proglumide has been researched along with Stomach Ulcer in 21 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eleven male and five female gastric ulcer outpatients as well as twenty eight male and seven female duodenal ulcer outpatients received Proglumide (1200 mg/day) or magnesiumtrisilicate (1320 mg/day) in a prospective double blind study." | 9.04 | Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial). ( Kutz, K; Lindstaedt, H; Mayershofer, R; Miederer, SE, 1979) |
| "In a double-blind trial 16 persons with gastric ulcer and 35 with duodenal ulcer were treated as out-patients with 1200 mg proglumide daily or 1320 mg magnesium tricilicate daily (as an "active placebo") for four weeks." | 9.04 | [Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)]. ( Kutz, K; Lindstaedt, H; Miederer, SE; Wuttke, H, 1979) |
| "Eleven male and five female gastric ulcer outpatients as well as twenty eight male and seven female duodenal ulcer outpatients received Proglumide (1200 mg/day) or magnesiumtrisilicate (1320 mg/day) in a prospective double blind study." | 5.04 | Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial). ( Kutz, K; Lindstaedt, H; Mayershofer, R; Miederer, SE, 1979) |
| "In a double-blind trial 16 persons with gastric ulcer and 35 with duodenal ulcer were treated as out-patients with 1200 mg proglumide daily or 1320 mg magnesium tricilicate daily (as an "active placebo") for four weeks." | 5.04 | [Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)]. ( Kutz, K; Lindstaedt, H; Miederer, SE; Wuttke, H, 1979) |
| "Ten patients had a early recurrence (within 2 years); eight had a late one (more than 2 years)." | 2.38 | [Treatment of recurrent ulcers after parietal cell vagotomy. Analysis of 18 cases]. ( Caamano, A; Orsoni, P; Picaud, R; Touchet, J, 1992) |
| "Treatment with camostate or diversion of pancreatic juice that raised plasma CCK level to that observed with administration of CCK-8, also accelerated ulcer healing and this effect was also attenuated by LOX but not by L-365,260." | 1.30 | Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R, 1999) |
| " Omeprazole, which suppresses acid very effectively, may be problematic in the critically ill, limited by its oral dosage form, acid-labile properties, and potential drug interactions." | 1.28 | Controlling gastric pH: the impact of newer agents on the critically ill patient. ( Earnest, DL, 1990) |
| "Cimetidine, which was used as a standard antiulcer drug for comparison, also produced a similar protective effect in most of the models used by us." | 1.27 | Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987) |
| " Administration of aspirin decreased the gastric mucosal hexosamine and induced the onset of ulcer, while administration of proglumide suppressed the gastric lesions in proportion to dosage and correspondingly prevented a decrease of the hexosamine." | 1.26 | The role of gastric mucosal hexosamine in aspirin-induced ulcers. ( Aono, M; Moriga, M; Murakami, M; Uchino, H, 1980) |
| "Pretreatment with proglumide accelerated GP synthesis in the normal glandular stomach and restored the GP decrease caused by fasting." | 1.26 | Effect of proglumide on glycoprotein synthesis in aspirin-induced gastric erosions in rats. ( Iwaki, K; Kimura, K; Sanai, K; Umetsu, T, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (76.19) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lux, G | 1 |
| Rösch, W | 1 |
| Giorgi-Conciato, M | 1 |
| Daniotti, S | 1 |
| Ferrari, PA | 1 |
| Gaetani, M | 1 |
| Petrin, G | 1 |
| Sala, P | 1 |
| Valentini, P | 1 |
| Moriga, M | 2 |
| Aono, M | 2 |
| Murakami, M | 2 |
| Uchino, H | 2 |
| Rehner, M | 1 |
| Asshauer, E | 1 |
| Spina, G | 1 |
| Fox, U | 1 |
| Glässer, AU | 1 |
| Umetsu, T | 1 |
| Kimura, K | 1 |
| Sanai, K | 1 |
| Iwaki, K | 1 |
| Konturek, SJ | 3 |
| Brzozowski, T | 3 |
| Pytko-Polonczyk, J | 1 |
| Drozdowicz, D | 2 |
| Konturek, PC | 2 |
| Kwiecién, S | 2 |
| Pajdo, R | 2 |
| Brzozowska, I | 1 |
| Hahn, EG | 2 |
| Galeone, M | 1 |
| Moise, G | 1 |
| Ferrante, F | 1 |
| Cacioli, D | 1 |
| Casula, PL | 1 |
| Bignamini, AA | 1 |
| Christensen, E | 1 |
| Juhl, E | 1 |
| Tygstrup, N | 1 |
| Miederer, SE | 2 |
| Lindstaedt, H | 2 |
| Kutz, K | 2 |
| Mayershofer, R | 1 |
| Wuttke, H | 1 |
| Touchet, J | 1 |
| Orsoni, P | 1 |
| Caamano, A | 1 |
| Picaud, R | 1 |
| Earnest, DL | 1 |
| Brailski, Kh | 1 |
| Mendizova, A | 1 |
| Dimitrov, B | 1 |
| Vladimirov, B | 1 |
| Koparandova, O | 1 |
| Tariq, M | 1 |
| Parmar, NS | 1 |
| Ageel, AM | 1 |
| Li, JB | 1 |
| Jin, YQ | 1 |
| Ito, M | 2 |
| Tanaka, T | 1 |
| Suzuki, Y | 2 |
| Fujii, A | 1 |
2 reviews available for proglumide and Stomach Ulcer
| Article | Year |
|---|---|
[Conservative treatment of gastric ulcer].
