proglumetacin has been researched along with Inflammation in 2 studies
proglumetacin : A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats." | 7.67 | Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1987) |
| "The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats." | 3.67 | Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ono, N | 2 |
| Sunami, A | 2 |
| Yamasaki, Y | 2 |
| Yamamoto, N | 2 |
| Miyake, H | 2 |
2 other studies available for proglumetacin and Inflammation
| Article | Year |
|---|---|
Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Dinoprostone; | 1987 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Capillary Permeability; Carrageenan; Ed | 1986 |