proline has been researched along with Alzheimer Disease in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.60) | 18.7374 |
| 1990's | 15 (19.48) | 18.2507 |
| 2000's | 23 (29.87) | 29.6817 |
| 2010's | 27 (35.06) | 24.3611 |
| 2020's | 10 (12.99) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, Y; Ke, D; Li, HL; Li, L; Liu, R; Mahaman, YAR; Wang, JZ; Wang, Q; Wang, X; Wu, G; Zhang, B | 1 |
| Akbari, V; Farrokhi, A; Ghobadi, S; Khodarahmi, R; Mehrabi, M; Mohammadi, S | 1 |
| Futai, E; Hidaka, M; Ogawa, T; Suzuki, R; Takahashi, H; Yoshida, C | 1 |
| Bera, K; Cantrelle, FX; Dupré, E; Hanoulle, X; Hritz, J; Landrieu, I; Lasorsa, A; Malki, I; Merzougui, H; Sinnaeve, D | 1 |
| He, J; He, Y; Li, M; Liu, M; Sun, Z; Yang, J | 1 |
| Akbari, V; Bijari, N; Karima, S; Khodarahmi, R; Mehrabi, M; Ojaghi, S; Ranjbar, S; Sankian, M | 1 |
| Beaver, JD; Diamond, MI; Gupta, A; Hitt, BD; Joachimiak, LA; Shang, P; Singh, R; White, CL; Yang, T | 1 |
| Irie, K | 1 |
| Mallajosyula, SS; Mittal, J; Rani, L | 1 |
| Cook, DB; Dubal, DB; Gaitán, JM; Moon, HY; Okonkwo, OC; Stremlau, M; van Praag, H | 1 |
| An, SSA; Bagyinszky, E; Giau, VV; Kim, S; Park, J; Shim, K; Youn, YC | 1 |
| Han, Y; Kong, L; Liu, L; Liu, Z; Sun, H; Wang, X; Yu, J; Zhang, A | 1 |
| Huang, YR; Ji, M; Liu, DQ; Liu, RT; Wang, SW; Xie, XX; Yu, XL; Zhang, LX; Zhang, Y | 1 |
| Borlongan, CV; Currier, G; Habib, A; Hou, H; Koilraj, S; Munna, SA; Rongo, D; Sawmiller, D; Shytle, RD; Tan, J | 1 |
| Janusz, M; Zabłocka, A | 1 |
| Driver, JA; Lu, KP; Zhou, XZ | 1 |
| Berlau, DJ; Cheema, AK; Federoff, HJ; Fiandaca, MS; Fisher, SG; Haley, JM; Hall, WJ; Kawas, CH; MacArthur, LH; Mapstone, M; Mhyre, TR; Nazar, MD; Peltz, CB; Peterson, DR; Rich, SA; Tan, MT; Zhong, X | 1 |
| Acker, C; Azose, M; Buthorn, J; D'Abramo, C; Davies, P; Greenwald, BS; Jimenez, H; Koppel, J; Lesser, M; Lewis, J; Liu, Z | 1 |
| Akagi, K; Hanaki, M; Irie, K; Monobe, Y; Murakami, K; Suzuki, T | 1 |
| Chen, S; He, S; Huang, Y; Shi, Y; Wu, Y; Xia, M; Xu, C; Xu, J; Zang, W; Zhang, J; Zhao, T | 1 |
| Bejerano-Sagie, M; Ben-Gedalya, T; Burstyn-Cohen, T; Cabral, WA; Cohen, E; Frere, S; Friedmann-Morvinski, D; Marini, JC; Moll, L; Slutsky, I | 1 |
| Cohen, TJ; Constance, BH; Hwang, AW; James, M; Yuan, CX | 1 |
| Harmsen, B; Leyssens, T; Robeyns, K; Wouters, J | 1 |
| Biernat, J; Chinnathambi, S; Hascher, A; Jeganathan, S; Mandelkow, E; Mandelkow, EM | 1 |
| Irie, K; Masuda, Y; Nakanishi, A; Ohashi, R; Shimizu, T; Shirasawa, T; Takegoshi, K; Uemura, S | 1 |
| Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N | 1 |
