Compounds > proline

proline and Carcinoma, Hepatocellular

proline has been researched along with Carcinoma, Hepatocellular in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19909 (16.36)18.7374
1990's6 (10.91)18.2507
2000's8 (14.55)29.6817
2010's22 (40.00)24.3611
2020's10 (18.18)2.80

Authors

AuthorsStudies
Bao, X; Chen, Q; Chen, S; Han, X; Huang, J; Liu, Y; Qiu, Y; Sheng, H; Wang, T; Yin, S; Yu, H; Zhang, C1
Ding, D; Dong, W; Hou, G; Liu, G; Sun, D; Tian, T; Yang, Y; Zhou, W1
Abu-Gharbieh, E; Abushawish, KYI; Al-Hroub, HM; Alzoubi, KH; Bustanji, Y; El-Huneidi, W; Elgendy, SM; Giddey, AD; Mousa, M; Omar, HA; Semreen, MH; Soares, NC; Soliman, SSM1
Adamski, J; Ardanaz, E; Barranco, MR; Bonet, C; Breeur, M; Bueno-de-Mesquita, B; Chirlaque, MD; Dossus, L; Eichelmann, F; Ferrari, P; Grioni, S; Gunter, MJ; Heath, AK; His, M; Jenab, M; Johansson, M; Kaaks, R; Katzke, V; Keski-Rahkonen, P; Keun, H; Key, TJ; Kyrø, C; Laouali, N; Manjer, J; Muller, D; Nøst, TH; Olsen, KS; Overvad, K; Palli, D; Panico, S; Quirós, JR; Rentoft, M; Rinaldi, S; Rothwell, JA; Sacerdote, C; Sandanger, TM; Sandsveden, M; Scalbert, A; Schmidt, JA; Schulze, MB; Severi, G; Tjønneland, A; Travis, RC; Tsilidis, K; Tumino, R; Viallon, V; Vidman, L1
Bartosch, B; Fedorov, VS; Golikov, MV; Ivanov, AV; Ivanova, ON; Kochetkov, SN; Krasnov, GS; Kudryavtseva, AV; Snezhkina, AV; Valuev-Elliston, VT; Zakirova, NF1
Biondi, B; Brustolin, L; Fregona, D; Marchiò, L; Nardon, C; Pettenuzzo, N; Pontisso, P; Quarta, S1
Chow, P; Denil, S; Ding, Z; Ericksen, RE; Escande-Beillard, N; Gruenewald, S; Haegebarth, A; Han, W; Lee, QY; Loh, A; Reversade, B; Steckel, M; Toh, HC; Wai Ho, TS1
Chung, RT; Holmes, JA1
Aguilar, H; Asatryan, A; Bondin, M; Cacoub, P; Carvalho, A; Castro, RE; Charafeddine, M; Cohen, DE; Dieterich, D; Felizarta, F; Hu, YB; Khan, N; Marinho, RT; Poordad, F; Siddique, A1
Chen, X; Yan, N1
Bondin, M; Brown, A; Burroughs, M; Chayama, K; Dylla, DE; Emmett, A; Feld, JJ; Forns, X; Gordon, SC; Heo, J; Hou, J; Jacobson, IM; Lampertico, P; Marcinak, J; Pol, S; Tatsch, F; Zhang, Z1
Rostkowska, K; Simon, K; Szymanek-Pasternak, A1
Fang, C; Gao, P; Geng, P; Guo, L; Hu, C; Li, E; Liu, Y; Sun, M; Tang, L; Wang, C; Wang, J; Wang, Y; Xu, G; Yin, P; Yu, J; Zeng, J; Zhuang, Z1
Berak, H; Białkowska, J; Bolewska, B; Fleischer-Stępniewska, K; Flisiak, R; Garlicki, A; Janczewska, E; Karpińska, E; Karwowska, K; Nazzal, K; Piekarska, A; Simon, K; Tomasiewicz, K; Tronina, O; Tuchendler, E; Zarębska-Michaluk, D; Łucejko, M1
Giménez-Manzorro, A; Herranz-Alonso, A; Matilla-Peña, A; Revuelta-Herrero, JL; Sanjurjo-Sáez, M1
