proline has been researched along with Benign Neoplasms in 85 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (16.47) | 18.7374 |
1990's | 4 (4.71) | 18.2507 |
2000's | 23 (27.06) | 29.6817 |
2010's | 20 (23.53) | 24.3611 |
2020's | 24 (28.24) | 2.80 |
Authors | Studies |
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AlKhazindar, M; Bojarska, J; El-Mowafi, SA; Elnagdy, S; Mieczkowski, A; Mohammed, EHM; Parang, K; Shalash, AO; Skwarczynski, M; Toth, I; Wolf, WM; Ziora, ZM | 1 |
Phang, JM | 4 |
Bridges, E; Cuozzo, F; Eales, KL; Escribano-Gonzalez, C; Eskla, KL; Harris, AL; Hodson, DJ; Lavery, GG; Luuk, H; Nixon, C; Rana, H; Roberts, J; Shaaban, A; Tennant, DA; Vellama, H; Vera-Siguenza, E; Vettore, LA; Walker, PD; Westbrook, RL | 1 |
Bersenev, A; Cao, H; Chen, S; Chow, RD; Clark, P; Dai, X; Dong, MB; Du, Y; Errami, Y; Guo, J; Kim, HR; Lam, SZ; Montgomery, RR; Park, JJ; Peng, L; Tang, E; Wang, G; Yang, Q; Ye, L; Zhang, Y | 1 |
Greenbaum, B; Hoyos, D; Levine, AJ | 1 |
Madrigal Perez, LA; Nava, GM | 1 |
Gao, Y; Li, L; Li, Y; Xiu, M | 1 |
Enyedy, ÉA; Kovács, H; May, NV; Nezafat Yazdi, Z; Özvegy-Laczka, C; Pivarcsik, T; Pósa, SP; Pósa, V; Spengler, G; Szakács, G; Szatmári, I; Tóth, S; Ugrai, I | 1 |
Blagih, J; Fendt, SM; Hennequart, M; Labuschagne, CF; Legrave, NM; Pilley, SE; Vandekeere, A; Vousden, KH | 1 |
Bodor, A; Ecsédi, P; Nyitray, L; Sebák, F | 1 |
Kay, EJ; Rufini, A; Zanivan, S | 1 |
Barber, LJ; Bassani-Sternberg, M; Choudhary, JS; Gerlinger, M; Newey, A; Yu, L | 1 |
Baszanowska, W; Huynh, TYL; Lewoniewska, S; Palka, J; Zareba, I | 1 |
Bai, C; Chen, C; Chu, Q; Cui, Y; Li, B; Liu, M; Ruan, Y; Wang, Y; Yang, C; Ying, G | 1 |
Gao, J; Mao, J; Tang, J; Wang, X; Zhang, H; Zhang, J | 1 |
Béhé, M; Berger, P; De Foresta, M; Deupi, X; Dobitz, S; Ritler, A; Romantini, N; Schibli, R; Walther, C; Wennemers, H; Wilhelm, P | 1 |
Armando, R; Cabrera, M; Chinestrad, P; Gomez, DE; Gómez, DLM; Maggio, J; Menna, PL; Pifano, M | 1 |
Chang, JF; Gan, ZX; Liu, KN; Liu, YZ; Sun, F; Sun, J; Yang, XM; Zhang, L; Zhang, W | 1 |
Bogner, AN; Stiers, KM; Tanner, JJ | 1 |
Borgatti, M; Forlani, G; Petrollino, D; Ragno, D; Sabbioni, G | 1 |
Bie, J; Li, Y; Liu, M; Luo, J; Song, C | 1 |
Liu, S; Liu, Y; Mao, C; Shi, Y; Tao, Y; Xiao, D | 1 |
Tennant, DA; Vettore, LA; Westbrook, RL | 1 |
Geng, P; Qin, W; Xu, G | 1 |
Burke, TR; Dyba, M; Hamazaki, J; Hymel, D; Liu, F; Lu, X; Murata, S; Nowicka, U; Randles, L; Sridharan, V; Tarasov, SG; Tarasova, NI; Walters, KJ; Zhao, XZ | 1 |
Chng, WJ; Chu-Farseeva, YY; Dymock, BW; Mustafa, N; Poulsen, A; Tan, EC; Yen, JJY | 1 |
Chen, S; Liu, B; Liu, L; Liu, M; Luo, J; Qi, H; Ren, M; Vucenik, I; Wang, Z; Yang, X; Yu, M; Zhu, WG; Zou, J | 1 |
Dahabreh, IJ; Lau, J; Murray, S; Schmid, CH; Trikalinos, TA; Varvarigou, V | 1 |
Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
Gatter, KC; Harris, AL; Li, D; Masiero, M; McIntyre, A; Pezzella, F; Schofield, CJ; Snell, CE; Turley, H | 1 |
