |
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.
Topics: Animals; Antibodies; Antibody Specificity; Brain; Cell Line, Transformed; Disease Models, Animal; Epitope Mapping; Humans; Huntingtin Protein; Immunoglobulin Variable Region; In Vitro Techniques; Luminescent Proteins; Mutation; Nerve Tissue Proteins; Neurotoxicity Syndromes; Nuclear Proteins; Penicillamine; Peptides; Proline; Protein Binding; Protein Structure, Tertiary; Transfection | 2008 |
A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Camellia sinensis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Food; Kidney; Liver; Lysine; Male; Mice; Mice, Inbred ICR; Organ Size; Plant Extracts; Proline | 2008 |
Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
Topics: Animals; Aorta, Abdominal; Apoptosis; Carotid Artery Injuries; Cell Cycle; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperplasia; Male; Metabolic Syndrome; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Proline; Rats; Rats, Zucker; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Triazenes; Tyrosine | 2008 |
Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in rats.
Topics: Analysis of Variance; Animals; Antibodies; Antioxidants; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; Interleukin-6; Male; NF-kappaB-Inducing Kinase; Pain Measurement; Pain Threshold; Proline; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Temporomandibular Joint; Temporomandibular Joint Disorders; Thiocarbamates; Up-Regulation | 2009 |
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy.
Topics: Animals; Animals, Newborn; Arginine; Biophysics; Calcium Channels, T-Type; Cell Line, Transformed; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Exons; Humans; In Vitro Techniques; Membrane Potentials; Models, Molecular; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Point Mutation; Proline; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Transgenic; Seizures; Transfection | 2009 |
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzamides; Dipeptides; Disease Models, Animal; Drug Discovery; Gap Junctions; Mice; Peptide Library; Proline; Structure-Activity Relationship | 2009 |
Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Concanavalin A; Dimethyl Sulfoxide; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Interleukin-10; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Proline; Thiocarbamates; Thiourea; Tumor Necrosis Factor-alpha | 2010 |
The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Benzamides; Connexin 43; Dipeptides; Disease Models, Animal; Dogs; Electric Conductivity; Female; Gap Junctions; Heart Atria; Heart Conduction System; Male; Molecular Structure; Oligopeptides; Pericarditis; Postoperative Complications; Proline; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological | 2009 |
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Pathways; Proline; Septum of Brain; Serine; Stilbamidines; tau Proteins; Valine | 2009 |
Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.
Topics: Analysis of Variance; Animals; Axons; Bacterial Proteins; Disease Models, Animal; Humans; Inclusion Bodies; Intercellular Signaling Peptides and Proteins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Nerve Tissue Proteins; Neurofilament Proteins; Ophthalmoscopy; Organ Culture Techniques; Phosphorylation; Proline; Retinal Ganglion Cells; Serine; tau Proteins; Tauopathies | 2011 |
Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects.
Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Anti-Asthmatic Agents; Asthma; CHO Cells; Citrus; Cough; Cricetinae; Cricetulus; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Female; Guinea Pigs; In Vitro Techniques; Plant Extracts; Proline; Synephrine | 2009 |
Central l-proline attenuates stress-induced dopamine and serotonin metabolism in the chick forebrain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Chickens; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Drug Administration Routes; Electrochemistry; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Proline; Restraint, Physical; Serotonin; Stress, Psychological | 2009 |
Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Benzamides; Disease Models, Animal; Dogs; Drug Discovery; Gap Junctions; Mice; Proline; Rats; Structure-Activity Relationship; Tachycardia, Ventricular | 2009 |
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.
Topics: Alkylation; Animals; Apoptosis; Disease Models, Animal; Echocardiography; Fatty Acids; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophil Infiltration; Nitric Oxide; Proline; Thiocarbamates; Transcription Factor RelA | 2010 |
GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.
Topics: Animals; Anti-Arrhythmia Agents; Benzamides; Coronary Circulation; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proline; Tachycardia, Ventricular; Time Factors; Ventricular Premature Complexes | 2009 |
Loss of responses to visual but not electrical stimulation in ganglion cells of rats with severe photoreceptor degeneration.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Animals, Newborn; Disease Models, Animal; Electric Stimulation; Histidine; Light; Membrane Proteins; Mutation; Perilipin-2; Photoreceptor Cells; Proline; Rats; Rats, Sprague-Dawley; Reaction Time; Retinal Degeneration; Retinal Ganglion Cells | 2009 |
Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzamides; Cardiac Pacing, Artificial; Connexin 43; Disease Models, Animal; Dogs; Fibrosis; Gap Junctions; Heart Atria; Heart Conduction System; Immunohistochemistry; Proline; Refractory Period, Electrophysiological | 2009 |
Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.
Topics: Animals; Bufanolides; Canrenone; Cardiomyopathies; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Drug Interactions; Endomyocardial Fibrosis; Fibroblasts; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Ouabain; Procollagen; Proline; Rats; Renal Insufficiency; Spironolactone; Tritium; Uremia | 2009 |
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.
