Compounds > proline

proline and DDPAC

proline has been researched along with DDPAC in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (55.56)24.3611
2020's4 (44.44)2.80

Authors

AuthorsStudies
Aburas, J; Brown, AEX; Fleming, AC; Gao, FB; Gendron, TF; Ghadge, G; Gu, Y; Islam, P; Kankel, MW; Kiskinis, E; Kratsios, P; Krishnan, G; Roos, RP; Sonobe, Y; Warren, EC1
Fairman, R; Lee, EB; Nelson, SCK; Viera Ortiz, AP; Zhang, Y1
Babu, M; Becker, S; de Opakua, AI; Favretto, F; Rankovic, M; Zweckstetter, M1
Blair, IP; Cain, AK; Fat, SCM; Fifita, JA; Grima, N; Henden, L; Heng, B; Hogan, AL; Lee, A; Maharjan, R; McCann, EP; Morsch, M; Rayner, S; Tarr, I; Williams, KL; Wright, A; Wu, S; Yang, S; Zhang, KY; Zhang, ZH; Zhao, Q1
Huang, YR; Ji, M; Liu, DQ; Liu, RT; Wang, SW; Xie, XX; Yu, XL; Zhang, LX; Zhang, Y1
Hattori, S; Matsuoka, M; Shibagaki, Y; Suzuki, H1
Barroso, C; Coelho, M; de Mendonça, A; Duyckaerts, C; Martins, M; Miltenberger-Miltenyi, G; Pimentel, J; Pires, C; Valadas, A; Verdelho, A1
Ichida, JK; Krishnamurthy, K; Lin, S; Markandaiah, SS; Monaghan, J; Pandey, UB; Pasinelli, P; Shi, Y; Shneider, NA; Tan, W; Trotti, D; Wen, X; Westergard, T1
Abdelkarim, S; Adamson, G; Clark, CN; Clarke, J; Fisher, EM; Fox, NC; Fratta, P; Howard, R; Lu, CH; Malaspina, A; Mead, S; Morgan, S; Orrell, R; Pittman, A; Plagnol, V; Rohrer, JD; Rossor, MN; Sharma, N; Sidle, K; Warren, JD1

Other Studies

9 other study(ies) available for proline and DDPAC

ArticleYear
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
    Nature communications, 2021, 10-15, Volume: 12, Issue:1

    Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Caenorhabditis elegans; Dipeptides; Female; Frontotemporal Dementia; Gene Editing; Gene Knockdown Techniques; Glycine; HEK293 Cells; Humans; Middle Aged; Motor Neurons; Nerve Degeneration; Proline

2021
C9orf72 proline-arginine dipeptide repeats disrupt the proteasome and perturb proteolytic activities.
    Journal of neuropathology and experimental neurology, 2023, 10-20, Volume: 82, Issue:11

    Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Dipeptides; DNA Repeat Expansion; Drosophila melanogaster; Frontotemporal Dementia; Humans; Proline; Proteasome Endopeptidase Complex; Proteolysis

2023
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis.
    Nature communications, 2021, 06-07, Volume: 12, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Arginine; Biopolymers; Brain; C9orf72 Protein; Catalytic Domain; Crystallography, X-Ray; Dipeptides; DNA Repeat Expansion; Frontotemporal Dementia; Humans; Nuclear Magnetic Resonance, Biomolecular; Peptidylprolyl Isomerase; Proline; Protein Aggregates; Protein Binding; Protein Folding; Recombinant Proteins; Repetitive Sequences, Amino Acid

2021
Splicing factor proline and glutamine rich intron retention, reduced expression and aggregate formation are pathological features of amyotrophic lateral sclerosis.
    Neuropathology and applied neurobiology, 2021, Volume: 47, Issue:7

    Topics: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Glutamine; Humans; Introns; Motor Neurons; Proline; RNA Splicing Factors

2021
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
    Alzheimer's research & therapy, 2018, 06-19, Volume: 10, Issue:1

    Topics: Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Immunologic; Exploratory Behavior; Female; Frontotemporal Dementia; Hepatitis B Vaccines; Immunization; Immunodominant Epitopes; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Proline; Recognition, Psychology; Serine; tau Proteins; Treatment Outcome; Vaccines, Virus-Like Particle

2018
The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.
    Cell death & disease, 2018, 09-24, Volume: 9, Issue:10

    Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Arginine; C9orf72 Protein; Cell Line, Tumor; Cell Survival; DEAD-box RNA Helicases; Dipeptides; Frontotemporal Dementia; HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Microsatellite Repeats; Neurons; Proline; Ribosomes; RNA, Ribosomal

2018
Phenotypic variability of familial and sporadic Progranulin p.Gln257Profs*27 mutation.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 37, Issue:2

    Topics: Aged; DNA Mutational Analysis; Family Health; Female; Frontotemporal Dementia; Glutamine; Humans; Intercellular Signaling Peptides and Proteins; Magnetic Resonance Imaging; Mental Status Schedule; Middle Aged; Mutation; Phenotype; Progranulins; Proline

2013
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
    Neuron, 2014, Dec-17, Volume: 84, Issue:6

    Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Antisense Elements (Genetics); Arginine; C9orf72 Protein; Cell Death; Dipeptides; DNA Repeat Expansion; Drosophila melanogaster; Frontotemporal Dementia; Humans; Motor Neurons; Neurons; Primary Cell Culture; Proline; Protein Aggregation, Pathological; Proteins; Spinal Cord

2014
CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.
    Brain : a journal of neurology, 2016, Volume: 139, Issue:Pt 2

    Topics: Amyotrophic Lateral Sclerosis; Cohort Studies; Frontotemporal Dementia; Genetic Variation; Humans; Mitochondrial Proteins; Mutation; Penetrance; Proline; Serine

2016