Amidon, GL; Dahan, A; Landowski, CP; Mittal, S; Wolk, O; Wu, Z; Yang, P | 1 |
Fischer, JW; Hancock, CN; Liu, W; Phang, JM | 1 |
Brimble, MA; Harris, PW | 1 |
Czyzewska, U; Kononczuk, J; Miltyk, W; Moczydlowska, J; Palka, J; Surażyński, A | 1 |
Abboud, MI; Cantrelle, FX; Chowdhury, R; Claridge, TD; Domene, C; Ge, W; Hardy, AP; Landrieu, I; Leung, IK; Pugh, CW; Ratcliffe, PJ; Schofield, CJ; Tian, YM | 1 |
Asara, JM; Chakraborty, AA; Cheng, JQ; Gan, W; Guo, J; Inuzuka, H; Kaelin, WG; Liu, P; Novak, J; Signoretti, S; Toker, A; Wang, B; Wei, W; Yuan, M; Zhang, J; Zhang, L; Zhang, Q; Zheng, X | 1 |
Chen, Y; Erber, L; Gao, Y; Liu, B; Ruan, HB; Zhou, T | 1 |
Allen, DW; Carolan, VA; Claude, E; Clench, MR; Djidja, MC; Scriven, P | 1 |
Liu, Y; Pandhare, J; Phang, JM | 1 |
Coenen, HH; Haas, R; Hamacher, K; Kobbe, G; Langen, KJ; Pauleit, D; Salber, D; Stoffels, G | 1 |
Jodoin, J; Laroche-Pierre, S; LeBlanc, AC | 1 |
Bastús, NG; Giralt, E; Kogan, MJ; López-Iglesias, C; Pereiro, E; Pujals, S; Puntes, VF | 1 |
Gunduz, M; Mita, Y; Naomoto, Y; Ouchida, M; Sakai, A; Shimizu, K; Tanabe, S; Toyooka, S; Yamamoto, H; Yasuda, Y | 1 |
Abu-Zahra, H; Banerjee, S; Bergwitz, C; Jüppner, H; Kaji, H; Miyauchi, A; Sugimoto, T | 1 |
Kalinovsky, T; Monterrey, JC; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
Kaelin, WG | 1 |
Clark, BR; Fox, D; Leroy, J; Murphy, CD; O'Connor, S | 1 |
Liu, W; Phang, JM | 1 |
Bonner, JD; Boyd, J; Chong, G; De La Chapelle, A; Ellis, NA; Farber, D; Figer, A; Foulkes, WD; Friedman, E; Gaff, CL; Gebert, J; Gordon, PH; Greenwood, CM; Gregersen, PK; Gruber, SB; Hamel, N; Hampel, H; Horwitz, M; King, MC; Lee, C; MacNamara, E; Macrae, FA; Marcus, V; Markowitz, A; Nafa, K; Offit, K; Paillerets, BB; Rennert, G; Shia, J; Thiffault, I; Tomsho, L; Walsh, T; Weitzel, JN | 1 |
Della Pietra, AC; Dumont, P; George, DL; Leu, JI; Murphy, M | 1 |
Albright, CF; Arnone, M; Grafstrom, RH; Kendall, M; Pan, W; Seitz, SP; Wasserman, ZR | 1 |
Bojesen, SE; Nordestgaard, BG; Tybjaerg-Hansen, A | 1 |
HERMAN, C; HIWETT, J; VAN ROBERTSON, WB | 1 |
ERB, W; HEMPEL, K | 1 |
BAUER, JM; WU, C | 1 |
LORINCZ, AB; RYAN, WL | 1 |
Akaike, T; Fang, J; Greish, K; Maeda, H; Sawa, T | 1 |
Lu, KP | 1 |
Braunstein, I; Brosh, R; Erez, N; Ginsberg, D; Kogan, I; Milyavsky, M; Rotter, V; Shats, I; Stambolsky, P; Tang, X; Tzukerman, M | 1 |
Kentsis, A; Miller, F; Osman, R; Pan, ZQ | 1 |
Barbi, C; Bonafé, M; Franceschi, C; Gravina, S; Mondello, C; Monti, D; Rossi, M; Salvioli, S; Storci, G; Tiberi, L; Tocco, F; Trapassi, C | 1 |
Krummel, KA; Lee, CJ; Liu, CW; Rodewald, LW; Tang, M; Toledo, F; Wahl, GM | 1 |
Fojo, T | 1 |
Krummel, KA; Lee, CJ; Liu, CW; Rodewald, LW; Toledo, F; Wahl, GM | 1 |
Baiula, M; Cardillo, G; Gentilucci, L; Spampinato, S; Sparta, A; Squassabia, F; Tolomelli, A | 1 |
Ishida, T; Kashima, T; Makino, K; Soemantri, A | 1 |
Ishibashi, M; Ohtsuki, T | 1 |