| Bousquet, O; Lauzon, M; Leclerc, N; Paiement, J; Perreault, S | 1 |
| Cano-Abad, MF; García, AG; Moreno-Ortega, AJ; Ruiz-Nuño, A | 1 |
| Cao, L; Chen, SD; Cheng, Q; Cui, PJ; Deng, YL; Ding, JQ; Ma, JF; Tang, HD; Wang, G; Wang, Y; Xu, W; Zhang, T; Zheng, L | 1 |
| Alegret, M; Antúnez, C; Boada, M; Carrasco, JM; Galán, JJ; González-Pérez, A; Hernández, I; López-Arrieta, J; Marín, J; Martínez-Lage, P; Moreno, C; Morón, FJ; Real, LM; Ruiz, A; Tárraga, L | 1 |
| Bagnoli, S; Bessi, V; Bracco, L; Cellini, E; Guarnieri, BM; Lucenteforte, E; Nacmias, B; Piaceri, I; Sorbi, S; Tedde, A | 1 |
| Stewart, MG | 1 |
| Barbiroli, A; Bellotti, V; Bolognesi, M; Bonomi, F; Colombo, M; Giorgetti, S; Grandori, R; Raimondi, S; Ricagno, S; Santambrogio, C | 1 |
| Binder, LI; Fu, Y; Kanaan, NM; Reyes, JF; Vana, L | 1 |
| Abdul, HM; Butterfield, DA; Cai, J; Di Domenico, F; Markesbery, WR; Pierce, WM; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Bibow, S; Biernat, J; Blackledge, M; Mandelkow, E; Ozenne, V; Zweckstetter, M | 1 |
| Capone, R; Jang, H; Kagan, BL; Kotler, SA; Lal, R; Nussinov, R | 1 |
| Bigio, EH; Binder, L; Denial, S; Greenwood, A; Lu, KP; Nakamura, K; Nicholson, L; Zhou, XZ | 1 |
| Cardoso, BR; Cominetti, C; Cozzolino, SM; Freitas, MI; Jacob-Filho, W; Jaluul, O; Ong, TP | 1 |
| Ando, K; Bégard, S; Bélarbi, K; Blum, D; Bretteville, A; Buée, L; Caillet-Boudin, ML; Demey-Thomas, E; Dourlen, P; Drobecq, H; Eddarkaoui, S; Galas, MC; Ghestem, A; Hamdane, M; Landrieu, I; Lippens, G; Maurage, CA; Melnyk, P; Sambo, AV; Sergeant, N; Smet, C; Verdier, Y; Vingtdeux, V; Vinh, J | 1 |
| Lu, KP; Nakamura, K; Zhou, XZ | 1 |
| Liou, YC; Lu, KP; Vincent, I | 1 |
| Juszczak, LJ | 1 |
| Cardoso, SM; Oliveira, CR | 1 |
| Dowjat, WK; Kuchna, I; Wegiel, J; Wisniewski, T | 1 |
| Lu, KP | 1 |
| Selley, ML | 1 |
| Fukuda, H; Irie, K; Masuda, Y; Morimoto, A; Murakami, K; Nagao, M; Ohigashi, H; Shimizu, T; Shirasawa, T | 1 |
| Alvarez-de-la-Rosa, M; Avila, J; García-Segura, LM; Naftolin, F; Nilsen, J; Pérez, MM; Silva, I | 1 |
| Kobayashi, N; Ochiai, S; Sode, K; Usuzaka, E | 1 |
| Abdel-Meguid, SS; Babine, RE; Jin, L; Navaneetham, D; Pandey, P; Strickler, JE; Walsh, PN | 1 |
| Baud, S; Keeley, FW; Miao, M; Pomès, R; Rauscher, S | 1 |
| Alvarez, V; Calatayud, MT; Corao, AI; Coto, E; García-Castro, M; González, P; Lahoz, CH; Martínez, C; Menéndez, M; Peña, J | 1 |
| Aghajanov, M; Bosker, F; Gladkevich, A; Korf, J; Vahradyan, H; Yenkoyan, K | 1 |
| Caragounis, A; Crouch, PJ; Du, T; Filiz, G; Price, KA; White, AR | 1 |
| Baldwin, RA; Baxter, CF; Brinkman, SD; Pomara, N | 1 |
