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proglumide and Cancer of Stomach

proglumide has been researched along with Cancer of Stomach in 4 studies

Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.

Research Excerpts

ExcerptRelevanceReference
" To evaluate the involvement of this hormone in the proliferation of gastric tumors, we studied the effects of gastrin/CCK-receptor antagonists (L365,260 and L364,718), proglumide and C terminal-specific gastrin antibodies on the human gastric adenocarcinoma cell line HGT-1."3.68Evidence for autocrine growth stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line. ( Bali, JP; Chevillard, C; Laboisse, C; Laliberté, MF; Nonotte, I; Perrier-Meissonnier, S; Remy-Heintz, N, 1993)
"Treatment with proglumide and NS-398 significantly reduced the bcl-2 mRNA and protein expression in the MKN-45 cells (P < 0."1.33[Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell]. ( Cheng, YL; Ding, GX; Shao, Y; Su, H; Sun, WH; Xu, HC; Xue, YP; Zhang, LJ; Zhang, T, 2006)
"MKN45 gastric cancer cell line was cultured and the effects on gastrin and gastrin receptor antagonist proglumide proliferative rate, cell dynamic cycle distribution and the concentration of cAMP in the cells were observed in vitro."1.30[The action of proglumide blocking gastrin on gastric cancer cells]. ( Hou, L; Ni, Q; Wang, H; Yue, Z; Zhang, Q; Zhang, Y, 1999)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, WH1
Su, H1
Zhang, LJ1
Shao, Y1
Xu, HC1
Zhang, T1
Xue, YP1
Ding, GX1
Cheng, YL1
Remy-Heintz, N1
Perrier-Meissonnier, S1
Nonotte, I1
Laliberté, MF1
Chevillard, C1
Laboisse, C1
Bali, JP1
Wang, H1
Ni, Q1
Zhang, Y1
Yue, Z1
Zhang, Q1
Hou, L1
Harrison, JD1
Jones, JA1
Morris, DL1

Trials

1 trial available for proglumide and Cancer of Stomach

ArticleYear
The effect of the gastrin receptor antagonist proglumide on survival in gastric carcinoma.
    Cancer, 1990, Oct-01, Volume: 66, Issue:7

    Topics: Aged; Female; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pr

1990

Other Studies

3 other studies available for proglumide and Cancer of Stomach

ArticleYear
[Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell].
    Zhonghua yi xue za zhi, 2006, Jan-24, Volume: 86, Issue:4

    Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2

2006
Evidence for autocrine growth stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line.
    Molecular and cellular endocrinology, 1993, Volume: 93, Issue:1

    Topics: Adenocarcinoma; Antibodies; Benzodiazepinones; Cell Division; Devazepide; Gastrins; Growth Substance

1993
[The action of proglumide blocking gastrin on gastric cancer cells].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1999, Volume: 37, Issue:6

    Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Drug Antagonism; Gastrins; Humans; Pro

1999