Baicus, C; Constantinescu, I; Diculescu, M; Dumitru, R; Gavrila, D; Istratescu, D; Manuc, M; Manuc, T; Oproiu, A; Preda, CM; Sandra, I; Tieranu, C; Vasilescu, C; Voiosu, T1
Bublak, R1
Liu, CJ1
Bukh, J; Gottwein, JM; Humes, D; Jensen, SB; Li, YP; Ramirez, S1
Dekio, F; Malik, S; Wen, JW1
Hou, L; Jiang, L; Lu, X; Ma, P; Shi, Y; Yao, M; Zhang, P1
Feng, XD; Li, RQ; Wang, L; Zhang, Y; Zhang, YH1
Andreone, P; Gamal, N; Vitale, G1
Antonov, K; Atanasova, E; Boyanova, Y; Jelev, D; Krastev, Z; Mateva, L; Petkova, T; Tomov, B; Zheleva, N1
Johnson, S; Marx, SE; Misurski, D; Parisé, H; Saab, S; Sanchez Gonzalez, Y; Virabhak, S; Wang, A1
Gonzalez, YS; Johnson, S; Juday, T; Misurski, D; Parisé, H; Saab, S; Virabhak, S; Wang, A1
Alric, L; Anty, R; Beaulieux, F; Botta-Fridlund, D; Bouix, C; Canva, V; Carrieri, MP; Conti, F; D'Alteroche, L; Duclos-Vallée, JC; Durand, F; Duvoux, C; Fontaine, H; Lebray, P; Leroy, V; Maynard, M; Métivier, S; Pageaux, GP; Paul, C; Petrov-Sanchez, V; Pradat, P; Roche, B; Roque-Afonso, AM; Samuel, D; Vilotitch, A; Wellems, C1
Albillos, A; Ampuero, J; Arenas, J; Bañares, R; Calleja, JL; Crespo, J; Diago, M; Fernandez, I; García-Eliz, M; García-Samaniego, J; Gea, F; Jorquera, F; Lens, S; Llaneras, J; Llerena, S; Mariño, Z; Morillas, RM; Muñoz, R; Navascues, CA; Pascasio, JM; Perelló, C; Rincón, D; Rodriguez, CF; Ruiz-Antorán, B; Sacristán, B; Serra, MA; Simon, MA; Torras, X; Turnes, J1
Pár, A; Pár, G1
Feng, JL; Li, GP; Pu, ZJ; Su, JD; Wei, BL; Wu, LF; Ye, YQ1
Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW1
Bukh, J; Ghanem, L; Gottwein, JM; Jensen, TB; Scheel, TK1
Francque, S; Ho, E; Michielsen, P1
BAUER, JM; WU, C1
PERAINO, C; PITOT, HC1
Hsu, JM; Huang, CY; Lee, YC; Yu, CT1
Cong, WM; Dong, H; Liu, SF; Wu, MC; Zhu, GS; Zhu, ZZ1
Chi, KH; Chou, SL; Kao, SJ; Tseng, FW; Wang, HE; Wang, YS; Wu, HC; Yen, SH; Yu, HM1
Chen, Y; Ding, SS; Hu, P; Shi, PC; Wu, XZ1
Fan, ST; Kwong, YL; Lee, TK; Pang, R; Poon, RT; Tse, E; Wong, KB1
Lee, SJ; Lim, KT1
Gao, H; He, S; Tang, WX; Wang, J1
Kishimoto, T; Kokura, K; Kumagai, Y; Makino, Y; Tamura, T; Wakamatsu, T1
Kawasaki, T; Ma, Y; Shida, H1
Ando, A; Del Monte, MA; Ito, S; Maeda, H; Masu, Y; Ueda, M; Uyama, M1
Bartsch, H; Frank, N; Lin, JK; Liu, GY1
Bills, DD; Nixon, JE; Scanlan, RA; Sinnhuber, RO; Wales, JH1
Boutron, A; Goenner, S; Lemonnier, A; Moatti, N; Soni, T1
Easton, AJ; McLachlan, A; Milich, DR; Raney, AK1
Ichihara, A; Nakamura, T1
Bienkowski, RS; Wu, CH; Wu, GY1
Goldberg, B; Green, H2
Downing, SJ; Harris, SC; Phang, JM; Valle, D1
Hogan, BL; Murden, S1