Donald, SP; Liu, Y; Pandhare, J; Phang, JM | 1 |
Hamacher, K; Herz, M; Schwaiger, M; Senekowitsch-Schmidtke, R; Stöcklin, G; Wester, HJ | 1 |
Jennes, L; Kakar, SS | 1 |
Bartholomew, B; Collard, MW; Huggenvik, JI; Michelson, RJ; Persinger, J; Ziemba, AJ | 1 |
Keshava, C; McCanlies, EC; Sharp, DS; Sun, Y; Weston, A | 1 |
Liou, YC; Lu, KP; Zhou, XZ | 1 |
Pees, HW | 1 |
Forman, D | 1 |
Jacob, J | 1 |
Keiser, HR; Sjoerdsma, A; Stein, HD | 1 |
Freytag, G; Grasedyck, K; Lindner, J | 1 |
Kimmig, J; Kreysel, HW | 1 |
Flowers, ES | 1 |
Stiller, KJ | 1 |
Hahn, K; Jesdinsky, HJ; Ladner, HA | 1 |
23 review(s) available for proline and Benign Neoplasms
Article | Year |
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Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold.
Topics: Diketopiperazines; Dipeptides; Drug Discovery; Humans; Neoplasms; Peptides, Cyclic; Proline | 2021 |
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein.
Topics: Genotype; Humans; Mutation, Missense; Neoplasms; Phenotype; Proline; Tumor Suppressor Protein p53 | 2022 |
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer.
Topics: Amino Acids, Branched-Chain; Glucose; Glutamine; Humans; Metabolome; Neoplasms; Proline | 2022 |
An update regarding the role of WNK kinases in cancer.
Topics: Alanine; Animals; Bicarbonates; Mammals; Neoplasms; Neovascularization, Pathologic; Proline; Serine; Sodium Chloride Symporters; Threonine | 2022 |
Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion.
Topics: Collagen; Extracellular Matrix; Humans; Immune Evasion; Neoplasms; Proline; Tumor Microenvironment | 2023 |
Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy.
Topics: Apoptosis; Autophagy; Humans; Neoplasm Proteins; Neoplasms; Proline; Proline Oxidase; Signal Transduction | 2020 |
Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target.
Topics: Animals; Gene Expression; Humans; Neoplasms; Proline; Pyrroline Carboxylate Reductases; Up-Regulation | 2021 |
PYCR, a key enzyme in proline metabolism, functions in tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Cycle; Humans; Neoplasms; Oxidation-Reduction; Proline; Pyrroline Carboxylate Reductases | 2021 |
Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy.
Topics: Animals; Apoptosis; Autophagy; Cellular Senescence; Humans; Neoplasms; Proline; Proline Oxidase; Signal Transduction | 2021 |
Proline metabolism and redox; maintaining a balance in health and disease.
Topics: Animals; Homeostasis; Humans; Neoplasms; Oxidation-Reduction; Proline; Protein Biosynthesis; Reactive Oxygen Species | 2021 |
Proline metabolism in cancer.
Topics: Animals; Apoptosis; Cell Proliferation; Humans; Neoplasm Metastasis; Neoplasms; Proline | 2021 |
Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses.
Topics: Humans; Neoplasms; Oxidation-Reduction; Proline; Proline Oxidase; Tumor Suppressor Protein p53 | 2019 |
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer.
