proglumide has been researched along with Schizophrenia in 6 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cholecystokinin (CCK), a neuropeptide which fulfills almost all criteria for neurotransmitter status, has been co-localized with dopamine in midbrain mesolimbic and mesocortical neurons that have been implicated in the pathogenesis of schizophrenia." | 5.06 | Does the cholecystokinin antagonist proglumide possess antipsychotic activity? ( Bunney, BS; Charney, DS; Glazer, WM; Heninger, GR; Innis, RB; Price, LH; Rubin, AL; Sternberg, DE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| White, FJ | 2 |
| Wang, RY | 2 |
| Whiteford, HA | 1 |
| Stedman, TJ | 1 |
| Welham, J | 1 |
| Csernansky, JG | 2 |
| Pond, SM | 1 |
| Hicks, PB | 1 |
| Vinogradov, S | 1 |
| Riney, SJ | 1 |
| Su, K | 1 |
| Bunney, BS | 2 |
| Chiodo, LA | 1 |
| Freeman, AS | 1 |
| Voigt, MM | 1 |
| Innis, RB | 1 |
| Charney, DS | 1 |
| Price, LH | 1 |
| Glazer, WM | 1 |
| Sternberg, DE | 1 |
| Rubin, AL | 1 |
| Heninger, GR | 1 |
3 trials available for proglumide and Schizophrenia
| Article | Year |
|---|---|
Placebo-controlled, double-blind study of the effects of proglumide in the treatment of schizophrenia.
Topics: Adult; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administrat | 1992 |
A preliminary dose-ranging trial of proglumide for the treatment of refractory schizophrenics.
Topics: Antipsychotic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administratio | 1989 |
Does the cholecystokinin antagonist proglumide possess antipsychotic activity?
Topics: Adult; Cholecystokinin; Female; Glutamine; Humans; Pilot Projects; Proglumide; Schizophrenia | 1986 |
3 other studies available for proglumide and Schizophrenia
| Article | Year |
|---|---|
Interactions of cholecystokinin octapeptide and dopamine on nucleus accumbens neurons.
Topics: Animals; Antipsychotic Agents; Dopamine; Drug Interactions; Glutamates; Glutamic Acid; Humans; Male; | 1984 |
Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system.
Topics: Animals; Anorexia Nervosa; Antipsychotic Agents; Apomorphine; Brain; Cholecystokinin; Glutamine; Hum | 1985 |
Interactions of cholecystokinin and dopamine in the nucleus accumbens.
Topics: Animals; Cholecystokinin; Dopamine; Glutamates; Glutamic Acid; Humans; Nucleus Accumbens; Perfusion; | 1985 |