Reviews

4 review(s) available for proline and Carcinoma, Hepatocellular

ArticleYear
New approaches in viraemic organ transplantation and antiviral therapies.
    Nature reviews. Gastroenterology & hepatology, 2020, Volume: 17, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Guanine; Hepatitis B, Chronic; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Liver Transplantation; Macrocyclic Compounds; Proline; Quinoxalines; Salvage Therapy; Sofosbuvir; Sulfonamides; Tenofovir; Transplants

2020
Treatment of patients with dual hepatitis C virus and hepatitis B virus infection: resolved and unresolved issues.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:1

    Topics: Antiviral Agents; Biomarkers; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Humans; Interferon-alpha; Liver Neoplasms; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Virus Activation

2014
ABT-450: a novel agent for the treatment of CHC genotype 1: focus on treatment-experienced patients.
    Expert review of anti-infective therapy, 2015, Volume: 13, Issue:3

    Topics: 2-Naphthylamine; Anilides; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver Cirrhosis; Liver Neoplasms; Macrocyclic Compounds; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Uracil; Valine

2015
Does antiviral therapy reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C?
    Minerva gastroenterologica e dietologica, 2012, Volume: 58, Issue:1

    Topics: Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Europe; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Liver Neoplasms; North America; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Risk Assessment; Treatment Outcome; Viral Load

2012

Trials

1 trial(s) available for proline and Carcinoma, Hepatocellular

ArticleYear
Long-term safety and efficacy results in hepatitis C virus genotype 1-infected patients receiving ombitasvir/paritaprevir/ritonavir + dasabuvir ± ribavirin in the TOPAZ-I and TOPAZ-II trials.
    Journal of viral hepatitis, 2020, Volume: 27, Issue:5

    Topics: 2-Naphthylamine; Anilides; Antiviral Agents; Carcinoma, Hepatocellular; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Liver Neoplasms; Proline; Ribavirin; Ritonavir; Sulfonamides; Sustained Virologic Response; Uracil; Valine

2020

Other Studies

50 other study(ies) available for proline and Carcinoma, Hepatocellular

ArticleYear
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 100

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Mice; Molecular Docking Simulation; Proline

2022
Metabolomics-based classification reveals subtypes of hepatocellular carcinoma.
    Molecular carcinogenesis, 2022, Volume: 61, Issue:11

    Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; Glutamates; Humans; Liver Neoplasms; Metabolomics; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Proline

2022
Multi-Omics Analysis Revealed a Significant Alteration of Critical Metabolic Pathways Due to Sorafenib-Resistance in Hep3B Cell Lines.
    International journal of molecular sciences, 2022, Oct-09, Volume: 23, Issue:19

    Topics: Alanine; Amino Acids; Antineoplastic Agents; Biomarkers; Calpain; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glucose; Humans; L-Iditol 2-Dehydrogenase; Liver Neoplasms; Metabolic Networks and Pathways; Nucleotides; Phosphatidylcholines; Proline; Protein Kinase Inhibitors; Proteome; Proteomics; Sorafenib; Succinic Acid; Superoxide Dismutase; Tyrosine; Ubiquitin Thiolesterase; Uridine Diphosphate

2022
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.
    BMC medicine, 2022, 10-19, Volume: 20, Issue:1