Topics: Adult; Aged; Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Chemokine CXCL16; Chemokine CXCL6; Chemokines, CXC; Chronic Disease; Collagen; Disease Models, Animal; Enzyme Activation; Extracellular Matrix; Female; Fibroblasts; Heart Failure; Heart Ventricles; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Middle Aged; Myocytes, Cardiac; Proline; Rats; Rats, Wistar; Receptors, Scavenger; RNA, Messenger; Up-Regulation; Ventricular Remodeling | 2009 |
Early behavioural markers of disease in P301S tau transgenic mice.
Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Cues; Disease Models, Animal; Exploratory Behavior; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Proline; Rotarod Performance Test; Serine; Spinal Cord; tau Proteins; Tauopathies; Visual Perception; Vocalization, Animal | 2010 |
Retinal metabolic state of the proline-23-histidine rat model of retinitis pigmentosa.
Topics: Adenosine Triphosphate; Age Factors; Animals; Apoptosis; Ca(2+) Mg(2+)-ATPase; Coumaric Acids; Creatine; Creatine Kinase; Disease Models, Animal; Disease Progression; Energy Metabolism; Histidine; L-Lactate Dehydrogenase; Membrane Transport Proteins; Monocarboxylic Acid Transporters; Mutation; Phosphocreatine; Phosphodiesterase Inhibitors; Piperazines; Proline; Purines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retina; Retinitis Pigmentosa; Sensory Rhodopsins; Sildenafil Citrate; Sodium-Potassium-Exchanging ATPase; Sulfones | 2010 |
'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Doxycycline; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Proline; Protein Structure, Tertiary; tau Proteins; Tauopathies | 2010 |
Proline impairs energy metabolism in cerebral cortex of young rats.
Topics: Age Factors; Aging; alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Brain Diseases, Metabolic; Cerebral Cortex; Disease Models, Animal; Drug Synergism; Energy Metabolism; Lipid Peroxidation; Oxidative Stress; Proline; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2010 |
Expressions of lymphotactin and its receptor, XCR, in Lewis rats with experimental autoimmune anterior uveitis.
Topics: Animals; Aqueous Humor; Autoimmune Diseases; Ciliary Body; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation; Immunoenzyme Techniques; Iris; Lymph Nodes; Lymphokines; NF-kappa B; Polymerase Chain Reaction; Proline; Rats; Rats, Inbred Lew; Receptors, CXCR; RNA, Messenger; Sialoglycoproteins; Thiocarbamates; Up-Regulation; Uveitis, Anterior | 2010 |
Cell-mediated neuroprotection in a mouse model of human tauopathy.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Transplantation; Cell- and Tissue-Based Therapy; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Growth Factor; Nerve Tissue Proteins; Neurons; Oligodendrocyte Transcription Factor 2; Proline; RNA, Messenger; Serine; Stem Cells; tau Proteins; Tauopathies | 2010 |
Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.
Topics: Animals; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, Animal; Female; Lung; Male; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neutrophils; Nicotiana; Oligopeptides; Proline; Prolyl Oligopeptidases; Pulmonary Emphysema; Serine Endopeptidases; Smoke; Smoking | 2011 |
Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; DNA Transposable Elements; Drosophila melanogaster; Female; Male; Mitochondria; Proline; Proline Oxidase; Sequence Deletion; Survival Analysis | 2011 |
Mutational and transcriptional analyses of the Staphylococcus aureus low-affinity proline transporter OpuD during in vitro growth and infection of murine tissues.
Topics: Amino Acid Transport Systems, Neutral; Animals; Betaine; Disease Models, Animal; DNA Mutational Analysis; Gene Expression Profiling; Mice; Mutant Proteins; Mutation, Missense; Proline; Rodent Diseases; Staphylococcal Infections; Staphylococcus aureus; Transcription, Genetic; Urinary Tract; Urinary Tract Infections | 2011 |
Anti-arthritic active fraction of Capparis spinosa L. fruits and its chemical constituents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capparis; Disease Models, Animal; Ethanol; Female; Male; Mice; Mice, Inbred ICR; Plant Extracts; Proline; Rats; Rats, Wistar; Water | 2011 |
Developmental cardiac hypertrophy in a mouse model of prolidase deficiency.
Topics: Animals; Cardiomegaly; Cell Size; Cloning, Molecular; Disease Models, Animal; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Heart; Mice; Mice, Inbred C3H; Mice, Inbred CBA; Mutation; Myocytes, Cardiac; Phenotype; Prolidase Deficiency; Proline; Zebrafish | 2011 |
Role of antioxidants on Na(+),K (+)-ATPase activity and gene expression in cerebral cortex of hyperprolinemic rats.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Cerebral Cortex; Disease Models, Animal; Drug Synergism; Gene Expression; Humans; Lipid Peroxidation; Oxidative Stress; Proline; Proline Oxidase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptic Membranes; Thiobarbituric Acid Reactive Substances; Vitamin E | 2011 |
Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.
Topics: Animals; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Proline; Receptors, Interleukin-8B; Sepsis | 2011 |
Effects of the group II mGlu receptor agonist 2R,4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury.
