proglumide has been researched along with Duodenal Ulcer in 20 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exogenous cholecystokinin (CCK) is known to effect gastric secretory and motor functions but its physiological role in the control of these functions in healthy subjects and duodenal ulcer (DU) patients is unknown." | 10.17 | Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori. ( Konturek, JW, 1994) |
| "Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU)." | 9.09 | Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, M; Konturek, SJ; Menzel, J; Stoll, R, 2001) |
| "In this study involving 10 young healthy subjects and 10 duodenal ulcer (DU) patients, 500 ml of a standard meal without or with addition of 15% soybean oil was given, and the gastric emptying rate and the pH profile and plasma levels of gastrin, CCK, pancreatic polypeptide (PP), and somatostatin were determined in separate tests with placebo or with antagonism of type-A CCK receptors (loxiglumide, 1200 mg orally)." | 9.07 | Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, SJ; Maczka, M; Stoll, R; Thor, P, 1994) |
| "Eleven male and five female gastric ulcer outpatients as well as twenty eight male and seven female duodenal ulcer outpatients received Proglumide (1200 mg/day) or magnesiumtrisilicate (1320 mg/day) in a prospective double blind study." | 9.04 | Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial). ( Kutz, K; Lindstaedt, H; Mayershofer, R; Miederer, SE, 1979) |
| "In a double-blind trial 16 persons with gastric ulcer and 35 with duodenal ulcer were treated as out-patients with 1200 mg proglumide daily or 1320 mg magnesium tricilicate daily (as an "active placebo") for four weeks." | 9.04 | [Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)]. ( Kutz, K; Lindstaedt, H; Miederer, SE; Wuttke, H, 1979) |
| "Cholecystokinin (CCK) has been implicated in the feedback control of gastric acid secretion in healthy subjects but its contribution to secretory disorders in DU patients has been little examined." | 6.68 | Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients. ( Bielański, W; Domschke, W; Konturek, JW; Konturek, SJ, 1996) |
| "Exogenous cholecystokinin (CCK) is known to effect gastric secretory and motor functions but its physiological role in the control of these functions in healthy subjects and duodenal ulcer (DU) patients is unknown." | 6.17 | Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori. ( Konturek, JW, 1994) |
| "Pretreatment with loxiglumide led to a marked increase in plasma gastrin response to the pH 6." | 5.29 | Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, SJ, 1995) |
| "Cholecystokinin (CCK) has been implicated in the feedback control of gastrin release and gastric acid secretion in healthy subjects." | 5.29 | Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients. ( Domschke, W; Gillessen, A; Konturek, JW; Konturek, SJ, 1995) |
| "Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU)." | 5.09 | Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, M; Konturek, SJ; Menzel, J; Stoll, R, 2001) |
| "In this study involving 10 young healthy subjects and 10 duodenal ulcer (DU) patients, 500 ml of a standard meal without or with addition of 15% soybean oil was given, and the gastric emptying rate and the pH profile and plasma levels of gastrin, CCK, pancreatic polypeptide (PP), and somatostatin were determined in separate tests with placebo or with antagonism of type-A CCK receptors (loxiglumide, 1200 mg orally)." | 5.07 | Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, SJ; Maczka, M; Stoll, R; Thor, P, 1994) |
| "Eleven male and five female gastric ulcer outpatients as well as twenty eight male and seven female duodenal ulcer outpatients received Proglumide (1200 mg/day) or magnesiumtrisilicate (1320 mg/day) in a prospective double blind study." | 5.04 | Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial). ( Kutz, K; Lindstaedt, H; Mayershofer, R; Miederer, SE, 1979) |
| "In a double-blind trial 16 persons with gastric ulcer and 35 with duodenal ulcer were treated as out-patients with 1200 mg proglumide daily or 1320 mg magnesium tricilicate daily (as an "active placebo") for four weeks." | 5.04 | [Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)]. ( Kutz, K; Lindstaedt, H; Miederer, SE; Wuttke, H, 1979) |
| "Cholecystokinin (CCK) has been implicated in the feedback control of gastric acid secretion in healthy subjects but its contribution to secretory disorders in DU patients has been little examined." | 2.68 | Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients. ( Bielański, W; Domschke, W; Konturek, JW; Konturek, SJ, 1996) |
| "Ten patients had a early recurrence (within 2 years); eight had a late one (more than 2 years)." | 2.38 | [Treatment of recurrent ulcers after parietal cell vagotomy. Analysis of 18 cases]. ( Caamano, A; Orsoni, P; Picaud, R; Touchet, J, 1992) |
| "Pretreatment with loxiglumide led to a marked increase in plasma gastrin response to the pH 6." | 1.29 | Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients. ( Domschke, W; Konturek, JW; Konturek, SJ, 1995) |
| "Cholecystokinin (CCK) has been implicated in the feedback control of gastrin release and gastric acid secretion in healthy subjects." | 1.29 | Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients. ( Domschke, W; Gillessen, A; Konturek, JW; Konturek, SJ, 1995) |
