proline and Anoxemia

proline has been researched along with Anoxemia in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199015 (28.30)18.7374
1990's2 (3.77)18.2507
2000's19 (35.85)29.6817
2010's9 (16.98)24.3611
2020's8 (15.09)2.80

Authors

AuthorsStudies
Li, B; Li, L; Meng, J; Wang, T; Zhang, G1
Germán-Acacio, JM; Gómez-Martín, D; Maravillas-Montero, JL; Mejía-Domínguez, NR; Páez-Franco, JC; Pérez-Fragoso, A; Ponce-de-León, A; Tamez-Torres, KM; Torres-Ruiz, J; Ulloa-Aguirre, A1
Chen, T; Chu, Y; Fang, K; Leng, Z; Li, Z; Sun, M; Xu, A; Xu, M; Zhang, L; Zhang, Y; Zhang, Z; Zhao, Z1
Babuta, M; Dai, X; Dang, F; Duan, LJ; Erickson, E; Fong, GH; Guan, D; Guo, R; Hu, J; Inuzuka, H; Jiang, C; Kaelin, WG; Karnoub, AE; Lee, YR; Lian, G; Liu, H; Liu, J; Liu, M; Lv, M; Meng, H; Miao, J; Pan, L; Shi, L; Szabo, G; Tu, Z; Wang, H; Wang, J; Wang, M; Wang, Y; Wei, W; Xie, X; Xu, D; Yan, P; Yu, W; Yuan, J; Zhang, T; Zhang, Z; Zhuang, Y1
Liang, H; Song, K1
Gao, Y; Guo, Y; Liu, Y; Lu, F; Piao, Y; Tan, S; Tang, Y1
Hua, C; Lin, J; Lv, Q; Shen, Z; Song, Y; Wang, J; Wang, M; Xue, Z; Ying, H; Zhou, B1
He, W; Hu, S; Wu, G1
Al-Ejeh, F; Brennan, DJ; Casciello, F; Gannon, F; Hill, MM; Kelly, G; Lee, JS; Ngiow, SF; Smyth, MJ; Stoll, T; Windloch, K; Young, A1
Clasen, SJ; Espenshade, PJ; Gu, H; Shao, W1
Fang, C; Gao, P; Geng, P; Guo, L; Hu, C; Li, E; Liu, Y; Sun, M; Tang, L; Wang, C; Wang, J; Wang, Y; Xu, G; Yin, P; Yu, J; Zeng, J; Zhuang, Z1
Cao, J; Li, X; Wang, J; Xiao, F1
Catrina, SB; Chatzidionysiou, K; Ekberg, NR; Eliasson, S; Falhammar, H; Gu, HF; Li, YW; Zheng, X1
Chesler, N; Hacker, T; Schreier, D; Song, G1
Abboud, MI; Cantrelle, FX; Chowdhury, R; Claridge, TD; Domene, C; Ge, W; Hardy, AP; Landrieu, I; Leung, IK; Pugh, CW; Ratcliffe, PJ; Schofield, CJ; Tian, YM1
Ahn, YS; Kim, CH; Kim, DG; Kim, HS; Kim, I; Lee, J; Seo, GH1
Amadori, D; Bonafe, M; Brigliadori, G; Fabbri, F; Gusolfino, D; Massa, I; Passardi, A; Ricci, M; Rosetti, M; Sansone, P; Storci, G; Tesei, A; Ulivi, P; Vannini, I; Zoli, W1
Chowdhury, R; Domene, C; Flashman, E; Hewitson, KS; Loenarz, C; McDonough, MA; Mecinović, J; Schofield, CJ1
Kalamaki, MS; Kanellis, AK; Merkouropoulos, G1
Du, L; Lin, R; Liu, Q; Meng, K; Pan, C; Wu, W; Zhao, L1
Chen, P; Dong, Q; Feng, J; Lan, A; Wang, C; Wang, X; Yang, C; Yang, Z; Zeng, F; Zhang, M1
Maxwell, PH; Mole, DR; Pugh, CW; Ratcliffe, PJ1
Chan, DA; Denko, NC; Giaccia, AJ; Sutphin, PD1
D'Angelo, G; Duplan, E; Frelin, C; Vigne, P1
Gorman, JJ; Lando, D; Peet, DJ; Whitelaw, ML1
Boyer, N; D'Angelo, G; Duplan, E; Frelin, C; Vigne, P1
Günzler, V; Hirsilä, M; Kivirikko, KI; Koivunen, P; Myllyharju, J1
Nikinmaa, M; Pursiheimo, S; Soitamo, AJ1
Bruick, RK; Donald, SP; Kasprzak, KS; Phang, JM; Salnikow, K; Zhitkovich, A1
Kentsis, A; Miller, F; Osman, R; Pan, ZQ1
Hirota, K; Kasuno, K; Kimura, H; Kurooka, H; Li, X; Okada, T; Torii, K; Yokota, Y; Yoshida, H1
Belinka, B; Lu, SE; Pachence, J; Poiani, GJ; Riley, DJ; Simon, PM; Tozzi, CA1
Graf, AV; Krushinskaya, YV; Maklakova, AS; Sokolova, NA1
Clancy, J; Klein, RM; McKenzie, JC1
Catravas, JD; Gillis, CN1
Herrig, JE; McWeeny, OJ; Robillard, JE; Weismann, DN1
Kato, S; Kawai, H; Matsuoka, M; Mochizuki, J; Odagawa, A; Shindo, K1
Burton, CJ; Combe, C; Dufourco, P; Harris, KP; Horsburgh, T; Walls, J; Weston, S1
Asahara, T; Maulik, N; Otani, H; Ray, PS; Sasaki, H; Zhu, L1
Chang, NS1
Kaelin, WG1
Hurych, J; Mirejovská, E; Mirejovský, P1
Hurych, J; Mirejovská, E; Ostádal, B; Pelouch, V; Procházka, J1
Anttinen, H; Kivirikko, KI; Oikarinen, A1
Romen, W1
Gregson, N; Hamberger, A; Lehninger, AL1
Prockop, DJ; Uitto, J2
Wajgt, A; Wender, M; Zgorzalewicz, B1
Lindy, S; Pedersen, FB; Turto, H; Uitto, J1
Beaty, C; Becker, B; Coben, LA; Cotlier, E1
Baerlocher, KE; Mohyuddin, F; Scriver, CR1
Chvapil, M; Hurych, J; Mirejovská, E1

