proglumide has been researched along with Colonic Neoplasms in 10 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of gastrin, proglumide (a gastrin receptor antagonist), and somatostatin on growth of human colon adenocarcinoma cell lines CX1, X56, and HT29 were examined in two experimental models." | 3.67 | Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. ( Smith, JP; Solomon, TE, 1988) |
| "Proglumide has no obvious effect on the growth of human large intestine carcinoma SW480 cell line, but can inhibit the growth-promoting effect of pentagastrin on large intestine carcinoma cells." | 1.30 | Effects of proglumide, a gastrin receptor antagonist, on human large intestine carcinoma SW480 cell line. ( He, S; He, Y; Shen, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mao, JD | 1 |
| Wu, P | 1 |
| Huang, JX | 1 |
| Wu, J | 1 |
| Yang, G | 1 |
| Shen, K | 1 |
| He, S | 1 |
| He, Y | 1 |
| Mełeń-Mucha, G | 1 |
| Yactayo, S | 1 |
| Patrice, T | 1 |
| Foultier, MT | 1 |
| Berrada, A | 1 |
| Xu, XN | 1 |
| Guo, YS | 1 |
| Baijal, M | 1 |
| Jin, GF | 1 |
| Thompson, JC | 3 |
| Townsend, CM | 3 |
| Singh, P | 3 |
| Schusdziarra, V | 1 |
| Smith, JP | 1 |
| Solomon, TE | 1 |
| Beauchamp, RD | 2 |
| Glass, EJ | 1 |
| Hoosein, NM | 1 |
| Kiener, PA | 1 |
| Curry, RC | 1 |
| Rovati, LC | 1 |
| McGilbra, DK | 1 |
| Brattain, MG | 1 |
| Le, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Innovations for Placental Assessment in Response to Environmental Pollution[NCT02786420] | 199 participants (Actual) | Observational | 2015-10-02 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for proglumide and Colonic Neoplasms
| Article | Year |
|---|---|
Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma.
Topics: Adenocarcinoma; Apoptosis; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; | 2014 |
Effects of proglumide, a gastrin receptor antagonist, on human large intestine carcinoma SW480 cell line.
Topics: Antineoplastic Agents; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Humans; Proglumide; Receptor | 1998 |
Effects of short term treatment with pentagastrin, proglumide, tamoxifen given separately or together with 5-fluorouracil on the growth in the murine transplantable Colon 38 cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bromodeoxyuridine; Cell Division | 2001 |
[Effect of gastrin and enprostil, a PGE2 analog, on colonic cancerous cell growth].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Combinations; Enprostil; Gastri | 1991 |
Growth-promoting effects of gastrin on mouse colon cancer cells in vitro: absence of autocrine effects.
Topics: Animals; Antibodies; Benzamides; Cell Cycle; Cell Division; Colonic Neoplasms; Gastrins; Growth Subs | 1990 |
[Gastrointestinal hormones and cancers of the gastrointestinal tract].
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line; Colonic Neoplasms; DNA Replication; Gastrins; Glu | 1989 |
Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Gastrins; Glutamine; Humans; M | 1988 |
Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Cell Line; Colon; Colonic Neoplasms; Gastric Fu | 1985 |
Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines.
Topics: Antibodies; Benzamides; Carcinoembryonic Antigen; Cell Division; Cell Line; Colonic Neoplasms; Gastr | 1988 |
Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon tumor in vivo by proglumide, a gastrin receptor antagonist.
Topics: Animals; Colon; Colonic Neoplasms; Gastrins; Glutamine; Male; Mice; Pentagastrin; Proglumide; Recept | 1987 |