    Topics: Carcinoma, Hepatocellular; Case-Control Studies; Glutamine; Histidine; Humans; Liver Neoplasms; Lysophosphatidylcholines; Male; Phosphatidylcholines; Proline; Prospective Studies; Risk Factors; Sphingomyelins

2022
Transcriptome Analysis of Redox Systems and Polyamine Metabolic Pathway in Hepatoma and Non-Tumor Hepatocyte-like Cells.
    Biomolecules, 2023, 04-21, Volume: 13, Issue:4

    Topics: Carcinoma, Hepatocellular; Gene Expression Profiling; Hepatocytes; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Oxidation-Reduction; Polyamines; Proline; Reactive Oxygen Species; Urea

2023
Au(iii)-Proline derivatives exhibiting selective antiproliferative activity against HepG2/SB3 apoptosis-resistant cancer cells.
    Dalton transactions (Cambridge, England : 2003), 2019, Nov-14, Volume: 48, Issue:42

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carbamates; Carcinoma, Hepatocellular; Cell Line, Tumor; Coordination Complexes; Gold; Humans; Liver Neoplasms; Proline; Serpins

2019
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
    Journal of hepatology, 2020, Volume: 72, Issue:4

    Topics: Aldehyde Dehydrogenase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; delta-1-Pyrroline-5-Carboxylate Reductase; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HaCaT Cells; HEK293 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, SCID; Proline; Pyrroline Carboxylate Reductases; Rats; Signal Transduction; Transcriptome; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2020
Stachydrine inhibits TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells through the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways.
    Anti-cancer drugs, 2021, 09-01, Volume: 32, Issue:8

    Topics: Cadherins; Carcinoma, Hepatocellular; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Proline; Signal Transduction; Smad2 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Vimentin

2021
Safety of Patients with Hepatitis C Virus Treated with Glecaprevir/Pibrentasvir from Clinical Trials and Real-World Cohorts.
    Advances in therapy, 2021, Volume: 38, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carcinoma, Hepatocellular; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Successful twice interrupted therapy of HCV infection in patients with cirrhosis with hepatocellular carcinoma before and after liver transplantation.
    BMJ case reports, 2017, Sep-15, Volume: 2017

    Topics: 2-Naphthylamine; Anilides; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Drug Therapy, Combination; Hepatitis C; Humans; Lactams, Macrocyclic; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Macrocyclic Compounds; Male; Middle Aged; Proline; Ribavirin; Ritonavir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Uracil; Valine

2017
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 01-15, Volume: 24, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Metabolome; Metabolomics; Phenotype; Proline; Sorafenib; Xenograft Model Antitumor Assays

2018
Durability of virologic response, risk of de novo hepatocellular carcinoma, liver function and stiffness 2 years after treatment with ombitasvir/paritaprevir/ritonavir±dasabuvir±ribavirin in the AMBER, real-world experience study.
    Journal of viral hepatitis, 2018, Volume: 25, Issue:11

    Topics: 2-Naphthylamine; Adult; Aged; Anilides; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver; Liver Cirrhosis; Liver Neoplasms; Macrocyclic Compounds; Male; Middle Aged; Poland; Proline; Ribavirin; Ritonavir; Sulfonamides; Treatment Outcome; Uracil; Valine; Viral Load

2018
Concomitant use of sorafenib with ombitasvir/paritaprevir/ritonavir and dasabuvir: Effectiveness and safety in clinical practice.
    Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:6

    Topics: 2-Naphthylamine; Aged; Anilides; Antineoplastic Agents; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver Neoplasms; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Ritonavir; Sorafenib; Sulfonamides; Treatment Outcome; Uracil; Valine

2018
Recurrence rate of hepatocellular carcinoma in patients with treated hepatocellular carcinoma and hepatitis C virus-associated cirrhosis after ombitasvir/paritaprevir/ritonavir+dasabuvir+ribavirin therapy.
    United European gastroenterology journal, 2019, Volume: 7, Issue:5