Reviews

4 review(s) available for proline and Anoxemia

ArticleYear
Hydroxyproline in animal metabolism, nutrition, and cell signaling.
    Amino acids, 2022, Volume: 54, Issue:4

    Topics: Animals; Collagen; Dietary Proteins; Hydroxyproline; Hypoxia; Proline; Signal Transduction

2022
Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.
    European journal of biochemistry, 2003, Volume: 270, Issue:5

    Topics: Asparagine; Hydroxylation; Hypoxia; Oxygen; Proline; Transcription Factors

2003
How oxygen makes its presence felt.
    Genes & development, 2002, Jun-15, Volume: 16, Issue:12

    Topics: Animals; Asparagine; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Nuclear Proteins; Oxygen; Proline; Protein Structure, Tertiary; Transcription Factors; Transcriptional Activation

2002
[On the pathogenesis of the glomerulosclerosis ultrastructural and autoradiographic investigations on the rat kidney (author's transl)].
    Veroffentlichungen aus der Pathologie, 1976, Issue:102

    Topics: Aging; Animals; Autoradiography; Basement Membrane; Collagen; Hemostasis; Hypertension; Hypoxia; Kidney Glomerulus; Ligation; Male; Morpholines; Nephrectomy; Nitroso Compounds; Proline; Rats; Renal Veins

1976

Other Studies

49 other study(ies) available for proline and Anoxemia

ArticleYear
Oxygen sensing and transcriptional regulation under hypoxia exposure in the mollusk Crassostrea gigas.
    The Science of the total environment, 2022, Dec-20, Volume: 853

    Topics: Amino Acids; Animals; Crassostrea; Hypoxia; Oxygen; Phylogeny; Procollagen-Proline Dioxygenase; Proline; RNA, Messenger

2022
Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and COVID-19 pathophysiology.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Amino Acids; COVID-19; Cystine; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Homeostasis; Humans; Hypoxia; Male; Oxidation-Reduction; Oxygen; Proline; Reactive Oxygen Species; SARS-CoV-2