Topics: Alleles; Bayes Theorem; Breast Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Female; Genes, p53; Genotyping Techniques; Humans; Loss of Heterozygosity; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Polymorphism, Genetic; Proline | 2013 |
Proline metabolism and cancer: emerging links to glutamine and collagen.
Topics: Animals; Collagen; Glutamine; Humans; Neoplasms; Proline; Proto-Oncogene Mas | 2015 |
Proline Oxidase (POX) as A Target for Cancer Therapy.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Humans; Molecular Targeted Therapy; Neoplasms; Oxidative Stress; Proline; Proline Oxidase; Reactive Oxygen Species; Signal Transduction | 2015 |
Proline metabolism and cancer.
Topics: Animals; Down-Regulation; Genes, Tumor Suppressor; Humans; Neoplasms; Proline; Proline Oxidase; Xenograft Model Antitumor Assays | 2012 |
Pinning down cell signaling, cancer and Alzheimer's disease.
Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biological; Models, Molecular; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Proline-Directed Protein Kinases; Protein Structure, Tertiary; Signal Transduction | 2004 |
Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Benz(a)Anthracenes; Caspases; Drug Screening Assays, Antitumor; Humans; Isoflavones; Neoplasms; Proline; Protein Kinases; Receptors, Death Domain; Sesquiterpenes; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2008 |
The metabolism of proline, a stress substrate, modulates carcinogenic pathways.
Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Catalysis; Gene Expression Regulation, Enzymologic; Ligands; Models, Biological; Neoplasms; PPAR delta; Proline; Proline Oxidase; Protein Kinases; Thiazolidinediones; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2008 |
Pinning down proline-directed phosphorylation signaling.
Topics: Alzheimer Disease; Amino Acid Motifs; Animals; Humans; Models, Molecular; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Conformation; Proteins; Signal Transduction | 2002 |
The regulatory functions of proline and pyrroline-5-carboxylic acid.
Topics: Amino Acids; Animals; Biological Transport; Cell Communication; Cell Cycle; Charcoal; Glutamates; Glutamic Acid; Humans; Mitosis; NADP; Neoplasms; Ornithine; Oxidation-Reduction; Phosphoribosyl Pyrophosphate; Proline; Protein Biosynthesis; Purine Nucleotides; Pyrroles; Structure-Activity Relationship | 1985 |
Dietary exposure to N-nitroso compounds and the risk of human cancer.
Topics: Diet; Environmental Exposure; Humans; Neoplasms; Nitrates; Nitrites; Nitrosamines; Nitroso Compounds; Proline | 1987 |
The practice and application of electron microscope autoradiography.
Topics: Animals; Autoradiography; Bacillus subtilis; Carbohydrates; Carbon Isotopes; DNA; Emulsions; Escherichia coli; Guinea Pigs; Histocytochemistry; Histological Techniques; L Cells; Leucine; Lipids; Mathematics; Mice; Microscopy, Electron; Microtomy; Neoplasms; Pancreas; Paramecium; Photomicrography; Plants; Proline; Proteins; Radiation Effects; Radioisotopes; Rats; RNA; Staining and Labeling; Sulfur Isotopes; Thymidine; Thyroid Gland; Time Factors; Tritium; Triturus; Viruses; Xenopus | 1971 |
62 other study(ies) available for proline and Benign Neoplasms
Article | Year |
---|---|
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis.
Topics: Collagen; Extracellular Matrix; Humans; Hydroxyproline; Neoplasms; Proline; Small Molecule Libraries | 2021 |
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Topics: Cell Proliferation; Citric Acid Cycle; delta-1-Pyrroline-5-Carboxylate Reductase; Humans; Mitochondria; Neoplasms; Oxygen; Proline; Pyrroline Carboxylate Reductases; Tumor Microenvironment | 2022 |
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Topics: CD8-Positive T-Lymphocytes; Clustered Regularly Interspaced Short Palindromic Repeats; Gain of Function Mutation; Humans; Neoplasms; Proline; Receptors, Chimeric Antigen | 2022 |
Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells.
Topics: Antineoplastic Agents; Coordination Complexes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ferric Compounds; Ferrous Compounds; Humans; Ions; Ligands; Neoplasms; Organometallic Compounds; Proline; Ruthenium; Solubility; Water | 2022 |
Loss of attachment promotes proline accumulation and excretion in cancer cells.
