proglumetacin has been researched along with Rheumatoid Arthritis in 19 studies
proglumetacin : A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty out-patients with acute 'flare' of chronic rheumatoid arthritis were treated orally with either 150 mg proglumetacin or 250 mg naproxen twice daily over 3 weeks, according to a randomized, double-blind design." | 9.05 | Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients. ( da Costa, JT; da Silva, JP; Espŕito Santo, J; Gomes, JM; Queiroz, MV, 1983) |
| "A double-blind clinical trial was carried out on 2 parallel groups each of 20 in-and out-patients with classical or definite rheumatoid arthritis, to compare the efficacy and tolerance of proglumetacin, a new non-steroidal anti-inflammatory drug, with naproxen." | 9.05 | A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis. ( Bozsoky, S; Zahumenszky, Z, 1982) |
| "The efficacy of proglumetacin , a new non-steroidal antiinflammatory drug, was assessed in 32 patients with rheumatoid arthritis." | 7.67 | [Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis]. ( Lignière, GC; Murelli, M, 1984) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 7.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III." | 7.66 | [Proglumetacine in rheumatoid arthritis]. ( Boccassini, L; Caruso, I; Fumagalli, M; Greco, M; Montrone, F, 1983) |
| "Forty out-patients with acute 'flare' of chronic rheumatoid arthritis were treated orally with either 150 mg proglumetacin or 250 mg naproxen twice daily over 3 weeks, according to a randomized, double-blind design." | 5.05 | Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients. ( da Costa, JT; da Silva, JP; Espŕito Santo, J; Gomes, JM; Queiroz, MV, 1983) |
| "A double-blind clinical trial was carried out on 2 parallel groups each of 20 in-and out-patients with classical or definite rheumatoid arthritis, to compare the efficacy and tolerance of proglumetacin, a new non-steroidal anti-inflammatory drug, with naproxen." | 5.05 | A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis. ( Bozsoky, S; Zahumenszky, Z, 1982) |
| "The efficacy of proglumetacin , a new non-steroidal antiinflammatory drug, was assessed in 32 patients with rheumatoid arthritis." | 3.67 | [Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis]. ( Lignière, GC; Murelli, M, 1984) |
| "Fifty-five patients with osteoarthritis, rheumatoid arthritis or spondyloarthritis, joint pain and other rheumatic-inflammatory disorders were treated with proglumetacin, at different doses, during 3-60 days." | 3.66 | [Proglumetacin: a flexible and broad-spectrum antirheumatic agent]. ( Fontanesi, G; Giancecchi, F; Rotini, R; Tartaglia, I, 1983) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 3.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III." | 3.66 | [Proglumetacine in rheumatoid arthritis]. ( Boccassini, L; Caruso, I; Fumagalli, M; Greco, M; Montrone, F, 1983) |
| "Twenty-nine patients with gouty arthritis, rheumatoid arthritis and osteoarthritis were treated as outpatients with proglumetacin, at different doses, during 5-30 days." | 3.66 | [Proglumetacin for a wide spectrum of activity in clinical medicine]. ( Fossaluzza, V, 1983) |
| "Proglumetacin was well-tolerated by all patients." | 1.26 | Proglumetacin (protacine): a promising new treatment of the rheumatic joint. ( Rivera, IC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pellegrini, P | 1 |
| Cervi, G | 1 |
| Corcione, S | 1 |
| Espŕito Santo, J | 1 |
| da Silva, JP | 1 |
| da Costa, JT | 1 |
| Gomes, JM | 1 |
| Queiroz, MV | 1 |
| Grosse-Kielisch, C | 1 |
| Bach, GL | 1 |
| Fontanesi, G | 1 |
| Giancecchi, F | 1 |
| Rotini, R | 1 |
| Tartaglia, I | 1 |
| König, B | 1 |
| Pauri, A | 1 |
| Paolinelli, E | 1 |
| Murelli, M | 1 |
| Lignière, GC | 1 |
| Tonon, R | 1 |
| Simioni, M | 1 |
| Lazzarin, P | 1 |
| Bedendo, A | 1 |
| Todesco, S | 1 |
| Bozsóky, S | 2 |
| Zahumenszky, Z | 2 |
| Montrone, F | 1 |
| Fumagalli, M | 1 |
| Boccassini, L | 1 |
| Greco, M | 1 |
| Caruso, I | 1 |
| Fossaluzza, V | 1 |
| Larosa, F | 1 |
| Vittore, D | 1 |
| Mazzarisi, A | 1 |
| Molfetta, L | 1 |
| Rivera, IC | 1 |
| Loizzi, P | 1 |
| Pipitone, V | 1 |
| Bignamini, AA | 1 |
| Manero Guardiola, F | 1 |
| Chillon, F | 1 |
| Rodriguez de Guzman, F | 1 |
| Arias Vallejo, E | 1 |
| Marcos Sánchez, F | 1 |
| Parrilla Herranz, P | 1 |
| Veitia Fernández, R | 1 |
| Arranz Nieto, MJ | 1 |
| Durán Pérez-Navarro, A | 1 |
| Cianfanelli, M | 1 |
| Fiermonte, MA | 1 |
| Fiore, D | 1 |
| Dardano, B | 1 |
| Michela Zucco, FR | 1 |
7 trials available for proglumetacin and Rheumatoid Arthritis
| Article | Year |
|---|---|
[Clinical study of patients with primary polyarthritis. Cross-over comparative study of proglumetacin and naproxen].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; | 1983 |
Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoi | 1983 |
[Treatment of chronic polyarthritis. Double-blind study with proglumetacin compared to diclofenac].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double | 1983 |
Double-blind clinical trial of protacine versus oxyphenbutazone in rheumatic disorders.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoi | 1980 |
A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1982 |
[Proglumetacin in the treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Ind | 1989 |
[Clinical evaluation of proglumetacin malate in rheumatoid arthritis--a multi-institutional cooperative study].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1986 |
12 other studies available for proglumetacin and Rheumatoid Arthritis
| Article | Year |
|---|---|
[Proglumetacin: a flexible and broad-spectrum antirheumatic agent].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Drug Evaluation; Drug Tolerance; Female; Huma | 1983 |
[Therapy of rheumatoid polyarthritis. A year's experience with proglumetacin].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Fema | 1983 |
[Chiromorphoergometry and chirophotogrammetry in monitoring non-steroid anti-inflammatory agents].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Female; Hand; Humans; | 1983 |
[Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Tolerance; Female; Headache; Humans; Indoleacetic Acids; Ma | 1984 |
[Proglumetacin for the treatment of inflammatory and degenerative arthropathies].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Tolerance; Female; Humans; Indoleacetic Acids; Joint Diseas | 1984 |
Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indoleacetic Acids; Ma | 1983 |
[Proglumetacine in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Tolerance; Female; Humans; Indoleacetic Ac | 1983 |
[Proglumetacin for a wide spectrum of activity in clinical medicine].
Topics: Adult; Aged; Arthritis, Rheumatoid; Diabetes Complications; Drug Tolerance; Female; Gout; Humans; In | 1983 |
[Joint pain crises and chronic inflammatory-reactive phenomena: a unitary approach with proglumetacin].
Topics: Acute Disease; Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Tolerance; Female; Humans; | 1983 |
Proglumetacin (protacine): a promising new treatment of the rheumatic joint.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indoleacetic Acids; Jo | 1982 |
Open evaluation of the efficacy and endoscopic gastric tolerance of proglumetacin in chronic rheumatic in-patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Drug Tole | 1982 |
[Proglumetacin in the treatment of rheumatoid arthritis and arthrosis].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rh | 1988 |