2022
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
    Journal of experimental & clinical cancer research : CR, 2023, Mar-28, Volume: 42, Issue:1

    Topics: Arginine; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Hypoxia; Oxygen; Proline; Receptor, IGF Type 1; Tumor Microenvironment

2023
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation.
    Nature cell biology, 2023, Volume: 25, Issue:7

    Topics: Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Necroptosis; Proline; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor, Type I

2023
Comprehensive metabolomics and transcriptomics analysis reveals protein and amino acid metabolic characteristics in liver tissue under chronic hypoxia.
    PloS one, 2023, Volume: 18, Issue:9

    Topics: Amino Acids; Animals; Hypoxia; Liver; Mice; Proline; Transcriptome

2023
Metabolomic changes of blood plasma associated with two phases of rat OIR.
    Experimental eye research, 2020, Volume: 190

    Topics: Animals; Animals, Newborn; Biomarkers; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glutamine; Hyperoxia; Hypoxia; Metabolome; Metabolomics; Ornithine; Oxidative Stress; Oxygen; Proline; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinopathy of Prematurity

2020
Metabolomic Analysis of the Ameliorative Effect of Enhanced Proline Metabolism on Hypoxia-Induced Injury in Cardiomyocytes.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Apoptosis; Hypoxia; Membrane Potential, Mitochondrial; Metabolomics; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Proline; Rats; Reactive Oxygen Species; Signal Transduction

2020
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 07-03, Volume: 114, Issue:27

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease-Free Survival; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred C57BL; Prognosis; Proline; Protein Processing, Post-Translational; Recurrence; RNA, Small Interfering; Tumor Microenvironment

2017
Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation.
    eLife, 2017, 10-30, Volume: 6

    Topics: Adaptation, Physiological; Gene Expression Regulation, Fungal; Hydroxylation; Hypoxia; Proline; Protein Binding; Protein Interaction Mapping; Schizosaccharomyces; Schizosaccharomyces pombe Proteins

2017
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 01-15, Volume: 24, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Metabolome; Metabolomics; Phenotype; Proline; Sorafenib; Xenograft Model Antitumor Assays

2018
Mechanisms of vascular endothelial cell injury in response to intermittent and/or continuous hypoxia exposure and protective effects of anti-inflammatory and anti-oxidant agents.
    Sleep & breathing = Schlaf & Atmung, 2019, Volume: 23, Issue:2

    Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Coculture Techniques; Cyclic N-Oxides; Endothelial Cells; Humans; Hypoxia; Inflammation Mediators; Neutrophils; Oxidative Stress; Proline; Spin Labels; Thiocarbamates

2019
Protective Effect of the
    Journal of diabetes research, 2019, Volume: 2019

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Female; Genotype; Glucose; HEK293 Cells; Humans; Hyperglycemia; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Mutation; Polymorphism, Single Nucleotide; Proline; Risk Factors; Serine; Transcriptional Activation; Young Adult

2019
The role of collagen synthesis in ventricular and vascular adaptation to hypoxic pulmonary hypertension.
    Journal of biomechanical engineering, 2013, Volume: 135, Issue:2

    Topics: Adaptation, Physiological; Air; Animals; Blood Gas Analysis; Blood Vessels; Collagen; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Male; Mice; Mice, Inbred C57BL; Proline

2013
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
    Nature communications, 2016, 08-26, Volume: 7

    Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Fibroblasts; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoenzymes; Mice; Molecular Dynamics Simulation; Neoplasms; Oxygen; Polycythemia; Proline; Protein Binding; Protein Domains; Recombinant Proteins; Structure-Activity Relationship

2016
Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes.
    Neuroreport, 2008, Jul-02, Volume: 19, Issue:10

    Topics: Antineoplastic Agents; Astrocytoma; Cell Line, Tumor; Cell Nucleus; Dose-Response Relationship, Drug; Drug Interactions; Electrophoretic Mobility Shift Assay; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Proline; Protein Transport; Thiocarbamates; Time Factors; Zinc Sulfate

2008
Role of p53 codon 72 arginine allele in cell survival in vitro and in the clinical outcome of patients with advanced breast cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2008, Volume: 29, Issue:3