    Topics: 2-Naphthylamine; Aged; Anilides; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cyclopropanes; Hepatectomy; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver Cirrhosis; Liver Neoplasms; Macrocyclic Compounds; Middle Aged; Neoplasm Recurrence, Local; Proline; Prospective Studies; Radiofrequency Ablation; Ribavirin; Ritonavir; Sulfonamides; Treatment Outcome; Uracil; Valine

2019
[Therapy of hepatitis C: new inhibitors as hammers against HCV].
    MMW Fortschritte der Medizin, 2013, Jun-13, Volume: 155 Suppl 1

    Topics: Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Drugs, Investigational; Hepacivirus; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Oligopeptides; Proline; Protease Inhibitors

2013
Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors.
    Gastroenterology, 2014, Volume: 146, Issue:3

    Topics: Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Genotype; Hepacivirus; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Liver; Liver Neoplasms; Mutation; Oligopeptides; Proline; Protease Inhibitors; Pyrrolidines; Valine; Viral Nonstructural Proteins

2014
Liver transplantation in a child with multifocal hepatocellular carcinoma hepatitis C and management of post-transplant viral recurrence using boceprevir.
    Pediatric transplantation, 2014, Volume: 18, Issue:2

    Topics: Adolescent; Carcinoma, Hepatocellular; Child; Graft Survival; Hepatitis C; Humans; Interferons; Liver Neoplasms; Liver Transplantation; Male; Polyethylene Glycols; Postoperative Complications; Proline; Recurrence; Ribavirin; Severe Combined Immunodeficiency

2014
NF-κB increased expression of 17β-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol.
    Molecular and cellular endocrinology, 2015, Feb-05, Volume: 401

    Topics: Carcinoma, Hepatocellular; Cell Proliferation; Cyclin D1; Estradiol; Hep G2 Cells; Humans; Interleukin-6; Liver Neoplasms; Male; NF-kappa B; Peroxisomal Multifunctional Protein-2; Proliferating Cell Nuclear Antigen; Proline; Promoter Regions, Genetic; Thiocarbamates; Tumor Necrosis Factor-alpha; Up-Regulation

2015
Down-regulation of PTEN by HCV core protein through activating nuclear factor-κB.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:11

    Topics: Carcinoma, Hepatocellular; Cell Proliferation; Down-Regulation; Gene Expression Regulation; Genes, Reporter; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Proline; Promoter Regions, Genetic; PTEN Phosphohydrolase; RNA, Messenger; Signal Transduction; Thiocarbamates; Transfection; Viral Core Proteins

2014
Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin in cirrhosis after complete destruction of hepatocellular carcinoma.
    World journal of gastroenterology, 2016, Feb-28, Volume: 22, Issue:8

    Topics: 2-Naphthylamine; Aged; Anilides; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Macrocyclic Compounds; Male; Proline; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Uracil; Valine; Viral Load

2016
Cost-effectiveness of currently recommended direct-acting antiviral treatments in patients infected with genotypes 1 or 4 hepatitis C virus in the US.
    Journal of medical economics, 2016, Volume: 19, Issue:8

    Topics: 2-Naphthylamine; Adult; Aged; Aged, 80 and over; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Carcinoma, Hepatocellular; Cost-Benefit Analysis; Cyclopropanes; Drug Therapy, Combination; Female; Fibrosis; Fluorenes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver Neoplasms; Macrocyclic Compounds; Male; Markov Chains; Middle Aged; Models, Econometric; Proline; Quality-Adjusted Life Years; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Uracil; Valine

2016
Cost-Effectiveness of Genotype 1 Chronic Hepatitis C Virus Treatments in Patients Coinfected with Human Immunodeficiency Virus in the United States.
    Advances in therapy, 2016, Volume: 33, Issue:8

