proglumide has been researched along with Cancer of Stomach in 4 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To evaluate the involvement of this hormone in the proliferation of gastric tumors, we studied the effects of gastrin/CCK-receptor antagonists (L365,260 and L364,718), proglumide and C terminal-specific gastrin antibodies on the human gastric adenocarcinoma cell line HGT-1." | 3.68 | Evidence for autocrine growth stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line. ( Bali, JP; Chevillard, C; Laboisse, C; Laliberté, MF; Nonotte, I; Perrier-Meissonnier, S; Remy-Heintz, N, 1993) |
| "Treatment with proglumide and NS-398 significantly reduced the bcl-2 mRNA and protein expression in the MKN-45 cells (P < 0." | 1.33 | [Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell]. ( Cheng, YL; Ding, GX; Shao, Y; Su, H; Sun, WH; Xu, HC; Xue, YP; Zhang, LJ; Zhang, T, 2006) |
| "MKN45 gastric cancer cell line was cultured and the effects on gastrin and gastrin receptor antagonist proglumide proliferative rate, cell dynamic cycle distribution and the concentration of cAMP in the cells were observed in vitro." | 1.30 | [The action of proglumide blocking gastrin on gastric cancer cells]. ( Hou, L; Ni, Q; Wang, H; Yue, Z; Zhang, Q; Zhang, Y, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, WH | 1 |
| Su, H | 1 |
| Zhang, LJ | 1 |
| Shao, Y | 1 |
| Xu, HC | 1 |
| Zhang, T | 1 |
| Xue, YP | 1 |
| Ding, GX | 1 |
| Cheng, YL | 1 |
| Remy-Heintz, N | 1 |
| Perrier-Meissonnier, S | 1 |
| Nonotte, I | 1 |
| Laliberté, MF | 1 |
| Chevillard, C | 1 |
| Laboisse, C | 1 |
| Bali, JP | 1 |
| Wang, H | 1 |
| Ni, Q | 1 |
| Zhang, Y | 1 |
| Yue, Z | 1 |
| Zhang, Q | 1 |
| Hou, L | 1 |
| Harrison, JD | 1 |
| Jones, JA | 1 |
| Morris, DL | 1 |
1 trial available for proglumide and Cancer of Stomach
| Article | Year |
|---|---|
The effect of the gastrin receptor antagonist proglumide on survival in gastric carcinoma.
Topics: Aged; Female; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pr | 1990 |
3 other studies available for proglumide and Cancer of Stomach
| Article | Year |
|---|---|
[Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell].
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2 | 2006 |
Evidence for autocrine growth stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line.
Topics: Adenocarcinoma; Antibodies; Benzodiazepinones; Cell Division; Devazepide; Gastrins; Growth Substance | 1993 |
[The action of proglumide blocking gastrin on gastric cancer cells].
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Drug Antagonism; Gastrins; Humans; Pro | 1999 |