Topics: Aluminum; Antacids; Anti-Ulcer Agents; Benzimidazoles; Carbenoxolone; Domperidone; Gefarnate; Glycyr | 1980 |
[Treatment of recurrent ulcers after parietal cell vagotomy. Analysis of 18 cases].
Topics: Adult; Duodenal Ulcer; Follow-Up Studies; Gastrectomy; Histamine H1 Antagonists; Humans; Proglumide; | 1992 |
5 trials available for proglumide and Stomach Ulcer
| Article | Year |
|---|---|
Efficacy and safety of pirenzepine in peptic ulcer and in non ulcerous gastroduodenal diseases. A multicentre controlled clinical trial.
Topics: Adult; Benzodiazepinones; Carbenoxolone; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Duode | 1982 |
Double-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H2-blocker, cimetidine.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Gastric Ju | 1978 |
Treatment of gastric ulcer. The randomized clinical trials from 1964 to 1974 and their impact.
Topics: Adult; Aged; Antacids; Anti-Ulcer Agents; Carbenoxolone; Clinical Trials as Topic; Double-Blind Meth | 1978 |
Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial).
Topics: Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Glutamine; Humans; Male; Midd | 1979 |
[Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)].
Topics: Adult; Aged; Ambulatory Care; Double-Blind Method; Duodenal Ulcer; Female; Gastric Acidity Determina | 1979 |
14 other studies available for proglumide and Stomach Ulcer
| Article | Year |
|---|---|
The activity of N-acetylglucosamine kinase in rat gastric mucosa.
Topics: Animals; Aspirin; Gastric Mucosa; In Vitro Techniques; Male; Phosphotransferases; Phosphotransferase | 1980 |
[Ulcer therapy with the gastrin receptor antagonist proglumide. Results of the field study].
Topics: Drug Tolerance; Duodenal Ulcer; Gastrins; Glutamine; Humans; Patient Compliance; Proglumide; Recepto | 1981 |
Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat.
Topics: Anesthesia; Animals; Atropine; Cimetidine; Cysteamine; Gastric Acid; Hydrogen-Ion Concentration; Mal | 1982 |
The role of gastric mucosal hexosamine in aspirin-induced ulcers.
Topics: Animals; Aspirin; Gastric Mucosa; Glutamine; Hexosamines; Male; Proglumide; Rats; Stomach Ulcer; Wou | 1980 |
Effect of proglumide on glycoprotein synthesis in aspirin-induced gastric erosions in rats.
Topics: Acetylglucosamine; Animals; Aspirin; Fasting; Gastric Mucosa; Glutamine; Glycoproteins; Male; Proglu | 1980 |
Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspirin; Cholecystokinin; Dose-Response Relationship, | 1995 |
Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat.
Topics: Animals; Capsaicin; Cholecystokinin; Denervation; Dinoprostone; Dopamine Agents; Enzyme Inhibitors; | 1998 |
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Topics: Animals; Cholecystokinin; DNA Replication; Dopamine Agents; Esters; Gabexate; Gastric Mucosa; Gastri | 1999 |
Controlling gastric pH: the impact of newer agents on the critically ill patient.
Topics: Alprostadil; Anti-Ulcer Agents; Critical Care; Gastric Acid; Histamine H2 Antagonists; Humans; Hydro | 1990 |
[Treatment of peptic ulcer using proglumide (Milid)].
Topics: Adult; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Gast | 1989 |
Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats.
Topics: Animals; Cell Survival; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa | 1987 |
[Clinical and experimental studies on the treatment of peptic ulcer with jianwei yuyang tablets].
Topics: Adult; Animals; Duodenal Ulcer; Humans; Male; Medicine, Chinese Traditional; Medicine, East Asian Tr | 1987 |
Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Diterpenes; Gastric Mucosa; Glycoprot | 1986 |
Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Diterpenes; Male; Polyenes; Proglumid | 1985 |