    Topics: 2-Naphthylamine; Adult; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Carcinoma, Hepatocellular; Cost-Benefit Analysis; Cyclopropanes; Disease Progression; Drug Therapy, Combination; Fluorenes; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Lactams, Macrocyclic; Liver Cirrhosis; Liver Neoplasms; Macrocyclic Compounds; Markov Chains; Middle Aged; Polyethylene Glycols; Proline; Quality-Adjusted Life Years; Recombinant Proteins; Ribavirin; Ritonavir; Sofosbuvir; Sulfonamides; United States; Uracil; Valine

2016
Efficacy and safety of boceprevir-based triple therapy in HCV cirrhotic patients awaiting liver transplantation (ANRS HC29 BOCEPRETRANSPLANT).
    Clinics and research in hepatology and gastroenterology, 2017, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Female; France; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Proline; Quality of Life; Retrospective Studies; Ribavirin; Treatment Outcome

2017
Effectiveness, safety and clinical outcomes of direct-acting antiviral therapy in HCV genotype 1 infection: Results from a Spanish real-world cohort.
    Journal of hepatology, 2017, Volume: 66, Issue:6

    Topics: 2-Naphthylamine; Adult; Aged; Aged, 80 and over; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Carcinoma, Hepatocellular; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; Fluorenes; Genotype; Glomerular Filtration Rate; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Liver Neoplasms; Macrocyclic Compounds; Male; Middle Aged; Neoplasm Recurrence, Local; Proline; Retrospective Studies; Ribavirin; Ritonavir; Sofosbuvir; Spain; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Uracil; Uridine Monophosphate; Valine; Young Adult

2017
[The 43rd Annual Meeting of the European Association for the Study of the Liver (EASL), Milan, Italy, April 23-27, 2008].
    Orvosi hetilap, 2008, Jul-13, Volume: 149, Issue:28

    Topics: Antineoplastic Agents; Antiviral Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Clinical Trials as Topic; Delayed-Action Preparations; Europe; Hepatitis B; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Liver Diseases; Liver Neoplasms; Niacinamide; Oligopeptides; Patient Compliance; Phenylurea Compounds; Polyethylene Glycols; Proline; Pyridines; Recombinant Proteins; Ribavirin; Societies, Medical; Sorafenib

2008
Involvement of NF-kappaB activation in the apoptosis induced by extracellular adenosine in human hepatocellular carcinoma HepG2 cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2010, Volume: 88, Issue:4

    Topics: Adenosine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Extracellular Space; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Proline; Thiocarbamates

2010
In vivo and In vitro effect of a nutrient mixture on human hepatocarcinoma cell line SK-HEP-1.
    Experimental oncology, 2010, Volume: 32, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Ascorbic Acid; Camellia sinensis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Humans; Liver Neoplasms; Lysine; Male; Matrix Metalloproteinases; Mice; Mice, Nude; Neoplasms, Experimental; Plant Extracts; Proline; Tea; Xenograft Model Antitumor Assays

2010
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.
    Gastroenterology, 2011, Volume: 141, Issue:3

    Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins

2011
PEPITASE ACTIVITIES IN TISSUES OF TUMOR-BEARING RATS.
    Cancer research, 1963, Volume: 23

    Topics: Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Erythrocytes; Glycine; Leucine; Liver; Liver Neoplasms; Muscles; Neoplasms; Neoplasms, Experimental; Peptide Hydrolases; Peptides; Proline; Rats; Research; Sarcoma; Sarcoma, Experimental

1963
Proline synthesis and degradation in a minimal deviation hepatoma.
    Biochimica et biophysica acta, 1962, Aug-27, Volume: 62

    Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental; Proline

1962
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.
    The Journal of biological chemistry, 2004, Jul-30, Volume: 279, Issue:31

    Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Blotting, Western; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle; Cell Line; Cyclin B; Cycloheximide; Databases as Topic; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; F-Box Proteins; Genetic Vectors; Humans; Microscopy, Fluorescence; Mitosis; Models, Biological; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Neoplasm Proteins; Nocodazole; Phosphoproteins; Phosphorylation; Precipitin Tests; Proline; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Recombinant Proteins; Recombination, Genetic; RNA, Small Interfering; Sequence Homology, Amino Acid; Stem Cell Factor; Substrate Specificity; Temperature; Time Factors; Transfection; Ubiquitin