Topics: Amino Acids; Biological Transport; Extracellular Matrix; Macrophages; Neoplasms; Proline | 2023 |
Assignment of the disordered, proline-rich N-terminal domain of the tumour suppressor p53 protein using
Topics: Humans; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Proline; Protons; Tumor Suppressor Protein p53 | 2023 |
Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ.
Topics: Antigens; Humans; Interferon-gamma; Neoplasms; Peptides; Proline; Proteomics | 2023 |
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
Topics: A549 Cells; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; HeLa Cells; Hep G2 Cells; Humans; Lipogenesis; MCF-7 Cells; Metabolic Networks and Pathways; Mice; Mice, Nude; Neoplasms; Proline | 2020 |
Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.
Topics: Animals; Antineoplastic Agents; Caffeic Acids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Assays; Humans; Hydroxamic Acids; Hydroxyproline; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Molecular Docking Simulation; Neoplasms; Proline; Rats; Recombinant Proteins; Sulfones | 2020 |
Distance-Dependent Cellular Uptake of Oligoproline-Based Homobivalent Ligands Targeting GPCRs-An Experimental and Computational Analysis.
Topics: Animals; Cell Line, Tumor; Female; HEK293 Cells; Humans; Ligands; Mice, SCID; Molecular Dynamics Simulation; Neoplasms; Oligopeptides; Proline; Receptors, Bombesin; Receptors, Somatostatin | 2020 |
Rational design of PIN1 inhibitors for cancer treatment based on conformational diversity analysis and docking based virtual screening.
Topics: Antineoplastic Agents; Early Detection of Cancer; Enzyme Inhibitors; Humans; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Phosphorylation; Proline | 2022 |
Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Genetic Variation; HEK293 Cells; Histones; Humans; Lentivirus; Leucine; Mice; Mice, Nude; Mutation; Neoplasms; Nucleotides; Proline; Proto-Oncogene Proteins c-myc; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |
Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells.
Topics: Cell Proliferation; delta-1-Pyrroline-5-Carboxylate Reductase; Diphosphonates; Humans; Neoplasms; Proline; Pyrroline Carboxylate Reductases | 2021 |
Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Topics: Antineoplastic Agents; Benzylidene Compounds; Biophysics; Drug Screening Assays, Antitumor; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hexosyltransferases; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Neoplasms; Proline; Proteasome Endopeptidase Complex; Protein Binding; Protein Domains; Ubiquitin Thiolesterase | 2017 |
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.
Topics: Antineoplastic Agents; Apoptosis; Drug Design; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Janus Kinase 2; Molecular Docking Simulation; Neoplasms; Proline; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Vorinostat | 2018 |
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Topics: Acetylation; Cell Proliferation; delta-1-Pyrroline-5-Carboxylate Reductase; Humans; MCF-7 Cells; Mitochondria; Neoplasms; Peptide Fragments; Proline; Pyrroline Carboxylate Reductases; Sialoglycoproteins; Sirtuin 3 | 2019 |
Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines.
Topics: Antioxidants; Ascorbic Acid; Dimerization; Gelatinases; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lysine; Matrix Metalloproteinase 9; Neoplasms; Proline; Urokinase-Type Plasminogen Activator | 2014 |
Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.
Topics: Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Kaplan-Meier Estimate; MCF-7 Cells; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Procollagen-Proline Dioxygenase; Prognosis; Proline; Up-Regulation | 2014 |
Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.
Topics: Animals; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Dipeptides; Dipeptidyl Peptidase 4; Humans; Melphalan; Neoplasms; Oligopeptides; Prodrugs; Proline; Swine | 2014 |
Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.
Topics: Antigens, Neoplasm; Membrane Proteins; Neoplasms; Peptides; Proline; Thiazoles | 2015 |
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Fibroblasts; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoenzymes; Mice; Molecular Dynamics Simulation; Neoplasms; Oxygen; Polycythemia; Proline; Protein Binding; Protein Domains; Recombinant Proteins; Structure-Activity Relationship | 2016 |
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Topics: Cell Line, Tumor; Enzyme Activation; Humans; Hydroxylation; Hypoxia-Inducible Factor-Proline Dioxygenases; Mutation; Neoplasms; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Tumor Hypoxia; Tumor Microenvironment; Von Hippel-Lindau Tumor Suppressor Protein | 2016 |
Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells.
Topics: Cell Cycle Proteins; Cell Hypoxia; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; HeLa Cells; Humans; Hydroxylation; Models, Molecular; Neoplasms; Nuclear Proteins; Proline; Protein Interaction Maps; Proteomics; Transcription Factors | 2016 |
Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues.