| Hasegawa, M; Ihara, Y; Morishima-Kawashima, M; Suzuki, M; Takio, K; Titani, K; Yoshida, H | 1 |
| Hurle, MR; Martin, JD; Wetzel, R; Wood, SJ | 1 |
| Shiah, SG; Song, JS; Yang, SD; Yu, JS | 1 |
| Cutler, NR; Markowitz, J; Mickelson, W; Repetti, S; Sramek, JJ; Sudilovsky, A; Veroff, AE; Wardle, T | 1 |
| Grundke-Iqbal, I; Iqbal, K; Singh, TJ; Zaidi, T | 1 |
| Blanchard, PJ; Falkous, G; Ishiura, S; Mantle, D; Perry, EK | 1 |
| Baeuerle, PA; Kaltschmidt, B; Kaltschmidt, C; Uherek, M; Volk, B | 1 |
| Avila, J; Diaz-Nido, J; Moreno, FJ; Muñoz-Montaño, JR | 1 |
| Badmajew, E; Dowjat, WK; Kuchna, I; Kulczycki, J; Popovitch, E; Tarnawski, M; Wegiel, J; Wisniewski, HM; Wisniewski, T | 1 |
| Cantu, JM; Hernandez-Romo, JA; Leal, CA; Lin, C; Ramirez-Casillas, GA; Ramirez-Dueñas, MG; Rogaeva, EA; St George-Hyslop, PH | 1 |
| Aston, CE; DeKosky, ST; Ferrell, RE; Hardy, J; Kamboh, MI; Kokmen, E; Perez-Tur, J | 1 |
| Anderton, BH; Betts, JC; Blackstock, WP; Nebreda, AR; Reynolds, CH | 1 |
| Helisalmi, S; Hiltunen, M; Karvonen, MK; Koulu, M; Mannermaa, A; Pesonen, U; Pirskanen, M; Soininen, H; Uusitupa, M; Valve, R | 1 |
| De Strooper, B; Iwatsubo, T; Kopan, R; Morohashi, Y; Takasugi, N; Takikawa, R; Tomita, T; Watabiki, T | 1 |
| Brice, A; Campion, D; Durr, A; Frebourg, T; Hahn, V; Jacquemont, ML; Tallaksen, C | 1 |
| Liou, YC; Lu, KP; Zhou, XZ | 1 |
| Berling, B; Biernat, J; Goedert, M; Lichtenberg-Kraag, B; Mandelkow, E; Mandelkow, EM; Mercken, M; Meyer, H; Schröter, C; Steiner, B; Vandermeeren, A | 1 |
| Biernat, J; Goedert, M; Gustke, N; Mandelkow, E; Mandelkow, EM; Meyer, HE; Steiner, B | 1 |
| Barnes, NM; Cheng, CH; Costall, B; Naylor, RJ; Williams, TJ; Wischik, CM | 1 |
| Hsiao, K; Prusiner, SB | 1 |
| Cross, AJ; Deakin, JF; Simpson, MD; Slater, P | 1 |
7 review(s) available for proline and Alzheimer Disease
| Article | Year |
|---|---|
Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Humans; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Proline; Protein Conformation | 2014 |
Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease.
Topics: Alzheimer Disease; Humans; Isomerism; Mitosis; Models, Neurological; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Proline | 2003 |
Pinning down cell signaling, cancer and Alzheimer's disease.
Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biological; Models, Molecular; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Proline-Directed Protein Kinases; Protein Structure, Tertiary; Signal Transduction | 2004 |
Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders -- therapeutic potential or a mirage?