2004
Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population.
    World journal of gastroenterology, 2005, Jan-14, Volume: 11, Issue:2

    Topics: Amino Acid Substitution; Arginine; Base Sequence; Carcinoma, Hepatocellular; China; DNA Primers; Gene Frequency; Humans; Liver Neoplasms; Mutation, Missense; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Risk Factors; Tumor Suppressor Protein p53

2005
Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-kappaB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell.
    Biochemical pharmacology, 2005, Feb-15, Volume: 69, Issue:4

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Fluorouracil; Humans; Idoxuridine; Iodine Radioisotopes; Liver Neoplasms; NF-kappa B; Phenylbutyrates; Proline; Thiocarbamates; Thymidylate Synthase

2005
N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells.
    Cell biology international, 2006, Volume: 30, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Cycle; Cell Movement; Fenretinide; Fucose; Fucosyltransferases; Gelatinases; Humans; Liver Neoplasms, Experimental; Mice; Mice, Nude; Molecular Structure; Neoplasm Invasiveness; Neoplasm Transplantation; Proline; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured

2006
Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.
    Gastroenterology, 2007, Volume: 132, Issue:3

    Topics: Amino Acid Motifs; Animals; bcl-X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Hepatitis B; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Nude; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Proto-Oncogene Proteins c-myc; Reproducibility of Results; RNA, Messenger; Serine; Trans-Activators; Transcription Factor RelA; Transcription, Genetic; Transcriptional Activation; Transfection; Transplantation, Heterologous; Up-Regulation; Viral Regulatory and Accessory Proteins

2007
Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.
    The Journal of nutritional biochemistry, 2008, Volume: 19, Issue:3

    Topics: Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA; Enzyme Activation; Glycine; Glycoproteins; Humans; Liver Neoplasms; Mitochondria, Liver; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Proteins; Poly(ADP-ribose) Polymerases; Proline; Reactive Oxygen Species; Signal Transduction

2008
[Inhibition of NF-kappa B activity enhanced apoptosis induced by matrine in hepatocellular carcinoma cells].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2007, Volume: 15, Issue:12

    Topics: Alkaloids; Apoptosis; Carcinoma, Hepatocellular; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Matrines; NF-kappa B; Proline; Quinolizines; Thiocarbamates

2007
HTF: A b-ZIP transcription factor that is closely related to the human XBP/TREB5 and is activated by hepatocellular carcinoma in rats.
    Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Basic-Leucine Zipper Transcription Factors; Binding Sites; Carcinoma, Hepatocellular; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Glutamine; Humans; Leucine Zippers; Liver; Liver Neoplasms; Molecular Sequence Data; Neoplasm Proteins; Nuclear Proteins; Oligodeoxyribonucleotides; Open Reading Frames; Proline; Rats; Recombinant Proteins; Regulatory Factor X Transcription Factors; RNA, Messenger; Transcription Factors; Transcription, Genetic; X-Box Binding Protein 1

1996
Functional expression of human mannan-binding proteins (MBPs) in human hepatoma cell lines infected by recombinant vaccinia virus: post-translational modification, molecular assembly, and differentiation of serum and liver MBP.
    Journal of biochemistry, 1997, Volume: 122, Issue:4

    Topics: Aged; Amino Acid Sequence; Animals; Biopolymers; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line; Cloning, Molecular; Collagen; Collectins; Complement Activation; COS Cells; Humans; Hydroxylation; Liver; Lysine; Male; Mannans; Molecular Sequence Data; Proline; Protein Processing, Post-Translational; Rabbits; Recombination, Genetic; Tumor Cells, Cultured; Vaccinia virus

1997
Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:5

    Topics: Arginine; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line; Cell Survival; DNA; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Keratins; Liver Neoplasms; Ornithine; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proline