Topics: Antigens; Formaldehyde; Humans; Neoplasms; Oxidation-Reduction; Paraffin; Peptides; Proline; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2017 |
The metabolism of proline as microenvironmental stress substrate.
Topics: Collagen; delta-1-Pyrroline-5-Carboxylate Reductase; Dietary Proteins; Food; Homeostasis; Humans; Inflammation; Neoplasms; Proline; Proline Oxidase; Pyrroline Carboxylate Reductases; Stress, Physiological | 2008 |
cis-4-[(18)F]-Fluoro-l-proline fails to detect peripheral tumors in humans.
Topics: Adult; Aged; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neoplasms; Proline; Radionuclide Imaging | 2008 |
Helix 3 is necessary and sufficient for prion protein's anti-Bax function.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cells, Cultured; Cytoprotection; Humans; Mice; Neoplasms; Nerve Degeneration; Prion Diseases; Proline; Protein Structure, Secondary; PrPC Proteins | 2009 |
Shuttling gold nanoparticles into tumoral cells with an amphipathic proline-rich peptide.
Topics: Biological Transport; Gold; HeLa Cells; Humans; Metal Nanoparticles; Microscopy; Neoplasms; Peptides; Proline | 2009 |
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Incidence; Isoleucine; Japan; Lung Neoplasms; Male; Methionine; Middle Aged; Neoplasms; Polymorphism, Single Nucleotide; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Risk Factors | 2010 |
Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Calcinosis; Carrier State; Chlorocebus aethiops; Codon; COS Cells; DNA Primers; Exons; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glycosylation; Homozygote; Humans; Hypophosphatemia, Familial; Molecular Sequence Data; Neoplasms; Polymorphism, Single Nucleotide; Proline; Serine | 2009 |
Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; Ascorbic Acid; Camellia sinensis; Catechin; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lysine; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Micronutrients; Neoplasm Invasiveness; Neoplasms; Plant Extracts; Proline; Protease Inhibitors; Tetradecanoylphorbol Acetate | 2010 |
New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein.
Topics: Chromosome Mapping; Chromosomes, Human, Pair 3; Germ-Line Mutation; Humans; Kidney Neoplasms; Mutation; Neoplasms; Procollagen-Proline Dioxygenase; Proline; Succinate Dehydrogenase; Von Hippel-Lindau Tumor Suppressor Protein | 2010 |
Production of anticancer polyenes through precursor-directed biosynthesis.
Topics: Antineoplastic Agents; Fungi; HeLa Cells; Humans; Inhibitory Concentration 50; Neoplasms; Polyenes; Proline; Pyrones; Pyrroles | 2011 |
The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population.
Topics: Alanine; Case-Control Studies; Chromosomes, Human, Pair 2; Colorectal Neoplasms, Hereditary Nonpolyposis; Crystallography, X-Ray; DNA-Binding Proteins; Female; Founder Effect; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Heterozygote; Humans; Israel; Jews; Male; Microsatellite Repeats; Mutation, Missense; MutS Homolog 2 Protein; Neoplasms; Pedigree; Point Mutation; Polymorphism, Genetic; Proline; Protein Conformation; Proto-Oncogene Proteins | 2002 |
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
Topics: Apoptosis; Arginine; Cell Line; Chaperonin 60; Codon; Fatty Acids, Unsaturated; Genes, p53; Genetic Variation; HSP70 Heat-Shock Proteins; Humans; Membrane Proteins; Mitochondria; Neoplasms; Polymorphism, Genetic; Proline; Suppression, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53; Ubiquitin | 2003 |
Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display.
Topics: Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Extracellular Matrix; Genetic Vectors; Humans; Kinetics; Matrix Metalloproteinase 11; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Models, Molecular; Neoplasms; Peptide Library; Peptides; Proline; Protein Binding; Protein Structure, Tertiary; Substrate Specificity | 2003 |
Integrin beta3 Leu33Pro homozygosity and risk of cancer.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Cytosine; Denmark; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Integrin beta3; Leucine; Male; Middle Aged; Neoplasm Invasiveness; Neoplasms; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Thymine | 2003 |
The relation of ascorbic acid to the conversion of proline to hydroxyproline in the synthesis of collagen in the carrageenan granuloma.
