proline has been researched along with Ache in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (27.27) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Plotnikov, DV; Sever'yanova, LА | 1 |
| Cho, HY; Han, HC; Kim, YI; Lee, KS; Park, EH | 1 |
| Cherniakova, IV; Gudasheva, TA; Klodt, PM; Kolik, LG; Konstantinopol'skiĭ, MA; Kudrin, VS | 1 |
| Chen, W; Hu, S; Jiang, GQ; Jiang, X; Wei, J; Xu, GY; Zhang, HH; Zhou, YL; Zhu, H | 1 |
| Alewood, PF; Dekan, Z; Deuis, JR; Durek, T; Hoffmann, T; Lewis, RJ; Nassar, MA; Sousa, SR; Vetter, I; Weidner, C; Wingerd, JS; Winter, Z; Zimmermann, K | 1 |
| Carlton, SM; Du, J; Zhou, S | 1 |
| Feng, Y; Li, H; Shi, J; Sun, ZS; Zhang, J; Zhang, T | 1 |
| Lee, HG; Park, SK; Yoon, MH | 1 |
| Bolli, R; Lieby, P; Maeder, W; Pedrussio, R; Sebald, A; Spycher, M | 1 |
| Brugier, D; Harrison, A; Hough, J; Maw, GN; Newman, J; Otterburn, J; Price, J; Rawson, DJ; Thompson, LR; Turnpenny, P; Warren, AN | 1 |
| Carlton, SM; Du, J; Govea, R; Zhou, S | 1 |
| Chen, YZ; Jiang, CL; Song, LH; Wang, YX | 1 |
| Gamanos, M; Lai, W; Ledeboer, A; Maier, SF; Martin, D; Quan, N; Watkins, LR | 1 |
| Bai, ZT; Chai, ZF; Ji, YH; Jiang, F; Liu, T; Pang, XY | 1 |
| Burden, AC; Samanta, A | 1 |
| Sicuteri, F | 1 |
| Boura, AL; Svolmanis, AP | 1 |
| Beattie, D; Brown, M; Campbell, E; Dickenson, F; Ewan, S; Hughes, GA; Ko, SY; Lemaire, M; Lerpiniere, J; Patel, S; Urban, L; Walpole, C | 1 |
| Nakano, T; Taira, N | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Catalano, M; Libretti, A | 1 |
1 trial(s) available for proline and Ache
| Article | Year |
|---|---|
Captopril for the treatment of patients with hypertension and peripheral vascular disease.
Topics: Aged; Ankle; Arm; Blood Pressure; Capillaries; Captopril; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pain; Proline; Vascular Diseases | 1985 |
21 other study(ies) available for proline and Ache
| Article | Year |
|---|---|
Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects.
Topics: Aggression; Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Oligopeptides; Pain; Proline; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Tranquilizing Agents | 2018 |
Peripheral group II and III metabotropic glutamate receptors in the knee joint attenuate carrageenan-induced nociceptive behavior in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Carrageenan; Hindlimb; Hyperalgesia; Joints; Male; Nociception; Pain; Pain Threshold; Physical Stimulation; Proline; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Weight-Bearing | 2013 |
[Neurotensin NT (8- 13) dipeptide analog dilept increases the pain threshold and decreases the severity of morphine withdrawal syndrome in rats].
Topics: Animals; Dopamine; Frontal Lobe; Hypothalamus; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurotensin; Pain; Pain Threshold; Peptide Fragments; Proline; Rats; Serotonin; Severity of Illness Index; Substance Withdrawal Syndrome; Tyrosine | 2013 |
Enhanced binding capability of nuclear factor-κB with demethylated P2X3 receptor gene contributes to cancer pain in rats.
Topics: Action Potentials; Animals; Antineoplastic Agents; Bone Neoplasms; Case-Control Studies; Disease Models, Animal; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; Methylation; Neurons; NF-kappa B; Nitriles; Pain; Pain Management; Pain Threshold; Proline; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sulfones; Thiocarbamates | 2015 |
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.
Topics: Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetulus; Disease Models, Animal; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; NAV1.7 Voltage-Gated Sodium Channel; Nerve Fibers; Pain; Peptides; Phenyl Ethers; Proline; Saphenous Vein; Scorpion Venoms; Sodium Channel Blockers; Spider Venoms; Sulfonamides | 2016 |
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
Topics: Amino Acids; Animals; Capsaicin; Colforsin; Electrophysiological Phenomena; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; TRPV Cation Channels; Xanthenes | 2009 |
Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity.
