proglumetacin has been researched along with Arthritis, Rheumatoid in 19 studies
proglumetacin : A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty out-patients with acute 'flare' of chronic rheumatoid arthritis were treated orally with either 150 mg proglumetacin or 250 mg naproxen twice daily over 3 weeks, according to a randomized, double-blind design." | 9.05 | Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients. ( da Costa, JT; da Silva, JP; Espŕito Santo, J; Gomes, JM; Queiroz, MV, 1983) |
| "A double-blind clinical trial was carried out on 2 parallel groups each of 20 in-and out-patients with classical or definite rheumatoid arthritis, to compare the efficacy and tolerance of proglumetacin, a new non-steroidal anti-inflammatory drug, with naproxen." | 9.05 | A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis. ( Bozsoky, S; Zahumenszky, Z, 1982) |
| "The efficacy of proglumetacin , a new non-steroidal antiinflammatory drug, was assessed in 32 patients with rheumatoid arthritis." | 7.67 | [Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis]. ( Lignière, GC; Murelli, M, 1984) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 7.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III." | 7.66 | [Proglumetacine in rheumatoid arthritis]. ( Boccassini, L; Caruso, I; Fumagalli, M; Greco, M; Montrone, F, 1983) |
| "Forty out-patients with acute 'flare' of chronic rheumatoid arthritis were treated orally with either 150 mg proglumetacin or 250 mg naproxen twice daily over 3 weeks, according to a randomized, double-blind design." | 5.05 | Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients. ( da Costa, JT; da Silva, JP; Espŕito Santo, J; Gomes, JM; Queiroz, MV, 1983) |
| "A double-blind clinical trial was carried out on 2 parallel groups each of 20 in-and out-patients with classical or definite rheumatoid arthritis, to compare the efficacy and tolerance of proglumetacin, a new non-steroidal anti-inflammatory drug, with naproxen." | 5.05 | A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis. ( Bozsoky, S; Zahumenszky, Z, 1982) |
| "The efficacy of proglumetacin , a new non-steroidal antiinflammatory drug, was assessed in 32 patients with rheumatoid arthritis." | 3.67 | [Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis]. ( Lignière, GC; Murelli, M, 1984) |
| "Fifty-five patients with osteoarthritis, rheumatoid arthritis or spondyloarthritis, joint pain and other rheumatic-inflammatory disorders were treated with proglumetacin, at different doses, during 3-60 days." | 3.66 | [Proglumetacin: a flexible and broad-spectrum antirheumatic agent]. ( Fontanesi, G; Giancecchi, F; Rotini, R; Tartaglia, I, 1983) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 3.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III." | 3.66 | [Proglumetacine in rheumatoid arthritis]. ( Boccassini, L; Caruso, I; Fumagalli, M; Greco, M; Montrone, F, 1983) |
| "Twenty-nine patients with gouty arthritis, rheumatoid arthritis and osteoarthritis were treated as outpatients with proglumetacin, at different doses, during 5-30 days." | 3.66 | [Proglumetacin for a wide spectrum of activity in clinical medicine]. ( Fossaluzza, V, 1983) |
| "Proglumetacin was well-tolerated by all patients." | 1.26 | Proglumetacin (protacine): a promising new treatment of the rheumatic joint. ( Rivera, IC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pellegrini, P | 1 |
| Cervi, G | 1 |
| Corcione, S | 1 |
| Espŕito Santo, J | 1 |
| da Silva, JP | 1 |
| da Costa, JT | 1 |
| Gomes, JM | 1 |
| Queiroz, MV | 1 |
| Grosse-Kielisch, C | 1 |
| Bach, GL | 1 |
| Fontanesi, G | 1 |
| Giancecchi, F | 1 |
| Rotini, R | 1 |
| Tartaglia, I | 1 |
| König, B | 1 |
| Pauri, A | 1 |
| Paolinelli, E | 1 |
| Murelli, M | 1 |
| Lignière, GC | 1 |
| Tonon, R | 1 |
| Simioni, M | 1 |
| Lazzarin, P | 1 |
| Bedendo, A | 1 |
| Todesco, S | 1 |
| Bozsóky, S | 2 |
| Zahumenszky, Z | 2 |
| Montrone, F | 1 |
| Fumagalli, M | 1 |
| Boccassini, L | 1 |
| Greco, M | 1 |
| Caruso, I | 1 |
| Fossaluzza, V | 1 |
| Larosa, F | 1 |
| Vittore, D | 1 |
| Mazzarisi, A | 1 |
| Molfetta, L | 1 |
| Rivera, IC | 1 |
| Loizzi, P | 1 |
| Pipitone, V | 1 |
| Bignamini, AA | 1 |
| Manero Guardiola, F | 1 |
| Chillon, F | 1 |
| Rodriguez de Guzman, F | 1 |
| Arias Vallejo, E | 1 |
| Marcos Sánchez, F | 1 |
| Parrilla Herranz, P | 1 |
| Veitia Fernández, R | 1 |
| Arranz Nieto, MJ | 1 |
| Durán Pérez-Navarro, A | 1 |
| Cianfanelli, M | 1 |
| Fiermonte, MA | 1 |
| Fiore, D | 1 |
| Dardano, B | 1 |
| Michela Zucco, FR | 1 |
7 trials available for proglumetacin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Clinical study of patients with primary polyarthritis. Cross-over comparative study of proglumetacin and naproxen].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; | 1983 |
Double-blind evaluation of low-dose proglumetacin versus naproxen in rheumatoid arthritis out-patients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoi | 1983 |
[Treatment of chronic polyarthritis. Double-blind study with proglumetacin compared to diclofenac].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double | 1983 |
Double-blind clinical trial of protacine versus oxyphenbutazone in rheumatic disorders.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoi | 1980 |
A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1982 |
[Proglumetacin in the treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Ind | 1989 |
[Clinical evaluation of proglumetacin malate in rheumatoid arthritis--a multi-institutional cooperative study].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1986 |
12 other studies available for proglumetacin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Proglumetacin: a flexible and broad-spectrum antirheumatic agent].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Drug Evaluation; Drug Tolerance; Female; Huma | 1983 |
[Therapy of rheumatoid polyarthritis. A year's experience with proglumetacin].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Fema | 1983 |
[Chiromorphoergometry and chirophotogrammetry in monitoring non-steroid anti-inflammatory agents].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Female; Hand; Humans; | 1983 |
[Tolerance and efficacy of proglumetacine in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Tolerance; Female; Headache; Humans; Indoleacetic Acids; Ma | 1984 |
[Proglumetacin for the treatment of inflammatory and degenerative arthropathies].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Tolerance; Female; Humans; Indoleacetic Acids; Joint Diseas | 1984 |
Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indoleacetic Acids; Ma | 1983 |
[Proglumetacine in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Tolerance; Female; Humans; Indoleacetic Ac | 1983 |
[Proglumetacin for a wide spectrum of activity in clinical medicine].
Topics: Adult; Aged; Arthritis, Rheumatoid; Diabetes Complications; Drug Tolerance; Female; Gout; Humans; In | 1983 |
[Joint pain crises and chronic inflammatory-reactive phenomena: a unitary approach with proglumetacin].
Topics: Acute Disease; Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Tolerance; Female; Humans; | 1983 |
Proglumetacin (protacine): a promising new treatment of the rheumatic joint.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indoleacetic Acids; Jo | 1982 |
Open evaluation of the efficacy and endoscopic gastric tolerance of proglumetacin in chronic rheumatic in-patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Drug Tole | 1982 |
[Proglumetacin in the treatment of rheumatoid arthritis and arthrosis].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rh | 1988 |