Topics: Alzheimer Disease; Animals; Caspases; Clinical Trials as Topic; Cognition; Crush Syndrome; Humans; Hypothalamus; Immunity; Intercellular Signaling Peptides and Proteins; Neurodegenerative Diseases; Neurotoxicity Syndromes; Oxidative Stress; Peptides; Pituitary Gland; Proline | 2007 |
The role of metals in modulating metalloprotease activity in the AD brain.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Brain; Cell Culture Techniques; Chelating Agents; Clioquinol; Copper; Disease Models, Animal; Egtazic Acid; Enzyme Activation; ErbB Receptors; Humans; Intracellular Space; Matrix Metalloproteinases, Secreted; Mitogen-Activated Protein Kinases; Plaque, Amyloid; Proline; Thiocarbamates; Trace Elements; Zinc | 2008 |
Pinning down proline-directed phosphorylation signaling.
Topics: Alzheimer Disease; Amino Acid Motifs; Animals; Humans; Models, Molecular; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Conformation; Proteins; Signal Transduction | 2002 |
Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Codon; Genetic Markers; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Transgenic; Models, Genetic; Prions; Proline; PrPSc Proteins | 1991 |
2 trial(s) available for proline and Alzheimer Disease
| Article | Year |
|---|---|
Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain-Derived Neurotrophic Factor; Cathepsin B; Cognition; Exercise; Fatty Acids, Omega-3; Female; Gastrointestinal Microbiome; Humans; Hydroxyproline; Klotho Proteins; Lipid Metabolism; Male; Metabolomics; Middle Aged; Proline; Risk Factors | 2021 |
A pilot clinical trial of the angiotensin-converting enzyme inhibitor ceranapril in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Organophosphorus Compounds; Pilot Projects; Proline | 1993 |
68 other study(ies) available for proline and Alzheimer Disease
| Article | Year |
|---|---|
Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration.
Topics: Alzheimer Disease; Animals; Mice; Mice, Inbred C57BL; Phosphorylation; Proline; tau Proteins; Tauopathies | 2022 |
Investigation of the role of prolines 232/233 in RTPPK motif in tau protein aggregation: An in vitro study.
Topics: Alanine; Alzheimer Disease; Humans; Mutant Proteins; Proline; Protein Aggregates; tau Proteins | 2022 |
Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Humans; Mutation; Proline | 2023 |
Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Binding Sites; Humans; Nuclear Proteins; Peptides; Phosphorylation; Proline; Protein Binding; src Homology Domains; tau Proteins; Tumor Suppressor Proteins | 2023 |
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer's Disease.
Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; D-Aspartic Acid; Humans; Neurodegenerative Diseases; Phenylalanine; Proline; Tandem Mass Spectrometry | 2023 |
Effective Reduction of Tau Amyloid Aggregates in the Presence of Cyclophilin from
Topics: Allergens; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Cyclophilins; Pollen; Proline; tau Proteins; Urea | 2023 |
Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Brain; Epitopes; Humans; Pick Disease of the Brain; Proline; tau Proteins; Tauopathies | 2023 |
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Models, Molecular; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Proline; Protein Aggregates; Protein Aggregation, Pathological; Protein Structure, Tertiary | 2020 |
Effect of Phosphorylation and O-GlcNAcylation on Proline-Rich Domains of Tau.
Topics: Alzheimer Disease; Brain; Humans; Phosphorylation; Proline; Protein Processing, Post-Translational; tau Proteins | 2020 |
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.
Topics: Adult; Alzheimer Disease; Asian People; Atrophy; Codon; Dementia; Exons; Genetic Association Studies; Genetic Predisposition to Disease; Helix-Loop-Helix Motifs; Humans; Leucine; Magnetic Resonance Imaging; Mutation, Missense; Neuroimaging; Parietal Lobe; Presenilin-1; Proline | 2017 |
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Dicarboxylic Acids; Disease Models, Animal; Early Diagnosis; Glucuronic Acid; Glyoxylates; Humans; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Pentoses; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Starch; Sucrose; Tryptophan | 2017 |
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
Topics: Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Immunologic; Exploratory Behavior; Female; Frontotemporal Dementia; Hepatitis B Vaccines; Immunization; Immunodominant Epitopes; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Proline; Recognition, Psychology; Serine; tau Proteins; Treatment Outcome; Vaccines, Virus-Like Particle | 2018 |
Comparing the effect of the novel ionic cocrystal of lithium salicylate proline (LISPRO) with lithium carbonate and lithium salicylate on memory and behavior in female APPswe/PS1dE9 Alzheimer's mice.
