proline has been researched along with Akinetic-Rigid Variant of Huntington Disease in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lindholm, D; Myöhänen, TT; Norrbacka, S | 1 |
| Lashuel, HA; Lemke, EA; Pappu, RV; Ruff, KM; Tan, PS; Warner, JB | 1 |
| André, EA; Braatz, EM; Liu, JP; Zeitlin, SO | 1 |
| Clabough, EB; Neveklovska, M; Steffan, JS; Zeitlin, SO | 1 |
| Agrawal, N; Cattaneo, E; Illes, K; Lukacsovich, T; Marsh, JL; Pallos, J; Pandolfi, PP; Rockabrand, E; Slepko, N; Steffan, JS; Thompson, LM; Trotman, LC; Zhu, YZ | 1 |
| Abraham, C; Bauer, B; Buessow, K; Büssow, K; Coleman, SH; Droege, A; Fritzsche, A; Goehler, H; Gutekunst, CA; Haenig, C; Hasenbank, R; Herbst, M; Knoblich, M; Lalowski, M; Landwehrmeyer, BG; Lehrach, H; Lindenberg, KS; Ludewig, AH; Scherzinger, E; Stelzl, U; Stroedicke, M; Suopanki, J; Waelter, S; Wanker, EE; Worm, U | 1 |
| Baksi, K; Bhattacharyya, NP; Chattopadhyay, B; Mukhopadhyay, S | 1 |
| Akileswaran, L; Coghlan, VM; Manczak, M; Reddy, PH; Sayer, JA | 1 |
| Bertolotti, A; Dehay, B | 1 |
| Kato, Y; Kurita, J; Miyakawa, T; Tanokura, M | 1 |
| Bertolotti, A; Dehay, B; Trottier, Y; Weber, C | 1 |
| Allan, BM; Baird, PA; Hansen, S; MacLeod, PM; Perry, TL; Wright, JM | 1 |
| Blanchard, PJ; Falkous, G; Ishiura, S; Mantle, D; Perry, EK | 1 |
| Bates, GP; Eickhoff, H; Hasenbank, R; Lehrach, H; Scherzinger, E; Sittler, A; Wälter, S; Wanker, EE; Wedemeyer, N | 1 |
| Czudek, C; Reynolds, GP | 1 |
| Diamond, S; Hansen, S; Perry, TL; Stedman, D | 1 |
| Hansen, S; Lesk, D; Perry, TL | 1 |
1 trial(s) available for proline and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Failure of aminooxyacetic acid therapy in Huntington disease.
Topics: Acetates; Adult; Amino Acids; Aminooxyacetic Acid; Double-Blind Method; Female; Humans; Huntington Disease; Hydroxyproline; Isoniazid; Male; Middle Aged; Ornithine; Proline | 1980 |
16 other study(ies) available for proline and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington's disease.
Topics: Acetylcysteine; Biocatalysis; Cell Survival; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Huntingtin Protein; Huntington Disease; Peptides; Proline; Prolyl Oligopeptidases; Proteasome Endopeptidase Complex; Protein Aggregates; Protein Aggregation, Pathological; Serine Endopeptidases; Trinucleotide Repeats | 2019 |
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.
Topics: Exons; Fluorescence Resonance Energy Transfer; Humans; Huntingtin Protein; Huntington Disease; Peptides; Proline; Reproducibility of Results | 2017 |
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
Topics: Animals; Autophagy; Brain; Cells, Cultured; Disease Models, Animal; Gene Knock-In Techniques; Huntingtin Protein; Huntington Disease; Male; Maze Learning; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Peptides; Proline; Protein Domains; Sequence Deletion | 2017 |
Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Behavior, Animal; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Intracellular Space; Mice; Mice, Transgenic; Molecular Sequence Data; Nerve Tissue Proteins; Nuclear Proteins; Phosphorylation; Proline; Proline-Rich Protein Domains; Sequence Deletion | 2012 |
SUMO modification of Huntingtin and Huntington's disease pathology.
Topics: Animals; Animals, Genetically Modified; Cell Line; Cell Nucleus; Corpus Striatum; Cytoplasm; Drosophila; Genes, MDR; HeLa Cells; Humans; Huntingtin Protein; Huntington Disease; Lysine; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Proline; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; SUMO-1 Protein; Transcription, Genetic; Transfection; Ubiquitin | 2004 |
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Cell Cycle Proteins; Chlorocebus aethiops; COS Cells; Glutathione; GTPase-Activating Proteins; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; PC12 Cells; Phosphoproteins; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; RNA Interference; Tissue Distribution; Two-Hybrid System Techniques | 2004 |
Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Arginine; Deoxyribonucleases; Female; Genetic Variation; Genotype; Glucan 1,3-beta-Glucosidase; Humans; Huntington Disease; Lysine; Male; Odds Ratio; Poly-ADP-Ribose Binding Proteins; Polymorphism, Single Nucleotide; Proline; Trinucleotide Repeat Expansion; Tumor Suppressor Protein p53 | 2005 |
Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
Topics: Aged; Animals; Brain; Cell Line; Cell Nucleus; Female; Humans; Huntingtin Protein; Huntington Disease; Male; Mice; Middle Aged; Mutation; Nerve Tissue Proteins; Neurons; Nuclear Matrix; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Peptides; Proline; Protein Binding; Protein Structure, Tertiary; Two-Hybrid System Techniques | 2005 |
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.
Topics: Centrifugation, Density Gradient; Formates; Gene Deletion; Green Fluorescent Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Huntingtin Protein; Huntington Disease; Microscopy, Fluorescence; Molecular Chaperones; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Proline; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sucrose | 2006 |
Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.
Topics: Amino Acid Motifs; Carrier Proteins; Humans; Huntington Disease; Leucine; Ligands; Magnetic Resonance Spectroscopy; Peptides; Proline; Proline-Rich Protein Domains; Protein Structure, Tertiary; Rett Syndrome; Ribonucleoprotein, U1 Small Nuclear; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Tryptophan | 2006 |
Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Dimerization; Epitope Mapping; Humans; Huntingtin Protein; Huntington Disease; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Nuclear Proteins; Proline; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Dementia; Female; Humans; Huntington Disease; Lewy Bodies; Male; Parkinson Disease; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Tissue Distribution | 1996 |
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain Chemistry; Carrier Proteins; COS Cells; Exons; Gene Expression; Glutamine; Humans; Huntingtin Protein; Huntington Disease; Nerve Tissue Proteins; Nuclear Proteins; Peptide Fragments; Precipitin Tests; Proline; Rabbits; Repetitive Sequences, Nucleic Acid; RNA, Messenger; src Homology Domains; Subcellular Fractions; Yeasts | 1998 |
[3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain.
Topics: Aged; Aging; Binding Sites; Brain; Cadaver; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Nipecotic Acids; Postmortem Changes; Proline; Sodium; Tritium | 1990 |
Plasma-aminoacid levels in Huntington's chorea.
Topics: Adult; Alanine; Amino Acids; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine; Valine | 1969 |
[Plasma amino acid levels in children of patients with Huntington's chorea].
Topics: Adolescent; Adult; Alanine; Amino Acids; Child; Child, Preschool; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine | 1972 |