Topics: Ascorbic Acid; Carrageenan; Collagen; Encephalomyelitis; Granuloma; Hydroxyproline; Neoplasms; Proline; Vitamins | 1959 |
[Autoradiographic studies on protein and melanin metabolism in different cell types in melanoma in mice (Harding-Passey type)].
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Melanins; Melanoma; Mice; Neoplasms; Neoplasms, Experimental; Proline; Proteins; Tyrosine | 1962 |
PEPITASE ACTIVITIES IN TISSUES OF TUMOR-BEARING RATS.
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Erythrocytes; Glycine; Leucine; Liver; Liver Neoplasms; Muscles; Neoplasms; Neoplasms, Experimental; Peptide Hydrolases; Peptides; Proline; Rats; Research; Sarcoma; Sarcoma, Experimental | 1963 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
Topics: Animals; Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Body Weight; Camptothecin; Cell Line, Tumor; Cisplatin; Coloring Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Male; Metalloporphyrins; Mice; Mitomycin; Neoplasms; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Polyethylene Glycols; Proline; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2004 |
p53-dependent down-regulation of telomerase is mediated by p21waf1.
Topics: Base Sequence; Blotting, Southern; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p21; DNA; DNA Mutational Analysis; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; Genes, Reporter; Histone Deacetylases; Humans; Luciferases; Molecular Sequence Data; Mutation; Neoplasms; Plasmids; Point Mutation; Proline; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Telomerase; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 2004 |
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Lysine; Models, Molecular; Mutation; Mutation, Missense; Neoplasms; Peptides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1.
Topics: Adult; Age Factors; Aged, 80 and over; Aging; Alleles; Antineoplastic Agents; Apoptosis; Arginine; beta-Galactosidase; Bromodeoxyuridine; Cell Cycle; Cell Death; Cell Separation; Cells, Cultured; Chromatin Immunoprecipitation; Codon; Cyclin-Dependent Kinase Inhibitor p21; Fibroblasts; Flow Cytometry; Homozygote; Humans; Luciferases; Microscopy, Fluorescence; Neoplasms; Oligonucleotides; Oxidative Stress; Polymorphism, Genetic; Proline; Propidium; Protein Isoforms; Transfection | 2005 |
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
Topics: Animals; Apoptosis; Cells, Cultured; DNA; DNA Damage; Gene Expression Regulation, Neoplastic; Mice; Mice, Transgenic; Mutation; Neoplasms; Proline; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Transcriptional Activation; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2006 |
Can mutations in gamma-actin modulate the toxicity of microtubule targeting agents?
Topics: Actins; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leucine; Microtubules; Mutation; Neoplasms; Proline; RNA, Small Interfering; Tubulin; Tubulin Modulators; Valine; Vincristine | 2006 |
Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.
Topics: Amino Acid Sequence; Animals; Apoptosis; Binding Sites; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Conserved Sequence; DNA Damage; Fibroblasts; Gene Targeting; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutant Proteins; Neoplasms; Point Mutation; Proline; Protein Binding; Protein Structure, Tertiary; Recombination, Genetic; Structure-Activity Relationship; Transcriptional Activation; Tumor Suppressor Protein p53 | 2007 |
Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Line, Tumor; Fibronectins; Humans; Inhibitory Concentration 50; Molecular Mimicry; Molecular Structure; Neoplasms; Oligopeptides; Peptide Library; Proline; Protein Conformation; Structure-Activity Relationship | 2007 |
TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania.
Topics: Amino Acid Substitution; Arginine; Asia, Southeastern; Codon; Gene Frequency; Genetic Predisposition to Disease; Humans; Neoplasms; Oceania; Polymorphism, Genetic; Population; Proline; Tumor Suppressor Protein p53 | 2007 |
Introduction to second proline symposium.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Gene Expression Regulation, Neoplastic; Humans; Metabolism; Models, Biological; Neoplasms; Neurophysiology; Ornithine-Oxo-Acid Transaminase; Proline | 2008 |
Preclinical evaluation of 4-[18F]fluoroprolines: diastereomeric effect on metabolism and uptake in mice.
