prodigiosin and Chronic-Disease

The efficiency of the Soviet prodigiozan in therapy of chronic non-specific diseases of the lungs (18 cases with bronchial asthma and 26 cases with chronic pneumonia of the 1st and 2nd stages) in the phase of exacerbation was studied. The results of the treatment were estimated by the clinico-roentgenological pictures. The effect of prodigiozan on breathing and the functional state of the adrenal gland was studied in particular. Satisfactory results were obtained in the patients suffering from chronic pneumonia of the 1st and 2nd stages without clinical signs of the bronchial tree affection and in the patients with infection-allergic forms of bronchial asthma. Modest results were observed in the patients suffering from chronic pneumonia of the 1st and 2nd stages with the bronchial tree affection, especially when exacerbated by the asthma syndrome. In some patients the results of the treatment with prodigiozan were not stable. Prodigiozan improved the bronchial permeability, stimulated the sympatho-adrenal system and had no effect on the adrenal cortex.

Topics: 11-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Asthma; Chronic Disease; Clinical Trials as Topic; Epinephrine; Follow-Up Studies; Humans; Hypersensitivity; Lung Diseases; Norepinephrine; Pneumonia; Prodigiosin; Respiratory Function Tests; Time Factors

136 patients suffering from chronic cholecystitis were treated in the phase of exacerbation with antibiotics in combination with prodigiosan. It was found that inclusion of prodigiosan into the therapeutic complex had a positive effect on the immediate and late results of the treatment. Since intramuscular administration of prodigiosan was accompanied by a number of side effects, a method of the drug administration by means of electrophoresis on the area of the bile bladder was tested. It was shown that prodigiosan administered by the method of electrophoresis totally preserved its stimulating capacity with respect to the host. As with intramuscular administration of prodigiosan, the general reaction of the host and positive dynamics of the clinical and laboratory indices of the active process were observed and the content of lysozyme in the blood phagocytes reliably increased. The method of prodigiosan administration by means of electrophoresis was better tolerated by the patients and no side effects characteristic of the drug intramuscular administration were noted. When indicated, the use of prodigiosan by means of electrophoresis is recommended.

Topics: Adult; Chloramphenicol; Cholecystitis; Chronic Disease; Drug Therapy, Combination; Female; Gallbladder; Humans; Injections, Intramuscular; Iontophoresis; Male; Middle Aged; Prodigiosin

Treatment of 188 patients suffering from chronic osteomyelitis of various etiology and localization with prodigiosan, a bacterial lipopolysaccharide favoured an increase in the nonspecific immunobiological reactivity: the phagocytic activity and leucocytic intensity increased, the average titers of iso- and heteroagglutinins, as well as the complementary activity of the serum became higher. The results of the clinico-laboratory studies are indicative of advisable use of prodigiosan in complex therapy of cases with chronic osteomyelitis.

Topics: Adult; Agglutinins; Antibodies, Heterophile; Antigen-Antibody Reactions; Chronic Disease; Complement System Proteins; Female; Humans; Injections, Intramuscular; Isoantibodies; Male; Middle Aged; Osteomyelitis; Postoperative Care; Preoperative Care; Prodigiosin

Topics: Carbenicillin; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Muramidase; Prodigiosin; Proteus Infections; Skin Ulcer

Topics: Adolescent; Adult; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Immunotherapy; Middle Aged; Oleandomycin; Pelvic Inflammatory Disease; Prodigiosin; Tetracycline; Trichomonas Infections; Urethritis; Uterine Cervicitis

Topics: Adult; Alanine Transaminase; Anti-Bacterial Agents; Aspartate Aminotransferases; Chronic Disease; Eczema; Female; Humans; Liver; Male; Middle Aged; Prodigiosin; Uracil

Topics: Anti-Bacterial Agents; Bile; Cholecystitis; Chronic Disease; Complement System Proteins; Humans; Muramidase; Polysaccharides, Bacterial; Prodigiosin; Serratia marcescens

Topics: Adult; Aged; Anti-Bacterial Agents; Chronic Disease; Humans; Middle Aged; Pigments, Biological; Pneumonia; Prodigiosin; Pyrroles; Respiration

Topics: Adult; Anti-Bacterial Agents; Ascorbic Acid; Brucellosis; Chronic Disease; Drug Hypersensitivity; Female; Humans; Immunotherapy; Male; Middle Aged; Muramidase; Oleandomycin; Phagocytosis; Physical Therapy Modalities; Pigments, Biological; Prodigiosin; Pyrroles; Serratia marcescens; Stimulation, Chemical; Tetracycline; Vitamins