Topics: Animals; Brain Injuries; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; Male; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2011 |
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Topics: Animals; Animals, Genetically Modified; Cell Count; Cytoskeletal Proteins; Disease Models, Animal; Doxycycline; Environment; Gene Expression Regulation; Hippocampus; Indoles; Leucine; Mice; Mutation; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Proline; RNA, Messenger; tau Proteins; Tauopathies | 2011 |
Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Disease Models, Animal; Female; Functional Laterality; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Humans; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Stem Cells; Phosphorylation; Proline; Serine; Stem Cell Transplantation; tau Proteins; Tauopathies; Time Factors | 2011 |
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics | 2011 |
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Dopamine; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Mutation; Neurons; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, trkB; Time Factors | 2011 |
Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Count; Disease Models, Animal; Down-Regulation; Immunohistochemistry; In Situ Nick-End Labeling; Male; Matrix Metalloproteinase 9; Optic Nerve; Proline; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Ganglion Cells; Thiocarbamates | 2011 |
Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Animals; Antipsychotic Agents; Anxiety; Disease Models, Animal; Drug Interactions; Female; Haloperidol; Locomotion; Male; Proline; Proline Oxidase; Social Behavior; Sulpiride; Time Factors; Zebrafish | 2012 |
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Disease Models, Animal; Grape Seed Extract; Humans; Leucine; Male; Mice; Mice, Transgenic; Molecular Weight; Mutation; Polyphenols; Proline; Psychomotor Performance; Spinal Cord; tau Proteins; Tauopathies | 2012 |
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Homocysteine; Infusions, Intraventricular; Male; Metalloporphyrins; Proline; Rats; Rats, Wistar; Seizures; Statistics, Nonparametric; Superoxides; Time Factors | 2012 |
Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.
Topics: Animals; Blotting, Northern; Codon; Disease Models, Animal; Electroretinography; Gene Expression Regulation; Gene Knock-In Techniques; Genotyping Techniques; Green Fluorescent Proteins; Histidine; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mutagenesis, Site-Directed; Mutation; Proline; Recombinant Fusion Proteins; Retinal Photoreceptor Cell Inner Segment; Retinal Photoreceptor Cell Outer Segment; Retinitis Pigmentosa; Rhodopsin | 2011 |
The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; DNA Primers; Female; Flow Cytometry; Genes, p53; Immunohistochemistry; Lymphangiogenesis; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pancreatic Neoplasms; Polymerase Chain Reaction; Proline | 2012 |
Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.
Topics: Age Factors; Animals; Bacterial Proteins; Brain; Cells, Cultured; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Female; Humans; Leucine; Luminescent Proteins; Male; Mice; Mice, Transgenic; Neurons; Phosphorylation; Proline; Synaptosomes; tau Proteins | 2011 |
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leucine; Male; Mutation; Neuroblastoma; Okadaic Acid; Pentylenetetrazole; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Selenic Acid; Selenium Compounds; tau Proteins; Time Factors; Transfection | 2012 |
Dysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Disease Models, Animal; Histidine; Mutation; Nerve Regeneration; Proline; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinitis Pigmentosa; Rhodopsin; Xenopus laevis | 2012 |
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Frontal Lobe; Hippocampus; Humans; Isomerism; Mice; Mice, Inbred C57BL; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Proline; tau Proteins | 2012 |
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Topics: Administration, Oral; Amides; Amidohydrolases; Animals; Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Disease Models, Animal; Haemophilus influenzae; Humans; Injections, Intravenous; Microbial Sensitivity Tests; Models, Molecular; Proline; Rats; Respiratory Tract Infections; Streptococcus pneumoniae; Structure-Activity Relationship | 2012 |
Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
Topics: Animals; Appetite; Appetite Depressants; Bradykinin; Carboxypeptidases; Cell Line; Disease Models, Animal; Fibrinolytic Agents; Humans; Mice; Mice, Inbred C57BL; Nitric Oxide; Prekallikrein; Proline; Protease Inhibitors; Thrombosis | 2012 |
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; NIMA-Interacting Peptidylprolyl Isomerase; Oxidation-Reduction; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Processing, Post-Translational; Proteome; Serine; tau Proteins; Tauopathies | 2013 |
Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Behavior, Animal; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Intracellular Space; Mice; Mice, Transgenic; Molecular Sequence Data; Nerve Tissue Proteins; Nuclear Proteins; Phosphorylation; Proline; Proline-Rich Protein Domains; Sequence Deletion | 2012 |
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Topics: Animals; Brain; CD59 Antigens; Disease Models, Animal; Green Fluorescent Proteins; Humans; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Phosphorylation; Proline; Receptors, Complement; Signal Transduction; tau Proteins; Tauopathies | 2012 |
CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism.
Topics: Abscess; Animals; Bacterial Proteins; Disease Models, Animal; Genome, Bacterial; Kidney Diseases; Mice; Mutation; Proline; Staphylococcal Infections; Staphylococcus aureus; Transcription Factors | 2012 |
Effect of NF-κB inhibitor PDTC on a herpetic stromal keratitis mouse model.
Topics: Animals; Anti-Inflammatory Agents; Cornea; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Herpesvirus 1, Human; Interleukin-12; Interleukin-1beta; Interleukin-4; Interleukin-6; Keratitis, Herpetic; Mice; Mice, Inbred BALB C; Neutrophils; NF-kappa B; Proline; Thiocarbamates; Ultraviolet Rays | 2012 |
Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.
