Page last updated: 2024-11-03

proglumide and Pain, Postoperative

proglumide has been researched along with Pain, Postoperative in 5 studies

Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.

Pain, Postoperative: Pain during the period after surgery.

Research Excerpts

ExcerptRelevanceReference
"In patients who reported mild postoperative pain, we evoked a nocebo response, a phenomenon equal but opposite to placebo."2.68Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. ( Amanzio, M; Benedetti, F; Casadio, C; Maggi, G; Oliaro, A, 1997)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benedetti, F2
Amanzio, M2
Maggi, G2
Casadio, C1
Oliaro, A1
Lehmann, KA1
Schlüsener, M1
Arabatsis, P1
Lavigne, GJ1
Hargreaves, KM1
Schmidt, EA1
Dionne, RA1
Pagnoni, B1
Ortalli, G1
Rovati, LC1
Tiengo, M1

Trials

4 trials available for proglumide and Pain, Postoperative

ArticleYear
Potentiation of placebo analgesia by proglumide.
    Lancet (London, England), 1995, Nov-04, Volume: 346, Issue:8984

    Topics: Double-Blind Method; Drug Synergism; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebo

1995
Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide.
    Pain, 1997, Volume: 71, Issue:2

    Topics: Analgesics, Non-Narcotic; Cholecystokinin; Double-Blind Method; Female; Humans; Hyperalgesia; Male;

1997
Failure of proglumide, a cholecystokinin antagonist, to potentiate clinical morphine analgesia. A randomized double-blind postoperative study using patient-controlled analgesia (PCA).
    Anesthesia and analgesia, 1989, Volume: 68, Issue:1

    Topics: Adult; Cholecystokinin; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Syner

1989
Proglumide potentiates morphine analgesia for acute postsurgical pain.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:6

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Synergism; Female; Glutamine; Humans; Male; Molar,

1989

Other Studies

1 other study available for proglumide and Pain, Postoperative

ArticleYear
[Possible potentiation of morphine analgesia by proglumide].
    Minerva anestesiologica, 1988, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Drug Synergism; Drug Therapy, Combination; Female; Glutamine; Humans; Middle Aged

1988