    Topics: Adult; Aged; Alleles; Arginine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Codon; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Hypoxia; Kaplan-Meier Estimate; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Proline; Transfection; Tumor Suppressor Protein p53; Up-Regulation

2008
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
    Structure (London, England : 1993), 2009, Jul-15, Volume: 17, Issue:7

    Topics: Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Humans; Hydroxylation; Hydroxyproline; Hypoxia; Hypoxia-Inducible Factor 1; Ketoglutaric Acids; Models, Molecular; Oxygen; Procollagen-Proline Dioxygenase; Proline; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Signal Transduction; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2009
Can ornithine accumulation modulate abiotic stress tolerance in Arabidopsis?
    Plant signaling & behavior, 2009, Volume: 4, Issue:11

    Topics: Adaptation, Physiological; Amino-Acid N-Acetyltransferase; Arabidopsis; Arginine; Gene Expression; Genes, Plant; Hypoxia; Ornithine; Oxygen; Plants, Genetically Modified; Polyamines; Proline; Solanum lycopersicum; Stress, Physiological

2009
Hypoxia activates heparanase expression in an NF-kappaB dependent manner.
    Oncology reports, 2010, Volume: 23, Issue:1

    Topics: Antioxidants; Disease Progression; Enzyme Activation; Extracellular Matrix; Glucuronidase; Hypoxia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Oligonucleotides, Antisense; Oxygen; Proline; RNA, Messenger; Thiocarbamates; Time Factors

2010
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cobalt; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Sulfide; Hypoxia; Interleukin-1beta; Interleukin-6; Interleukin-8; NF-kappa B; Nitrobenzenes; Proline; Reactive Oxygen Species; Signal Transduction; Sulfonamides; Thiocarbamates

2011
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
    Advances in enzyme regulation, 2002, Volume: 42

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cobalt; Dose-Response Relationship, Drug; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Ketoglutaric Acids; Ligases; Oxygen; Plasmids; Proline; Protein Biosynthesis; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reticulocytes; Time Factors; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2002
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
    The Journal of biological chemistry, 2002, Oct-18, Volume: 277, Issue:42

    Topics: Amino Acids, Dicarboxylic; Animals; Chelating Agents; Cobalt; Deferoxamine; Fibroblasts; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron; Luciferases; Mice; Mice, Knockout; Proline; Protein Binding; Transcription Factors; Transfection

2002
Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation.
    The Journal of biological chemistry, 2003, Apr-25, Volume: 278, Issue:17

    Topics: Adaptation, Physiological; Animals; Cyclosporine; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Procollagen-Proline Dioxygenase; Proline; Rats; Transcription Factors; Transcription, Genetic

2003
Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    The Journal of biological chemistry, 2003, Oct-03, Volume: 278, Issue:40

    Topics: Animals; Blotting, Northern; Blotting, Western; DNA-Binding Proteins; Down-Regulation; Feedback, Physiological; Glutathione Transferase; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Ketoglutaric Acids; Ligases; Molecular Sequence Data; Nuclear Proteins; Oxygen; Peptides; Procollagen-Proline Dioxygenase; Proline; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Succinic Acid; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein

2003
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11

    Topics: Animals; Binding Sites; Catalysis; Cell Line; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Insecta; Ketoglutaric Acids; Kinetics; Mixed Function Oxygenases; Molecular Sequence Data; Nuclear Proteins; Oxygen; Peptides; Procollagen-Proline Dioxygenase; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; Time Factors; Trans-Activators; Transcription Factors

2004
Redox state regulates HIF-1alpha and its DNA binding and phosphorylation in salmonid cells.
    Journal of cell science, 2004, Jul-01, Volume: 117, Issue:Pt 15

    Topics: Acetylcysteine; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cell Line; Cysteine; Dimerization; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress; Oxygen; Phosphorylation; Proline; Propyl Gallate; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; RNA; Time Factors; Transcription Factors; Transcriptional Activation

2004
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.
    The Journal of biological chemistry, 2004, Sep-24, Volume: 279, Issue:39

    Topics: Ascorbic Acid; Blotting, Western; Carcinogens; Cell Line; Chromatography, High Pressure Liquid; Cobalt; Cysteine Endopeptidases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Ketoglutaric Acids; Models, Biological; Multienzyme Complexes; Mutation; Nickel; Nuclear Proteins; Oxygen; Plasmids; Procollagen-Proline Dioxygenase; Proline; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein

2004
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Lysine; Models, Molecular; Mutation; Mutation, Missense; Neoplasms; Peptides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2005
Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells.
    Kidney international, 2005, Volume: 68, Issue:2

    Topics: Antineoplastic Agents; Cell Nucleus; Cell Survival; Cells, Cultured; Drug Synergism; Gene Expression Regulation; Genistein; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules, Proximal; NF-kappa B; Oxygen; Plasminogen Activator Inhibitor 1; Proline; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Signal Transduction; Thiocarbamates; Transcription Factors; Tumor Necrosis Factor-alpha

2005
Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:4

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Hydroxyproline; Hypertension, Pulmonary; Hypoxia; Infusion Pumps; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Lysine; Male; Polyethylene Glycols; Prodrugs; Proline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Treatment Outcome

2006
Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
    Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:1

    Topics: Animals; Female; Hypoxia; Male; Mental Disorders; Oligopeptides; Pregnancy; Prenatal Exposure Delayed Effects; Proline; Rats; Risk-Taking

2006
Autoradiographic analysis of cell proliferation and protein synthesis in the pulmonary trunk of rats during the early development of hypoxia-induced pulmonary hypertension.
    Blood vessels, 1984, Volume: 21, Issue:2

    Topics: Animals; Autoradiography; Cardiomegaly; Cell Division; Hypertension, Pulmonary; Hypoxia; Male; Organ Size; Proline; Protein Biosynthesis; Pulmonary Artery; Rats; Rats, Inbred Strains; Tritium

1984
Metabolism of [3H]benzoyl-phenylalanyl-alanyl-proline by pulmonary angiotensin converting enzyme in vivo: effects of bradykinin, SQ 14225 or acute hypoxia.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:2

    Topics: Animals; Bradykinin; Captopril; Dogs; Female; Hypoxia; In Vitro Techniques; Lung; Male; Oligopeptides; Peptidyl-Dipeptidase A; Proline; Rabbits

1981
Organ tissue blood flow responses to hypoxemia in lambs: effect of angiotensin converting enzyme inhibitor.
    Pediatric research, 1983, Volume: 17, Issue:3

    Topics: Adrenal Glands; Animals; Blood Circulation; Blood Pressure; Captopril; Coronary Circulation; Heart Rate; Hypoxia; Intestine, Small; Liver Circulation; Muscles; Proline; Regional Blood Flow; Renin-Angiotensin System; Sheep; Spleen

1983
Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.
    The Journal of antibiotics, 1993, Volume: 46, Issue:6

    Topics: Animals; Brain; Fermentation; Hypoxia; Lipid Peroxidation; Male; Mice; Proline; Pyrroles; Rats; Rats, Wistar; Streptomyces

1993
Hypoxia induces intercellular adhesion molecule-1 on cultured human tubular cells.
    Kidney international, 1997, Volume: 51, Issue:6

    Topics: Antioxidants; Cell Survival; Cells, Cultured; Cytokines; Humans; Hypoxia; Intercellular Adhesion Molecule-1; Kidney Tubules; Oxygen; Proline; Thiocarbamates

1997
Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Arteries; Blood Pressure; Capillaries; Coronary Vessels; Dobutamine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Hypoxia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; NF-kappa B; Oxidation-Reduction; Oxygen; Proline; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thiocarbamates; Time Factors

2001
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Animals; Ankyrins; Apoptosis; Cell Division; Cell Line; Cell Nucleus; COS Cells; Cytosol; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Etoposide; Genes, Dominant; Humans; Hyaluronoglucosaminidase; Hypoxia; I-kappa B Proteins; Liver; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; NF-KappaB Inhibitor alpha; Phosphorylation; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Serine; Spleen; Staurosporine; Threonine; Time Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays

2002
Effect of hyperbarism on collagenous protein metabolism in granulation tissue.
    Physiologia Bohemoslovaca, 1975, Volume: 24, Issue:4

    Topics: Animals; Atmospheric Pressure; Collagen; Granulation Tissue; Hydroxyproline; Hyperbaric Oxygenation; Hypoxia; Proline; Protein Biosynthesis; Rats