Topics: Amino Acids; Analgesics; Animals; Citrates; Dose-Response Relationship, Drug; Freund's Adjuvant; Hyperesthesia; Inflammation; Male; Neuroglia; Pain; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Xanthenes | 2009 |
Potentiation of morphine antiallodynic efficacy by ACPT-III, a group III metabotropic glutamate receptor agonist, in rat spinal nerve ligation-induced neuropathic pain.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Ligation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Nerves; Treatment Outcome | 2010 |
Local tolerance and stability up to 24 months of a new 20% proline-stabilized polyclonal immunoglobulin for subcutaneous administration.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Edema; Erythema; Female; Humans; Hypotension; Immunoenzyme Techniques; Immunoglobulin Fc Fragments; Immunoglobulin G; Injections, Intravenous; Injections, Subcutaneous; Male; Pain; Proline; Protein Multimerization; Rabbits; Rats; Spectrophotometry; Temperature; Time Factors | 2011 |
Part 3: Design and synthesis of proline-derived α2δ ligands.
Topics: Animals; Drug Design; Humans; Inhibitory Concentration 50; Ligands; Molecular Structure; Pain; Proline; Rats; Swine | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Skin; TRPV Cation Channels; Xanthenes | 2011 |
The analgesic domain of interferon-alpha2b contains an essential proline(39) residue.
Topics: Analgesics; Animals; Brain; Glycine; Humans; Interferon alpha-2; Interferon-alpha; Male; Molecular Structure; Mutagenesis, Site-Directed; Pain; Proline; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2002 |
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
Topics: Animals; Antioxidants; Calcium-Binding Proteins; Cell Count; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; HIV Envelope Protein gp120; Immunohistochemistry; In Situ Hybridization; Male; Microfilament Proteins; NF-kappa B; Pain; Pain Measurement; Peptides; Platelet Endothelial Cell Adhesion Molecule-1; Proline; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiocarbamates; Time Factors | 2005 |
Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Pain; Proline; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Scorpion Venoms | 2007 |
Fever, myalgia, and arthralgia in a patient on captopril and allopurinol.
Topics: Aged; Allopurinol; Captopril; Drug Synergism; Fever; Humans; Joint Diseases; Male; Muscular Diseases; Pain; Proline | 1984 |
Enkephalinase inhibition relieves pain syndromes of central dysnociception (migraine and related headache).
Topics: Acute Disease; Adult; Animals; Aprotinin; Bradykinin; Captopril; Drug Therapy, Combination; Ergotamine; Female; Guinea Pigs; Headache; Humans; Hypertension; Male; Mice; Middle Aged; Migraine Disorders; Neprilysin; Pain; Phenylalanine; Proline; Protease Inhibitors | 1981 |
Converting enzyme inhibition in the rat by captopril is accompanied by potentiation of carrageenin-induced inflammation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Carrageenan; Dinoprostone; Drug Synergism; Edema; Inflammation; Male; Pain; Proline; Prostaglandins E; Rats; Rats, Inbred Strains; Time Factors | 1984 |
2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.
Topics: Analgesics; Animals; Aspirin; Binding, Competitive; Brain; Drug Design; Guinea Pigs; Humans; Hyperalgesia; Kinetics; Molecular Structure; Naphthalenes; Neurokinin-1 Receptor Antagonists; Pain; Phenylthiourea; Proline; Rabbits; Rats; Receptors, Neurokinin-1; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship | 1998 |
Potentiation of the algogenic action of bradykinin by an inhibitor of angiotensin I converting enzyme, captopril (SQ 14,225).
Topics: Acetylcholine; Animals; Bradykinin; Captopril; Dogs; Drug Synergism; Female; Femoral Artery; Injections, Intra-Arterial; Male; Mesenteric Arteries; Pain; Peptidyl-Dipeptidase A; Proline; Vocalization, Animal | 1979 |
Modulation of the antinociceptive effect of morphine by casomorphin derivatives.
Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Pain; Phenylalanine; Proline; Stereoisomerism; Structure-Activity Relationship | 1991 |
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan | 1989 |