1998
Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins.
    Molecular carcinogenesis, 1998, Volume: 22, Issue:4

    Topics: Alcohol Deterrents; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Disulfiram; Ditiocarb; G1 Phase; Humans; Microtubule-Associated Proteins; NF-kappa B; Oxidation-Reduction; Proline; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Thiocarbamates; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

1998
Null carcinogenic effect of large doses of nitrosoproline and nitrosohydroxyproline in Wistar rats.
    Food and cosmetics toxicology, 1976, Volume: 14, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Dimethylnitrosamine; Drug Synergism; Fatty Acids, Unsaturated; Hydroxyproline; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Proline; Rats

1976
Amino acid transport systems in the human hepatoma cell line Hep G2.
    Biochemical and biophysical research communications, 1992, Nov-30, Volume: 189, Issue:1

    Topics: Alanine; Amino Acids; Biological Transport; Carcinoma, Hepatocellular; Humans; Kinetics; Lithium; Liver Neoplasms; Proline; Serine; Sodium; Tumor Cells, Cultured

1992
Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1.
    Journal of virology, 1991, Volume: 65, Issue:11

    Topics: Animals; Antigens, Surface; Antigens, Viral; Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Line; DNA-Binding Proteins; Genetic Vectors; Genome, Viral; Glutamine; Hepatitis B virus; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Plasmids; Proline; Promoter Regions, Genetic; Rats; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection

1991
Control of growth and expression of differentiated functions of mature hepatocytes in primary culture.
    Cell structure and function, 1985, Volume: 10, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Cell Membrane; Cells, Cultured; Contact Inhibition; DNA Replication; Epidermal Growth Factor; Gene Expression Regulation; Growth Substances; Insulin; Liver; Liver Neoplasms; Liver Regeneration; Proline; Rats; Tryptophan Oxygenase

1985
Limitation on sensitivity of measuring collagen degradation: studies with cultured liver cells.
    Connective tissue research, 1986, Volume: 14, Issue:3

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Collagen; Humans; Hydroxyproline; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Molecular Weight; Proline; Rats; Rats, Inbred Strains

1986
The synthesis of collagen and protocollagen hydroxylase by fibroblastic and nonfibroblastic cell lines.
    Proceedings of the National Academy of Sciences of the United States of America, 1968, Volume: 59, Issue:4

    Topics: Animals; Burkitt Lymphoma; Carcinoma, Hepatocellular; Collagen; Culture Techniques; Fibroblasts; HeLa Cells; Humans; Liver Neoplasms; Mice; Mixed Function Oxygenases; Neoplasms, Experimental; Proline; Tritium

1968
Relation between collagen synthesis and collagen proline hydroxylase activity in mammalian cells.
    Nature, 1969, Jan-18, Volume: 221, Issue:5177

    Topics: Animals; Carcinoma, Hepatocellular; Clone Cells; Collagen; Culture Techniques; Fibroblasts; HeLa Cells; Humans; Hydroxyproline; Kinetics; L Cells; Liver Neoplasms; Lymphocytes; Mixed Function Oxygenases; Proline; Rabbits; Reticulocytes; Tritium

1969
Proline biosynthesis: multiple defects in Chinese hamster ovary cells.
    Biochemical and biophysical research communications, 1973, Aug-21, Volume: 53, Issue:4

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cricetinae; Female; Fibroblasts; Glutamates; Humans; Liver Neoplasms; Lung; Male; Ornithine; Ovary; Proline; Rats; Transaminases

1973
Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
    Journal of cellular physiology, 1974, Volume: 83, Issue:3

    Topics: Amino Acids; Animals; Arginine; Asparagine; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Culture Media; Cycloheximide; Drug Synergism; Glutamine; Glycine; Immune Sera; Leucine; Liver Neoplasms; Neoplasm Proteins; Ornithine; Proline; Pyridoxal; Rats; Serine; Stimulation, Chemical; Time Factors

1974