Topics: Alzheimer Disease; Animals; Behavior; Body Weight; Conditioning, Psychological; Fear; Female; Hindlimb Suspension; Lithium Carbonate; Lithium Compounds; Locomotion; Maze Learning; Memory; Mice; Mice, Transgenic; Motor Activity; Proline; Salicylates; Spatial Memory | 2019 |
Colostrinin: a proline-rich polypeptide complex of potential therapeutic interest.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Immunity, Innate; Intercellular Signaling Peptides and Proteins; Mice; Neurites; Peptides; Proline; Psychotropic Drugs; Th1 Cells; Th2 Cells | 2013 |
Plasma phospholipids identify antecedent memory impairment in older adults.
Topics: Aged; Alzheimer Disease; Asparagine; Biomarkers; Carnitine; Cognitive Dysfunction; Cohort Studies; Dipeptides; Female; Humans; Longitudinal Studies; Lysophosphatidylcholines; Malates; Male; Memory Disorders; Metabolome; Neuropsychological Tests; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Proline; Prospective Studies; Sensitivity and Specificity; Sphingomyelins; Ursodeoxycholic Acid | 2014 |
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins | 2014 |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Models, Molecular; Neurons; Neurotoxins; Peptide Fragments; Proline; Protein Multimerization; Protein Stability; Protein Structure, Secondary | 2015 |
Probable novel PSEN2 Pro123Leu mutation in a Chinese Han family of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Asian People; Codon; Diagnostic Imaging; Exons; Genetic Association Studies; Humans; Leucine; Mutation, Missense; Presenilin-2; Proline | 2015 |
Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.
Topics: Alzheimer Disease; Amino Acid Substitution; Animals; Brain; Cell Line; Mice; Mice, Knockout; Molecular Chaperones; Presenilin-1; Proline; Protein Aggregation, Pathological; Protein Folding | 2015 |
Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.
Topics: Acetylation; Alzheimer Disease; Antibodies; Brain; Calpain; Catalysis; Humans; Lysine; Mass Spectrometry; Microtubules; Phosphorylation; Proline; Protein Binding; Protein Domains; Protein Isoforms; Protein Processing, Post-Translational; Proteolysis; Recombinant Proteins; tau Proteins; Tauopathies | 2016 |
A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical.
Topics: Alzheimer Disease; Crystallization; Nootropic Agents; Pharmaceutical Preparations; Piperidines; Proline; X-Ray Diffraction | 2017 |
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
Topics: Alzheimer Disease; Antibodies; Circular Dichroism; Epitopes; Guanidine; Microscopy, Electron, Transmission; Mutation; Phosphorylation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; tau Proteins | 2008 |
Identification of physiological and toxic conformations in Abeta42 aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Magnetic Resonance Spectroscopy; Mutation; PC12 Cells; Peptide Fragments; Proline; Protein Binding; Protein Structure, Secondary; Rats; Reproducibility of Results | 2009 |
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Pathways; Proline; Septum of Brain; Serine; Stilbamidines; tau Proteins; Valine | 2009 |
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Endoplasmic Reticulum, Rough; Female; Humans; Leucine; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Mitochondria; Mutation; Proline; Qa-SNARE Proteins; Receptors, Peptide; Spinal Cord; Subcellular Fractions; tau Proteins | 2009 |
Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1.
Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Calcium; Calcium Channels; Endoplasmic Reticulum; HeLa Cells; Humans; Kinetics; Leucine; Membrane Glycoproteins; Mitochondria; Mutation; Proline | 2010 |
CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Calcium Channels; Case-Control Studies; China; Female; Humans; Leucine; Male; Membrane Glycoproteins; Polymorphism, Genetic; Proline; Risk Factors | 2010 |
CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channels; Female; Gene Frequency; Genes, Recessive; Genotype; Humans; Leucine; Male; Membrane Glycoproteins; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Proline; Spain | 2010 |
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
Topics: Age of Onset; Aged; Alzheimer Disease; Calcium Channels; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Italy; Leucine; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Proline | 2010 |
New insight into mode of action of Colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Apoptosis; Dietary Supplements; Fas Ligand Protein; Humans; Intercellular Signaling Peptides and Proteins; Peptides; Proline | 2010 |
The effects of an ideal beta-turn on beta-2 microglobulin fold stability.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloidosis; beta 2-Microglobulin; Crystallography, X-Ray; Humans; Mutation; Proline; Protein Folding; Protein Stability; Protein Structure, Secondary | 2011 |
Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Nitrosation; Proline; tau Proteins; Tyrosine | 2011 |
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics | 2011 |
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.
Topics: Alzheimer Disease; Humans; Phosphorylation; Point Mutation; Proline; Protein Folding; tau Proteins | 2011 |
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Crystallography, X-Ray; Cysteine; DNA Mutational Analysis; Humans; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Peptide Fragments; Phenylalanine; Point Mutation; Proline | 2012 |
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Frontal Lobe; Hippocampus; Humans; Isomerism; Mice; Mice, Inbred C57BL; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Proline; tau Proteins | 2012 |
Glutathione peroxidase 1 Pro198Leu polymorphism in Brazilian Alzheimer's disease patients: relations to the enzyme activity and to selenium status.
Topics: Aged; Alzheimer Disease; Base Sequence; Brazil; Case-Control Studies; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Selenium | 2012 |
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; NIMA-Interacting Peptidylprolyl Isomerase; Oxidation-Reduction; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Processing, Post-Translational; Proteome; Serine; tau Proteins; Tauopathies | 2013 |
Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications.
Topics: Alzheimer Disease; Brain; Humans; Molecular Targeted Therapy; Neurites; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Signal Transduction; tau Proteins | 2013 |
Comparative vibrational spectroscopy of intracellular tau and extracellular collagen I reveals parallels of gelation and fibrillar structure.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Cattle; Collagen Type I; Gels; Hydrogen Bonding; Microscopy, Electron; Molecular Sequence Data; Proline; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; tau Proteins; Thermodynamics; Vibration; Water | 2004 |
Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid beta peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Blotting, Western; Calcium-Binding Proteins; Caspases; Cell Line, Tumor; Membrane Glycoproteins; Nerve Tissue Proteins; NF-kappa B; Peptide Fragments; Proline; Superoxide Dismutase; Synaptotagmin I; Synaptotagmins; Thiocarbamates; Transcription, Genetic | 2003 |
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Codon; Disease Progression; Female; Gene Expression; Genotype; Humans; Male; Membrane Proteins; Mice; Middle Aged; Mutation, Missense; Neurites; Neuroblastoma; Neurofibrillary Tangles; Neurologic Examination; Pedigree; Phenotype; Presenilin-1; Proline; Serine; Transfection; Tumor Cells, Cultured | 2004 |
Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons.
Topics: Alzheimer Disease; Amidohydrolases; Animals; Antioxidants; Arginine; Brain; Cells, Cultured; Cognition Disorders; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feedback, Physiological; Homocysteine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Proline; Rats; Thiocarbamates; Up-Regulation | 2004 |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Mutagenesis; Peptide Fragments; Proline; Protein Structure, Secondary; Recombinant Proteins | 2004 |
Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Binding Sites; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Estradiol; Estrogen Antagonists; Female; Humans; Male; Neuroblastoma; Neurons; Okadaic Acid; Phosphorylation; Proline; Rats; Tamoxifen; tau Proteins | 2005 |
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Bone Marrow Cells; Circular Dichroism; DNA; DNA, Complementary; Gene Library; Humans; Light; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Parkinson Disease; Peptides; Polymerase Chain Reaction; Proline; Protein Binding; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Scattering, Radiation; Synucleins; Time Factors; Ubiquitin-Protein Ligases; Ultraviolet Rays; Valine | 2005 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Disulfides; DNA Mutational Analysis; Dose-Response Relationship, Drug; Factor XIa; Humans; Inhibitory Concentration 50; Kinetics; Lysine; Models, Molecular; Models, Statistical; Mutation; Partial Thromboplastin Time; Phenylalanine; Plasmids; Point Mutation; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin; Time Factors; Vesicular Transport Proteins | 2005 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy; Glycine; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Thiazoles; Triticum | 2006 |
Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Myogenic Regulatory Factors; Odds Ratio; Peptides; Polymorphism, Genetic; Proline | 2007 |
Proline in the cerebrospinal fluid of normal subjects and Alzheimer's-disease patients, as determined with a new double-labeling assay technique.