Topics: Amino Acid Sequence; Animals; Cell Line; Disease Models, Animal; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Multiple System Atrophy; Oncogene Proteins; Parkinson Disease; Peroxiredoxins; Point Mutation; Proline; Protein Deglycase DJ-1; Protein Stability; Protein Structure, Quaternary; Rats; Transfection | 2013 |
Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Bacterial Infections; Cecum; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Interleukin-10; Interleukin-6; Kinetics; Lipopolysaccharides; Male; Nitrogen Oxides; Proline; Punctures; Rats; Rats, Wistar; Sepsis; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
Genetic factors in idiopathic pulmonary fibrosis: transforming growth factor-beta implicated at last.
Topics: Animals; Codon; Disease Models, Animal; Disease Progression; Exons; Humans; Polymorphism, Genetic; Proline; Pulmonary Fibrosis; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Selective opening of the blood-tumor barrier by a nitric oxide donor and long-term survival in rats with C6 gliomas.
Topics: Animals; Antineoplastic Agents; Blood; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Carboplatin; Carotid Artery, Internal; Disease Models, Animal; Glioma; Injections, Intra-Arterial; Injections, Intravenous; Male; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Proline; Rats; Rats, Sprague-Dawley; Survival Rate; Time Factors | 2003 |
Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
Topics: Acetylcholine; Adrenocorticotropic Hormone; Animals; Animals, Outbred Strains; Disease Models, Animal; Injections, Intraperitoneal; Male; Mast Cells; Mesentery; Oligopeptides; Peptide Fragments; Proline; Rats; Stress, Psychological | 2003 |
A model of chronic heart failure in spontaneous hypertensive rats (SHR).
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Heart Failure; Heart Rate; Hydroxyproline; Hypertrophy, Left Ventricular; Lung; Magnetic Resonance Imaging; Male; Myocardial Contraction; Myocardial Infarction; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2004 |
Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1).
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Line, Tumor; Disease Models, Animal; DNA Primers; DNA-Binding Proteins; Genetic Markers; Genetic Predisposition to Disease; Genetic Variation; Immunity, Innate; Lymphoma; Mice; Mice, Inbred BALB C; Neoplasms, Radiation-Induced; Polymorphism, Single Nucleotide; Proline; Serine; Thymus Neoplasms; Transcription Factor MTF-1; Transcription Factors; Transfection | 2005 |
[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].
Topics: Acetic Acid; Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Injections, Intraperitoneal; Male; Oligopeptides; Proline; Protective Agents; Rats; Stomach Ulcer | 2004 |
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Topics: Age Factors; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Movement Disorders; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Proline; Synucleins; tau Proteins | 2005 |
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.
Topics: Alanine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Proline; Synucleins | 2005 |
Synthesis of alveolar bone Sharpey's fibers during experimental tooth movement in the rat.
Topics: Alveolar Process; Animals; Autoradiography; Bone Matrix; Collagen; Disease Models, Animal; Female; Maxilla; Periodontium; Proline; Rats; Rats, Sprague-Dawley; Tooth; Tooth Movement Techniques; Tritium; Ultrasonography | 2005 |
Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Hippocampus; Indazoles; Male; NF-kappa B; Nitric Oxide; Piperazines; Proline; Purines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sildenafil Citrate; Stress Disorders, Post-Traumatic; Sulfones; Thiocarbamates | 2005 |
Chronic hyperprolinemia provokes a memory deficit in the Morris water maze task.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Chronic Disease; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Proline; Rats; Rats, Wistar; Reaction Time | 2005 |
Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis.
Topics: Animals; Aqueous Humor; Autoimmune Diseases; Cattle; Chemokine CX3CL1; Chemokines, CX3C; Ciliary Body; CX3C Chemokine Receptor 1; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Immunohistochemistry; Iris; Leukocytes; Melanins; Membrane Proteins; NF-kappa B; Proline; Rats; Rats, Inbred Lew; Receptors, Cytokine; Receptors, HIV; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Up-Regulation; Uveitis, Anterior | 2005 |
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
Topics: Animals; Antioxidants; Calcium-Binding Proteins; Cell Count; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; HIV Envelope Protein gp120; Immunohistochemistry; In Situ Hybridization; Male; Microfilament Proteins; NF-kappa B; Pain; Pain Measurement; Peptides; Platelet Endothelial Cell Adhesion Molecule-1; Proline; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiocarbamates; Time Factors | 2005 |
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antioxidants; Arthritis; Cholesterol; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Female; Inflammation; Pipecolic Acids; Proline; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triglycerides | 2006 |
Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues.
Topics: Amino Acid Transport Systems, Neutral; Animals; Bacterial Proteins; Blotting, Northern; Disease Models, Animal; Gene Expression Regulation, Bacterial; Humans; Lac Operon; Mice; Osmolar Concentration; Proline; Recombinant Fusion Proteins; Staphylococcal Infections; Staphylococcus aureus; Symporters; Transcriptional Activation | 2006 |
Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice.
Topics: Animals; Blotting, Western; Body Weight; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Forelimb; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; NF-kappa B; Proline; Regeneration; Thiocarbamates | 2006 |
Glutamate-related gene expression changes with age in the mouse auditory midbrain.
