proglumide has been researched along with Colorectal Neoplasms in 5 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-one patients with advanced colorectal cancer were entered into a randomized controlled trial of treatment with proglumide--a gastrin receptor antagonist." | 9.06 | A pilot randomized control trial of proglumide (a gastrin receptor antagonist) in advanced colorectal cancer. ( Ballantyne, KC; Charnley, RM; Jones, J; Morris, DL, 1990) |
| "The growth-regulating effects of pentagastrin, gastrin and the gastrin-receptor antagonist proglumide were investigated in three established cell lines derived from human colorectal carcinomas in vitro and after transplantation into nude mice." | 7.67 | Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide. ( Crone, C; Eggstein, S; Farthmann, EH; Imdahl, A, 1989) |
| "Forty-one patients with advanced colorectal cancer were entered into a randomized controlled trial of treatment with proglumide--a gastrin receptor antagonist." | 5.06 | A pilot randomized control trial of proglumide (a gastrin receptor antagonist) in advanced colorectal cancer. ( Ballantyne, KC; Charnley, RM; Jones, J; Morris, DL, 1990) |
| "The growth-regulating effects of pentagastrin, gastrin and the gastrin-receptor antagonist proglumide were investigated in three established cell lines derived from human colorectal carcinomas in vitro and after transplantation into nude mice." | 3.67 | Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide. ( Crone, C; Eggstein, S; Farthmann, EH; Imdahl, A, 1989) |
| "Eleven colorectal cancer patients underwent hepatic resection for liver metastasis." | 1.30 | [Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis]. ( Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Kabuto, T; Kameyama, M; Murata, K; Nakano, H; Ohigashi, H; Sasaki, Y; Tsugawa, T; Yasuda, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anand, A | 2 |
| Kameyama, M | 2 |
| Nakamori, S | 1 |
| Imaoka, S | 2 |
| Yasuda, T | 2 |
| Nakano, H | 2 |
| Ohigashi, H | 2 |
| Hiratsuka, M | 2 |
| Sasaki, Y | 2 |
| Kabuto, T | 2 |
| Ishikawa, O | 2 |
| Murata, K | 1 |
| Tsugawa, T | 1 |
| Furukawa, H | 1 |
| Morris, DL | 1 |
| Charnley, RM | 1 |
| Ballantyne, KC | 1 |
| Jones, J | 1 |
| Imdahl, A | 1 |
| Eggstein, S | 1 |
| Crone, C | 1 |
| Farthmann, EH | 1 |
2 trials available for proglumide and Colorectal Neoplasms
| Article | Year |
|---|---|
[Adjuvant chemo-endocrine chemotherapy with gastrin antagonist after resection of liver metastasis in colorectal cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adj | 1994 |
A pilot randomized control trial of proglumide (a gastrin receptor antagonist) in advanced colorectal cancer.
Topics: Adenocarcinoma; Carcinoembryonic Antigen; Colorectal Neoplasms; Humans; Liver Neoplasms; Neoplasm Re | 1990 |
3 other studies available for proglumide and Colorectal Neoplasms
| Article | Year |
|---|---|
Colorectal carcinoma: prognostic significance of gastrin.
Topics: Colorectal Neoplasms; Gastrins; Humans; Indoles; Liver Neoplasms; Predictive Value of Tests; Proglum | 1995 |
[Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Doxoru | 1998 |
Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide.
Topics: Animals; Carcinoembryonic Antigen; Carcinoma; Cell Division; Colorectal Neoplasms; Gastrins; Glutami | 1989 |