Topics: Adult; Aged; Alzheimer Disease; Carbon Radioisotopes; Dementia; Dinitrofluorobenzene; Humans; Isotope Labeling; Middle Aged; Proline; Reference Values; Tritium | 1984 |
Proline-directed and non-proline-directed phosphorylation of PHF-tau.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Molecular Sequence Data; Neurofibrils; Peptide Mapping; Phosphopeptides; Phosphorylation; Proline; Rats; tau Proteins | 1995 |
Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Circular Dichroism; Humans; In Vitro Techniques; Mass Spectrometry; Microscopy, Electron; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Structure-Activity Relationship | 1995 |
Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Glycogen Synthase Kinase 3; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Proline; Serine; tau Proteins | 1993 |
Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Epitopes; Humans; Immunoblotting; Kinetics; Phosphorylation; Proline; Protein Kinase C; Protein Kinases; Substrate Specificity; tau Proteins | 1996 |
Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Dementia; Female; Humans; Huntington Disease; Lewy Bodies; Male; Parkinson Disease; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Tissue Distribution | 1996 |
Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Catalase; Cells, Cultured; Cerebellum; Humans; Neurons; NF-kappa B; Peptide Fragments; Proline; Rats; Rats, Wistar; Thiocarbamates | 1997 |
Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.
Topics: Alzheimer Disease; Animals; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Kinetin; Lithium; Neurons; Okadaic Acid; Phosphorylation; Proline; Purines; Rats; tau Proteins | 1997 |
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cerebellum; Dentate Gyrus; Down Syndrome; Entorhinal Cortex; Female; Hippocampus; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Point Mutation; Poland; Presenilin-1; Proline | 1998 |
A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Humans; Leucine; Membrane Proteins; Mexico; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Presenilin-1; Proline | 1998 |
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apolipoproteins E; Exons; Female; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Proline; Reference Values; Registries; Risk Factors; United States | 1999 |
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Anticoagulants; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Heparin; In Vitro Techniques; Insecta; JNK Mitogen-Activated Protein Kinases; Mass Spectrometry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neurofibrillary Tangles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Signal Transduction; tau Proteins | 2000 |
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Genotype; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2000 |
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Caenorhabditis; Cattle; Cell Line; Drosophila melanogaster; Endopeptidases; Humans; Kinetics; Membrane Proteins; Mice; Molecular Sequence Data; Mutation, Missense; Presenilin-1; Presenilin-2; Proline; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 2001 |
Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Dementia; Genetic Predisposition to Disease; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Mutation; Paraparesis, Spastic; Presenilin-1; Proline | 2002 |
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Binding Sites; Brain; Cattle; Cloning, Molecular; Humans; Microtubules; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Plasmids; Proline; Protein Kinases; Serine; Swine; tau Proteins | 1992 |
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.
Topics: Alzheimer Disease; Amino Acid Sequence; Brain; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Microtubules; Molecular Sequence Data; Mutation; Phosphorylation; Proline; Protein Binding; Protein Kinases; Serine; tau Proteins; Threonine | 1992 |
Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cerebellum; Female; Frontal Lobe; Humans; Male; Organophosphorus Compounds; Peptidyl-Dipeptidase A; Proline; Temporal Lobe; Tritium | 1991 |
Loss of cortical GABA uptake sites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Proline; Receptors, GABA-A | 1988 |