prodigiosin and Candidiasis--Oral

The effect of various doses of prodigiozan on Candida infection was studied under experimental and clinical conditions. Hamsters and guinea pigs were used in the experiments. Prodigiozan was administered intramuscularly to the hamsters in doses of 100 gamma/kg of the body weight 1 hour before the infection and intracutaneously to the guinea pigs in doses of 50 gamma/kg 2 days before the infection. The results showed that the drug accelerated the recovery of the animals. In complex therapy of a group of 22 patients with candidosis of the mouth mucosa of various localization prodigiozan was administered thrice in doses of 50 gamma/kg. This provided faster elimination of the pathological process.

Topics: Animals; Candida; Candidiasis, Oral; Clinical Trials as Topic; Cricetinae; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Guinea Pigs; Humans; Injections, Intramuscular; Male; Mouth Mucosa; Prodigiosin; Time Factors