Topics: Animals; Bone Neoplasms; Collagen; Fluorine Radioisotopes; Half-Life; Humans; Kidney; Liver; Mice; Neoplasms; Neoplasms, Experimental; Osteosarcoma; Proline; Radionuclide Imaging; Radiopharmaceuticals; Stereoisomerism; Tissue Distribution | 1999 |
Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; Expressed Sequence Tags; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Organ Specificity; Phosphoproteins; Proline; RNA, Messenger; Securin; Testis; Transfection; Tumor Cells, Cultured | 1999 |
Nuclear DEAF-1-related (NUDR) protein contains a novel DNA binding domain and represses transcription of the heterogeneous nuclear ribonucleoprotein A2/B1 promoter.
Topics: 5' Untranslated Regions; Base Sequence; Binding Sites; DNA-Binding Proteins; Gene Expression Regulation; Helix-Loop-Helix Motifs; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Proline; Promoter Regions, Genetic; Repressor Proteins; Thymidine Kinase; Transcription Factors; Transcription, Genetic | 1999 |
DNA sequence variants of p53: cancer and aging.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Codon; Genes, p53; Genetic Predisposition to Disease; Genetic Variation; Genotype; Haplotypes; Humans; Middle Aged; Neoplasms; Odds Ratio; Polymorphism, Genetic; Proline | 1999 |
[The lymphocyte cytotoxicity test in tumor immunology (author's transl)].
Topics: Animals; Antigens, Neoplasm; B-Lymphocytes; Cells, Cultured; Chromium Radioisotopes; Culture Media; Cytological Techniques; Cytotoxicity Tests, Immunologic; Epitopes; False Positive Reactions; Humans; Immunity, Cellular; Immunologic Techniques; Lymphocytes; Melanoma; Mice; Mitosis; Neoplasms; Proline; Rabbits; Rats; Surface Properties; T-Lymphocytes; Thymidine; Tritium; Urinary Bladder Neoplasms | 1975 |
Proline-hydroxylase activity in human blood.
Topics: Adolescent; Adult; Aged; Anesthesia; Bone Diseases; Child; Circadian Rhythm; Collagen; Collagen Diseases; Female; Humans; Liver Diseases; Male; Middle Aged; Mixed Function Oxygenases; Neoplasms; Proline; Surgical Procedures, Operative | 1970 |
[Comparative autoradiographic and quantitative radiochemical studies on the same material].
Topics: Anabolic Agents; Animals; Arteriosclerosis; Autoradiography; Carbon Isotopes; Connective Tissue; Connective Tissue Cells; Cyclophosphamide; Fractures, Bone; Glycosaminoglycans; Hydrocortisone; Mice; Neoplasms; Proline; Radiochemistry; Radiometry; Rats; Regeneration; Sulfates; Sulfur Isotopes; Thymidine; Tritium; Wound Healing; Wounds and Injuries | 1968 |
[Metabolism of glycosaminoglycane, collagen, and kidney function in dermatomyositis].
Topics: Autoradiography; Blood Proteins; Collagen; Dermatomyositis; Female; Glomerular Filtration Rate; Glucosamine; Glycosaminoglycans; Hexosamines; Histocytochemistry; Humans; Hydroxyproline; In Vitro Techniques; Kidney; Male; Neoplasms; Proline; Skin; Sulfates; Sulfur Radioisotopes; Tritium | 1974 |
Relationship between exposure to asbestos, collagen formation, ferruginous bodies, and carcinoma.
Topics: Asbestos; Benzopyrenes; Carcinogens; Cell Membrane Permeability; Citric Acid Cycle; Collagen; Electron Transport; Energy Metabolism; Environmental Exposure; Humans; Hydroxylation; Iron; Ketoglutaric Acids; Macrophages; Magnesium; Metalloproteins; Neoplasms; Oxygen Consumption; Phagocytosis; Procollagen-Proline Dioxygenase; Proline; Protein Binding | 1974 |
Problems of in-vitro incubation with radioactive precursors.
Topics: Animals; Antineoplastic Agents; Cytidine; Humans; Neoplasms; Phenylalanine; Proline; Rats; Thymidine; Tritium | 1973 |
[Concentration changes of free amino acids in blood plasma of patients under radiotherapy. (With reference to statistical results)].
Topics: Alanine; Amino Acids; Bronchial Neoplasms; Carcinoma; Cobalt Isotopes; Dysgerminoma; Esophageal Neoplasms; Female; Genital Neoplasms, Female; Hodgkin Disease; Humans; Leucine; Male; Neoplasms; Phenylalanine; Proline; Radiation Injuries; Sex Factors; Statistics as Topic; Tyrosine; Urinary Bladder Neoplasms; Valine | 1972 |