proglumide has been researched along with Chronic Disease in 5 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated." | 9.10 | Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002) |
| "The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain." | 9.08 | The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998) |
| "The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated." | 5.10 | Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002) |
| "The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain." | 5.08 | The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998) |
| "Two murine models were used to determine whether CCK receptor blockade with proglumide could prevent and reverse histologic and biochemical features of chronic pancreatitis: the 6-week repetitive chronic cerulein injection model and the modified 75% choline-deficient ethionine (CDE) diet." | 3.96 | Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis. ( Cao, H; Ciofoaia, V; Kallakury, B; Nadella, S; Smith, JP; Tucker, RD, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nadella, S | 1 |
| Ciofoaia, V | 1 |
| Cao, H | 1 |
| Kallakury, B | 1 |
| Tucker, RD | 1 |
| Smith, JP | 1 |
| Shiratori, K | 1 |
| Takeuchi, T | 1 |
| Satake, K | 1 |
| Matsuno, S | 1 |
| McCleane, GJ | 2 |
| Brailski, Kh | 1 |
| Mendizova, A | 1 |
| Dimitrov, B | 1 |
| Vladimirov, B | 1 |
| Koparandova, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1/2 Trial to Test the Safety of a CCK Receptor Antagonist, Proglumide, in Management of Chronic Pancreatitis Symptoms and Pain for 12 to 24 Months[NCT05551858] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2022-11-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for proglumide and Chronic Disease
| Article | Year |
|---|---|
Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan.
Topics: Acute Disease; Administration, Oral; Adult; Amylases; Chronic Disease; Female; Hormone Antagonists; | 2002 |
The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cholecystokinin; Chronic Disease; Cross-Over Stu | 1998 |
3 other studies available for proglumide and Chronic Disease
| Article | Year |
|---|---|
Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis.
Topics: Animals; Ceruletide; Chronic Disease; Disease Models, Animal; Fibrosis; Inflammation; Lipase; Mice; | 2020 |
The cholecystokinin antagonist proglumide has an analgesic effect in chronic pancreatitis.
Topics: Adult; Analgesia; Cholecystokinin; Chronic Disease; Humans; Male; Pancreas; Pancreatitis; Proglumide | 2000 |
[Treatment of peptic ulcer using proglumide (Milid)].
Topics: Adult; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Gast | 1989 |