| "Cimetidine, which was used as a standard antiulcer drug for comparison, also produced a similar protective effect in most of the models used by us." | 1.27 | Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giorgi-Conciato, M | 1 |
| Daniotti, S | 1 |
| Ferrari, PA | 1 |
| Gaetani, M | 1 |
| Petrin, G | 1 |
| Sala, P | 1 |
| Valentini, P | 1 |
| Rehner, M | 1 |
| Asshauer, E | 1 |
| Galeone, M | 2 |
| Moise, G | 2 |
| Casula, PL | 2 |
| Bignamini, AA | 2 |
| Bergemann, W | 1 |
| Consentius, K | 1 |
| Braun, HE | 1 |
| Hirschmann, H | 1 |
| Marowski, B | 1 |
| Munck, A | 1 |
| Rehs, HU | 1 |
| Stopik, D | 1 |
| Wilke, G | 1 |
| Marletta, F | 1 |
| Catalano, F | 1 |
| Mangiameli, A | 1 |
| Brogna, A | 1 |
| Daniele, S | 1 |
| Scollo, L | 1 |
| Blasi, A | 1 |
| Konturek, JW | 8 |
| Konturek, SJ | 7 |
| Domschke, W | 7 |
| Gillessen, A | 1 |
| Thor, P | 1 |
| Maczka, M | 1 |
| Stoll, R | 3 |
| Bielański, W | 1 |
| Menzel, J | 1 |
| Konturek, M | 1 |
| Ferrante, F | 1 |
| Cacioli, D | 1 |
| Miederer, SE | 2 |
| Lindstaedt, H | 2 |
| Kutz, K | 2 |
| Mayershofer, R | 1 |
| Wuttke, H | 1 |
| Touchet, J | 1 |
| Orsoni, P | 1 |
| Caamano, A | 1 |
| Picaud, R | 1 |
| Brailski, Kh | 1 |
| Mendizova, A | 1 |
| Dimitrov, B | 1 |
| Vladimirov, B | 1 |
| Koparandova, O | 1 |
| Tariq, M | 1 |
| Parmar, NS | 1 |
| Ageel, AM | 1 |
| Li, JB | 1 |
| Jin, YQ | 1 |
3 reviews available for proglumide and Duodenal Ulcer
| Article | Year |
|---|---|
Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Topics: Adult; Anti-Bacterial Agents; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Eating; Gastric Acid; G | 1994 |
Role of cholecystokinin in the control of gastric acid secretion and gastrin release in dogs and healthy and duodenal ulcer subjects.
Topics: Animals; Cholecystokinin; Dogs; Duodenal Ulcer; Gastric Acid; Gastrins; Humans; Proglumide; Receptor | 1993 |
[Treatment of recurrent ulcers after parietal cell vagotomy. Analysis of 18 cases].
Topics: Adult; Duodenal Ulcer; Follow-Up Studies; Gastrectomy; Histamine H1 Antagonists; Humans; Proglumide; | 1992 |
10 trials available for proglumide and Duodenal Ulcer
| Article | Year |
|---|---|
Efficacy and safety of pirenzepine in peptic ulcer and in non ulcerous gastroduodenal diseases. A multicentre controlled clinical trial.
Topics: Adult; Benzodiazepinones; Carbenoxolone; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Duode | 1982 |
[Two-year study on incidence of ulcer recurrence following proglumide therapy. A comparative study].
Topics: Cimetidine; Duodenal Ulcer; Female; Follow-Up Studies; Glutamine; Humans; Male; Middle Aged; Proglum | 1981 |
[Duodenal ulcer - multicenter double-blind study with proglumide].
Topics: Adult; Aged; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Female; Glutamine; Humans; Magnesium | 1981 |
Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Topics: Adult; Anti-Bacterial Agents; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Eating; Gastric Acid; G | 1994 |
Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Gastric Acid; Gastric Emptying; Gastrins; Huma | 1994 |
Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Gastric Acid; Gastric Mucosa; Gastrins; Helicobacter Infecti | 1996 |
Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients.
Topics: Adolescent; Adult; Analysis of Variance; Cholecystokinin; Duodenal Ulcer; Follow-Up Studies; Gastric | 2001 |
Double-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H2-blocker, cimetidine.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Gastric Ju | 1978 |
Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial).
Topics: Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Glutamine; Humans; Male; Midd | 1979 |
[Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)].
Topics: Adult; Aged; Ambulatory Care; Double-Blind Method; Duodenal Ulcer; Female; Gastric Acidity Determina | 1979 |
8 other studies available for proglumide and Duodenal Ulcer
| Article | Year |
|---|---|
[Ulcer therapy with the gastrin receptor antagonist proglumide. Results of the field study].
Topics: Drug Tolerance; Duodenal Ulcer; Gastrins; Glutamine; Humans; Patient Compliance; Proglumide; Recepto | 1981 |
[Effect of acute administration of proglumide on serum gastrin and basal gastric acid secretion in normal subjects and patients with duodenal ulcer].
Topics: Adult; Duodenal Ulcer; Gastric Acid; Gastrins; Glutamine; Humans; Middle Aged; Proglumide | 1981 |
Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.
Topics: Adult; Case-Control Studies; Cholecystokinin; Duodenal Ulcer; Food; Gastric Acid; Gastrins; Hormone | 1995 |
Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Eating; Gastric Acid; Gastrins; Helicobacter Infections; Hel | 1995 |
Endogenous CCK in the control of gastric secretory response to meal in normal subjects and duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Eating; Gastric Acid; Gastric Mucosa; Humans; Hydrogen-Ion C | 1994 |
[Treatment of peptic ulcer using proglumide (Milid)].
Topics: Adult; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Gast | 1989 |
Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats.
Topics: Animals; Cell Survival; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa | 1987 |
[Clinical and experimental studies on the treatment of peptic ulcer with jianwei yuyang tablets].
Topics: Adult; Animals; Duodenal Ulcer; Humans; Male; Medicine, Chinese Traditional; Medicine, East Asian Tr | 1987 |