Topics: Aging; Animals; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Female; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Inferior Colliculi; Male; Mice; Mice, Inbred CBA; Neurotoxins; Oligonucleotide Array Sequence Analysis; Ornithine-Oxo-Acid Transaminase; Presbycusis; Proline; Up-Regulation | 2007 |
L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Topics: Animals; Burns, Chemical; Chemotactic Factors; Chemotaxis, Leukocyte; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Burns; Female; Humans; Isomerism; Male; Neutrophils; Oligopeptides; Proline; Rabbits; Sodium Hydroxide | 2006 |
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Arginine; Bone Marrow Cells; Bone Resorption; CD11b Antigen; Cell Differentiation; Cherubism; Disease Models, Animal; Hematologic Diseases; Homozygote; Inflammation; Intracellular Signaling Peptides and Proteins; Lymph Nodes; Macrophage Colony-Stimulating Factor; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Myeloid Cells; Osteoclasts; Phosphorylation; Proline; Protein-Tyrosine Kinases; RANK Ligand; Spleen; Syk Kinase; Tumor Necrosis Factor-alpha | 2007 |
Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Catechin; Dietary Supplements; Disease Models, Animal; Female; Liver Neoplasms, Experimental; Lysine; Mice; Mice, Inbred A; Neuroblastoma; Proline | 2008 |
Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin.
Topics: Animals; Animals, Genetically Modified; Cattle; Cell Line, Transformed; Darkness; Disease Models, Animal; Gene Expression Regulation; Histidine; Humans; Mice; Microscopy, Electron, Scanning; Mutation; Peptide Fragments; Proline; Retinal Rod Photoreceptor Cells; Retinaldehyde; Retinitis Pigmentosa; Rhodopsin; Transfection; Xenopus laevis | 2007 |
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
Topics: Age Factors; Analysis of Variance; Animals; Antibodies; Behavior, Animal; Brain; Cell Line, Tumor; Dementia; Disease Models, Animal; Humans; Immunotherapy; Leucine; Mice; Mice, Transgenic; Motor Activity; Neuroblastoma; Proline; Psychomotor Performance; Recognition, Psychology; Sex Factors; tau Proteins | 2007 |
Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia.
Topics: Animals; Apoptosis; Carotid Arteries; Carotid Artery Injuries; Cell Death; Cell Proliferation; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Endothelium, Vascular; Gels; Hyperplasia; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanotechnology; Nitric Oxide; Nitric Oxide Donors; Proline; Rats; Rats, Sprague-Dawley; Time Factors; Tunica Intima | 2008 |
A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.
Topics: Acrocephalosyndactylia; Animals; Arginine; Biomimetics; Cells, Cultured; Chondrogenesis; Disease Models, Animal; Humans; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Ossification, Heterotopic; Osteogenesis; Proline; Receptor, Fibroblast Growth Factor, Type 2; Skeleton | 2008 |
Metachromatic leukodystrophy: genetics, pathogenesis and therapeutic options.
Topics: Animals; Disease Models, Animal; Hematopoietic Stem Cell Transplantation; Humans; Leucine; Leukodystrophy, Metachromatic; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Proline | 2008 |
The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Cross-Linking Reagents; Disease Models, Animal; Free Radical Scavengers; Male; Melatonin; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proline; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha | 2008 |
Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.
Topics: Animals; Cell Count; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ileum; Myenteric Plexus; Nerve Tissue Proteins; Neurons; Odds Ratio; Oligopeptides; Prions; Proline; Scrapie; Sheep; Somatostatin; Time Factors; Vasoactive Intestinal Peptide | 2008 |
Antihypertensive activity of captopril (SQ 14,225), an orally active inhibitor of angiotensin converting enzyme in conscious two-kidney perinephritic hypertensive dogs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Hypertension, Renal; Male; Perinephritis; Proline; Renin | 1981 |
Effect of converting enzyme and angiotensin II inhibitors in chronic one kidney bipolar ligated hypertension.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Hypertension, Renal; Hypertension, Renovascular; Male; Proline; Rats; Renin | 1981 |
Hepatic collagen synthesis in a rat model of cirrhosis, and its modification by colchicine.
Topics: Animals; Colchicine; Collagen; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; Procollagen-Proline Dioxygenase; Proline; Rats; Rats, Inbred Strains | 1981 |
Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse.
Topics: Animals; Collagen; Disease Models, Animal; DNA; Hydroxyproline; Mice; Mice, Mutant Strains; Organ Culture Techniques; Proline; Scleroderma, Systemic; Skin | 1984 |
[An experimental model of osteoarthritis. II.- Biochemical study of collagen and proteoglycans].
Topics: Animals; Cartilage, Articular; Chemical Phenomena; Chemistry; Collagen; Disease Models, Animal; Hydroxyproline; Osteoarthritis; Papain; Proline; Proteoglycans; Rabbits | 1984 |
Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.
Topics: Animals; Biological Transport; Cell-Free System; Disease Models, Animal; Dogs; Fanconi Syndrome; Female; Glucose; Kidney; Kinetics; Male; Microvilli; Proline | 1981 |
Vasodepressor property of the converting enzyme inhibitor captopril (SQ 14 225): the role of factors other than renin-angiotensin blockade in the rat.
Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Captopril; Disease Models, Animal; Female; Hypertension; Nephrectomy; Proline; Rats; Renin; Saralasin | 1980 |
Decreased luminal membrane transport of phosphate in chronic renal failure.
Topics: Animals; Biological Transport; Disease Models, Animal; Dogs; Glucose; Kidney Failure, Chronic; Kidney Tubules, Proximal; Kinetics; Microvilli; Parathyroid Glands; Phosphates; Proline; Sodium | 1982 |
Neonatal iminoglycinuria: evidence that the prolinuria originates in selective deficiency of transport activity in the proximal nephron.
Topics: Animals; Biological Transport; Disease Models, Animal; Dogs; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney; Kidney Tubules; Nephrons; Proline; Rats; Rats, Inbred Strains | 1982 |
Effect of crilvastatin, a new cholesterol lowering agent, on unesterified LDL-cholesterol metabolism into bile salts by rat isolated hepatocytes.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Binding Sites; Cells, Cultured; Cholesterol, LDL; Culture Media; Disease Models, Animal; Emulsions; Hypercholesterolemia; Liver; Male; Micelles; Proline; Rats; Rats, Wistar | 1995 |
Enhanced gamma-aminobutyric acid-mediated responses in nucleus tractus solitarius of hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Analysis of Variance; Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Glutamates; Glutamic Acid; Heart Rate; Hypertension; Male; Neurotransmitter Agents; Nipecotic Acids; Organophosphorus Compounds; Pressoreceptors; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, GABA-B; Sodium Chloride; Solitary Nucleus; Vigabatrin | 1993 |
Effect of prenatal dexamethasone administration: fetal rabbit intestinal nutrient uptake and disaccharidase development.
Topics: Analysis of Variance; Animals; Dexamethasone; Disaccharidases; Disease Models, Animal; Embryonic and Fetal Development; Enterocolitis, Pseudomembranous; Female; Fetal Growth Retardation; Fetal Organ Maturity; Glucose; Intestinal Absorption; Intestine, Small; Maternal-Fetal Exchange; Microvilli; Pregnancy; Proline; Rabbits | 1994 |
Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease.
Topics: Animals; Benzopyrans; Bone and Bones; Bone Development; Collagen; Deficiency Diseases; Disease Models, Animal; Female; Glycosylation; Hydroxylation; Knee Joint; Lysine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Proline; Protein Denaturation; Protein Processing, Post-Translational; Reproduction; Selenium; Skin; Tensile Strength; Tibia; Trypsin | 1993 |
Intra-abdominal sepsis impairs colonic reparative collagen synthesis.
Topics: Abdomen; Anastomosis, Surgical; Animals; Blotting, Northern; Collagen; Colon; Disease Models, Animal; Gene Expression; Infections; Male; Proline; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA; Wound Healing | 1996 |
A serine-to-proline mutation in the copper-transporting P-type ATPase gene of the macular mouse.
Topics: Adenosine Triphosphatases; Animals; Carrier Proteins; Cation Transport Proteins; Copper-Transporting ATPases; Deoxyribonuclease BamHI; Disease Models, Animal; Female; Homozygote; Humans; Male; Menkes Kinky Hair Syndrome; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Point Mutation; Proline; Recombinant Fusion Proteins; Sequence Analysis, DNA; Serine | 1997 |
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Male; Mice; Morpholines; Phenytoin; Proline; Rats; Rats, Sprague-Dawley; Valproic Acid | 1997 |
Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice.
Topics: Animals; Antigens, Fungal; Cell Division; Cells, Cultured; Coccidioidomycosis; Disease Models, Animal; Drug Evaluation; Female; Fungal Proteins; Fungal Vaccines; Gene Expression; Glycoproteins; Mice; Mice, Inbred BALB C; Proline; T-Lymphocytes; Vaccines, Synthetic | 1998 |
Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.
Topics: Animals; Animals, Genetically Modified; Dependovirus; Disease Models, Animal; Genes, Dominant; Genetic Therapy; Histidine; Photoreceptor Cells; Point Mutation; Proline; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Retinal Rod Photoreceptor Cells; Retinitis Pigmentosa; Rhodopsin; RNA, Catalytic; Rod Opsins | 1998 |
Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Naphthalenes; Nerve Fibers; Neuralgia; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Proline; Receptors, Neurokinin-1; Spinal Cord | 1998 |
Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome.
Topics: Acidosis; Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypotension; Infusions, Intravenous; Interleukin-1; NF-kappa B; Proline; Pyrrolidines; Rabbits; Random Allocation; Systemic Inflammatory Response Syndrome; Thiocarbamates | 1999 |
A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Bacterial Proteins; Cadherins; Cell Line; Disease Models, Animal; Endocytosis; Female; Guinea Pigs; Humans; Listeria monocytogenes; Listeriosis; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Phylogeny; Proline; Protein Binding; Rats; Recombinant Fusion Proteins; Species Specificity | 1999 |
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines | 2000 |
Total synthesis and antifungal evaluation of cyclic aminohexapeptides.