1975
Effect of intermittent high altitude hypoxia on the synthesis of collagenous and non-collagenous proteins of the right and left ventricular myocardium.
    Cardiovascular research, 1978, Volume: 12, Issue:5

    Topics: Altitude Sickness; Animals; Cardiomegaly; Collagen; Heart Ventricles; Hypoxia; Male; Myocardium; Proline; Protein Biosynthesis; Proteins; Rats

1978
Further studies on the effect of the collagen triple-helix formation on the hydroxylation of lysine and the glycosylations of hydroxylysine in chick-embryo tendon and cartilage cells.
    The Biochemical journal, 1977, Sep-15, Volume: 166, Issue:3

    Topics: Animals; Cartilage; Chick Embryo; Collagen; Dithiothreitol; Hydroxylation; Hydroxylysine; Hydroxyproline; Hypoxia; Lysine; Proline; Tendons

1977
The effect of acute exercise on amino acid incorporation into mitochondria of rabbit tissues.
    Biochimica et biophysica acta, 1969, Aug-20, Volume: 186, Issue:2

    Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Aging; Amino Acids; Animals; Brain; Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Hypoxia; Leucine; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen; Physical Exertion; Proline; Protein Biosynthesis; Quaternary Ammonium Compounds; Rabbits; Swimming; Testosterone

1969
Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation.
    Biochemistry, 1974, Oct-22, Volume: 13, Issue:22

    Topics: Animals; Binding Sites; Carbon Radioisotopes; Cartilage; Chick Embryo; Chromatography, Gel; Collagen; Disulfides; Electrophoresis, Polyacrylamide Gel; Hydroxyproline; Hypoxia; Iodoacetates; Isotope Labeling; Kinetics; Microbial Collagenase; Proline; Protein Binding; Protein Conformation; Protein Precursors; Time Factors; Trypsin

1974
Protein synthesis in vitro by the rat brain in course of experimental cyanide encephalopathy.
    Experimentelle Pathologie, 1974, Volume: 9, Issue:3

    Topics: Animals; Brain; Brain Diseases; Cyanides; Demyelinating Diseases; Disease Models, Animal; Female; Hypoxia; Leucine; Male; Myelin Sheath; Nerve Tissue Proteins; Poisoning; Proline; Rats

1974
Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia.
    Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1

    Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Chromatography, Gel; Collagen; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Hydroxylysine; Hypoxia; Isotope Labeling; Lysine; Mixed Function Oxygenases; Nitrogen; Proline; Protein Conformation; Protein Precursors; Temperature; Tendons; Time Factors

1974
Lactate, lactate dehydrogenase and protocollagen proline hydroxylase in rat skin autograft.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1971, Volume: 352, Issue:8

    Topics: Animals; Collagen; Hypoxia; L-Lactate Dehydrogenase; Lactates; Male; Mixed Function Oxygenases; Proline; Rats; RNA; Skin Transplantation; Transplantation, Autologous

1971
Transport of amino acids by rabbit choroid plexus in vitro.
    Brain research, 1971, Jul-09, Volume: 30, Issue:1

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Carrier Proteins; Choroid Plexus; Cold Temperature; Cyanides; Diffusion; Dinitrophenols; Glycine; Hydrogen-Ion Concentration; Hypoxia; Mathematics; Organ Culture Techniques; Ouabain; Proline; Rabbits; Sodium

1971
The ontogeny of amino acid transport in rat kidney. II. Kinetics of uptake and effect of anoxia.
    Biochimica et biophysica acta, 1971, Dec-03, Volume: 249, Issue:2

    Topics: Aminoisobutyric Acids; Animals; Animals, Newborn; Biological Transport; Carbon Isotopes; Cyanides; Depression, Chemical; Glycine; Hypoxia; Kidney; Kinetics; Proline; Rats; Stimulation, Chemical; Temperature

1971
Effect of long-term hypoxia on protein synthesis in granuloma and in some organs in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 135, Issue:3

    Topics: Animals; Carbon Isotopes; Collagen; Female; Granuloma; Hydroxyproline; Hypoxia; Intestine, Small; Liver; Lung; Myocardium; Proline; Protein Biosynthesis; Rats

1970