Topics: Acute Disease; Amines; Amphotericin B; Animals; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Dose-Response Relationship, Drug; Echinocandins; Female; Fungal Proteins; Mice; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Proline; Solubility; Structure-Activity Relationship; Yeasts | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; Immunoassay; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thiocarbamates; Tyrosine; Vasodilation | 2000 |
Antioxidant therapy attenuates JNK activation and apoptosis in the remote noninfarcted myocardium after large myocardial infarction.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Apoptosis; Disease Models, Animal; Enzyme Activation; Heart; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardium; Oxidative Stress; Probucol; Proline; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2001 |
Inhibition of the initial wave of NF-kappaB activity in rat muscle reduces ischemia/reperfusion injury.
Topics: Active Transport, Cell Nucleus; Animals; Binding, Competitive; Disease Models, Animal; Infusions, Intravenous; Leukocyte Common Antigens; Macrophage-1 Antigen; Male; Muscle, Skeletal; Neutrophils; NF-kappa B; Proline; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Thiocarbamates | 2001 |
AWD 140-190: a potent anticonvulsant in the amygdala-kindling model of partial epilepsy.
Topics: Administration, Oral; Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsies, Partial; Female; Humans; Injections, Intraperitoneal; Kindling, Neurologic; Morpholines; Proline; Rats; Rats, Wistar | 2001 |
Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction.
Topics: Animals; Collagen; Dilatation, Pathologic; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; Female; Fibrosis; Heart Ventricles; Hemodynamics; Hydroxyproline; Myocardial Infarction; Procollagen-Proline Dioxygenase; Proline; Rats; Rats, Wistar; Recovery of Function; Stroke Volume; Ventricular Function, Left | 2001 |
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Topics: Animals; Arginase; Arginine; Cells, Cultured; Disease Models, Animal; Eflornithine; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Granuloma; Interleukin-12; Liver; Liver Cirrhosis; Lung Diseases, Parasitic; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium avium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine Decarboxylase Inhibitors; Ovum; Proline; Schistosomiasis mansoni; Th1 Cells; Th2 Cells; Tuberculosis; Up-Regulation | 2001 |
Role of group II and group III metabotropic glutamate receptors in spinal cord injury.
Topics: Aminobutyrates; Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hyperalgesia; Male; Motor Activity; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating | 2002 |
Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Division; Collagen Type I; Collagen Type III; Collagenases; Disease Models, Animal; Gene Expression; Glycyrrhetinic Acid; Liver Cirrhosis; Plasmids; Procollagen; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thymidine; Tritium | 2001 |
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.
Topics: Acrosin; Animals; Chlorodiphenyl (54% Chlorine); Dimethyl Sulfoxide; Disease Models, Animal; Enzyme Precursors; Female; Fertilization in Vitro; Gene Expression; Infertility; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Oocytes; Proline; Protein Structure, Tertiary; Time Factors; Zona Pellucida | 2002 |
Inhibitors of the renin-angiotensin system in experimental hypertension, with a note on the measurement of angiotensin I, II and III during infusion of converting-enzyme inhibitor.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Dogs; Female; Hypertension, Renal; Male; Oligopeptides; Proline; Rats; Saralasin; Teprotide | 1979 |
Effects of the oral converting enzyme inhibitor, SQ 14225, in a model of low cardiac output in dogs.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Ascites; Blood Pressure; Cardiac Output; Constriction; Creatinine; Disease Models, Animal; Dogs; Edema; Female; Heart Failure; Kidney; p-Aminohippuric Acid; Proline; Renin; Sodium; Vena Cava, Superior | 1979 |
Influence of various antihypertensive agents on lifespan of renal hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diuretics; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Male; Proline; Rats; Sodium Chloride Symporter Inhibitors | 1979 |
An experimental model of hepatic fibrosis induced by the administration of dibutyltin dichloride.
Topics: Animals; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyproline; Liver; Male; Organotin Compounds; Proline; Rats; Time Factors | 1979 |
Synthesis of lung collagen in hamsters with elastase-induced emphysema.
Topics: Animals; Collagen; Cricetinae; Disease Models, Animal; Pancreatic Elastase; Proline; Pulmonary Emphysema; Solubility | 1978 |
Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators.
Topics: Animals; Bone and Bones; Bone Resorption; Disease Models, Animal; Mice; Organ Culture Techniques; Osteoclasts; Osteopetrosis; Parathyroid Hormone; Proline; Vitamin A | 1977 |
Pathogenesis of spontaneous hypertension as a model for essential hypertension.
Topics: Acetylcholinesterase; Animals; Blood Pressure; Brain; Carboxy-Lyases; Disease Models, Animal; Hypertension; Levodopa; Proline; Rats; Renin; Vascular Resistance | 1977 |
Fascioliasis: role of proline in bile duct hyperplasia.
Topics: Animals; Bile Ducts; Biliary Tract Diseases; Disease Models, Animal; Fascioliasis; Hyperplasia; Proline; Rats | 1977 |
Wound healing: a model for the study of diabetic angiopathy.
Topics: Animals; Capillaries; Collagen; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Disease Models, Animal; DNA; DNA Replication; Ear; Fibroblasts; Mice; Microscopy, Electron; Proline; Thymidine; Wound Healing | 1976 |
Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa.
Topics: Animals; Codon; Disease Models, Animal; Electroretinography; Fundus Oculi; Humans; Mice; Mice, Transgenic; Microscopy, Electron; Mutation; Ophthalmoscopy; Photoreceptor Cells; Proline; Restriction Mapping; Retina; Retinal Vessels; Retinitis Pigmentosa; Rhodopsin; Rod Opsins | 1992 |
Lung collagen synthesis and deposition in tight-skin mice with genetic emphysema.
Topics: Animals; Collagen; Disease Models, Animal; Emphysema; Female; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron; Models, Genetic; Proline; Tritium | 1992 |
Therapy and prevention of hypertension of M-SHRSP.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cerebrovascular Disorders; Diet; Disease Models, Animal; Disease Susceptibility; Fish Flour; Hydralazine; Hypertension, Malignant; Male; Organophosphorus Compounds; Proline; Rats; Rats, Inbred SHR | 1991 |
Tetracycline administration restores osteoblast structure and function during experimental diabetes.
Topics: Alkaline Phosphatase; Animals; Calcium-Transporting ATPases; Diabetes Mellitus, Experimental; Disease Models, Animal; Humerus; Male; Minocycline; Osteoblasts; Osteoporosis; Proline; Rats; Rats, Inbred Strains; Tetracyclines | 1991 |
Uptake of labelled proline in the degenerating retina of goldfish.
Topics: Animals; Disease Models, Animal; Goldfish; Neurons; Photoreceptor Cells; Proline; Retina; Retinal Degeneration | 1990 |
Pathogenesis of acute myocardial necrosis in inbred mice infected with coxsackievirus B3.
Topics: Animals; Cardiomyopathies; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Hypersensitivity, Delayed; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Necrosis; Proline; Species Specificity; T-Lymphocytes, Cytotoxic | 1988 |
Early changes in acute cardiac overload: studies on adenyl cyclase activity, cyclic 3'5'-AMP, and myosin synthesis.
Topics: Adenylyl Cyclases; Animals; Collagen; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Heart Ventricles; Lysine; Myocardial Contraction; Myocardial Infarction; Myocardium; Myoglobin; Myosins; Proline | 1972 |
Protein synthesis in vitro by the rat brain in course of experimental cyanide encephalopathy.
Topics: Animals; Brain; Brain Diseases; Cyanides; Demyelinating Diseases; Disease Models, Animal; Female; Hypoxia; Leucine; Male; Myelin Sheath; Nerve Tissue Proteins; Poisoning; Proline; Rats | 1974 |
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine; Haplorhini; Humans; Injections, Intraperitoneal; Leucine; Mice; Oligopeptides; Pargyline; Proline; Reserpine; Secologanin Tryptamine Alkaloids | 1973 |
Animal model for hyperprolinaemia: deficiency of mouse proline oxidase activity.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Mice; Mice, Inbred Strains; Oxidoreductases; Proline; Proteinuria | 1972 |
Metabolic changes in infarcted and non-infarcted myocardium during the postinfarction period.
Topics: Acid Phosphatase; Adenosine Diphosphate; Adenosine Triphosphate; Anabolic Agents; Animals; Disease Models, Animal; Dogs; Glucuronidase; Heart; Heart Ventricles; Lactates; Myocardial Contraction; Myocardial Infarction; Myocardium; Norepinephrine; Phosphocreatine; Proline; Pyruvates; Time Factors | 1972 |
Heparin osteoporosis. An experimental model using rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Collagen; Disease Models, Animal; Female; Fibroblasts; Heparin; Humerus; Hydroxyproline; Hypersensitivity; Injections, Subcutaneous; Leukopenia; Microradiography; Mitosis; Osteoporosis; Proline; Radius; Rats; Tritium; Ulna; Wound Healing | 1973 |
Rebound of rat carrageenin granuloma following cessation of anti-inflammatory steroid therapy.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Collagen; Disease Models, Animal; DNA; Granuloma; Hydrocortisone; Male; Proline; Proteins; Rats; Thymidine; Time Factors; Tritium | 1974 |
Alteration of proline hydroxylase activity by glucocorticoids.
Topics: Adrenalectomy; Animals; Betamethasone; Collagen; Depression, Chemical; Disease Models, Animal; Granuloma; Hydrocortisone; Liver; Lysosomes; Male; Methylprednisolone; Mixed Function Oxygenases; Polyvinyls; Proline; Rats; Triamcinolone | 1971 |
[Behavior of serum amino acids in rats with experimentally produced hyperphenylalaninemia].
Topics: Alanine; Amino Acids; Animals; Disease Models, Animal; Glutamates; Phenylalanine; Proline; Rats; Threonine | 1971 |
Protocollagen proline hydroxylase activity in experimental pulmonary fibrosis of rats.
Topics: Animals; Ascorbic Acid; Collagen; Disease Models, Animal; Hydroxyproline; Iron; Ketoglutaric Acids; Mixed Function Oxygenases; Proline; Pulmonary Fibrosis; Rats; Silicosis | 1970 |